陈忠周，男，1974年生，教授，博士生导师。入选 2007年教育部 "新世纪优秀人才支持计划"。 主要是利用X-射线方法研究蛋白质的晶体结构，如所解的jmjd2a结构是世界上第一个具有活性中心的组蛋白去甲基化酶(Histone demethylase)家族的结构以及最近解出jmjd2a复合物结构阐述了组蛋白去甲基化酶是如何选择性地催化组蛋白底物。作为第一作者曾经在cell, PNAS, 和化学著名的期刊JOC, JPCA等发表多篇高质量论文。

工作经历

教育

研究方向

获奖情况

所加入的协会

论文与专著

工作经历

2002-2007 美国国立犹太人医学研究中心免疫系

2007-目前 中国农业大学生物学院

教育

1992-1997 清华大学化学系物理化学及仪器分析专业理学学士

1994-1997 清华大学经济管理学院企业管理专业理学学士

1997-2002 清华大学生命科学院生命有机磷专业理学博士

研究方向

蛋白质表达，纯化和蛋白质晶体学以及信号传导和转录，药物设计等

获奖情况

2007: 入选 2007年教育部 "新世纪优秀人才支持计划"

2006: NJMRC Vestal Viola Coulter Scholarship

2006: Elected to Sigma Xi

2004: Nomination awards of the national outstanding Doctoral dissertations by the Ministry of Education (全国百篇优秀博士论文提名奖)and First grade outstanding Ph. D. dissertation of Tsinghua University

1992-2002: Various scholarships of Tsinghua University in every year.

Other than these,

1997: Excellent undergraduate Thesis and Honored Graduate of Tsinghua University.

1994: Scholarship from Hongkong alumni of Tsinghua University.

1993: Second Prize - 5th Mathematics contest of undergraduate course(北京市高等数学本科甲组二等奖), Beijing, 1993

1992: Quintessence Student of Fujian Province.

所加入的协会

Sigma Xi

American crystallographic association

论文与专著

1. Zhongzhou Chen, Jianye Zang, Fei Lan, Xia Hong, Qin Wang, Shaodong Dai, Kirk Hansen, Yang Shi, and Gongyi Zhang. The Structural Basis of Recognition between JMJD2A and Histone Tail. PNAS, 2007, June 26, vol. 104, no. 26, 10818–10823. (Similar results are reported later by other groups on Nature 2007 Jul 5;448(7149):87-91 and Nat Struct Mol Biol. 2007 Aug;14(8):689-95)

2. Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, Moss T, Refaeli Y, Bowler R, Wenzel SE, Chen Z, Zdunek J, Breed R, Young R, Allaire E, Martin RJ. Function and Regulation of SPLUNC1 Protein in Mycoplasma Infection and Allergic Inflammation. J Immunol. 2007 Sep 15;179(6):3995-4002.

3. Zhongzhou Chen, Jianye Zang, Johnathan Whetstine,Xia Hong,Foteini Davrazou,Tatiana G. Kutateladze, Michael Simpson, Qilong Mao, Cheol-Ho Pan, Shaodong Dai, James Hagman,Kirk Hansen, Yang Shi, Gongyi Zhang. Structural Insights into Histone Demethylation by JMJD2 Family Members. Cell, 2006, 125, 691–702.

4. Johnathan R. Whetstine, Amanda Nottke, Fei Lan, Maite Huarte, Sarit Smolikov, Zhongzhou Chen, Eric Spooner, En Li, Gongyi Zhang, Monica Colaiacovo, Yang Shi. Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases. Cell, 2006, 125, 467–481.

5. Zhong-Zhou Chen, Yan-Mei Li, Hai-Yan Wang, Jin-Tang Du, Yu-Fen Zhao. Theoretical Study on the Rearrangement of beta-OH and gamma-OH in ESI Mass Spectrometry by N-Phosphorylation.Journal of Physical Chemistry A, 2004, 108, 7686-7690.

6. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao, Yu-Feng Tong, Jin-Feng Wang. Comparing the Activities of alpha-COOH and beta-COOH in N-Phosphoryl Aspartic Acids by NMR and Theoretical Study. Journal of Organic Chemistry, 2003, 68, 4052-4058.

7. Zhong-Zhou Chen, Yan-Mei LI, Yu-Fen Zhao. Hydrolysis of Dipeptide Esters with Newlase F Mixed Enzyme. Journal of Chemical Research(Synopses), 2003, 1, 1.

8. Zhong-Zhou Chen, Yan-Mei Li, Jing Ma, Bo Tan, Satoshi Inagaki, Yu-Fen Zhao, Comparing the activities of alpha-COOH and gamma-COOH in N-phosphoryl glutamic acid by theoretical study. Journal of Physical Chemistry A, 2002, 106, 11565-11569

9. Zhong-Zhou Chen, Yan-Mei Li, Xi Peng, Fu-Rong Huang, Yu-Fen Zhao. The Use of Crude Lipase in Deprotection of C-terminal Protecting Groups. Journal of Molecular Catalysis B: Enzymatic, 2002,18, 243–249

10. Zhong-Zhou Chen, Shui-Bing Chen, Yi Chen, Yan-Mei Li, Jing Chen, Yu-Fen Zhao. Negative-ion ESI Mass Spectrometry of N-Phosphoryl Amino Acids and dipeptides. Rapid Commun. Mass Spectrom. 2002, 16: 790-796

11. Zhong-Zhou Chen, Yu-Feng Tong, Shui-Bing Chen, Yi Chen, Yan-Mei Li, Yu-Fen Zhao. Direction of Peptide Formation from N-Phosphoryl Amino Acids. Chinese Science Bull. 2002,47, 1866-1870

12. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Comparing the Penta-Coordinate Phosphoric Intermediates from N-Dimethylphosphoryl L-Aspartic Acid. Phosphorus Sulfur Silicon Relat. Elem., 2002, 177,2073-2074

13. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Differentiation of alpha-COOH from beta-COOH in Aspartic acids by N-Phosphorylation. International Journal of Quantum Chemistry, 2001, 83, 41-51.

14. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yi Chen, Chang-Mei Cheng, Yu-Fen Zhao Differentiation of alpha-COOH from gamma-COOH in Glutamic Acids by N-Phosphorylation. Journal of Molecular Structure: THEOCHEM, 2001, 574, 163-175.

15. Zhong-Zhou Chen, Yan-Mei Li, Yu-Fen Zhao. Hydrolysis of Dipeptide Esters with Newlase F Mixed Enzyme. Journal of Chemical Research(M), 2003, 0101–0110

16. Jin-Tang Du, Yan-Mei Li, Zhong-Zhou Chen, Shi-Zhong Luo, Yu-Fen Zhao. The self-catalytic esterification reaction of O-phosphoryl serine derivative. Chinese Chemical Letters, 2005,16, 856-858

17. Jin-Tang Du, Yan-Mei Li, Zhong-Zhou Chen, Yang Jiang, Ru-Gang Zhong, Yu-Fen Zhao. Theoretical studies on N-phosphorylized amino acids properties by quantum chemical calculation.Chemical Journal Of Chinese Universities-Chinese,2005, 26, 540-545

18. Bo Tan, Matthew C. Lee, Meng Cui, Tong Liu, Zhong-Zhou Chen, Yan-Mei Li, Yong Ju, Yu-Fen Zhao, Kaixian Chen, Hualiang Jiang.A common intermediate for prebiotic synthesis of proteins and nucleosides: a density functional theory (DFT) study on the formation of penta-coordinate phosphorus carboxylic–phosphoric mixed anhydride from N-phosphoryl amino acids. Journal of Molecular Structure (Theochem), 2004,672, 51–60.

19. Yang Jiang, Bo Tan, Zhong-Zhou Chen, Tong Liu, Ru-Gang Zhong, Yan-Mei Li, David Jeremy Stewart, Yu-Fen Zhao, Hua-Liang Jiang. Phosphoryl Group Differentiating alpha-Amino Acids From beta- and gama-Amino Acids in Prebiotic Peptide Formation. International Journal of Quantum Chemistry, 2003, 94, 232–241.

20. Shi-Zhong Luo, Yan-Mei Li, Zhong-Zhou Chen, H Abe, Li-Pin Cui, H Nakanishi, Xu-Rong Qin, Yu-Fen Zhao. Synthesis and matrix assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry study of phosphopeptide. Letters In Peptide Science,2003, 10, 57-62.

21. Hua Fu, JH Xu, RJ Wang, Zhong-Zhou Chen, GZ Tu, QZ Wang, Yu-Fen Zhao. Synthesis, crystal structure, and diastereomeric transfer of pentacoordinated phosphoranes containing valine or iso-leucine residue. Phosphorus Sulfur Silicon Relat. Elem.,2003, 178, 1963-1971.

22. Zhong-Zhou Chen, Yan-Mei Li, Gang Zhao, Yu-Fen Zhao. “The Application of Enzymatic Protecting Group in the Organic Synthesis”. Organic Chemistry (Chinese), 2001, 21, 273-277

23. Zhong-Zhou Chen, Yan-Mei Li, Xiu-Fen Kou, Xue Li, Fu-Rong Huang, Hai-Yan Wang, Ming-Ming Ma, Yu-Fen Zhao. Hydrolysis of Dipeptide Heptyl Esters with Newlase F. Chinese chemical letter, 2001, 12, 693-696.

24. Zhong-Zhou Chen, Bo Tan, Yan-Mei Li, Yu-Fen Zhao. Theoretical Study on the Activity of a-COOH and b-COOH of N-Phosphoryl Aspartic Acids. Chinese Chemical Letter, 2001, 12, 1093-1096.

25. Gang Zhao, Yan-Mei Li, Zhong-Zhou Chen, Yu-Fen Zhao. Chemical Synthesis of O-Phosphopeptide and Their Analogous”. Organic Chemistry (Chinese), 2001, 21, 8-15

26. Zhong-Zhou Chen, Yan-Mei Li, G.Zhao, Yu-Fen Zhao. The Properties and Synthesis of Conjugated Linoleic Acids. China Oils and Fats (Chinese), 2000, 25(5), 41-45

27. Zhong-Zhou Chen, Yan-Mei Li, Gang Zhao, Yu-Fen Zhao. Study in the synthesis of b-peptides and its secondary structures, Chemistry (Chinese), 1999, 11, 21-29.

28. Zenghua Wu, Ling Xu, Zhong-zhou Chen, xinyao Hu. Computer aided study on the influence of catalysts on the coal ignition property(I). The influence of alkali and alkaline earth metal salts on the coal ignition property. Computers and Applied Chemistry(Chinese), 1996, 13, 270-273.