简介

研究方向

代表性论文

其他相关

简介

童建华，女，1988年毕业于上海复旦大学遗传工程专业，1997年获得法国巴黎第七大学人类遗传学博士学位。现任上海交通大学医学院附属瑞金医院上海血液学研究所研究员，博士生导师，招收生物化学与分子生物学专业硕博连读生。

研究方向

长期从事有关白血病发病及治疗分子机制的基础研究，参加了血研所一系列重大的科研项目，在维甲酸诱导分化治疗APL的基础理论研究方面取得了可喜的成绩。近年来，主要针对髓系白血病细胞分化和凋亡过程中的信号转导途径以及相关基因的功能进行深入研究，曾在国际上率先报道了环腺苷酸具有参与介导As2O3诱导分化APL细胞的功能，为阐明As2O3诱导缓解治疗APL的作用机制提供了依据。这些年来，童建华先后承担了多项国家自然科学基金项目和国家科技部863计划，并先后获得了上海市科委启明星计划和上海市教委曙光计划的资助。

代表性论文

1.Tong J-H（corresponding author）. Rig-G as a key mediator of the anti-proliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc. Natl. Acad. Sci. USA, 2006, in press

2.Tong J-H（corresponding author）. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyalocytic leukemia cell differentiation. Leukemia,2004, 18, 285-292

3.Tong J-H（corresponding author）. Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk. Blood, 2002,99,1014-1022

4.Tong J-H (first author), Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: Molecular cloning and analysis of its promoter region. Genomics, 2000, 69, 380-390.

5.Tong J-H (first author), Jem-1, a novel nuclear co-factor: localization and functional interaction with AP-1. Leukemia, 1999, 13, pp1982-1992.

6.Tong J-H (first author), Fant X, Duprez E, Benoit G, Uphoff C-C, Drexler H-G, Pla J-C, Lofvenberg E and Lanotte M.Expression patterns of the JEM-1 gene in normal and tumor cells:ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells. Leukemia,1998,12,pp1733.

7.Tong J-H (co-first author), Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes.Proc. Natl. Acad. Sci. USA, 1997, 94, 7406-7411

8.Tong J-H (co-first author), JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated by retinoids during t(15;17) promyelocytic leukaemia maturation.Oncogene, 1997, 14, 1563-1570

9.Tong J-H (first author), Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants. Oncogene, 1992, 7, 311

其他相关

招生要求：生物类、医学类、医学检验类专业毕业生，有工作经验者更佳。

联系方式：上海瑞金医院血液学研究所，邮编: 200025，