人名，学者，女。华东师范大学生命科学学院生命医学研究所副教授，硕士导师。高级研究助理。研究方向为雄性激素受体基因表达调控与前列腺癌和 蛋白SUMO修饰。曾参与一项973课题，“染色质解码的基础与临床研究”。发表论文14篇。

简介

简历(学习经历 工作经历)

研究方向

科研项目

代表性的论文

简介

李纪文，华东师范大学生命科学学院生命医学研究所生物化学与分子生物学学科组副教授级高级研究助理。硕士导师。

简历

学习经历

1986-1990: 学士学位，生物化学专业，复旦大学

1995-1997: 硕士学位，生物化学专业，Hood College, Frederick, Maryland, USA，

工作经历

1990-1994：研究助理，中国科学院上海有机生化所生物化学系。

1997-2003：研究技术员，Department of Cell Biology, Baylor College of Medicine, USA.

2003-2007：高级研究助理，Department of Cell Biology, Baylor College of Medicine, USA.

2007-至今：副教授，华东师范大学生命科学学院生命医学研究所

研究方向

1) 雄性激素受体基因表达调控与前列腺癌

2) 蛋白SUMO修饰

科研项目

1、2008年至今参与一项973课题，“染色质解码的基础与临床研究”。

2、参与上海市科委细胞信号传导平台建设研究。

代表性的论文

1.Chen, H.-B., Li, J., and Yang, J. 1992. Expression of a chemically synthesized gene for the mature rbcS from tobacco in E. coli.. In”Research in Photosynthesis” (Murata, n., ed), vol. III, 645-648.

2.Stolow, M.A; Bauzon, D.D;Li, J; Sedgwick, T; Liang, V.C-T; Sang, Q.A; and Shi, Y-B. (1996). Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development. Molecular Biology of the Cell, Vol. 7, 1471-1483.

3.Li, J; Liang, V.C-T; Sedgwick, T; Wong, J; and Shi, Y-B. 1998. Unique organization and involvement of GAGA factors in transcriptional regulation of the Xenopus stromelysin-3 gene. Nucleic Acids Res. 26(12): 3018-3025

4. Li, J., O’Malley B.W and Wong J. 2000. p300 requires its HAT activity and SRC-1 interaction motif to facilitate TR activation in chromatin. Mol. Cell. Biol. 20: 2031-2042.

5. Li, J,. Wang, J; Wang, J; Nawaz, Z; Liu, J., Jun, Q., and Wong J. 2000. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19(16): 4342-4350.

6. Huang, Z., Li, J. and Wong J. 2002. Androgen receptor possesses an intrinsic-hormone-independent trans-activation activity. Molecular Endocrinology. 16: 924-937.

7. Li, J; Lin, Q; Wade, P., Wang, W and Wong J. 2002. Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. Genes & Development 16: 687-692.

8. Li, J., Lin, Q., Yoon, H-G., Huang, Z., Strahl, B.D., Allis, C.D., and Wong J. 2002. Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Mol Cell Biol 22 (16): 5688-5697.

9.Yoon HG, Chan DW, Huang ZQ, Li, J, Fondell JD, Qin J and Wong J. 2003. Purification and Functional Characterization of the Human N-CoR Complex: the Roles of HDAC3 and two WD-40 Repeat Subunits TBL1 and TBLR1. EMBO J 22(6):1336-1346.

10. Lee KC#, Li, J#, Cole PA, Wong J* and Kraus L*. 2003. Transcriptional activation by thyroid hormone receptor involves chromatin remodeling, histone acetylation, and cooperative stimulation by p300 and SRC coactivators. Molecular Endocrinology, 17(5):908-22. (#equal contribution and co-corresponding authors.)

11.Huang ZQ, Li, J, Sachs LM, Cole PA and Wong J. 2003. A Role for Cofactor-Cofactor and Cofactor-Histone Interaction in Targeting of CBP/p300, SWI/SNF and Mediator for transcription. EMBO J 22(9):2146-2155.

12.Stewart MD, Li J and Wong J. 2005 Relationship between H3 lysine 9 methylation, transcription repression and heterochromatin protein 1 recruitment. Mol Cell Biol;25(7):2525-38.

13.Burd CJ, Petre CE, Morey LM, Wang Y, Revelo MP, Haiman CA, Lu S, Fenoglio-Preiser CM, Li J, Knudsen ES, Wong J and Knudsen KE. 2006 Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation. Proc Natl Acad Sci U S A; 103:2190-5.

14.Li, J., Fu J, Toumazou C, Yoon HG, and Wong J. 2006. A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. Mol Endocrinol 20:776-85.