个人简介

研究方向

承担科研项目

部分论文及专利(部分论文 专利)

获奖情况

个人简介

学校/单位：南开大学

招生专业：高分子化学与物理

现任职务:南开大学化学学院副院长

简　历:1989年获博士学位后留南开大学高分子所任讲师，1992年晋升为副教授，1996年晋升为教授。2000年7月，任南开大学化学院副院长，高分子所所长。 现任国家基金委材料学部评审委员，天津市重大科技攻关项目、产业化项目评审专家。2000年入选教育部跨世纪优秀青年培养计划,天津市“131”工程第一层次培养计划。

研究方向

主要研究方向：

1、吸附分离材料的结构设计及吸附机制研究

2、纳米肝靶向给药系统研究

3、诱导抗凝血生物化表面的设计和构建

承担科研项目

国家自然科学基金重点项目及多项面上项目，“973”子课题，天津市科技支撑重点项目，天津市自然科学基金重点项目

部分论文及专利

部分论文

1.Zhi Yuan*, Endotoxin adsorbent using dimethylamine ligands, Biomaterials, 2005, 26(15): 2741-2747

2.Zhi Yuan*, Adsorption mechanism at molecular level between polymers anduremic octapeptide by 2D 1H NMR technique, Biomacromolecules, 2006, 7(6): 1811-1818

3.Zhi Yuan*, Synthesis and characterization of novel functionalized polyesters with pendent hydroxyl arms, Polymer, 2006, 47: 6978-6985

4.Zhi Yuan*, Studies on endotoxin removal adsorbents with amino acid ligands, Journal of Chromatography B, 2007, 852: 288－292

5.Zhi Yuan*, Synthesis, degradability and cell affinity of poly(DL-lactide-co-RS-hydroxyethyl-β-malolactonate), Journal of Biomedical Materials Research, 2008, 87(2): 459-469

6.Zhi Yuan*, A Novel Copolymer Poly(lactide-co-β-malic acid) with Extended Carboxyl Arms Offering Better Cell Affinity and Hema-compatibility for Blood Vessel Engineering, Tissue Engeering, 2009, 15(1): 65-73

7.Zhi Yuan*, The Prominent Effect of the Secondary Structures of Oligopeptides on the Interaction between Peptides and Polymers, Polymer, 2009, 50(6): 1602-1608

8.Zhi Yuan*, Rapid and efficient screening of adsorbent for oligopeptide using molecular docking and isothermal titration calorimetry, Journal of Separation Science, 2009, 32: 2462-2468

9.Zhi Yuan*, Blood compatibility evaluation of poly(D,L-lactide-co-beta-malic acid) modified with the GRGDS sequence, Colloids and Surfaces B: Biointerfaces, 2010,75(1): 370-376

10.Zhi Yuan*, Glycyrrhetinic acid-modified chitosan / poly(ethylene glycol) nanoparticles for liver-targeted delivery, Biomaterials, 2010, 31(17): 4748-4756

11.Zhi Yuan*, Adsorbents with high selectivity for uremic middle molecular peptides containing Asp-Phe-Leu-Ala-Glu sequence, Langmuir, 2010, 26(10), 7181-7187

12.Zhi Yuan*, Colorimetric Determination of Bis-phosphorylated Peptide Using Zn(ii)-Dipicolyamine Functionalized Gold Nanoparticles, Sensors & Actuators: B, 2010, 147(2): 687-690

13.Zhi Yuan*, Ping-Chuan Sun*, Silk Fibroin/Montmorillonite Nanocomposites: Effect of pH on the Conformational Transition and Clay Dispersion. Biomacromolecules, 2010, 11(7): 1796-1801

14.Zhi Yuan*, Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(benzyl L-glutamate) micelles for liver targeting therapy, Acta Biomaterialia, 2010, 6(10): 3927-3935

15.Zhi Yuan*, Insight into glycyrrhetinic acid: the role of the hydroxyl group on liver targeting, International Journal of Pharmaceutics, 2010, 400(1-2): 153-157

16.Zhi Yuan*, Design, optimization and evaluation of specific affinity adsorbent for oligopeptides, Journal of Chromatography A, 2010, 1217(48): 7539-7546

17.Zhi Yuan*, HUVEC Cell Affinity Evaluation and Integrin-Mediated Mechanism Study on PHSRN-Modified Polymer, Colloids and Surfaces B: Biointerfaces, 2011, 84(1): 6-12

18.Zhi Yuan*, Effects of Oligopeptide's Conformational Changes on its Adsorption, Colloids and Surfaces B: Biointerfaces, 2011, 83(2): 229-236

19.Zhi Yuan*, A comparison study between polymeric ligand and monomeric ligand for oligopeptide adsorption, Journal of Colloid and Interface Science, 2011, 355: 478–485

20.Zhi Yuan*, Glycyrrhetinic acid-functionalized degradable micelles as liver-targeted drug carrier, Journal of Materials Science: Materials in Medicine, 2011, 22: 853-863

21.Zhi Yuan*, An Efficient Molecular Docking Method for Adsorbent Screening, Chromatography B, 2011, 879: 1605-1609

专利

1. 袁直等, 中国发明专利, ZL 93107357.x

2. 袁直等, 中国发明专利, ZL 93107356.1

3. 袁直等, 中国发明专利, ZL 03 144231.5

4. 袁直等, 中国发明专利, ZL 03 144383.4

5. 袁直等, 中国发明专利, ZL200510015172.7

6. 袁直等, 中国发明专利, ZL 200810052636.5

7. 袁直等, 中国发明专利, ZL 200810052635.0,

8. 袁直等, 中国发明专利, CN101444720

9. 袁直等, 国际专利, 申请号PCT/CN2009/000150

10. Zhi Yuan et al, US Patent, Application Number 12338966

11. 袁直等, 中国发明专利, 申请号200910068769.6

12. 袁直等, 中国发明专利, 申请号200910070231.9

获奖情况

曾获中国化学会青年化学奖、国家科技进步二等奖，天津青年科技奖、科技部杜邦科技创新奖、天津市科技进步二等奖、教育部科技进步三等奖；荣获全国先进女职工称号。