蒋序林 Xulin Jiang

学位：博士学位

（出生年月：1967年3月）

职称职务：教授、博士生导师

学科专业：高分子化学与物理

研究方向：

1. 可控高分子的合成、改性及共轭技术的研究，

2. 基因药物用新型可降解高分子载体的研究，

3. 热敏性两亲性可降解高分子药物靶向载体的研究（抗肿瘤药物、多肽、蛋白质药物），

4. HPLC分离与表征高分子。

主要主持科研项目：

1 国家自然科学基金项目21174109 长循环-靶向-逃逸-示踪-多功能高分子胶束药物载体及其细胞相互作用的研究（资助时间2012.01-2015.12, 60万）

2 国家自然科学基金项目21074100 稳定化热敏肿瘤靶向高分子纳米胶束载药系统的研究（资助时间 2011.01-2013.12, 37万)

3 国家自然科学基金项目20774068 点击化学合成降解梳形聚合物及用于基因载体的研究（资助时间 2008.01-2010.12, 29万）

4 20744002 HPLC用于新型生物医用高分子的分离与表征

5 博士点基金新教师项目 点击化学可控合成基因载体用新型可降解星形阳离子高分子

学习及工作简历：

1985,9-1989,7 成都科技大学优秀生试点班, 高分子材料系, 学士

1989,9-1992,6 成都科技大学高分子材料工程国家重点实验室，硕士 (导师：徐僖院士，郑邦乾教授)

1992,7-2000,9 上海交通大学化学化工学院高分子材料系 助教，讲师，副教授

2000,9-2004,5 荷兰阿姆斯特丹大学高分子分析组, 博士 (导师: Prof. Dr. P. J. Schoenmakers)

2004,6-2006,10 荷兰乌特勒支大学药学院药剂系博士后 (导师: Prof. Dr. W.E. Hennink)

2006,11-至今：武汉大学化学学院生物医用高分子材料教育部重点实验室（教授，博导）

近期代表性研究论文:

29 Xulin Jiang, Yan-feng Chu，Jia Liu， Guang-yan Zhang and Renxi Zhuo（2011） Aueous SEC Ananlysis of Cationic Polymers as Gene Carries，Chines Journal of Polymer Science 29（4），421-426.

28 Jiang, X. L., Liu, J., Xu, L., and Zhuo, R. X. (2011) Disulfide-Containing Hyperbranched Polyethylenimine Derivatives via Click Chemistry for Nonviral Gene Delivery. Macromolecular Chemistry and Physics 212, 64-71.

27 Liu, J., Jiang, X. L., Xu, L., Wang, X. M., Hennink, W. E., and Zhuo, R. X. (2010) Novel Reduction-Responsive Cross-Linked Polyethylenimine Derivatives by Click Chemistry for Nonviral Gene Delivery. Bioconjugate Chemistry 21, 1827-1835.

26 L.-H. LI; X.-L. Jiang*; R.-X. Zhuo. Synthesis and Characterization of Thermoresponsive Polymers Containing Reduction-Sensitive Disulfide Linkage, J Polym Sci Part A: Polym Chem 2009, 47(22): 5989–5997

25 Wan, H.; Chen, Y.; Chen, L.; Zhu, X.; Yan, D.; Li, B.; Liu, T.; Zhao, L.; Jiang, X.; Zhang, G. Supramolecular Control of the Branched Topology of Poly(sulfone-amine) from Divinylsulfone and Hexamethylenediamine, Macromolecules, 2008, 41(2), 465-470

24 Jie Xue, Li Zhou, Peng He, Xinyuan Zhu, Deyue Yan and Xulin Jiang, Supramolecular end-group separation of linear polymers with different terminals through host-guest interaction，Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2008, 61, 83-88

23 C. Lin, Z.-Y. Zhong, M. C. Lok, X..-L. Jiang, W. E. Hennink, J. Feijen, J. F. J. Engbersen, “Novel Bioreducible Poly(amido amine)s for Highly Efficient Gene Delivery”, Bioconjugate Chem., 2007, 18(1), 138 – 145.

22 X.-L, Jiang, M. C. Lok, C. F. van Nostrum, W. E. Hennink, “Degradable-Brushed pHEMA-pDMAEMA Synthesized via ATRP and Click Chemistry for Gene Delivery”, Bioconjugate Chem., 2007, 18(6), 2077-2084

21 Lin, C.; Zhong, Z.; Lok, M. C.; Jiang, X.; Hennink, W. E.; Feijen, J.; Engbersen, J. F. J., Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection, J Controlled Release, 2007, 123, 67-75

20 K. D. F. Vlugt-Wensink, X.-L.Jiang, G. Schotman, G. Kruijtzer, A. Vredenberg, J.T. Chung, Z. Zhang, C. Versluis, D. Ramos, R. Verrijk, W. Jiskoot, D. J. A. Crommelin, W. E. Hennink, “In Vitro Degradation Behavior of Microspheres Based on Cross-Linked Dextran”, Biomacromolecules, 2006, 7(11), 2983-2990.

18 X. Jiang, A. van der Horst, M.J. van Steenbergen, N. Akeroyd, C.F. van Nostrum, P.J. Schoenmakers and W.E. Hennink, “Aqueous size-exclusion chromatography of cationic polymers for gene delivery”, J. Controlled Release, 2006, 116(2), e69-e71.

18 C. Hiemstra, Z.Y. Zhong, X. Jiang, W.E. Hennink, P.J. Dijkstra and J. Feijen, “PEG–PLLA and PEG–PDLA multiblock copolymers: Synthesis and in situ hydrogel formation by stereocomplexation”, J. Controlled Release, 2006, 116(2), e17-e19.

17. Chao Lin, Zhiyuan Zhong, Martin C. Lok, Xulin Jiang, Wim E. Hennink, Jan Feijen and Johan F.J. Engbersen，“Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: Synthesis and in vitro gene transfer properties”, J. Controlled Release, 2006, 116(2), 130-137.

16. X.-L, Jiang, A. van der Horst, M. J. van Steenbergen, C. F. van Nostrum, P. J. Schoenmakers, W. E. Hennink, “Molar-Mass Characterization of Cationic Polymers for Gene Delivery by Aqueous SEC with Online Multi-Angle Light Scattering Detection”, Pharmaceut. Res., 2006，23(3), 595-603.

15 X.-L, Jiang, A. van der Horst, V. Lima, P. J. Schoenmakers, “Comprehesive Two-Dimentional Liquid Chromatography for the Characterization of Functional Acrylate Polymers”, J. Chromatogr. A, 2005, 1076(1-2), 51-61.

14. V. Lima V, X.-L. Jiang, J. Brokken-Zijp, P. J. Schoenmakers, B. Klumperman, R. Van Der Linde, “Synthesis and characterization of telechelic polymethacrylates via RAFT polymerization”m, J. Polym. Sci.: Polym. Chem., 2005, 43(5), 959-973.

13. X.-L. Jiang, P. J. Schoenmakers, X.-W. Lou, V. Lima, J. L. J. van Dongen, and J. Brokken-Zijp, “Separation and Characterization of Functional Poly(n-Butyl Acrylate) by Critical Liquid Chromatography”, J. Chromatogr. A, 2004, 1055(1-2), 123-133.

12 H.-Q. Zhang, X.-L. Jiang, R. van der Linde, “Synthesis of Hydroxyl End-Capped Telechelic Polymers with Poly(Methyl Methacrylate)-block-Poly(n-Butyl Acrylate) Backbones via Atom-Transfer Radical Polymerisation”, Polymer, 2004, 45 (5), 1445-1466.

11. X.-L. Jiang, P. J. Schoenmakers, J. L.M van Dongen, X.W. Lou, V. Lima, J. Brokken-Zijp, “Mass-Spectrometric Characterization of Functional Poly(Methyl Methacrylate) in Combination with Critical Liquid Chromatography”, Anal. Chem., 2003, 75(20), 5517-5524.

10 X.-L. Jiang, V. Lima, P. J. Schoenmakers, “Robust Isocratic Liquid Chromatography Separation of Functional Poly(Methyl Methacrylate)”, J. Chromatogr. A, 2003, 1018(1), 19-27.

09 X.-L. Jang, A. van der Horst, P. J. Schoenmakers, “Breakthrough of Polymers in Interactive Liquid Chromatography”, J. Chromatogr. A, 2002, 982 (1), 55-68.

08 J.-Y. Li, D.-Y. Yan, X.-L. Jiang, Q. Chen, “Formation of the Crystalline Inclusion Complex between Gamma-Cyclodextrin and Poly(N-acetylethylenimine)”, Polymer, 2002, 43, 2625-2629.

07 夏平 蒋序林 颜德岳, “耐热性星型甲基丙烯酸甲酯基共聚物的合成”，高等学校化学学报,2002. 23(2), 336-338.

06 W.-X. Wang, D.-Y. Yan, X.-L. Jiang, C. Detrembleur, P. Lecomte, R. Jér?me, “Reverse Atom-Transfer Radical Polymerization at Room Temperature”, Macromol. Rapid Commun. 2001, 22, 439-443.

05 P. Xia, Q.-S. Hu, X.-L. Qian, X.-L. Jiang, D.-Y. Yan, “Simultaneous Measurement of Free Rdical Decay in Polymerization of MMA Initiated by AIBN Using ESR and Its Kinetic Model”, Chinese J. Polym. Sci. 2001, 19 (1), 33-38.

04 X.-L. Jiang, P. Xia, D.-Y. Yan, W.-L. Liu, “Atom Transfer Radical Copolymerization of Styrene and N-cyclohexylmaleimide”, J. Polym. Sci.: Polym. Chem., 2000, 38(8), 1203.

03 X.-L. Jiang, D.-Y. Yan, Y.-L. Zhong, W.-L. Liu, and Q.-X. Chen. “Atom Transfer Radical Copolymerization of MMA and N-cyclohexylmaleimide”, Polym. Int., 2000, 49, 893-897.

02 X.-L. Jiang, Y.-L. Zhong, D.-Y. Yan, and H. Yu, “Hyperbranched Copolymers of p-(Chloromethyl)styrene and N-Cyclohexylmaleimide Synthesized by ATRP”, J. Appl. Polym. Sci., 2000, 78(11), 1992-1997.

01 蒋序林 颜德岳 刘万里, “原子转移自由基聚合（ATRP）合成耐热性共聚物”，高等学校化学学报,2000. 21(10), 1613-1615.