1 南朝梁南平王

2 首都师范大学生物系教授

3 著名画家

4 南京中医药大学

南平元襄王伟，字文达，太祖萧顺之第八子也。幼清警好学。齐世，起家晋安镇北法曹行参军府，迁骠骑，转外兵。高祖为雍州，虑天下将乱，求迎伟及始兴王憺来襄阳。俄闻已入沔，高祖欣然谓佐吏曰：“吾无忧矣。”义师起，南康王承制，板为冠军将军，留行雍州开府事。义师发后，州内储备及人皆虚竭。魏兴太守裴师仁、齐兴太守颜僧都并据郡不受命，举兵将袭雍州，伟与始兴王憺遣兵于始平郡待师仁等，要击大破之，州境以安。

高祖既克郢、鲁，下寻阳，围建业，而巴东太守萧慧训子璝及巴西太守鲁休烈起兵逼荆州，屯军上明，连破荆州。镇军萧颖胄遣将刘孝庆等距之，反为璝所败，颖胄忧愤暴疾卒，西朝凶惧。尚书仆射夏侯详议征兵雍州，伟乃割州府将吏，配始兴王嶦往赴之。嶦既至，璝等皆降。和帝诏以伟为使持节、都督雍、梁、南、北秦四州郢州之竟陵司州之随郡诸军事、宁蛮校尉、雍州刺史，将军如故。寻加侍中，进号镇北将军。

天监元年，加散骑常侍，进督荆、宁二州，余如故。封建安郡王，食邑二千户，给鼓吹一部。四年，徙都督南徐州诸军事、南徐州刺史，使持节、常侍、将军如故。五年，至都，改为抚军将军、丹阳尹，常侍如故。六年，迁使持节、都督扬、南徐二州诸军事、右军将军、扬州刺史。未拜，进号中权将军。七年，以疾表解州，改侍中、中抚军，知司徒事。九年，迁护军、石头戍军事，侍中、将军、鼓吹如故。其年，出为使持节、散骑常侍、都督江州诸军事、镇南将军、江州刺史，鼓吹如故。十一年，以本号加开府仪同三司。其年，复以疾陈解。十二年，征为抚军将军，仪同、常侍如故，以疾不拜。十三年，改为左光禄大夫。加亲信四十人，岁给米万斛，布绢五千匹，药直二百四十万，厨供月二十万，并二卫两营杂役二百人，倍先。置防阁白直左右职局一百人。伟末年疾浸剧，不复出藩，故俸秩加焉。

十五年，所生母陈太妃寝疾，伟及临川王萧宏侍疾，并衣不解带。及太妃薨，毁顿过礼，水浆不入口累日，高祖每临幸譬抑之。伟虽奉诏，而毁瘠殆不胜丧。十七年，高祖以建安土瘠，改封南平郡王，邑户如故。迁侍中、左光禄大夫、开府仪同三司。普通四年，增邑一千户。五年，进号镇卫大将军。中大通元年，以本官领太子太傅。四年，迁中书令、大司马。五年，薨，时年五十八。诏敛以衮冕，给东园秘器。又诏曰：“旌德纪功，前王令典；慎终追远，列代通规。故侍中、中书令、大司马南平王伟，器宇宏旷，鉴识弘简。爰在弱龄，清风载穆，翼佐草昧，勋高樊、沔，契阔艰难，劬劳任寄。及赞务论道，弘兹衮职。奄焉薨逝，朕用震恸于厥心。宜隆宠命，式昭茂典。可赠侍中、太宰，王如故。给羽葆鼓吹一部，并班剑四十人。谥曰元襄。”

伟少好学，笃诚通恕，趋贤重士，常如不及。由是四方游士，当世知名者，莫不毕至。齐世，青溪宫改为芳林苑，天监初，赐伟为第，伟又加穿筑，增植嘉树珍果，穷极雕丽，每与宾客游其中，命从事中郎萧子范为之记。梁世藩邸之盛，无以过焉。而性多恩惠，尤愍穷乏。常遣腹心左右，历访闾里人士，其有贫困吉凶不举者，即遣赡恤之。太原王曼颖卒，家贫无以殡敛，友人江革往哭之，其妻儿对革号诉。革曰：“建安王当知，必为营理。”言未讫而伟使至，给其丧事，得周济焉。每祁寒积雪，则遣人载樵米，随乏绝者即赋给之。晚年崇信佛理，尤精玄学，著《二旨义》，别为新通。又制《性情》、《几神》等论其义，僧宠及周舍、殷钧、陆倕并名精解，而不能屈。

概述

获奖

研究领域

发表论文

◎ 概述

萧伟，博士，首都师范大学生物系教授。1. 学士/1982 南京农业大学

2. 硕士/1984 多伦多大学（University of Toronto）

3. 博士/1988萨斯喀彻温大学（University of Saskatchewan）

4. 博士后 /1990-1992 哈佛大学（Harvard University）

◎ 获奖

萨斯喀彻温大学年度最佳研究奖（2008）

萨斯喀彻温大学医学院研究生会（CMGSS）年度最佳导师奖（2007）

人物传记被收录于《千禧年的加拿大》（CANADA at the Millennium）（2000）

人物传记被收录于《加拿大名人录》（Canadian Who’s Who）(自1996)

◎ 研究领域

泛素（Ubiquitin，Ub）是一种高度保守的小蛋白（76个氨基酸），普遍存在于从单细胞酵母到人类的所有真核细胞内，并且表达水平很高。通过一系列的酶促反应，泛素在泛素结合酶（E2或Ubc）和泛素连接酶（E3）的帮助下连接到目的蛋白。接着在一个被称为多聚泛素链的泛素多聚体形成后，结合有多聚泛素链的目的蛋白被26S蛋白酶体降解，而这个过程是许多细胞活动调节的重要手段，2004年的诺贝尔奖授予了“泛素化的发现和它在蛋白降解中的作用”就说明了它的重要性。深入研究揭示，上述泛素链是由下一个泛素表面的Lys48残基结合在上一个泛素的C末端甘氨酸残基而形成的，随后又发现泛素链也可经由表面Lys63残基形成。在所有生物中发现的泛素结合酶中，只有Ubc13能够专一通过Lys63连接泛素。Ubc13的独特性质是基于它和另一个被称作泛素结合酶异构体的蛋白的结合，而这种异构体也是Lys63多聚泛素化过程所必须的。更重要的是，被Lys63连接的泛素所结合的目的蛋白不是为了降解，而是为了改变其活性。此外，在其他泛素化类型中，单一泛素化也被认为是一种新颖的蛋白质活性调节机制，拓宽了人们对泛素化功能的认识。本实验室的主要兴趣在于发现上述非常规泛素化过程和探索相关途径的分子机制。因为一些研究的很透彻的非常规泛素化目的蛋白参与一些重要的细胞代谢过程，如DNA损伤耐受、细胞周期检验点、自然免疫和应激反应，而且这些过程在人类疾病中起关键作用，如癌症，抗病及衰老，所以这项研究将会对包括癌症在内的多种疾病诊断和治疗产生直接影响。

◎ 发表论文

Zhang, M., Hanna, M., Li, J., Butcher, S., Dai, H. and Xiao, W. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Tox. Sci. 113: 401-411.

Ball, L.G., Zhang, K., Cobb, J.A., Boone, C. and Xiao, W. (2009) The yeast Shu complex couples error-free PRR to homologous recombination. Mol. Microbiol. 73: 89-102. [Text]

Ball, L. and Xiao, W. (2009) Ataxia telangiectasia and its overlap with Nijmegen breakage syndrome and Ataxia-like disorders. In: Ahmad, S. (ed.) Molecular Mechanisms of Ataxia Telangiectasia. Chapter 10, pp.91-100. Landes Biosciences Publication, Texas. [Text]

Pelzer, L., Pastushok, L., Moraes, T., Glover, J.N.M., Ellison, M.J., Ziola, B. and Xiao, W. (2009) Biological significance of structural differences between two highly conserved Ubc variants. Biochem. Biophy. Res. Comm. 378: 563-568. [Text]

Fu, Y., Pastushok, L. and Xiao, W. (2008) DNA damage-induced gene expression in Saccharomyces cerevisiae. FEMS Microbol. Rev. 32: 908-926. [Text]

Huen, M.S.Y., Yuan, J., Yamamoto, M., Akira, S., Ashley, C., Xiao, W. and Chen, J. (2008) Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol. Cell. Biol. 19: 6104-6112. [Text]

Anderson, H.J., Vonarx, E.J., Pastushok, L., Nakagawa, M., Katafuchi, A., Gruz, P., Di Rubbo, A., Grice, D.M., Osmond, M.J., Sakamoto, A., Nohmi, T., Xiao, W. and Kunz, B.A. (2008) Arabidopsis thaliana Y-family DNA polymerase η catalyses translesion synthesis and interacts functionally with PCNA2. Plant J. 55: 895-908. [Text]

Fu, Y., Zhu, Y. Zhang, K., Yeung, M., Durocher, D. and Xiao, W. (2008) Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Cell 133: 601-611. [Text]

Zhang, M., Liang, Y., Zhang, X., Xu, Y., Dai, H. and Xiao, W. (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol. Sci. 103: 68-76. [Text]

Rostek, C., Turner, E., Robbins, M., Rightnar, S., Xiao, W., Obenaus, A. and Harkness, T.A.A. (2008) Involvement of homologous recombination repair after proton-induced DNA damage. Mutagenesis 23: 119-129. [Text]

Brun, J., Chiu, R.K., Lockhart, K., Xiao, W., Wouters, B.G. and Gray, D.A. (2008) hMMS2 serves a redundant role in human PCNA polyubiquitination. BMC Mol. Biol. 9: 24. [Text]

Wen, R., Torres-Acosta, J.A., Pastushok, L., Lai, X., Pelzer, L., Wang, H. and Xiao, W. (2008) Arabidopsis UEV1D promotes lysine-63-linked polyubiquitination and is involved in DNA damage response. Plant Cell 20: 213-227. [Text]

Andersen, P.L., Xu, F. and Xiao, W. (2008) Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res. 18: 162-173. [Text]

Dworaczek, H. and Xiao, W. (2007) Xeroderma pigmentosum: a glimpse into nucleotide excision repair, genetic instability, and cancer. Crit. Rev. Oncogen. 13: 159-177. [Text]

Kunz, B.A. and Xiao, W. (2007) DNA damage tolerance in plants via translesion synthesis. Genes, Genomes, Genomics 1: 89-99. [Text]

Pastushok, L., Spyracopoulos, L. and Xiao, W. (2007) Two Mms2 residues cooperatively interact with ubiquitin and are critical for Lys63 polyubiquitination in vitro and in vivo. FEBS Lett. 581: 5343-5348. [Text]

Hanna, M., Ball, L.G., Tong, A.H., Boone, C. and Xiao, W. (2007) Pol32 is required for Polζ-dependent translesion synthesis and prevents double-strand breaks at the replication fork. Mutat. Res. 625: 164-176. [Text]

Mercier, P., Lewis, M.J., Hau, D.D., Saltibus, L.F., Xiao, W. and Spyracopoulos, L. (2007) Structure, interactions, and dynamics of the RING domain from human TRAF6. Protein Sci. 16: 602-614. [Text]

Barbour, L., Ball, L.G., Zhang, K. and Xiao, W. (2006) DNA damage checkpoints are involved in postreplication repair. Genetics 174: 1789-1800. [Text]

Syed, N.A., Andersen, P.L., Warrington, R.C. and Xiao, W. (2006) Uev1A, a ubiquitin conjugating enzyme variant, inhibits stress-induced apoptosis through NF-κB activation. Apoptosis 11: 2147-2157. [Text]

Hau, D.D., Lewis, M.J., Saltibus, L.F., Pastushok, L., Xiao, W. and Spyracopoulos, L. (2006) Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains. Biochemistry 45: 9866-9877. [Text]

Wen, R., Newton, L., Li, G., Wang, H. and Xiao, W. (2006) Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants. Plant Mol. Biol. 61: 241-253. [Text]

Fu, Y. and Xiao, W. (2006) Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes. Nucleic Acids Res. 34: 1876-1883. [Text]

Lewis, M.J., Saltibus, L.F., Hau, D.D., Xiao, W. and Spyracopoulos, L. (2006) Structural basis for non-covalent interaction between ubiquitin and the ubiquitin conjugating enzyme variant human Mms2. J. Biomol. NMR 34: 89-100. [Text]

Barbour, L. and Xiao, W. (2006) Mating type regulation of cellular tolerance to DNA damage is specific to the DNA postreplication repair and mutagenesis pathway. Mol. Microbiol. 59: 637-650. [Text]

Andersen, P., Zhou, H., Pastushok, L., Moraes, T., McKenna, S., Ziola, B., Ellison, M.J., Dixit, V.M. and Xiao, W. (2005) Distinct regulation of Ubc13 functions by two Uev proteins Mms2 and Uev1A. J. Cell Biol. 170: 745-755. [Text]

Ball, L.G. and Xiao, W. (2005) Molecular basis of ataxia telangiestasia and related diseases. Acta Pharmacologica Sinica 26: 897-907. [Text]

Pastushok, L., Moraes, T.F., Ellison, M.J. and Xiao, W. (2005) A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. J. Biol. Chem. 280: 17891-17900. [Text]

Pastushok, L. and Xiao, W. (2004) DNA Postreplication repair modulated by ubiquitination and sumoylation. Advances in Protein Chemistry 69: 279-306. [Text]

Zhu, Y and Xiao, W. (2004) Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element. Nucleic Acids Res. 32: 5066-5075. [Text]

Wooff, J., Pastushok, L., Hanna, M., Yu, F. and Xiao, W. (2004) The TRAF6 RING finger domain mediates physical interaction with Ubc13. FEBS Lett. 566: 229-233. [Text]

Zhou, H., Wertz, I., O'Rourke, K., Ultsch, M., Seshagiri, S., Eby, M., Xiao, W. and Dixit, V.M. (2004) Bcl10 activates the NF-κB pathway through ubiquitination of NEMO. Nature 427: 167-171. [Text]

Hanna, M.D., Meadows, K.L., Chow, B.L., Jinks-Robertson, S., Doetsch, P.W. and Xiao, W. (2004) Involvement of two endonuclease III homologs in the base excision repair for the processing of DNA alkylation damage in Saccharomyces cerevisiae. DNA Repair 3: 51-59 [Text]

Barbour, L. and Xiao, W. (2003) Regulation of alternative replication bypass pathways at stalled replication forks and its effects on genome stability: a yeast model. Mutat. Res. 532: 137-155. [Text]

Fu, Y. and Xiao, W. (2003) Functional domains required for the Saccharomyces cerevisiae Mus81-Mms4 endonuclease complex formation and nuclear localization. DNA Repair 2: 1435-1447 [Text]

Bawa, S. and Xiao, W. (2003) A single amino acid substitution in Msh5 results in DNA alkylation tolerance. Gene 315: 177-182. [Text]

Jia, X. and Xiao, W. (2003) Compromised DNA repair enhances sensitivity of the RNR3-lacZ genotoxic testing system. Toxicol. Sci. 75: 82-88. [Text]

McKenna, S., Hu, J., Moraes, T., Xiao, W., Ellison, M.J. and Spyracopoulos, L. (2003) Energetics and specificity of interactions within Ub.UEV.Ubc13 human ubiquitin conjugation complexes. Biochemistry 42: 7922-7930. [Text]

McKenna, S., Moraes, T., Pastushok, L., Ptak, C., Xiao, W., Spyracopoulos, L. and Ellison, M.J. (2003) An NMR based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2/Ubc13: The structural basis for lysine 63 chain catalysis. J. Biol. Chem. 278: 13151-13158. [Text]

Brown, M., Zhu, Y., Hemmingsen, S, and Xiao, W. (2002) Structural and functional conservation of error-free postreplication repair in Schizosaccharomyces pombe. DNA Repair 1: 869-880. [Text]

Jia, X., Zhu, Y. and Xiao, W. (2002) A stable and sensitive genotoxic testing system based on DNA damage induced gene expression in Saccharomyces cerevisiae. Mutat. Res. 519: 83-92. [Text]

Li, Z., Xiao, W., McCormick, J.J. and Maher, V.M. (2002) Identification of a protein essential for a major pathway used by human cells to avoid UV-induced DNA damage. Proc. Natl. Acad. Sci. USA 99: 4459-4464. [Text]

Ashley, C., Pastushok, L., McKenna, S., Ellison, M.J. and Xiao, W. (2002) Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. Gene 285: 183-191. [Text]

Broomfield, S. and Xiao, W. (2002) Suppression of genetic defects within the RAD6 pathway by srs2 is specific for error-free postreplication repair but not for damage induced mutagenesis. Nucleic Acids Res. 30: 732-739. [Text]

Hryciw, T., Tang, M., Fontanie, T. and Xiao, W. (2002) MMS1 protects against replication-dependent DNA damage in Saccharomyces cerevisiae. Mol. Genet. Genomics 266: 848-857. [Text]

Villalobo, E., Morin, L., Moch, C., Lescasse, R., Hanna, M., Xiao, W. and Baroin-Tourancheau, A. (2002) A homolog of CROC-1 in a ciliated protist (Sterkiella histriomuscorum) testifies to the ancient origin of the ubiquitin-conjugating enzyme variant family. Mol. Biol. Evol. 19: 39-48. [Text]

Xiao, W., Chow, B.L., Hanna, M. and Doetsch, P.W. (2001) Deletion of the MAG1 glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases. Mutat. Res. 487: 137-147. [Text]

McKenna, S., Spyracopoulos, L., Moraes, T., Pastushok, L., Ptak, C., Xiao, W. and Ellison, M.J. (2001) Non-covalent interaction between ubiquitin and the human DNA repair protein Mms2 is required for Ubc13-mediated poly-ubiquitination. J. Biol. Chem. 276: 40120-40126. [Text]

Zhu, Y. and Xiao, W. (2001) Two alternative cell cycle checkpoint pathways differentially control DNA damage induction of the yeast MAG1 and DDI1 expression. Mol. Genet. Genomics 266: 436-444. [Text]

Moraes, T.F., Edwards, R.A., McKenna, S., Pastushok, L., Xiao, W., Glover, J.N.M. and Ellison, M.J. (2001) Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. Nature Structural Biol. 8: 669-673. [Text]

Broomfield, S., Hryciw, T. and Xiao, W. (2001) DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae. Mutat. Res. 486: 167-184. [Text]

Dai, H., Zhao, R., Haug, B., Hemmingsen, S.M. and Xiao, W. (2001) Isolation by phage display and characterization of a single-chain antibody specific for O6-methyldeoxyguanosine. Chinese Science Bulletin 46: 1024-1029. [Text]

Franko, J., Ashley, C. and Xiao, W. (2001) Molecular cloning and functional characterization of two murine cDNAs encoding Ubc-like proteins involved in DNA repair and mutagenesis. Biochem. Biophys. Acta. 1519: 70-77. [Text]

Barbour, L., Zhu, Y. and Xiao, W. (2000) Improving synthetic lethal screens by regulating the yeast centromere sequence. Genome 43: 910-917. [Text]

Xiao, W., Chow, B.L., Broomfield, S. and Hanna, M. (2000) The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways. Genetics 155: 1633-1641. [Text]

Brusky, J., Zhu, Y. and Xiao, W, (2000) UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae. Curr. Genet. 37: 168-174. [Text]

Chamankhah, M., Fontanie, T. and Xiao, W. (2000) The Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functions. Genetics 155: 569-576. [Text]

Xiao, W., Fontanie, T., Bawa, S. and Kohalmi, L. (1999) REV3 is required for spontaneous but not methylation damage-induced mutagenesis of Saccharomyces cerevisiae cells lacking O6-methylguanine DNA methyltransferase. Mutat Res. 431: 155-165. [Text]

Bawa S. and Xiao, W. (1999) Methionine reduces spontaneous and alkylation-induced mutagenesis in Saccharomyces cerevisiae cells deficient in O6-methylguanine-DNA methyltransferase. Mutat Res. 430: 99-107. [Text]

Xiao, W,. Chow, B.L., Fontanie, T., Ma, L., Bacchetti, S., Hryciw, T. and Broomfield, S. (1999) Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae. Mutat. Res. 431: 155-165. [Text]

Chamankhah, M. and Xiao, W. (1999) Formation of the yeast Mre11-Rad50-Xrs2 complex is correlated with DNA repair and telomere maintenance. Nucleic Acids Res. 27: 2072-2079. [Text]

Chamankhah, M., Wei, Y.-F. and Xiao, W. (1998) Isolation of hMRE11B:failure to complement yeast mre11 defects due to species-specific protein interactions. Gene 225: 107-116. [Text]

Chamankhah, M. and Xiao, W. (1998) Molecular cloning and genetic characterization of the Saccharomyces cerevisiae NGS1/MRE11. Current Genet. 34: 368-374. [Text]

Zhu, Y. and Xiao, W. (1998) Differential regulation of two closely clustered yeast genes, MAG1 and DDI1, by cell-cycle checkpoints. Nucleic Acids Res. 26: 5402-5408. [Text]

Kunz, B.A., Henson, E.S., Karthikeyan, R., Kuschak, T., McQueen, S.A., Scott, C.A. and Xiao, W. (1998) Defects in base excisioin repair combined with elevated intracellular dCTP levels dramatically reduce mutation induction in yeast by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine. Envir. Mol. Mutag. 32: 173-178. [Text]

Ma, L., Broomfield, S., Lavery, C., Lin, S., Xiao, W. and Bacchetti, S. (1998) Up-regulation of CIR1/CROC-1 expression upon cell immortalization and in tumour-derived human cell lines. Oncogene 17: 1321-1326. [Text]

Xiao, W., Lin, S.L., Broomfield, S., Chow, B.L. and Wei, Y.F. (1998) The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. Nucleic Acids Res. 26: 3908-3914 [Text]

Xiao, W., Lechler, T., Chow, B.L., Fontanie, T., Agustus, M., Carter, K.C. and Wei, Y.-F. (1998) Identification, chromosomal mapping and tissue-specific espression of hREV3 encoding a putative human DNA polymerase ζ. Carcinogenesis 19: 945-949. [Text]

Xiao, W., Chow, B.L. and Milo, C.N. (1998) Mms4, a putative transcriptional (co)activator, protects Saccharomyces cerevisiae cells from endogenous and environmental DNA damage. Mol. Gen. Genet. 257: 614-623. [Text]

Xiao, W. and Chow, B.L. (1998) Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage. Curr. Genet. 33: 92-99. [Text]

Broomfield, S., Chow, B.L. and Xiao, W. (1998) MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway. Proc. Natl. Acad. Sci. USA 95: 5678-2683. [Text]

Bawa, S. and Xiao, W. (1997) A mutation in the MSH5 gene results in alkylation tolerance. Cancer Res. 57: 2715-2720. [Text]

Liu, Y., Dai, H. and Xiao, W. (1997) UASMAG1, a yeast cis-acting element that regulates the expression of MAG1, is located within the protein coding region of DDI1. Mol. Gen. Genet. 255: 533-542. [Text]

Liu, Y. and Xiao, W. (1997) Bidirectional regulation of two DNA-damage-inducible genes, MAG1 and DDI1, from Saccharomyces cerevisiae. Mol. Microbiol. 23: 777-789. [Text]

Xiao, W., Chow, B.L. and Rathgeber, L. (1996) The repair of DNA methylation damage in Saccharomyces cerevisiae. Curr. Genet. 30: 461-468. [Text]

Xiao, W. and Rank, G.H. (1996) The 2μm plasmid of laboratory yeast strains is a type-1/type-2 hybrid. Yeast 12: 809-813. [Text]

Xiao, W., Nowak, M., Laferte, S. and Fontanie, T. (1996) Mutagenicity and toxicity of the DNA alkylation carcinogens 1,2-dimethylhydrazine and azoxymethane in Escherichia coli and Salmonella typhimurium. Mutagenesis 11: 241-245. [Text]

Xiao, W., Rathgeber, L., Fontanie, T. and Bawa, S. (1995) DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells. Carcinogenesis 16: 1933-1939. [Text]

Xiao, W. and Fontanie, T. (1995) Expression of the human MGMT O6-methylguanine DNA methyltransferase gene in a yeast alkylation-sensitive mutant: its effects on both exogenous and endogenous DNA alkylation damage. Mutat. Res. 336: 133-142. [Text]

Xiao, W., Fontanie, T. and Tang, M. (1994) UBP5 encodes a putative yeast ubiquitin-specific protease that is related to the human Tre-2 oncogene product. Yeast 10: 1497-1502. [Text]

Rank, G.H., Xiao, W. and Pelcher, L.E. (1994) Transpogenes: the transposition-like integration of short sequence DNA into the yeast plasmid creates the STB locus and plasmid-size polymorphism. Gene 147: 55-61. [Text]

Xiao, W., Penugonde, V. and Rank, G.H. (1994) The MAG1-3-methyladenine DNA glycosylase gene is closely linked to the SPT15 TATA-binding TFIID gene on chromosome V-R in Saccharomyces cerevisiae. Yeast 10: 687-691. [Text]

Rank, G.H., Xiao, W. and Arndt, G.M. (1994) Evidence for Darwinian selection of the 2μm plasmid STB locus in Saccharomyces cerevisiae. Genome 37: 12-18. [Text]

Xiao, W., Singh, K.K., Chen, B., Samson, L. (1993) A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae. Mol. Cell. Biol. 13: 7213-7221. [Text]

Xiao, W. and Samson, L. (1993) In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells. Proc. Natl. Acad. Sci. USA 90: 2117-2121. [Text]

Xiao, W. and Rank, G.H. (1993) Polymorphism of 2μm plasmids in industrial strains of Saccharomyces cerevisiae. Appl. Microbiol. & Biotechnol. 39: 80-86. [Text]

Xiao, W. and Samson, L. (1992) The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions. Nucleic Acids Res. 20: 3599-3606. [Text]

Xiao, W., Derfler, B., Chen, J. and Samson, L. (1991) Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene. EMBO J. 10: 2179-2186. [Text]

Rank, G.H. and Xiao, W. (1991) Alteration of industrial food and beverage yeasts by recombinant DNA technology. Ann. New York Acad. Sci. 646: 155-171.

Rank, G.H., Casey, G.P., Xiao, W. and Pringle, A.T. (1991) Polymorphism within the nuclear and 2μm genomes of Saccharomyces cerevisiae. Curr. Genet. 20: 189-194. [Text]

Xiao, W., Pelcher, L.E. and Rank, G.H. (1991) Sequence diversity of yeast 2μm RAF gene and its coevolution with STB and REP1. Gene 101: 75-80. [Text]

Xiao, W., Pelcher, L.E. and Rank, G.H. (1991) DNA sequence divergence and functional conservation at the STB locus of yeast 2μm circle variants. J. Bacteriol. 171: 1181-1186. []

Xiao, W., Pelcher, L.E. and Rank, G.H. (1991) Evidence for cis- and trans-acting element coevolution of the 2μm circle genome in Saccharomyces cerevisiae. J. Mol. Evol. 32: 145-152. [Text]

Xiao, W., and Rank, G.H. (1990) Curing industrial Saccharomyces yeasts of parasitic 2μm plasmid. J. Am. Soc. Brew. Chem. 48: 107-110.

Xiao, W. and Rank, G.H. (1990) Branched chain amino acid regulation of the ILV2 locus in Saccharomyces cerevisiae. Genome 33: 596-603. [Text]

Xiao, W. and Rank, G.H. (1990) Cloning of industrial Saccharomyces 2μm plasmid variants by in vivo site-specific recombination. Plasmid 23: 67-70. [Text]

Xiao, W. and Rank, G.H. (1990) An improved method for yeast 2μm plasmid curing. Gene 88: 241-245. [Text]

Xiao, W. and Rank, G.H. (1989) The construction of recombinant industrial yeasts free of bacterial sequences by direct gene replacement into a nonessential region of the genome. Gene 76: 99-107. [Text]

Rank, G.H., Arndt, G. and Xiao, W. (1989) FLP-FRT mediated intra-chromosomal recombination on a tandemly duplicated YEp integrant at the ILV2 locus of chromosome XIII in S. cerevisiae. Curr Genet. 15: 107-112. [Text]

Xiao, W. and Rank, G.H. (1988) The yeast ILV2 gene is under general amino acid control. Genome 30: 984-986. [Text]

Rank, G.H., Casey, G. and Xiao, W. (1988) Gene transfer in industrial Saccharomyces yeasts. Food Biotechnol. 2: 1-41.

Xiao, W. (1988) Stability of cloned Brassica napus chloroplast DNA fragments in the cyanobacterium Anacystis nidulans R2. Mol. Gen. Genet. 214: 307-312.

Casey, G.P., Xiao, W. and Rank, G.H. (1988) Construction of α-galactosidase-positive strains of industrial baker's (Saccharomyces cerevisiae) yeasts. J. Am. Soc. Brew. Chem. 46: 67-71.

Casey, G.P., Xiao, W. and Rank, G.H. (1988) Application of pulsed field chromosome electrophoresis in the study of chromosome XIII and the electrophoretic karyotype of industrial strains of Saccharomyces yeasts. J. Inst. Brew. 94: 239-243.

Rank, G.H., Xiao, W., Kolenovsky, A. and Arndt, G. (1988) FLP recombinase induction of the breakage-fusion-bridge cycle and gene conversion in Saccharomyces cerevisiae. Curr. Genet. 13: 273-281.

Casey, G.P., Xiao, W. and Rank, G.H. (1988) A convenient dominant selection marker for gene transfer in industrial strains of Saccharomyces yeast: SMR1 encoded resistance to the herbicide sulfometuron methyl. J. Inst. Brew. 94: 93-97.

Xiao, W., Saxena, P.K., King, J. and Rank, G.H. (1987) A transient duplication of the acetolactate synthase gene in a cell culture of Datura innoxia. Theor. Appl. Genet. 74: 417-422.

Xiao, W., Reith, M., Erickson, L.R., Williams, J.P. and Straus, N.A. (1986) Mapping the chloroplast genome of triazine resistant canola. Theor. Appl. Genet. 71: 716-723.

◎ 人物介绍

萧伟1982年生于山东，济南。2006年进修于天津美术学院。中国美术协会会员，现攻读中国美术学院花鸟系硕士研究生。其作品特点既有霍春阳的简淡冲和、虚静空灵。又有孙其峰花鸟的意兼工。擅长山

水，花鸟，书法，篆刻。其花鸟作品多次参加全国联展并获奖，三件作品分别获第八，九，届。花鸟作品一

等奖。并被多加机构收藏。实力派青年画家， 出版有-----萧伟花鸟精选

青年画家萧伟花鸟集。作品曾在北京、上海、天津、广州、兰州、台湾 展出。有多幅作品被大型画册、报纸、杂志刊登。

萧伟，男，1959年10月出生，教授，中药学博士，研究员级高级工程师，博士生导师，享受国务院特殊津贴。现任江苏康缘药业股份有限公司董事长，国家药典会委员，全国人大代表，《世界科学技术-中医药现代化》、《中草药》、《中国中药杂志》、《中国天然药物》、《亚洲传统医药》编委。

他在康缘药业任职期间，凭借其深厚的专业技术底蕴，致力于中药新产品、新工艺、新剂型的开发与研究，并取得了较好的实绩。先后主持开发国家级新药60余项（含中药一类新药1个，二类新药16个，其中包括中药注射液10个），已获得中药新药证书38个，化药新药证书9个，这些新药上市以来，已累计实现销售额近40亿元；主持国家“863”科研项目1项、国家“九五”、“十五”科技攻关项目各1项、 “十一五”科技支撑计划项目1项、国家重大新药创制项目1项、国家发改委高技术产业化示范工程3项等省级以上重大项目30余项；作为主要发明人申请国内外专利147件，已有92件获得授权；在核心期刊上发表论文30余篇，发表论著2篇。

主要社会兼职：

1、第九届药典委员会委员

2、国家自然科学基金项目审评专家

3、全国中药标准化技术委员会委员

4、中国中药协会理事

5、江苏省现代化科技产业基地咨询组专家

6、江苏省医药行业协会理事、常务理事、副会长

7、江苏省新药审评专家

8、国家中医药管理局和江苏省药品监督管理局科技成果奖审评专家

9、第四届省自然科学基金委员会生物医药学科组成员

10、《世界科学技术-中医药现代化》、《中国中药杂志》、《中国天然药物》、《亚洲传统医学》编委。