全哲山，男, 1961年3月生,1991年毕业于北京医科大学(现北京大学医学部)获硕士学位，2005年于韩国圆光大学校获得理学博士学位。现任延边大学药学院药物化学教研部主任，教授，博士生导师，吉林省突出贡献中青年专家，吉林省拔尖创新人才，吉林省重点学科药物化学学科带头人，国家自然科学基金同行评议专家，国外“Bioorg Med Chem ”、“Bioorg Med Chem Lett” 、“Eur J Med Chem”、”Arch Pharm”等期刊论文评审专家数据库成员。在国内外发表论文100多篇，其中在SCI收录的杂志上发表学术论51多篇，累计影响因子83, 被引用248次。申请中国发明专利4项, 其中1项授权，并有2项获得国家科技重大专项资助，进入临床前开发阶段。获吉林省有突出贡献中青年专家，吉林省拔尖创新人才称号。

【研究方向与兴趣】

一直从事药物化学教学与科研工作，研究方向为先导化合物的寻找与结构优化，主讲《药物化学》、《药物合成反应》、《新药设计与开发》等课目。已指导27名硕士研究生获得硕士，3名获得博士学位。现有硕士研究生12人，博士研究生3人。

【承担的科研项目】

1.抗癫痫一类新药-Q808胶囊的临床前研究(2011ZX09102-003-03)，科技部“重大新药创制”专项, 2011-2013年，700万(承担120万)。

2.抗癫痫候选药物W112的研究（2012ZX09103-101-044），科技部“重大新药创制” 专项, 2012-2014年，150万，项目负责人。

3.喹啉并三唑酮类衍生物的合成及抗癫痫作用研究（81160382），国家自然科学基金课题.2012-2014年，项目负责人。

4.吡唑烷酮类衍生物的合成及抗癫痫作用研究（项目号30460151），国家自然科学基金课题.2005-2007年，项目负责人。

5.喹喔啉酮衍生物的合成及抗癫痫作用研究．（项目编号，30760290）．国家自然科学基金，2008-2010，项目负责人。

6.二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究。（项目批准号：30860340），国家自然科学基金，2009-2011，项目负责人。

7.抗癫痫新药三唑喹酮的研制（项目编号，207024），教育部重点项目，2007-2009，项目负责人。

8.三唑酮并喹啉类化合物的合成及抗癫痫作用研究，教育部留学回国启动项目，2008-2010，项目负责人。

【获奖】

1.“吡唑烷酮类抗癫痫先导化合物的寻找与结构优化”，吉林省科学技术进步三等奖，吉林省政府，2006年,项目负责人。

2.“抗癫痫候选药物Q808的研究”， 吉林省科学技术进步二等奖，吉林省科技厅，2011年，项目负责人。

3. “7-烷氧基-4，5-二氢[1, 2, 4]三唑并[4, 3-a]喹啉的开链物4-(4-烷氧基苯基)-3-乙基-4H-1,2,4-三唑衍生物的合成及惊厥作用”，吉林省自然科学学术二等奖，吉林省科学技术协会，2009年，项目负责人。

【申请专利】

1.用作抗癫痫药的1,2,4-三唑并[4,3-a]喹啉-1-酮衍生物及其可药用盐, 中国发明专利，专利号200610016578.1，发明人，全哲山，孙先宇，魏成喜

2.用作抗抑郁药的5-烷氧基-四唑并[1,5-a]喹啉酮衍生物及其可药用盐，申请号200910004690.7，发明人，全哲山，邓先清

3.用作抗癫痫药的6-（取代苯氧基）-四唑并[5,1-a]酞嗪衍生物及其可药用盐，申请号，20081065734.X，发明人，全哲山

4.一类用作抗癫痫药的化合物及其可用药用盐，申请号，201110170659.8，发明人，全哲山

【近年主要发表论文】

2011年

51. Ming-Xia Song, Chun-Bo Zhang, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan *. Synthesis and anticonvulsant activity evaluation of 6-phenyl-7H [1, 2, 4]triazolo[3, 4-b][1, 3, 4]thiadiazines. Lett Drug Des Dis, 2011,8 (9), pp. 769-773

50. Xian-Qing Deng, Li-Na Quan, Ming-Xia Song, Cheng-Xi Wei, Zhe-Shan Quan *. Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. Eur J Med Chem. 2011, 46, 2955-2963

49. Hai-Ling Yu, Xian Qing Deng, Ying-Jun Li, Ying Chun Li, Zhe-Shan Quan *, Xian-Yu Sun.

N-palmitoylethanolamide, an endocannabinoid, exhibits antidepressant effects in the forced swim test and the tail suspension test in mice. Pharmacol Rep. 2011, 63(3), 834-839

48. Xian-Qing Deng, Di Wu, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and antidepressant-like action of N-(2-hydroxyethyl)cinnamamide derivatives in mice. Med Chem Res, 2011, 20, 1273-1279

47. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and evaluation of 7-substituted-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-ones as anticonvulsant and hypnotic agents.Med Chem Res, 2011, 20，996-1004

46. Li-Ping Guan, Xin Sui, Xian-Qing Deng, Dong-Hai Zhao, You-Le Qu, Zhe-Shan Quan*.

N-palmitoylethanolamide derivatives: synthesis and studies on anticonvulsant and antidepressant activities.

Med Chem Res, 2011, 20，601-605

45. Cheng-Xi Wei, Zhou Guo, Fu-Nan Li,Zhi-Gang Sun, Zhe-Shan Quan*. Design, Synthesis and Anticonvulsant Activity Evaluation of 6-Alkoxy-[1,2,4]triazolo[3,4-a]phthalazin-3(2H)-ones. Asia J Chem, 2011, 24 (1), 127-131

2010年

44. Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li,Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles. Med Chem.2010, 6(5):313-320.

43. Xian-Yu Sun, Chuan Hu, Cheng-Xi Wei, Zhi-Gang Sun* Zhe-Shan Quan*. Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem, 2010, 45, 4807-4812

42. Chuan Hu, Zhi-Gang Sun, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of Some Cinnamylpiperazine. Derivatives. Lett Drug Des Discov，2010, 7(5), 661-664

41. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Zhe-Shan Quan*. Synthesis and antidepressant-like action of 9-alkoxy-7H-furo[3,2-g]chromen-7-ones in mice. Arzneimittelforschun, 2010, 29, 587

40. Xian-Qing Deng, Cheng-Xi Wei, Fu-Nan Li , Zhi-Gang Sun*, Zhe-Shan Quan*. Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity. Eur J Med Chem, 2010, 45, 3080-3086

39. Cheng-Xi Wei, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun*, and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res, 2010, 33, 655-662

38. Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Kyu-Yun Chai,Zhi-Gang Sun* and Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinolines. Bull Korean Chem Soc. 2010, 31, 447

37. Li-Ping Guan*, Xin Sui, Xian-Qing Deng, Ying-Chun Quan, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine. Eur J Med Chem, 2010, 45, 1746–1752

36. Li-Qiu Zhang,Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Dengand Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of Some 7-Alkoxy-2H-1,4-benzothiazin-3(4H)-ones and 7-Alkoxy-4H-

[1,2,4]triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull, 2009, 58, 326—331

35.Xian-Yu Sun, Cheng-Xi Wei, Xian-Qiang Deng, Zhi-Gang Sun*, Zhe-Shan Quan*. Evaluation of the anticonvulsant activity of 6-(4-chlorophenyoxy)-tetrazolo[5,1-a]phthalazine in various experimental seizure models in mice.Pharmacol Rep,2010, 62, 273-277

34. Xian-Yu Sun, Cheng-Xi Wei, Xian-Qing Deng, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and primary anticonvulsant activity evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine derivatives. Arzneimittelforschung, 2010, 60, (6), 289.

2009年

33. Cheng-Xi Wei, Di Wu, Kyu-Yun Chai, Zhe-Shan Quan*. Synthesis of 6-(3-substituted-4H-1,2,4-triazol-4-yl)-2- phenylbenzo[d]oxazoles as potential anticonvulsant agents. Med Chem Res, 2010, 19, 925-935

32. Huo-Jian Wang, Xian-Qing Deng, Cheng-Xi Wei, Fu-Lan Li, and Zhe-Shan Quan*. Synthesis and Evaluation on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a]quinazolines.

Arch. Pharm, 2009, 342, 671-675

31. Cheng-Xi Wei, Wei Zhang, Zhe-Shan Quan*, Rong-Bi Han, Ri-Shan Jiang and Feng-Yu Piao*.

Synthesis, Anticonvulsant Evaluation of 2,3,4,5-Tetrahydro-7-alkoxy-1H-2-benzazepin-1-ones.

Lett Drug Des Dis, 2009, 6, 548-553

30.Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao1, Zhe-Shan Quan*. Characterization of the anticonvulsant activity of doxepin in various experimental seizure models in mice. Pharmacol Rep, 2009, 61, 245–251

29. Xian-Yu Sun, Li-Ping Guan, Lei Zhang, Cheng-Xi Wei, Hu-Ri Piao and Zhe-Shan Quan*.

Design. Synthesis and Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]

phthalazin-4-one Derivatives. J Brazil Chem Soc, 2009, 20，826-836

28. Li-Ping Guan, Dong-Hai Zhao, Zhe Jiang, Hu-Ri Piao, Zhe-Shan Quan*. Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models.Pharmazie，2009，64，248-251

27.Li-Ping Guan, Cheng-Xi Wei, Xian-Qing Deng, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*.

Synthesis and anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med Chem, 2009, 44，3654-3657

26. Lei Zhang, Li-Ping Guan, Xian-Yu Sun, Kyu-Yun Chai and Zhe-Shan Quan*. Synthesis and Anticonvulsant activity Evaluation of 6-Alkoxy-[1,2,4] triazolo[3,4-a]phthalazines. Chem Biol Drug Des. 2009, 73, 313-319

25. Cheng-Xi Wei, Li-Ping Guan, Jing-Hao Jia, Kyu-Yun Chai, and Zhe-Shan Quan*. Synthesis of 2-Substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as Potential Anticonvulsant Agents.Arch PharmRes, 2009, 32，23-31

24. Li-Ping Guan, Dong-Hai Zhao, Jing-Hui Xiu, Xin Sui, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis and Anticonvulsant activity ofN-(2-hydroxyethyl) amide derivatives. Arch Pharm, 2009, 342, 34-40

23. Li-Jun Guo, Cheng-Xi Wei, Jing-Hao Jia, Li-Ming Zhao, Zhe-Shan Quan*. Design, Synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur J Med Chem, 2009, 44, 954-958 22. Xian-Yu Sun, Lei Zhang, Cheng-Xi Wei, Piao Huri, Quan Zhe shan*. Synthesis of 8-Alkoxy-5,6-dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones With Anticonvulsant Activity, and Assessment of Their Acute Toxicity.Eur J Med Chem, 2009, 44, 1265-1270

21. Xiang-Shu Cui, Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee Young-Ae Ha and Zhe-Shan Quan*, Synthesis and anticonvulsant evaluation of 3-Substituted -4- (4-hexyloxyphenyl)-4H-1,2,4-triazoles.

Med Chem Res, 2009, 18, 49-58

2008

20. Li-Ping Guan, Qing-Hao Jin, Shou-Feng Wang, Fu-Nan Li, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 5-Phenyl[1,2,4]triazolo[4,3-a]quinolines. Arch Pharm, 2008, 341, 774-779

19. Li-Ping Guan, Guan-Rong Tian, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*.

Synthesis and anticonvulsant activity of 1-substituted-7-methoxy-1,2,4-triazolo [4, 3-a]quinoline.

Turk J Chem, 2008, 32，181-189

18. Zhong-Tai Piao,Li-Ping Guan, Li-Ming Zhao, Hu-Ri Piao, Zhe-Shan Quan*. Synthesis of Novel 7-benzyl-amino-2H-benzo[b] [1,4]oxazin-3(4H)-ones as Anticonvulsant Agents. Eur J Med Chem, 2008, 43, 1216-1221

17. Xian-Yu Sun, Cheng-Xi Wei, Kyu-Yun Chai,Hu-Ri Piao and Zhe-Shan Quan*. Synthesis and anti-inflammatory activities of some novel 7-alkoxy-1-amino-4,5-dihydro-[1,2,4]triazole[4,3-a]quinolines.

Arch Pharm, 2008, 341, 288-293

2007

16. Jing Chen, Xian-Yu Sun, Kyu-Yun Chai, Jin-Seok Lee, Mi-Sun Song and Zhe-Shan Quan*.

Synthesis and anticonvulsant evaluation of 4-(4-alkoxylphenyl)-3-ethyl-4H-1,2,4-triazoles as open-chain analogues of 7-alkoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines. Bioorg Med Chem. 2007, 15，6775-81

15. Cui Xiangshu, Guan Liping, Li Hailan, Piao Huri, Quan Zheshan*.

Synthesis and anticonvulsant activity of 7-benzylamino-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines*.

Prog Nat Sci, 2007, 17, 1104

14. Li-Ping Guan, Qing-Hao Jin, Guan-Rong Tian, Kyu-Yun Chai, Zhe-Shan Quan*. Synthesis of some quinoline-2(1H)-one and [1,2,4]triazolo[4,3-a]quinoline derivatives as potent anticonvulsant. J Pharm Pharm Sci,2007,10，254-262

13. Jin Yun-Zhe, Guan Li-Ping, Zao Li-Ming, Piao Hu-Ri, Quan Zhe-Shan*. Synthesis and Anticonvulsant Activity Study of 7-Substituted Phenoxyl-4,5-dihydro[1,2,4]triazolo[4,3-a]quinolines and Quinoline- 1 (2 H)-ones. Chinese J Org Chem, 2007, 28（12）,1567-1572

12. Cheng-Xi Wei, Fu-Nan Li, Long-Xuan Zhao, Li-Ming Zhao, Zhe-Shan Quan*. Synthesis of 2-substituted-7-heptyloxy-4,5-dihydro-[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with anticonvulsant activity. Arch Pharm, 2007, 340，491

2006

11. Hong-Guang Jin, Xian-Yu Sun, Kyu-Yun Chai, Hu-Ri Piao and Zhe-Shan Quan*. Anticonvulsant and toxicity evaluation of some 7-alkoxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline-1(2H)-ones. Bioorg Med Chem, 2006, 14, 6868-6873

10. Jun-Min Wang, Chang-Soo Jun, Kyu-Yun Chai, Kyung-Chell Kwak,Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 1-substituted benzyl-N-substituted-1,2,3-triazole-4-Formamides. Prog Nat Sci, 2006, 16, 925-929

9. Xian-Yu Sun, Gao Li,Chang-Soo Jun,Kyu-Yun Chai, Hu-Ri Piao and Zhe-Shan Quan*. Synthesis of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and evaluation of their anticonvulsant properties.Arch Pharm Res, 2006, 29, 1080-1085

2005

8. Zhi-Feng Xie,Kyu-Yun Chai, Hu-Ri Piao, Kyung Chell Kwak and and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines. Bioorg Med Chem Lett, 2005, 15, 4803-4805. 7. Li-Ming Zhao, Hai-Shan Jin, Liang-Peng Sun, Zhe-Shan Quan*. Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives. Bioorg Med Chem Lett. 2005,15,5027-5029

6. Cui Li-Jing, Xie Zhi-Feng, Hu-Ri Piao, Gao Li, Kyu-Yun Chai. Quan Zhe-Shan*. Synthesis and Anticonvulsant Activity of 1-Substituted-7- Benzyloxy-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline.

Biol Pharm Bull, 2005, 28, 1216-1220

5. Zhe-Shan Quan, Jun-Min Wang, Jun-Rae Rho, Kyung-Chell Kwak,Hee Cheol Kang, Chang-Soo Jun, and Kyu-Yun Chai.Synthesis of 6- alkyloxyl-3,4-dihydro-2(1H)-quinolionesand their Anticonvulsant Activities.Bull korea chem Sci, 2005, 26, 1757-1760

4. Guan Li-Ping, Ji-Xing Nan,Xue-Jun Jin,Qing-Hao Jin, Kyung-Chell Kwak, Kyu-yun Chai1 and Zhe-Shan Quan*. Protective Effects of Chalcone Derivantsfor Acute Liver Injury in Mice. Arch Pharm Res, 2005, 28,

81-86

2003-2004

3. Zhe-Shan Quan*,Li-Ming Zhao, Fu-Nan Li, Hu-Ri Piao. Synthesis of 2,3-disubstituted-5-hydroxybenzofuran derivatives. Chinese J Org Chem,2004, 24, 1637-1639

2. Li-Ping Guan，Xiu-Mei Yin, Hong-Mei Quan, Zhe-Shan Quan *. Synthesis of hydroxylated chalcones and related derivatives. Chinese J Org Chem, 2004, 24, 1274-1277

1. Zhe-Shan Quan*，Yutak Ozaki, Sang-Won Kiu, Hu-Ri Piao. A new synthesis method of 2,5-dialkyl-1,4-benzenediol derivatives. Chinese J Org Chem，2003, 23, 1299-1302