| 词条 | 王柯敏 |
| 释义 | § 简介 主要从事化学生物传感新原理、新方法研究，在分子、细胞和活体水平上的化学、生物信息获取及表征等方面进行了系统研究，获得了创造性的研究成果，先后承担国家“973”子项目、“863”项目、国家科技攻关计划项目、科技部国际合作重点项目、国家自然科学基金重点项目、教育部重大项目等30余项，在Proc. Natl. Acad. Sci. USA、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Nucleic Acids Res.、Chem. Commun.、Anal. Chem.、Biomaterials、Biosen. Bioelectron.等国际知名杂志、国内外核心学术刊物及重要的国际学术会议上发表论文200余篇，已获得发明专利授权25项；获湖南省自然科学一等奖（2009）、湖南省科技进步一等奖（2003）等奖项。 § 履历 1992年9月至1997年2月，先后任湖南大学化学化工系副主任、主任、化学化工学院院长，1997年3月至1999年5月先后任湖南大学副校长、常务副校长，1999年6月任湖南大学校长。2003年3月任省科技厅厅长。 § 研究方向： 纳米及分子水平上的生物分析化学、分子工程、纳米生物医学器件、化学与生物传感器 § Selected Publications: 1.H. Shi, X. He, K. Wang*, X. Wu, X. Ye, Q. Guo, W. Tan, Z.Qing, X. Yang, B. Zhou. "Activatable Aptamer Probe for Contrast-Enhanced in vivo Cancer Imaging Based on Cell Membrane Protein-Triggered Conformation Alteration", Proceedings of the National Academy of Sciences 2011, doi: 10.1073/pnas.1016197108s. 2.J. Huang, Y. Wu, Y.Chen, Z. Zhu, X. Yang, C. Yang*, K.Wang*, W. Tan*. "Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids", Angewandte Chemie International Edition 2011, 50, 401-404. 3. H. Shi, Z. Tang, Y. Kim, H. Nie, Y.F. Huang, X. He, K. Deng, K. Wang*, W. Tan*, In vivo Fluorescence Imaging of Tumors using Molecular Aptamers Generated by Cell-SELEX, Chem. Asian J.，5 (2010) 2209-2213. 4. D. Liu, X. He*, K. Wang*, C. He, H. Shi, L. Jian, Biocompatible Silica Nanoparticles−Insulin Conjugates for Mesenchymal Stem Cell Adipogenic Differentiation, Bioconjugate. Chem.，21 (2010) 1673-1684. 5. H. Shi, X. He, Y. Yuan, K. Wang*, D. Liu, Nanoparticle-Based Biocompatible and Long-Life Marker for Lysosome Labeling and Tracking, Anal. Chem.， 82 (2010) 2213-2220. 6. Y. Wang, X. He, K. Wang*, X. Ni, A sensitive ligase-based ATP electrochemical assay using molecular beacon-like DNA, Biosens. Bioelectron.，25 (2010) 2101-2106. 7. J. Liu, X. Yang, K. Wang*, D. Wang, P. Zhang, Chemical etching with tetrafluoroborate: a facile method for resizing of CdTe nanocrystals under mild conditions, Chem. Commun.，(2009) 6080-6082. 8. Q. Guo, X. Yang, K. Wang*, W. Tan, W. Li, H. Tang, H. Li, Sensitive fluorescence detection of nucleic acids based on isothermal circular strand-displacement polymerization reaction, Nucleic Acids Res.，37 (2009) e20. 9. K. Wang*, Z. Tang, C.J. Yang, Y. Kim, X. Fang, W. Li, Y. Wu, C.D. Medley, Z. Cao, J. Li, P. Colon, H. Lin, W. Tan*, Molecular engineering of DNA: molecular beacons, Angew. Chem. Int. Ed.，48 (2009) 856-870. 10. X. He, X. Wu, K. Wang*, B. Shi, L. Hai, Methylene blue-encapsulated phosphonate-terminated silica nanoparticles for simultaneous in vivo imaging and photodynamic therapy, Biomaterials，30 (2009) 5601-5609. 11. X. He, H. Nie, K. Wang*, W. Tan, X. Wu, P. Zhang, In Vivo Study of Biodistribution and Urinary Excretion of Surface-Modified Silica Nanoparticles, Anal. Chem.，80 (2008) 9597-9603. 12.L. Yang, H. Li, K. Wang*, W. Tan, W. Yang, J. Zheng, Atomic Force Microscopy Study of the Effect of Pulsed Electric Field on Staphylococcus epidermidis, Anal. Chem.， 80 (2008) 6222-6227. 13. W. Li, X. Yang, K. Wang*, W. Tan, Y. He, Q. Guo, H. Tang, J. Liu, Real-Time Imaging of Protein Internalization Using Aptamer Conjugates, Anal. Chem.，80 (2008) 5002-5008. 14. J. Wen, X. Yang, K. Wang*, W. Tan, X. Zuo, H. Zhang, Telomerase catalyzed fluorescent probes for sensitive protein profiling based on one-dimensional microfluidic beads array, Biosens. Bioelectron. 23 (2008) 1788-1792. |
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