个人履历

实验室主要研究方向

代表性论文

个人履历

清华大学教授，博士生导师 。1962年5月生于陕西。1978-1989就读于西北农业大学并获博士学位， 1995-1998在美国圣路易斯大学、华盛顿大学和阿拉巴马大学等医学院从事访问学 者和博士后研究。1990-1995受聘西北农业大学副教授，1998-2005受聘清华大学副教授， 2005年受聘清华大学教授。

实验室主要研究方向

1．细胞信号传导(包括TGF-beta,FGF,Wnt及STAT)的分子机理

2．肿瘤发生的分子机理

3．泛素化修饰对细胞增殖与分化的影响。

代表性论文

Yu Rong, Long Cheng, Hongxiu Ning, Jizhen Zou, Yuanjiang Zhang, Fang Xu, Li Liu, Zhijie Chang*, and Xin-Yuan Fu*. WT1 and STAT3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor. Cancer Research 66: 8049-8057, 2006. (co-corresponding authors)

Xinjun Zhang, Xi He, Xin-Yuan Fu*, Zhijie Chang*. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. Journal of Cell Science 119: 1053-62, 2006. (co-corresponding authors)

Hong Xin, Xialian Xu, Linyu Li, Hongxiu Ning, Yu Rong, Yu Shang, Yinyin Wang, Xin-Yuan Fu, and Zhijie Chang*. CHIP controls the sensitivity of TGF-β signaling by maintaining the basal level of Smad3 through ubiquitin-mediated degradation. J. Biol. Chem. 280: 20842-20850, 2005.

Linyu Li, Hong Xin, Xialian Xu, Mei Huang, Xinjun Zhang, Yue Chen, Shuping Zhang, Xin-Yuan Fu* and Zhijie Chang*. CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol. Cell. Biol. 24: 856-864, 2004. (co-corresponding authors).

Shiqin Xiong, Qiuhui Zhao, Zhili Rong, Guanrong Huang, Yiling Huang, Peila Chen, Shuping Zhang, Li Liu, and Zhijie Chang*. hSef inhibits PC12 cell differentiation by interfering with Ras-Mitogen-activated MAPK signaling. J. Biol. Chem. 278: 50273-50282, 2003.