姜志宏 教授

Curriculum Vitae of Zhi-Hong JIANG

姜志宏 教授

澳门科技大学澳门药物与健康应用研究所所长

中药质量研究国家重点实验室(澳门科技大学)副主任

简介:

姜志宏教授于1987年毕业于中国药科大学，1990年于同校取得硕士学位。1994年获日本国费奖学金资助留学日本，1998在长崎大学获得药学博士学位。1999年至2001年间在美国哈佛医学院生物化学与分子药理学系进行博士后研究工作,从事抗肿瘤抗生素与小RNA形成共价键附加物的研究。2001年姜志宏博士受聘于香港浸会大学中医药学院任助理教授，2005年提升为副教授， 2008年任教授。曾担任教学部副主任和中药学硕士课程主任。2011年7月任澳门科技大学澳门药物与健康应用研究所所长，兼任中药质量研究国家重点实验室副主任。

姜教授的研究方向包括天然药物化学，代谢组学，中药质量标准研究，与生物大分子 (DNA, RNA，peptide)相互作用的药理活性物质的分子机理的研究。姜教授在国际学术刊物上共发表了130余篇SCI论文，于2006年获香港浸会大学校长奖（学术研究），2007年荣获「国家杰出青年科学基金．海外及香港、澳门青年学者合作研究基金奖」, 2008年获得Elsevier出版社刊物Bioorganic & Medicinal Chemistry的“「被引用次数最多论文奖」。”他的研究得到香港研究资助局，香港卫生署，国家自然科学基金，美国国立卫生研究院和制药企业的资助。

学历:

1987年7月，中国药科大学 理学学士学位

1990年7月，中国药科大学 理学硕士学位

1998年3月，日本长崎大学 药学博士学位

工作经历:

1990年7月-1994年3月，中国药科大学助教，讲师

1996年10月-2001年9月，日本长崎大学 药学部 助手（文部教官）

1999年11月-2001年9月，哈佛医学院生物化学与分子药理学系 博士后

2001年10月-2005年6月，香港浸会大学中医药学院 助理教授

2005年7月-2008年8月，香港浸会大学中医药学院 副教授

2008年9月-2011年6月，香港浸会大学中医药学院 教授

2011年7月-今，澳门科技大学 教授

授课科目: 中药化学选论；中药学研究进展

研究领域: 天然药物化学，代谢组学，生物有机化学，中药质量标准

专业会员: 美国化学会；日本药学会；香港质谱学会

获奖：香港浸会大学学术研究校长奖（2006年），国家杰出青年科学基金．海外及香港、澳门青年学者合作

研究基金奖（2007年）, Elsevier出版社刊物Bioorganic & Medicinal Chemistry“被引用次数最多论文

奖”（2008年）”

研究论文:

1) Y. Liu, Ke,K. Y. Wu,S. Liu,W.-H. Chen,S. Jiang,Z.-H. Jiang. An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid-Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem, 6, 1654-1664, 2011.

2) D. S-H Chan,B. Y.-W. Man,H. Yang,M. H.-T. Kwan, L.-P. Bai, Z.-H. Jiang, D.-L. Ma, C.-H. Leung. Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-Quadruplex DNA stabilizer. Biochimie, 93, 1055-1064, 2011.

3) J. Wang, C. Y. Leung, H. M. Ho, S. Chai, L. F. Yau, Z. Zhao, Z.-H. Jiang. Quantitative Comparison of Ginsenosides and Polyacetylenes in Wild and Cultivated American Ginseng. Chem. & Biodivers., 7, 975-983, 2010.

4) X.-Y. Wen, S.-Y. Wu, Z.-Q. Li, Z. Liu, J.-J. Zhang, G.-F. Wang, Z.-H. Jiang, S.-G. Wu. An Anti-proliferative Natural Polyphenol Compound can Regulate the Expression of MicroRNAs in HepG2 Cancer Cells. Phytotherapy Research, 23, 778-784, 2009.

5) L.-P. Bai, M. Hagihara, Z.-H. Jiang, K. Nakatani. Ligand Binding to Tandem G-quadruplexes from Human Telomeric DNA. ChemBioChem, 9, 2583-2587, 2008.

6) L.-P. Bai, Z. Cai, Z. Zhao, K. Nakatani, Z.-H. Jiang. Site-Specific Binding of Chelerythrine and Sanguinarine to Single Pyrimidine Bulge in Hairpin DNA. Analytical Bioanalytical Chemistry, 392, 709-716, 2008.

7) Z.-H. Jiang, Q. Yang, T. Tanaka, I. Kouno. Bicyclic Polyketide Lactones from Chinese Medicinal Ants Polyrhacis lamellidens.J. Nat. Prod., 71, 724-727, 2008.

8) Z.-H. Jiang, X.-Y. Wen, T. Tanaka, S.-Y. Wu, Z. Liu, H. Iwata, Y. Hirose, S. Wu, I. Kouno. Cytotoxic Hydrolyzable Tannins from Balanophora japonica. J. Nat. Prod., 71, 719-723, 2008.

9) J. Liu, C. S. Lee, K.-M. Leung, Z. Yan, B. Shen, Z. Zhao, Z.-H. Jiang. Quantification of Two Polyacetylenes in Radix Ginseng and Related Panax Herbs Using a Gas Chromatography-Mass Spectrometric Method. J. of Agricultural and Food Chemistry, 55, 8830-8835, 2007.

10) G.-S. Qian, Q. Wang, Kelvin S.-Y. Leung, Y. Qin, Z. Zhao, Z.-H. Jiang. Quality Assessment of Rhizoma et Radix Notopterygii by HPTLC, HPLC Fingerprinting and HPLC Quantitative Analysis. J. of Pharmaceutical and Biomedical Analysis, 44, 812-817, 2007.

Curriculum Vitae of Zhi-Hong JIANG

Professor, PhD

Director of Macau Institute for Applied Research in Medicine and Health

Deputy Director of State Key Laboratory for Quality Research in Chinese Medicines

Macau University of Science and Technology

Professor Jiang obtained the Bachelor and Master degrees from China Pharmaceutical University in 1987 and 1990, respectively. He earned his PhD degree from Nagasaki University, Japan in 1998. After postdoctoral training in Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, USA from 1999-2001, he joined School of Chinese Medicine, Hong Kong Baptist University in 2001 as an assistant professor, and was promoted to be an associate professor in 2005 and full professor in 2008. He was Associate Director of Teaching Division and Director of Master Program of Pharmaceutical Sciences in Chinese Medicine. In July 2011, he moved to Macau University of Science and Technology (MUST), and took the positions of Director of Macau Institute for Applied Research in Medicine and Health, and Deputy Director of State Key Laboratory for Quality Research in Chinese Medicines (MUST).

Prof. Jiang’s research fields include natural products chemistry, quality control of Chinese medicinal herbs, metabolomics, interaction of pharmacologically-active natural products with biomacromolecules (DNA, RNA, peptides). He has published more than 130 papers in SCI journals. He received a number of awards, including “HKBU Presidential Award for Outstanding Performance in Scholarly Work” in 2006, “National Outstanding Young Scientists Award (Overseas)” by the National Science Foundation of China (NSFC) in 2007, and "Most Cited Paper 2005-2008 Award" presented by the Elsevier. His research was financially supported by Research Grants Council of University Grants Committee of Hong Kong and Department of Health of HKSAR, National Natural Science Foundation of China, National Institutes of Health of U.S.A. and some pharmaceutical industries.

Education:

July, 1987, B. Sc. (China Pharmaceutical University, Nanjing, China)

July, 1990, M. Sc. (China Pharmaceutical University, Nanjing, China)

March, 1998, Ph. D. (Nagasaki University, Japan)

Professional Chronology:

Jul., 1990- Mar., 1994 Research Associate, Lecturer, China Pharmaceutical University, Nanjing, China

Oct., 1996-Sept., 2001 Research Assistant Professor, School of Pharmaceutical Sciences, Nagasaki University, Japan

Nov., 1999-Sept., 2001 (Sabbatical leave) Postdoctoral Research Fellow, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, U.S.A.

Oct., 2001-Jun., 2005 Assistant Professor, School of Chinese Medicine, Hong Kong Baptist University

Jul., 2005-Aug., 2008 Associate Professor, School of Chinese Medicine, Hong Kong Baptist University

Sept., 2008-June, 2011 Professor, School of Chinese Medicine, Hong Kong Baptist University

Jul., 2011-present Professor and Director, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology

Teaching Subjects:

1) Advanced Natural Products Chemistry

2) Prospect and Progress in Chinese Medicine Research

Research Fields:

1) Natural Products Chemistry

2) Metabolomics

3) Bioorganic Chemistry

4) Chemical Analysis of Chinese Herbs

Memberships:

1) American Chemical Society

2) Pharmaceutical Society of Japan

3) Hong Kong Society of Mass Spectrometry

Awards:

1) HKBU Presidential Award for Outstanding Performance in Scholarly Work, 2006

2) National Outstanding Young Scholar Award (Oversea Scholar), NSFC, 2007

3) Most Cited Paper Award (2005-2008) by “Bioorganic & Medicinal Chemistry”

Selected Publications:

1) Y. Liu, Ke,K. Y. Wu,S. Liu,W.-H. Chen,S. Jiang,Z.-H. Jiang. An Amphiphilic Conjugate Approach toward the Design and Synthesis of Betulinic Acid-Polyphenol Conjugates as Inhibitors of the HIV-1 gp41 Fusion Core Formation. ChemMedChem, 6, 1654-1664, 2011.

2) D. S-H Chan,B. Y.-W. Man,H. Yang,M. H.-T. Kwan, L.-P. Bai, Z.-H. Jiang, D.-L. Ma, C.-H. Leung. Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-Quadruplex DNA stabilizer. Biochimie, 93, 1055-1064, 2011.

3) J. Wang, C. Y. Leung, H. M. Ho, S. Chai, L. F. Yau, Z. Zhao, Z.-H. Jiang. Quantitative Comparison of Ginsenosides and Polyacetylenes in Wild and Cultivated American Ginseng. Chem. & Biodivers., 7, 975-983, 2010.

4) X.-Y. Wen, S.-Y. Wu, Z.-Q. Li, Z. Liu, J.-J. Zhang, G.-F. Wang, Z.-H. Jiang, S.-G. Wu. An Anti-proliferative Natural Polyphenol Compound can Regulate the Expression of MicroRNAs in HepG2 Cancer Cells. Phytotherapy Research, 23, 778-784, 2009.

5) L.-P. Bai, M. Hagihara, Z.-H. Jiang, K. Nakatani. Ligand Binding to Tandem G-quadruplexes from Human Telomeric DNA. ChemBioChem, 9, 2583-2587, 2008.

6) L.-P. Bai, Z. Cai, Z. Zhao, K. Nakatani, Z.-H. Jiang. Site-Specific Binding of Chelerythrine and Sanguinarine to Single Pyrimidine Bulge in Hairpin DNA. Analytical Bioanalytical Chemistry, 392, 709-716, 2008.

7) Z.-H. Jiang, Q. Yang, T. Tanaka, I. Kouno. Bicyclic Polyketide Lactones from Chinese Medicinal Ants Polyrhacis lamellidens.J. Nat. Prod., 71, 724-727, 2008.

8) Z.-H. Jiang, X.-Y. Wen, T. Tanaka, S.-Y. Wu, Z. Liu, H. Iwata, Y. Hirose, S. Wu, I. Kouno. Cytotoxic Hydrolyzable Tannins from Balanophora japonica. J. Nat. Prod., 71, 719-723, 2008.

9) J. Liu, C. S. Lee, K.-M. Leung, Z. Yan, B. Shen, Z. Zhao, Z.-H. Jiang. Quantification of Two Polyacetylenes in Radix Ginseng and Related Panax Herbs Using a Gas Chromatography-Mass Spectrometric Method. J. of Agricultural and Food Chemistry, 55, 8830-8835, 2007.

10) G.-S. Qian, Q. Wang, Kelvin S.-Y. Leung, Y. Qin, Z. Zhao, Z.-H. Jiang. Quality Assessment of Rhizoma et Radix Notopterygii by HPTLC, HPLC Fingerprinting and HPLC Quantitative Analysis. J. of Pharmaceutical and Biomedical Analysis, 44, 812-817, 2007.