于烨，男，1977年11月出生，理学博士，现任上海交通大学医学院医学科学研究院研究员,蛋白质结构与功能研究组组长。1997-2001，湖南农业大学理学院生物工程系生物工程专业，理学学士； 2001-2006，兰州大学生命科学学院，多肽生物化学与药物化学博士；2006-2010，中国科学院上海生命科学学院、神经科学研究所博士后；2011年-至今，上海交通大学医学院/医学科学研究院研究员,课题组长。

近年来一直从事蛋白质/多肽的结构和功能研究，擅长利用化学生物学、生物物理、分子药理、分子生物学、计算生物学等多学科交差的技术研究蛋白的结构与功能的关系及其相关的分子发现，取得了一系列较为重要的成果。已在Neuron, PLoS Biol., J Biol Chem, Cell Res., Mol Pain, Biochem Pharm., ChemMedChem, Peptides, J Neurosci., Neurosci., BBA Mol. Res., J Pharmacol Exp. Ther 等国际知名学术杂志上发表SCI论文20篇，其中第一作者14篇（含共同第一作者），篇均影响因子约5。主持完成国家自然科学基金委青年科学基金项目、“中国博士后科学基金”项目、“中国科学院王宽诚基金”资助项目、中国科学院上海生命科学研究院优秀青年人才领域前沿项目各1项。曾获兰州大学“香港求是基金会”研究生奖，中国博士后科学基金一等奖，中国科学院上海生命科学研究院优秀青年人才奖励，赛诺菲-安万特优秀青年人才奖励。

申请人代表性论文或者专利：

1. Yu, Y.*, #, Li, W.G.* ,Chen, Z.*, Jiang, H.L., Xu, T.L. et al. (2011). (*Co-first author). Atomic Level Characterization of the Nonproton Ligand-sensing Domain of ASIC3 Channel. J Biol Chem, 286(28):24996-5006

2. Yu, Y.*, Chen, Z.*, Li, W.G.*, Jiang, H.L., Xu, T.L. et al. (2010). (Co-first author). A non-proton ligand sensor of acid-sensing ion channels. Neuron 68(1):61-72.

Commented in “Small molecule ion channel match making: a natural fit for new ASIC ligands”, Bagriantsev, S.N. and Minor, D.L. Jr.Neuron.68(1):1-3.

3. Yang, H.Y.*, Yu, Y.*, Xu, T.L., Jiang H.L. et al. (2009). (Co-first author). Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biol.Jul;7(7) ):e1000151

4. Yang, H.Y.*, Yu, Y.*, Xu, T.L., Jiang H.L. et al. (2009). (Co-first author). Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation.Cell Res. 19(8):1035-7.

5. Duan. B.;Wang, Y.Z.,Yang, T.,Chu, X.P.;Yu,. Y., Xu ,T.L. et al. (2011). Extracellular Spermine Exacerbates Ischemic Neuronal Injury through Sensitization of ASIC1a Channels to Extracellular Acidosis. J Neurosci. 31: 2011-12.

6. Li, W.G.*;Yu, Y.*; Zhang, Z.D.;Cao, H.;Xu, T.L. (2010).(Co-first author).ASIC3 Channels Integrate Agmatine and Multiple Inflammatory Signals through the Nonproton Ligand Sensing Domain.Mol. Pain. 6 (1):88

7. Wang, C. L., Yao, J.L., Yu, Y., Wang. R. et al. (2008). Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling.Bioorg Med Chem. 16(12):6415-22.

8. Yu, Y.,Shao,X., Wang, R. et al. (2007). Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C-terminus. ChemMedChem 2(3): 309-17.

9. Yu, Y., Shao,X., Cui, Y., Wang, R. et al. (2007). In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: Evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides;28(4):859-70.

10. Yu, Y., Cui, Y., Wang, R. et al. (2007). In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for mu-opioid receptors, on mouse colonic motility. Biochem Pharmacol73(9):1384-93.

11. Wang, C.L., Yu., Y, Wang, R. et al. (2007) (Co-first author) Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats. Peptides28(4):871-7.

12. Yu, Y., Wang, C. L., Wang, R. et al. (2006). C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats.Peptides 27(1): 136-43.

13. Yu, Y., Cui, Y., Wang, R. et al. (2006). Endomorphin1 and endomorphin2, endogenous potent inhibitors of electrical field stimulation (EFS)-induced cholinergic contractions of rat isolated bronchus. Peptides27(7): 1846-51.

14. Yu, Y., Wang, X., Wang, R. et al. (2006). Abnormal modulation of cholinergic neurotransmission by endomorphin 1 and endomorphin 2 in isolated bronchus of type 1 diabetic rats. Peptides 27(11): 2770-7.

15. Liu, J., Yu, Y., Wang, R. et al. (2005). (Co-first author). Cardiovascular effects of endomorphins in alloxan-induced diabetic rats. Peptides 26(4): 607-14.

16. Xu, P. H., Cheng, Q., Li, H. F., Yu, Y., Wang, R. et al.(2005) The relaxant effect of dobutamine on porcine coronary arterial ring segments. Pharmazie. 60(5):375-7.

17. Fan, Y. Z., Chang, H., Yu, Y., Wang, R. et al. (2006). Thymosin alpha1 suppresses proliferation and induces apoptosis in human leukemia cell lines. Peptides27(9): 2165-73.

18. Fan, Y. Z., Chang, H., Yu, Y., Wang, R. et al. (2006). Thymopentin (TP5), an immunomo- dulatory peptide, suppresses proliferation and induces differentiation in HL-60 cells. Biochim Biophys Acta 1763(10): 1059-66.

19. Liu, H. M., Liu, X. F., Yao, J. L. Wang, C.L, Yu, Y., Wang, R. et al. (2006). Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. J Pharmacol Exp Ther 319(1): 308-16.

20. Wang, W., Yu, Y., Xu, T.L. et al. (2007). Modulation of acid-sensing ion channels by Cu in cultured hypothalamic neurons of the rat. Neuroscience145(2):631-641.

国家发明专利：

1.Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-1 (No. 200410073159.2.).

2. Wang, R., Yu, Y., Liu, H.M. C-terminus modified analogs of endomorphin-2 (No. 200710147468.3.).

3. Wang, R., Fan, Y.Z., Yu, Y., Chang, H. A new usage of polyhexose isolated from pumpkin (200710017285X.)