赖玉平 华东师范大学教授 博士生导师

简历：

研究方向：

论文：

所获荣誉

赖玉平 华东师范大学教授 博士生导师

简历：

2001年获华东师范大学生物化学与分子生物学学士学位；

2006年获华东师范大学生物化学与分子生物学博士学位；

2005年1月到2006年6月在美国国家卫生研究所(National Institutes of Health, NIH)过敏与感染疾病研究所(National Institute of Allergy and Infectious Diseases, NIAID)作联合培养博士研究生；

2006年9月到2010年1月在美国加州大学圣地亚哥分校(University of California, San Diego)医学院皮肤学系作博士后；

2010年1月底受聘为华东师范大学教授。

研究方向：

与宿主共生的一些细菌有益于宿主，这已成为近几年的研究热点。皮肤共生菌是如何增强皮肤免疫能力来抗衡微生物入侵和/或感染以及如何调节银屑病人的再生胰岛源蛋白3A 的表达是我们的主要研究方向。目前本课题组正与美国、韩国等国家的科学家合作，研究重点包括：1)表皮葡萄球菌的脂磷壁酸(lipoteichoic acid)对伤口炎症发生过程中Toll样受体3(Toll-like receptor 3, TLR3)信号通路的调控机理； 2)皮肤伤口炎症发生过程中炎症因子的产生机制和肿瘤坏死因子受体相关因子1(TNF receptor-associated factor 1, TRAF1)对TLR3信号通路所引发炎症的抑制机理；3）表皮葡萄球菌诱导抗菌肽β-防御素和鼠源再生胰岛源蛋白3-γ在皮肤伤口感染中的调节机制；4）REG3A在银屑病中的调节表达。

曾为多项美国国家卫生研究所(NIH)研究项目的主要承担人。

社会（学术）兼职

Membership of Professional Societies

Society for Investigative Dermatology

American Society for Microbiology

South California American Society for Microbiology Branch

论文：

1. Lai Y, Di Nardo A, Nakatsuji T, Leichtle A, Yang Y, Cogen AL, Wu Z-R, Hooper LV, Schmidt RR, von Aulock S, Radek KA, Huang C-M, Ryan AF, Gallo RL. Commensal bacteria regulate TLR3-dependent inflammation after skin injury. Nat Med. Cover Story. 2009, 15(12):1377-1382.

2. Lai Y, Gallo RL. AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol. Feature Review. 2009, 30(3): 131-141.

3. Lai Y, Gallo RL. Toll-like receptors in skin infections and inflammatory diseases. Infect Disord Drug Targets (Formerly ''Current Drug Targets - Infectious Disorders''). 2008, 8(3): 144-155.

4. Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE, Otto M. Gram-positive three-component antimicrobial peptide-sensing system. Proc Natl Acad Sci U S A. 2007, 104(22):9469-9474 (Co-first author).

5. Lai Y, Villaruz AE, Li M., Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2007, 63(2):497-506.

6. Lai YP, Peng YF, Zuo Y, Li J, Huang J, Wang LF, Wu ZR. Functional and structural characterization of recombinant dermcidin-1L, a human antimicrobial peptide. Biochem Biophys Res Commun. 2005, 328(1):243-250.

7. Lai YP, Huang J, Wang LF, Li J, Wu ZR. A new approach to random mutagenesis in vitro. Biotechnol Bioeng. 2004, 86(6): 622-627.

8. Leichtle A, Hernandez M, Ebmeyer J, Yamasaki K, Lai Y, Radek K, Choung YH, Euteneuer S, Pak K, Gallo R, Wasserman SI, Ryan AF. CC chemokine ligand 3 overcomes the bactericidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. J Immunol. 2010, 184(6):3087-3097.

9. Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial delta-toxin (phenol-soluble modulin-gamma) cooperates with host antimicrobial peptides to kill group A Streptococcus. PLoS One. 2010, 5(1):e8557.

10. Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, Macleod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol. 2010, 130(1): 192-200.

11. Li M, Rigby K, Lai Y, Nair V, Peschel A, Schittek B, Otto M. Staphylococcus aureus mutant screen reveals the interaction of human antimicrobial peptide dermcidin with membrane phospholipids. Antimicrob Agents Chemother. 2009, 53(10):4200-4210.

12. Di Nardo A, Yamasaki K, Dorschner RA, Lai Y, Gallo RL. Mast cell cathelicidin antimicrobial peptide prevents invasive group A Streptococcus infection of the skin. J Immunol. 2008, 180(11):7565-7573.

13. Li M, Cha DJ, Lai Y, Villaruz AE, Sturdevant DE, Otto M. The antimicrobial peptide-sensing system aps of Staphylococcus aureus. Mol Microbiol. 2007, 66(5): 1136-1147.

14. Yao Y, Vuong C, Kocianva S, Villaruz AE, Lai Y, Sturdevant DE, Otto, M. Characterization of the Staphylococcus epidermidis accessory gene regulator response: quorum-sensing regulation of resistance to innate host defense. J Infect Dis. 2006, 193(6):841-848.

专利：

15. Lai Y, Gallo RL. An Unique TNF alpha Inhibitor to Suppress Inflammation while Enhancing the Innate Immune System against Viral or Microbial Infections. U.S.A. patent. UCSD Ref. No. SD2008-129.

16. Gallo RL, Nizet V, Cogen A, Lai Y. Antimicrobial and anti-inflammatory therapies compositions. U.S.A. patent. UCSD Ref. No. SD2007-184.

17. Otto M, Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE. Gram-positive three-component antimicrobial peptide-sensing system. U.S.A. patent. Application No.60/930,709.

18. 赖玉平‚吴自荣‚黄静‚王林发‚左翼‚李骏. 一种高效表达重组人汗腺抗菌肽的基因工程菌及其构建方法和应用.专利号：200510023674.

所获荣誉

1. 美国Albert M. Kligman Travel Fellowship

2. 美国Outstanding graduate research at the National Institutes of Health (NIH)

3. 美国Graduate Partnerships Program Fellowship (NIAID, NIH)

4. 上海市优秀博士论文

5. 华东师范大学研究生优秀奖学金

6. 首届中华基因网“生命之光”征文竞赛二等奖

7. 华东师范大学非师范类奖学金