简介

工作经历：

教育背景：

学术积累：

近5年来主要论著

简介

帅心涛，化学与化工学院教授，中山医学院双聘教授，中山医学院生物医学工程中心负责人，光电及功能复合材料研究院“纳米生物技术”平台PI。以纳米医学技术为平台的肿瘤诊断及治疗研究，主要涉及肿瘤显像纳米探针、抗癌药物和核酸（例如：基因及RNAi等）的高效靶向传输等。

工作经历：

2005年6月开始：中山大学化学与化工学院高分子所教授。

2003年6月-2005年5月：美国凯斯西储大学研究员（研究助教授级）。

2002年1月-2003年5月：德国马尔堡大学洪堡学者。

2001年1月-2001年12月：美国北卡州立大学访问学者。

2000年10月-2000年12月：中国科学院工程塑料国家工程研究中心, 任研究三室主任。

1998年2月-2000年9月：中国科学院化学研究所，任副研究员及研究组长。其间赴日本名古屋大学及东京工业大学做访问研究一年。

1996年10月-1997年12月：波兰科学院聚合物化学研究所博士后。

教育背景：

1993年3月-1996年10月：北京理工大学化工与材料学院学习，获博士学位。

1986年9月-1993年2月：北京理工大学化工与材料学院学习，获学士及硕士学位。

学术积累：

一直从事新型生物降解及生物相容聚合物的合成及应用研究，近年来主要从事聚合物纳米医用材料的研究，在抗癌药物和核酸的传输以及肿瘤显像等方面取得一系列研究成果。

在包括《Macromolecules》、《Bioconjugate Chem.》、《Biomacromolecules》、《Chem. Mater.》、《Angew. Chem.》、《Chem. Commun.》、《Adv. Mater.》、《J. Controlled Release》、《Biomaterials》、《J. Biomed. Mater. Res.》等学术刊物上发表论文40多篇（其中，SCI收录论文35篇)，被国内外同行在SCI刊物上引用100多篇次（扣除自引）。

现为J. Controlled Release等7个国际学术期刊的审稿人。与欧、美、日等国家高水平研究室建立了稳固的学术联系，为开展高水平的国际合作奠定了坚实的基础。

近5年来，作为负责人承担2项纳米医学研究领域的国家自然科学基金项目。目前除了一项国家自然科学基金项目在研外，还承担一项中山大学高层次引进人才基金项目。

近5年来主要论著

近5年来主要论著（SCI影响因子4以上的论文）：

1. D. Cheng, G. Hong, W. Wang, R. Yuan, H. Ai, J. Shen*, B. Liang, J. Gao, X. Shuai*, “Nonclustered magnetite nanoparticle encapsulated biodegradable polymeric micelles with enhanced properties for in vivo tumor imaging”, J. Mater. Chem., DOI:10.1039/C0JM03783D.（IF=4.795）

2. N. Cao, D. Cheng, S. Zou, H. Ai, J. Gao, X. Shuai*, “The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells”, Biomaterials, Doi:10.1016/j.biomaterials.2010.11.061.（IF=7.365）

3. J. Dai, S. Zou, Y. Pei, D. Cheng, H. Ai, X. Shuai*, “Polyethylenimine-grafted Copolymer of Poly(L-lysine) and Poly(ethylene glycol) for Gene Delivery”, Biomaterials, Doi:10.1016/j.biomaterials.2010.10.044.（IF=7.365）

4. G. Liu, Z. Wang, J. Lu, C. Xia, F. Gao, Q. Gong, B. Song, X. Zhao, X. Shuai, X. Chen, H. Ai, Z. Gu, “Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging”, Biomaterials, 2011, 2, 528-537. （IF=7.365）

5. W. Zhang, Y. Li, L. Liu*, Q. Sun, X. Shuai*, W. Zhu, Y Chen*, “Amphiphilic Toothbrushlike Copolymers Based on Poly(ethylene glycol) and Poly(ε-caprolactone) as Drug Carriers with Enhanced Properties”, Biomacromolecules, 2010, 11, 1331-1338.（IF=4.502）

6. B. Liang, M. He, C. Chan, Y. Chen, X. Li, Y. Li, D. Zheng, M. Lin, H. Kung, X. Shuai*, Ying Peng*, “The Use of Folate-PEG-grafted-hybranched-PEI Nonviral Vector for the Inhibition of Glioma Growth In The Rat”, Biomaterials 2009, 30, 4014-4020.（IF=7.365）

7. J. Lu , S. Ma, J. Sun, C. Xia, C. Liu, Z. Wang, X. Zhao, F. Gao, Q. Gong, B. Song, X. Shuai, Hua Ai, Zhongwei Gu, “Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging”, Biomaterials 2009, 30,2919-2928.（IF=7.365）

8. G. Chen*, W. Chen, Z. Wu, R. Yuan, Hua Li, J. Gao, X. Shuai*, “MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression”, Biomaterials 2009, 30, 1962-1970.（IF=7.365）

9. H. Ai, C. Flask, B. Weinberg, X. Shuai, M. D. Pagel, D. Farrell, J. Duerk, J. Gao, “Magnetite-loaded polymeric micelles as novel magnetic resonance probe”, Adv. Mater. 2005, 17, 1949-1952.（IF=8.379）

10. S. Mao, X. Shuai, F. Unger, and T. Kissel, “Synthesis and characterization of water-soluble poly (ethylene glycol)-graft-trimethyl chitosan block copolymers and their application as insulin delivery carriers”, Biomaterials 2005, 26, 6343-6356.（IF=7.365）

11. X. Shuai, T. Merdan, F. Unger, T. Kissel, “Biodegradable Supra-molecular Vehicle Showing Combined Good Biocompatibility and High Gene Transfection Efficiency”, Bioconjugate Chem. 2005, 16, 322-329.（IF=4.35）

12. N. Nasongkla†, X. Shuai†, H. Ai, J. Gao, “cRGD-functionalized micelle (cRGD-PEG-PCL) for targeted doxorubicin delivery to tumor neovasculature”, Angew. Chem. Int. Edi. 2004, 43, 6323-6327.（共同第1, IF=11.829）

13. Y. Zhao, X. Shuai, C. Chen, F. Xi, “Synthesis of star block copolymers from dendrimer initiators by combing ring-opening polymerization and atom transfer radical polymerization”, Macromolecules 2004, 37, 8854-8862.（IF=4.539）

14. X. Shuai, H. Ai, N. Nasongkla, S. Kim, and J. Gao, “Micellar Carriers Based on Block Copolymers of Poly(e-caprolactone) and Poly(ethylene glycol) for Doxorubicin Delivery”, J. Controlled Release 2004, 98, 415-426.（IF=5.949）

15. X. Shuai, T. Merdan, and T. Kissel, “Core-crosslinked Polymeric Micelles as Paclitaxel carriers”, Bioconjugate Chem. 2004, 15, 441-448.（IF=4.35）

16. Y. Zhao, X. Shuai, C. Chen, F. Xi, “Synthesis of novel dendrimer-like star block copolymers with definite number of arms by combination of ROP and ATRP”, Chem. Commun. 2004, 14, 1608-1609.（IF=5.504）

17. X. Shuai, T. Merdan, F. Unger, W. Matthias, and T. Kissel, “Novel Biodegradable Ternary Copolymers hy-PEI-g-PCL-b-PEG: Synthesis, Characterization and Potential as Efficient Non-viral Gene Delivery Vectors”, Macromolecules 2003, 36, 5751-5759.（IF=4.539）

18. Y. Zhao, X. Shuai, C. Chen, F. Xi, “Synthesis and Characterization of Star-Shaped Poly(L-lactide)s Initiated with Hydroxyl-Terminated Poly(Amidoamine) (PAMAM-OH) Dendrimers”, Chem. Mater. 2003, 15, 2836-2843.（IF=5.368）

19. M. Wei, X. Shuai, A. E. Tonelli, “Melting and Crystallizatioin Behavior of Biodegradable Polymers Enzymatically Coalesced from Their Cyclodextrin Inclusion Complexes”, Biomacromolecules 2003, 4, 783-792.（IF=4.502）

20. X. Shuai, F. Porbeni, M. Wei, T. Bullions, A. E. Tonelli, “Stereo-selectivity in the Formation of Inclusion Complexes of Poly(3-hydroxybutyrate)s with Cyclodextrins”, Macromolecules 2002, 35, 3778-3780.（IF=4.539）

21. Y. Na, Y. He, X. Shuai, Y. Kikkawa, Y. Doi, and Y. Inoue, “Compatibilization Effect of Poly(e-caprolactone)-b-Poly(ethylene glycol) Block Copolymers and Phase Morphology Analysis in Immiscible Poly(lactide)/ Poly(e-caprolactone) Blends”, Biomacromolecules 2002, 3, 1179-1186.（IF=4.502）

22. X. Shuai, F. Porbeni, M. Wei, T. Bullions, A. E. Tonelli, “Formation of Inclusion Complexes of Poly(3-hydroxybutyrate)s with Cyclodextrins 1: Immobilization of Atactic Poly(R,S-3-hydroxybutyrate) and Miscibility Enhancement between Poly(R,S-3-hydroxy butyrate) and Poly(e-caprolactone)”, Macromolecules 2002, 35, 3126-3132.（IF=4.539）

23. X. Shuai, F. Porbeni, M. Wei, T. Bullions, A. E. Tonelli, “Inclusion Complex Formation between α,γ-Cyclodextrins and a Triblock Copolymer and the Cyclodextrin Type-Dependent Microphase Structures of their Coalesced Samples”, Macromolecules 2002, 35, 2401-2405. （IF=4.539）

24. X. Shuai, M. Wei, F. Porbeni, A. E. Tonelli, “Formation of and coalescence from the inclusion complex of a biodegradable block copolymer and a-cyclodextrin2: A novel means to modify the biodegradation behavor of biodegradable block copolymers”, Biomacromolecules 2002, 3, 201-207.（IF=4.502）

25. X. Shuai, F. Porbeni, M. Wei, I. Shin & A. E. Tonelli, “Formation of and coalescence from the inclusion complex of a biodegradable block copolymer and a-cyclodextrin: A novel means to modify the phase structure of biodegradable block copolymers”, Macromolecules 2001, 34, 7355-7361.（IF=4.539）

26. Y. He, J. Li, X. Shuai, Y. Inoue, “Reversible thinning/thickening phenomenon of polymer blends in aqueous media”, Macromolecules 2001, 34, 8166-8172.（IF=4.539）

27. Y. He, X. Shuai, A. Cao, K. Kasuya, Y. Doi, Y. Inoue, “Enzymatic biodegradation of synthetic atactic P(R, S-hydroxybutyrate) induced by amorphous polymer and the enzymatic degradation temperature window of amorphous systems”, Biomacromolecules 2001, 2, 1045-1051.（IF=4.502）

28. Y. He, He, X. Shuai, A. Cao, K. Kasuya, Y. Doi, Y. Inoue, "Enzymatic biodegradation of chemosynthetic atactic P(3HB) enhanced by an amorphous non-biodegradable polymer: blend of atactic P(3HB) with PMMA", Macromol. Rapid Comm., 2000, 21: 1277-1281.（IF= 4.146）