简介

主要研究方向

近期代表性论文

简介

肖庚富

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职称职务：教授，博导，出生： 1966年1月 湖北襄樊

学位： 博士

毕业学校：武汉大学

学科专业：微生物学、病毒学

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主要研究方向

：

1．朊病毒(Prion)与蛋白质构象病：朊蛋白折叠、转运（cellular trafficking）与蛋白质质量控制

2．病毒与细胞相互作用的分子机理：病毒囊膜蛋白介导细胞融合的机制；病毒侵染历程可视化；巨细胞病毒的蛋白组学与结合组学（interactome）

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近期代表性论文

：

1. Peng X, Pan J, Gong R, Liu Y, Kang S, Feng H, Qiu G, Guo D, Tien P, Xiao G*. Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein: implication for its fusion mechanism. J Biol Chem. 2007 Feb (published on Nov 14, 2006 as manuscript M606353200) (IF: 5.854)

2. Yin S, Yu S, Li C, Wong P, Chang B, Xiao F, Kang SC, Yan H, Xiao G, Grassi J, Tien P, Sy MS. Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack. J Biol Chem. 2006 Apr 21;281(16):10698-705. (IF: 5.854)

3. Sun G, Guo M, Shen A, Mei F, Peng X, Gong R, Guo D, Wu J, Tien P, Xiao G*. Bovine PrPC directly interacts with alphaB-crystalline. FEBS Lett. 2005 Oct 10;579(24):5419-24. (IF: 3.415)

4. Gong R, Peng X, Kang S, Feng H, Huang J, Zhang W, Lin D, Tien P*, Xiao G*. Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W. Biochem Biophys Res Commun. 2005 Jun 17;331 (4):1193-200. . (IF: 3.000)

5. Liu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Xiong H, Farmar J, Debnath AK, Tien P, Jiang S. Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. Lancet. 2004 Mar 20;363(9413):938-47. (Liu S and Xiao G made equal contributions). (IF:23.407)

6. Yu S, Jin L, Sy M, Mei F, Kang S, Sun G, Tien P, Wang F*, and Xiao G*. Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation. Eur J Hum Genet. 2004 Oct 8;12(10):867-70 (IF:3.251)