姓名：杨鲜梅职位：副教授获得荣誉：1、2002年12月获得美国德克萨斯大学奥斯汀分校分子遗传和微生物学Ph D学位 。2、2003年1月-2006年1月美国德克萨斯大学奥斯汀分校药理学院博士后。3、2006年7月-至今复旦大学生命科学学院遗传所副教授。目前以肝癌发生和发展的分子机制为主要研究方向。

出生年月：1973年10月

性别：女

职称： 副教授

简历：

2006年7月-至今：复旦大学生命科学学院遗传所 副教授

2003年1月-2006年1月：美国德克萨斯大学奥斯汀分校药理学院博士后

2002年12月：获得美国德克萨斯大学奥斯汀分校分子遗传和微生物学Ph D学位

主要研究方向：

肝癌发生和发展的分子机制。

获奖情况：

代表性论文和专著：

1．Banks, M.L., Yang, X., Mills, E.M., Sprague J.E. (2005) Temporal profile of core body and intracranial hyperthermia and striatal UCP5 expression in rats following MDMA administration. (写作中)

2． Mills, E.M., Yang, X., Sedensky, M.M., Hoppel C., Morgan, P., and Finkel, T. (2005) C. elegans expresses an uncoupling protein that regulates oxidative stress and fat storage. (写作中)

3． Sprague, J.E., Yang, X., Sommers J, Gilman T.L., and Mills, E.M. Roles of norepinephrine, free fatty acids, thyroid status and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis. Accepted by Journal of Pharmacology and Experimental Therapeutics in June 2006.

4． Mehta, S., Yang, X., Jayaram, M and Velmurugan, S. A noval role for the mitotic spindle during DNA segregation in yeast: Promoting 2 micron plasmid- cohesin association. Molecular and Cellular Biology, 12 (2005): 4283-4298

5． Yang, X., Wu, X., Choi, Y.E., Kern, J., and Kehrer, J.P. Effect of acrolein and glutathione depleting agents on thioredoxin. Toxicology, 204 (2004): 209-218

6． Watson, W.H., Yang, X., Choi, Y.E., Jones, D.P., and Kehrer, J.P. Thioredoxin and its role in toxicology (review article). Toxicological Sciences, 78 (2004): 3-14

7． Yang, X., Mehta, S., Uzri, D., Jayaram, M., andVelmurugan, S. Mutations in a partitioning protein and altered chromatin structure at the partitioning locus prevent cohesin recruitment by the Saccharomyces cerevisiae plasmid and cause plasmid missegregation. Molecular and Cellular Biology, 12 (2004): 5290-5303

8． Mehta, S., Yang, X., Chan, C.S., Dobson, M.L., Jayaram, M and Velmurugan, S. The 2 micron plasmid purloins the yeast cohesion complex: a mechanism for coupling plasmid partitioning and chromosome segregation? J. Cell Biology, 158 (2002): 625-637

9． Velmurugan, S., Yang, X., Chan, C.S., Dobson, M.L. and Jayaram, M. Partitioning of the 2m circle plasmid of Saccharomyces cerevisiae: functional coordination with chromosome segregation and plasmid encoded Rep protein distribution. J. Cell Biology, 149 (2000): 553-566

10． Brown, J.T, Yang, X.and Johnson, A.W. Inhibition of mRNA turnover in yeast by an xrn1 mutation enhances the requirement for eIF4E binding to eIF4G and for proper capping of transcripts by Ceg1p. Genetics, 155 (2000):31-42

11． Velmurugan, S., Ahn, Y.T., Yang, X., Wu, X. and Jayaram, M. The 2m plasmid stability system: analyses of the interactions among plasmid- and host-encoded components. Molecular and Cellular Biology, 12 (1998): 7466-7477