美国新泽西州州立罗格斯大学教授

简历

姓名: 刘贻章 （Alice Y.-C. Liu）

生日：1948 年7 月12 日

国籍：美国

学习简历： Mount Sinai 医学院生物药理博士

学士B.S. 香港中文大学Chinese University of Hong Kong, 1969

博士Ph.D. 纽约西奈山医学院Mount Sinai School of Medicine, 1974

博士後Postdoc, 耶鲁大学医学院药理学系Yale Medical School, Pharmacology 1974-77

专业职务: 美国新泽西州州立罗格斯大学教授

从事专业: 本科生老师，博士导师

任职单位: 罗格斯大学，细胞生物学及神经科学学系。

工作简历：

1977-1984 助教授,哈佛大学医学院药理学系

1984-1989 副教授,新泽西州立罗格斯大学生物科学系

1989-1998 正教授,新泽西州立罗格斯大学生物科学系

1994-1999 主任,罗格斯大学及罗伯特强生医学院细胞及发育生物学研究院

1998- 目前 正教授,新泽西州立罗格斯大学细胞生物及神经科学系

科研项目

我们实验室长期以来从事分子生物学的研究工作。近年来的研究工作主要集中在HSF1 在神经

细胞生长及凋亡的功能。

实验室主要科研项目如下：

（1） 转录因子HSF1 在细胞体内的氧化还原调控及功能。

（2） 伴侣蛋白（ Chaperones）及蛋白摺叠对神经细胞的保护作用。

（3） 神经细胞中HSF1 的调控与功能。

主要学术成就

我们实验室长期以来接受美国国家卫生总署（NIH）及国家科学基金会NSF 的支助。我们是最

早发现热应激反应与细胞老化与有关的实验室。这项结果已为许多实验室证明，并认为是生物

老化的一个重要的分子标志。我们实验室开创研究HSF1 在神经受创复原的作用对脊髓再生作

出理论上的贡献。我们实验室毕业有10 位博士，12 位硕士，并训练了8 位後博士。

重要学术活动

1982 Member, Special Study Section, NCI, NIH

1982 Member, Basic Neuropsychology Research Review Subcommittee, NIMH

1984-1988 Member, Pharmacological Sciences Review Committee, NIGMS, NIH

1987 Member, Review Team for NIH Center Grant application from U. Calif – San Francisco

1989-1995 Member, Cell Biology Panel, National Science Foundation

1993 Member, Biochemistry and Endocrinology Study Section, Amer. Cancer Soc.

1990-2001 Member, Editorial Board, Biological Signals

1999, 2000, 2003 & 2004 Member, Center for Scientific Review Special Emphasis Panel, NIH

1990-present Member, Basic Research Advisory Group, NJ Commission on Cancer Research

2007 Member, Center for Scientific Review Special Emphasis Panel, National Institutes of Health

2009 Member, Brain I study section, American Heart Assoc.

2009 Member, Center for Scientific Review Special Emphasis Panel, National Institutes of Health

2010 Member, Brain I study section, American Heart Assoc.

奖励：

1972 New York Board of Higher Education Award

1974-1977 NIH Post-doctoral Fellowship (1F22AM01521)

1977-1979 Medical Foundation Fellowship

1982-1985 American Cancer Society Scholar Award

学术论文： （peer reviewed journals）

1. Liu, A. Y.-C. and Bentley, P. J. (1971) A comparison of the toxicity of ouabain in vivo and in vitro in

the frog, Rana pipiens, and the toad, Bufo marinus, Comp. Gen. Pharmacol. 2: 476-478.

2. Liu, A. Y.-C. and Mittag, T. W. (1974) Membrane-bound acetylcholinesterase: comparison of

enzymes in sarcoplasmic reticulum and sarcolemma from striated muscle. Mol. Pharmacology

10: 283-292.

3. Liu, A. Y.-C. and Greengard, P. (1974) Aldosterone-induced increase in protein phosphatase

activity of toad bladder. Proc. Natl. Acad. Sci., U.S.A, 71: 3869-3873.

4. Liu, A. Y.-C. and Greengard, P. (1976) Regulation by steroid hormones of phosphorylation of a

specific protein common to several target organs. Proc. Natl. Acad. Sci., U.S.A. 73: 568-572.

5. Walter, U., Uno, I., Liu, A. Y.-C. and Greengard, P. (1977) Identification, characterization, and

quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a

photoaffinity ligand. J. Biol. Chem. 252: 6494-6500.

6. Walter, U., Uno., I., Liu, A. Y.-C. and Greengard, P. (1977) Study of autophosphorylation of

isoenzymes of cyclic AMP-dependent protein kinases. J. Biol. Chem. 252: 6588-6590.

7. Liu, A. Y.-C. (1980) Role of cyclic AMP-dependent protein kinase in the induction of tyrosine

aminotransferase. J. Biol. Chem. 255: 4421-4429.

8. Kiu, A. Y.-C., Fiske, W.W. and Chen, K.Y. (1980) Regulation of cyclic adenosine 3':5'-

monosphophate-binding protein in N-18 mouse neuroblastoma cells. Cancer Research 40:

4100-4108.

9. Culpepper, J. and Liu, A. Y.-C. (1981) Induction of tyrosine aminotransferase by cAMP captured in

phospholipid vesicles. J. Cell Biol. 88: 89-95.

10. Liu, A. Y.-C., Walter, U. and Greengard, P. (1981) Steroid hormones may regulate

autophosphorylation of cyclic adenosine 3':5'-monophosphate-dependent protein kinase in

target tissues. Eur. J. Biochem. 114: 539-548.

11. Liu, A. Y.-C., Chan, T. and Chen, K. Y. (1981) Specific induction of regulatory subunit of type I

cAMP-dependent protein kinase in differentiated N-18 mouse neuroblastoma cells. Cancer

Research 41: 4579-4587.

12. Smith, J. D. and Liu, A. Y.-C. (1981) Lectins induce tyrosine aminotransferase in hepatoma cells.

Science 214: 799-800.

13. Chen, K. Y. and Liu, A Y.-C. (1981) Differences in polyamine metabolism of the undifferentiated

and differentiated neuroblastoma cells. FEBS Letters 134: 71-74.

14. Chen, K. Y., Prespe, J., Parken, N. and Liu, A. Y.-C. (1982) Changes of ornithine decarboxylase

activity and polyamine content upon differentiation of mouse NB-15 neuroblastoma cells. J.

Cell. Physiol. 110: 285-290.

15. Liu, A. Y.-C. (1982) Differentiation-specific increase of cAMP-dependent protein kinase in the 3T3-

L1 cells. J. Biol. Chem. 257: 298-306.

16. Chen, K. Y. and Liu, A. Y.-C. (1983) Role of polyamines in the differentiation of mouse

neuroblastoma cells. Advances in Polyamine Research, Volume 4 (Bachrach, U., Kaye, A.

and Chayen, R., eds) pp. 743-755.

17. Chen, K. Y. and Liu, A. Y.-C. (1983) Differences in the mode of regulation of ornithine

decarboxylase and tyorsine aminotransferase in H-35 rat hepatoma cells shown by varying the

medium composition. Biochem. Biophys. Acta. 755: 244-252.

18. Chen, K. Y., Nau, D. and Liu, A. Y.-C. (1983) Effects of inhibitors of ornithine decarboxylase on

the differentiation of mouse neuroblastoma cells. Cancer Research 43: 2812-2818.

19. Culpepper, J. A. and Liu, A. Y.-C. (1983) Pretranslational control of tyrosine aminotransferase

synthesis by 8-bromo-cyclic AMP in H-4 rat hepatoma cells. J. Biol. Chem. 258: 13812-13818.

20. Liu, A. Y.-C. (1984) Modulation of the function and activity of cAMP-dependent protien kinase by

steroid hormones and its possible role in the mechanism of steroid hormone action. Trends in

Pharmacological Science 5: 106-108.

21. Liu, A. Y.-C. (1984) Modulation of the function and activity of cAMP-dependent protien kinase by

steroid hormones and its possible role in the mechanism of steroid hormone action. In

Receptors, Again (Lamble, J. W. and Abbot, A. C. eds), Elsevier Publications, pp. 279-283.

22. Liu, A. Y.-C. and Chen, K. Y. (1985) Differential effects of the phorbol ester tumor promotor, PMA,

on the morphological and biochemical differentiation of N-18 mouse neuroblastoma cells. J.

Cell. Physiol. 125: 387-392.

23. Liu, A. Y.-C., Chang, Z. F. and Chen, K. Y. (1986) Increased level of cAMP-dependent protein

kinase in aging human lung fibroblasts. J. Cell. Physiol. 128: 149-154.

24. Chen, K. Y., Chang, Z. F. and Liu, A. Y.-C. (1986) Changes of serum-induced ornithine

decarboxylase activity and putrescine content during aging of IMR-90 human diploid

fibroblasts. J. Cell. Physiol. 129: 142-146.

25. Liu, A. Y.-C., Kamalakannan, V. and Chen, K. Y. (1987) Identification of functional cAMPdependent

protein kinase in a "neurite-minus" mouse neuroblastoma cell line. Biochem.

Biophys. Acta. 928: 235-239.

26. Liu, A. Y.-C., Kamalakannan, V. and Lin, Z. (1987) Induction of the RI cAMP-binding protein in the

"neurite-minus" N1A-103 mouse neuroblastoma cell line. Biochem. Biophys Res. Commun.,

148: 350-356.

27. Liu, A. Y.-C., Lin, Z., Kamalakannan, V. and Chen, K. Y. (1988) Induction and quantitation of the

RI cAMP-binding protein in clonal mouse neuroblastoma cell lines: Evidence that the increase

in RI is not linked to neurite outgrowth. J. Neuroscience Research 19: 303-311.

28. Liu, A. Y.-C. and Lin, Z. (1988) Specificity of the action of cAMP agonists in the induction of RI

cAMP-binding protein in mouse neuroblastoma cells. Biochemical Pharmacology 37: 2005-

2011.

29. Smith, J. D. and Liu, A. Y.-C. (1988) The induction, desensitization, and deinduction of tyrosine

aminotransferase by 8-bromo-cAMP in H-4 rat hepatoma cells. Biochem. J., 251: 261-267.

30. Meyer, S., Lin, Z. and Liu, A. Y.-C. (1988) Neurite extension and increased expression of RI

cAMP-binding protein in ouabain-resistant neuroblastoma mutants. J. Neurochem., 51: 950-

959.

31. Smith, J. D. and Liu, A. Y.-C. (1988) Increased turnover of messenger RNA encoding tyrosine

aminotransferase can account for the desensitization and de-induction of tyrosine

aminotransferase by 8-bromo-cAMP treatment and removal. EMBO Journal 7: 3711-3716.

32. Liu, A. Y.-C., Lin, Z., Choi, H. S., Sorhage, F. and Li, B. (1989) Attenuated heat shock gene

expression in aging diploid fibroblasts. J. Biol. Chem. 264: 12037-12045.

33. Liu, A. Y.-C., Bae-Lee, M. S., Choi, H. S. and Li, B. (1989) Heat shock induction of HSP 89 is

regulated in cellular aging. Biochem. Biophys. Res. Commun. 162: 1302-1310.

34. Chen. K. Y., Chang, Z. F., Pang, J. H., He, G. S. and Liu, A. Y.-C. (1989) Polyamine metabolism

and cell-cycle-dependent gene expression in IMR-90 human diploid fibroblasts during

senescence in culture. Experimental Gerontology 24: 523-537.

35. Choi, H. S., Lin, Z., Li, B. and Liu, A. Y.-C. (1990) Age-dependent decrease in the heat-inducible

DNA sequence-specific binding activity in human diploid fibroblasts. J. Biol. Chem., 265:

18005-18011.

36. Liu, A. Y.-C., Choi, H. S. and Bae-Lee, M. S. (1990) Decreased heat shock response upon

adipose differentiation of 3T3-L1 cells. Biochem. Biophys. Res. Commun. 172: 1-7.

37. Choi, H. S., Li, B., Lin, Z., and Liu, A. Y.-C. (1991) cAMP and cAMP-dependent protein kinase

regulate the human hsp 70 gene promoter activity. J. Biol. Chem. 266: 11858-11865.

38. Liu, A. Y.-C., Li, B., Choi, H. S. and Lee, Y.- K. (1991) Molecular events involved in transcriptional

activation of heat shock genes become progressively refractory to heat stimulation during

aging of human diploid fibroblasts. J. Cell. Physiol. 149: 560-566.

39. Zhang, H. and Liu, A. Y.-C. (1992) Tributyltin is a potent inducer of the heat shock response in

human diploid fibroblasts. J. Cell. Physiol., 153: 460-466.

40. Chang N. T. and Liu, A. Y.-C. (1992) The heat induced hsp 70 promoter activity is negatively

regulated by serine phosphatases: evidence from the effects of okadaic acid. Biological

Signals, 1: 300-312.

41. Chang, N. T., Huang, L. E. and Liu, A. Y.-C. (1993) Okadaic acid markedly potentiated the heatinduced

hsp 70 promoter activity. J. Biol. Chem., 268: 1436-1439.

42. Liu, A. Y.-C., Bian, H. J., Huang, L. E. and Lee, Y. K. (1994) Transient cold shock induces the

heat shock response upon recovery at 37°C in human cells. J. Biol. Chem. 269: 14769-14775.

43. Huang, L. Eric, Zhang, H. Bae, S. W. and Liu, A. Y.-C. (1994) Thiol reducing reagents inhibit the

heat shock response: involvement of a redox mechanism in the heat shock signal transduction

pathway. J. Biol. Chem., 269: 30718-30725.

44. Huang, L. Eric, Caruccio, L., Liu, A. Y.-C. and Chen, K. Y. (1995) Rapid activation of the heat

shock transcription factor, HSF1, by hypo-osmotic stress in mammalian cells. Biochem.

Journal, 307: 347-352.

45. Liu, A. Y.-C., Lee, Y. K., Manalo, D., and Huang, L. E. (1996) Attenuated heat shock

transcriptional response in aging: Molecular mechanisms and implications in the biology of

aging. In Stress-inducible Cellular Responses (Ulrich Feige, Richard I. Morimoto, Ichiro

Yahara, and Barbara S. Polla, eds.), Birkhauser/Springer.

46. Lee, Y. K., Manalo, D. and Liu, A. Y.-C. (1996) Regulation and function of the heat shock

transcription factor in cell aging. Biological Signals 5: 180-191.

47. Liu, A. Y.-C., Chen, K. Y. and Denhardt, D. T. (1996) Transcription Factors and Cell Aging,

Kargar Publishing, Basal, Switzerland.

48. Caruccio, L., Bae, S., Liu, A. Y.-C. and Chen, K. Y. (1997) Rapid activation of the heat shock

transcription factor, HSF1, by hyper- and hypo-osmotic stress in mammalian cells. Biochemical

Journal, I327: 341-347.

49. Chen, K. Y. and Liu, A. Y.-C. , Editors (1997) Biochemistry and function of hypusine formation on

eukaryotic translation initiation factor 5A. Kargar Publishing, Basal, Switzerland.

50. Chen, K.Y., Lu, Jiebo and Liu, A.Y.-C. ( 2000) The activation of trans-acting factors in response to

hypo- and hyper-osmotic stress in mammalian cells. In " Environmental Stressors and Gene

Responses." (eds. Storey, K. B., and Storey, J), Elsevier Science Press, CT.

51. Lu, J.B., Park, J., Liu, A.Y-C. and Chen, K.Y. (2000) Osmotic stress-induced activation of HSF1

DNA binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol.

184:183-190.

52. Park, Jeonghyeon and Liu, A. Y.-C. (2000) Pervanadate induces the hyperphosphorylation but

not the activaton of human heat shock factor 1. J. Cell. Physiol. 185: 348-357.

53. Park, Jeonghyeon and Liu, A. Y.-C. (2001) c-Jun-N-terminal kinase phosphorylates the HSF1

transcriptional activation domain : Role of JNK in the regualtion of the heat shock response. J.

Cell. Biochemistry 82: 326-338.

54. Manalo, D. J. and Liu, A. Y.-C. (2001) Resolution, detection, and characterization of redox

conformers of human HSF1. J. Biol. Chem. 276: 23554-23561.

55. Manalo, D. J., Lin, Z. and Liu, A. Y.-C. (2002) Redox-dependent regulation of the function and

conformation of human HSF1. Biochemistry, 41: 2580-2588.

56. Lin, Z., Fan, Huang, F., Ma, Z-F., Xu, K., and Liu, A. Y.-C. (2003) Redox-dependent changes in

structure and function of hHSF1. Acta Biochemica et Biophysica Sinica. 35: 542-547.

57. Lin, Z., Fan, Huang, F., Ma, Z-F., Xu, K., and Liu, A. Y.-C. (2003) Human heat shock

transcription factor 1 may have integrated redox chemistry of cysteine sulfhydryl into its functional

responses. Chin J. Geriatr. 22: 417-420.

58. Khalil, S., Luciano, J., Chen, W., Liu, A. Y.-C. (2006) Dynamic regulation and involvement of the

heat shock transcriptional response in arsenic carcinogenesis. J. Cell Physiology. 207:562-569.

59. Oza J, Yang JX, Chen KY and Liu AY-C. (2008) Changes in the regulation of heat shock gene

expression in neural differentiation. Cell Stress & Chaperones 13(1): 73-84.

60. Yang JX, Oza J, Bridges K, Chen KY, Liu AY-C. (2008) Neural differentiation and the attenuated

heat shock response. Brain Research 1203: 39-50.

61. Yang JX, Bridges K, Chen KY, Liu AY-C. (2008) Riluzole increases the amount of latent HSF1

for an amplified heat shock response and cytoprotection. PLoSONE, 3(8):e2864. doi: 10.1371/

journal.pone.0002864.

62. Lu J, Gosslau A, Liu A Y-C and Chen KY (2008) PCR differential display-based identification of

regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by

black tea polyphenol theaflavin monogallate. European Journal of Pharmacology 601: 66-72.

63. Lee YK, Liu DJ, Lu J, Chen KY, and Liu, AY-C. (2009) Aberrant regulation and modification of

heat shock factor 1 in senescent human diploid fibroblasts. J. Cellular Biochemistry 106:267-278.

64. Gosslau A, Jao DL, Butler R, Liu AY-C, Chen KY. (2009) Thermal killing of human colon cancer

cells is associated with the loss of eukaryotic initiation factor 5A. Journal of Cellular Physiology,

219:485-493.