国际会议组委会及大会学术委员长

侯德兴，1982年1月毕业于湖南农业大学动物科技学院畜牧专业，之后留校任教。1985年考上日本文部省国费留学生，1991年3月获日本国立鹿儿岛大学博士学位，之后在著名的日本理化学研究所筑波生命科学中心做博士后，从事过人类基因组图谱、基因克隆、基因表达调控及细胞信息传递等重要分子生物学领域的研究，论文发表在《自然》、《自然遗传学》等世界一流的学术杂志上。1997年11月以后担任日本国立鹿儿岛大学副教授，1998年6月担任博士导师，2004年10月担任博士领衔导师，2009年开始受聘湖南农业大学“百人计划”特聘教授，2011年6月开始担任日本国立鹿儿岛大学教授。近5年来主要应用最新的分子生物学技术研究动物基因的表达调控和生理活性物质的细胞信号传递以及食品功能开发。承担了30多项研究课题，从国家、民间以及企事业单位共获得了3亿多日元的科研经费。获多次中国国家机构奖励、多家日本财团研究奖，多次日本国立鹿儿岛大学教育研究奖和重点领域基金奖。发表了75篇包括收录在Pubmed、SCI上的具有国际水准的高水平专业论文，其中包括世界一流的《自然》、《自然遗传学》、《基因与发育》、《欧洲分子生物学报》和《致癌》。论文引用总次数1600余次，申请了15项专利。培养了10多名博士生、40多名硕士生，受到数家相关专业的国际学会的邀请，赴美国、德国、希腊、澳大利亚、中国、日本、韩国和印度尼西亚等地多次进行主题讲演，并有担任国际会议组委会及大会学术委员长的丰富经验。同时，与国际上多家实验室有合作研究关系，担任着20多家国际分子生物学相关杂志的特约编委。研究成果被日本的《朝日新闻》、《读买新闻》、《科学新闻》、《日本经济新闻》、《日本农业新闻》等日本全国性的报纸和其它15家日本地方报纸报导过，并接受过人民日报驻东京记者站采访，将研究成果报导在中国多家媒体上。

一、基本情况

姓名：侯德兴

性别：男

出生日期：1959年6月7日

学位：农学博士、药学博士

工作单位：日本国立鹿儿岛大学农学院

职称：教授，博士领衔导师

二、学历和工作经历

学习和工作经历（从大学开始）

1978．2— 1982．1 湖南农业大学动物科技学院畜牧专业 学士

1982．2— 1985．10 湖南农业大学动物科技学院 助教

1985．10—1988．3 日本国立鹿儿岛大学研究生院畜牧专业 硕士

1988．3— 1991．3 日本国立鹿儿岛大学研究生院动物生物化学专业 博士

1991．4— 1995．2 日本物理化学研究所筑波生命科学中心 博士后

1995．3— 1996．3 日本国立小儿病院小儿医疗研究中心日本科技厅特别研究员

1996．4— 1997．10 日本物理化学研究所筑波生命科学中心 研究员

1997．11— 2011．5 日本国立鹿儿岛大学农学院 副教授

2011．6— 日本国立鹿儿岛大学农学院 教授

2009— 中国湖南农业大学百人计划 特聘教授

1998年6月 日本国立鹿儿岛大学研究生博士导师

2004年10月 日本国立鹿儿岛大学研究生 博士领衔导师

三、近期学术成就

1．从事过猪的品质鉴定，动物遗传育种学研究，获农业部科技成果进步奖.

2．从事过人和动物的基因克隆，基因结构分析和基因组图谱分析，将4000多个基因排列在人类第21条染色体上. 论文发表在《Genomics》上，被引用200多次.

3．从事癌基因的克隆表达，转录调控的研究，并首次克隆出果蝇的CBP转录因子，发现了在骨骼形成，早期发育与致癌等方面的重要功能，论文发表在《Nature》(自然)、《 Nature genetics》(自然遗传学)、《EMBO》(欧洲分子生物学杂志)、《欧洲生物化学学会通讯》等国际性的杂志上，被引用400多次.

4．从事营养成分的细胞及分子生物学领域的研究. 从食用植物、中草药中筛选出20余种机能成分，并对他们的信号传递和基因调控机制进行了研究，论文发表在《癌通讯》、国际肿瘤学杂志、国际细胞生物学杂志上，被引用300余次. 研究成果被日本的《朝日新闻》、《读买新闻》、《科学新闻》、《日本经济新闻》、《日本农业新闻》、《日本工业新闻》、《Japan Times》等全国性的报纸和其它日本15家地方报纸报导过，并被人民日报驻东京记者站采访，将研究成果报导在中国报纸上.

四、国内外学术组织机构任职

中国湖南农业大学 百人计划特聘教授

中国科学院长沙亚热带植物研究所 客座研究员

日本鹿儿岛医疗技术学校 兼职教授

日本国立医院南九州心血管中心护士学校 兼职教授

《抗氧化剂与氧化还原信号通道》（英国） 特约编委

《自由基生物学与医学》（美国） 特约编委

《食品与化学毒性学》（欧洲） 特约编委

《农业食品化学》（美国） 特约编委

《癌研究》（美国） 特约编委

《生化药理学》（美国） 特约编委

《细胞生物化学》（美国） 特约编委

《分子营养学》（美国） 特约编委

日本农林水产部食品供给研究中心 (2005 ~2006 ) 科技产业评委

日本濑户市 (2004 ~ ) 科技产业评委

学会

日本分子生物学会、日本营养粮食学会、日本农艺化学会、

日本食品科学工学会、美国AAAS（AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE）成员.

五，其他获奖及荣誉称号

2006年 日本鹿儿岛大学重点领域研究奖

2005年 日本鹿儿岛大学教育研究奖

2003年 中国国家自然科学基金委员会海外学者基金奖

2002 - 2003年 日本鹿儿岛大学校长基金奖

2001年　日本“云雀”食品科学基金会研究奖

2001年 中国国家外国专家局基金奖

2000年　日本“咖啡”科学技术基金会研究奖

1999年 日本松籁科学技术振兴财团研究奖

1999年 中国科学院海外学者基金奖

1998年 日本“浦上食品·食文化”财团研究

1996年 中国国家自然科学基金委员会海外学者基金奖

1994年 日本科技厅特别研究员奖金

1991 - 1993年 日本理化研究所博士后奖学金

1987年 中国农业部科学技术进步一等奖

1985-1990年 日本文部科学省（教育科学部）奖学金

获得专利：

专利号码 时间 国家 候选人的顺序

特开119412 2007年 日本 2人中排第一位

特开206489 2006年 日本 2人中排第二位

特开075790 2005年 日本 4人中排第一位

特开02004/020656 2004年 国际 2人中排第一位

特开359576 2004年 日本 4人中排第一位

特开352681 2004年 日本 6人中排第三位

特开350619 2004年 日本 6人中排第三位

特开267119 2004年 日本 7人中排第二位

特开024054 2004年　日本　3人中排第二位

特开342188 2003年　日本　3人中排第二位

特开277271 2003年　日本　2人中排第一位

特开267992 2003年 日本　2人中排第二位

特开265195 2003年 日本 2人中排第一位

特开033163 2003年 日本 3人中排第三位

特开069945 2001年 日本 4人中排第二位

七，授课情况

1. 应用分子生物学

2. 细胞信号传递与基因调控

3. 最新食品分子生物学实验

4. 生物化学

5. 动物细胞工程学

6. 基因工程学和细胞工程学实验

7．化学英语

CURRICULUM VITAE

NAME: KO Norioki

(Pen name: HOU De - Xing)

NATIONALITY: Japan

PRESENT POSITION: Associate Professor, PhD

Department of Biochemical Science &Technology,

Faculty of Agriculture,

Kagoshima University,

Korimoto 1 - 21 - 24, Kagoshima City,

890 - 0065 JAPAN.

Tel/Fax: +81 - 99 - 285 - 8649 (O)

Summary: Dr. De - Xing Hou has a strong theoretical and practical expertise in the area of molecular biology and food science. With 17 years professional experience, including 7 years post - doctoral research and 10 years professor experiences, he has developed interdisci - plinary fields across molecular biology, food and pharmacology with the advanced technology of DNA recombinant, cell engineer and food assay. He is an author of more than 46 scientific papers on PubMed (Hou DX), including several papers in the highest - ranking journals such as Nature, Nature Genetics and EMBO Journal, and of 13 patents on food processing and food functions. His international contacts with research teams in Japan, China, USA, Australia and Korea are yielding several international cooperations. He is also an active consultant with several companies in Japan in the field of functional food processing. Her present research interest is focusing on cancer chemoprevention by natural bioactive compounds and food factors.

1. EDUCATION:

2/1982 B.A., Animal Science, Hunan Agricultural University, Changsha, China.

3/1988 M.S., Animal Science, Kagoshima University, Kagoshima, Japan

3/1991 Ph.D., Biochemical genetics, Kagoshima University, Kagoshima, Japan

6/2006 Ph.D., Pharmacology, University of Tokyo, Tokyo, Japan

2. CHRONOLOGY OF EMPLOYMENT:

2/1982 –10/1985. Associate Research, College of Animal Science and Technology, Hunan Agricultural University, Changsha City, China.

4/1991 –2/1995. Postdoctoral Fellow, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Tsukuba Science City, Japan

3/1995 - 31996. Research Fellow of Science and Technology Agency of Japan, National Children’s Medical Research Center, Tokyo, Japan

4/1996 – 10/1997 Research Scientist, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN), Tsukuba Science City, Japan.

11/1997 - Date: Associate Professor, The Faculty of Agriculture, Kagoshima University, Kagoshima City, Japan

3. RECENT RESEARCH PROJECTS:

- Signal transduction and gene regulation in carcinogenesis

- Nutrigenomics of natural bioactive compounds and food

- Development of functional foods - benefit for human health

4. TEACHING IN UNIVERSITY:

For undergraduate students

- Animal Cell Science and Technology.

- Application of Biotechnology in Food Science.

- Experiment for DNA Recombinant and Cell Technology

- Biochemistry English

For graduated students:

- Advanced Gene Expression and Regulation

- Advanced Molecular Biology

- Nutrigenomics

5. Ph.D. COMMITTEES

Hideji YAMASHITA, Kagoshima University, 1999

Shigang LIN, Kagoshima University, 2004

Kazuyo YAMAJI, Kagoshima University, 2005

Xuhui TONG, Kagoshima University, 2005

Isselmou Ould RABAH, Kagoshima University, 2005

Takuhiro UTO, Kagoshima University, 2006

6. JOURNAL EDITORAL REFEREE:

- Cancer Research

- Free Radical and Biological Medical

- Molecular Cancer Therapeutics

- Biochemical Pharmacology

- Food and Chemical Toxicology

- Life Science

- Journal of Agriculture and Food Chemistry

- Bioscience, Biotechnology and Biochemistry

- The Journal of Nutritional Biochemistry

- Cancer Chemotherapy and Pharmacology

- Molecular Nutrition and Food Research

7. ORGANIZING COMMITTEES FOR National and International Symposia:

- Chair of the Scientific Committee of the “The International Symposium on Blueberry, Tokyo, Japan, 2001 - 2005

- Scientific Member of the Scientific Committee of the 3rd International Workshop on Anthocyanins (IWA’2004), Sydney, Australia, 2004

- Secretary of the Joined Congress of Japanese three - Societies in Biochemistry, Nutrition and Food. Kagoshima, Japan, 2003

8. ACADEMIC HONORS:

- 2005, Education and Research Award from President of Kagoshima University

- 2002, Investigator Award from President of Kagoshima University

- 2002, Investigator Award from All Japan Coffee Association Foundation

- 2001, Investigator Award from The Skylark Food Science Foundation, Japan

- 1999, Investigator Award from Shorai Foundation of Science and Technology, Japan

- 1998, Investigator Award from Urakami Foundation, Japan

- 1994, Fellowship of Science and Technology Agency of Japan

- 1991 - 1993, Postdoctoral Fellowship, The Institute of Physical and Research, Chemical Japan

- 1985 - 1990, Monbusho Scholarship, Ministry of Education, Science and Culture of Japan.

- 1988, Investigator Award, Chinese Ministry of Agriculture, China

- 1987, Investigator Award, Hunan Agricultural University, China

9. MEMBERS OF PROFESSIONAL SOCIETIES:

- AAAS member of USA

- The Japanese Society for Food Science and Technology

- The Japanese Society for Nutrition and Food Science

- The Molecular Biology Society of Japan

- The Japanese Society for Bioscience, Biotechnology and Agrochemistry

10. PATENTS:

13 patents in food processing and food functions

11. COMPETITIVE RESEARCH SUPPORT:

- Urakami Foundation, 1998

- Shorai Foundation for Science and Technology, 1999

- All Japan Coffee Association Foundation, 1999

- Skylark Food Science Institute Foundation, 2001

- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (13660130). 2001 - 2003

- New Kagoshima Study Grant, 2001 - 2003

- Cooperation of Innovative Technology and Advanced Research in Evolution Area (CITY AREA), 2002 - 2004

- Kagoshima University Found for Education and Research Activities, 2005

- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan (18580125). 2006 - 2008

12. SELECTED PUBULICATION IN MEDLINE (HOU DX):

46. Tanikawa S, Fujii M, Hou DX*. Action of Nrf2 and Keap1 in ARE - mediated NQO1 expression by quercetin. Free Radical Biology & Medicine. 42: 1690 - 1703 (2007).

45. Hou DX*, Masuzaki S, Uto T, Hashimoto F, Tanikawa S, Fujii M, Sakata Y: Green tea proanthocyanidins inhibit cyclooxygenase - 2 expression in LPS - activated mouse macrophages: molecular mechanisms and structure - activity relationship. Arch. Biochem. Biophys., 460: 67 - 74 (2007).

44. Uto T, Fujii M, Hou DX*:　Effects of 6 - (methylsulfinyl)hexyl isothiocyanate on cyclooxygenase - 2 expression induced by lipopolysaccharide, interferon - gamma and 12 - O - tetradecanoylphorbol - 13 - acetate. Oncol Rep. 17:233 - 238 (2007).

43. Al - Dabbas MM, Suganuma T, Kitahara K, Hou DX, Fujii M: Cytotoxic, antioxidant and antibacterial activities of Varthemia iphionoides Boiss. extracts. J.Ethnopharmaco.108: 287 - 293(2006).

42. Iwagawa,T,Hashimoto K,Okamura H,Kurawaki J, Nakatani M, Hou DX,Fujii M, Doe M, Morimoto Y, Takemura K: Biscembranes from the Soft Coral Sarcophyton glaucum. J. Nat. Prod., 69: 1130 - 1133(2006).

41. Hou DX*, Yanagita T, Uto T, Masuzaki S, Fujii M: Anthocyanidins inhibit cyclooxygenase - 2 expression in LPS - evoked macrophages: Structure - activity relationship and molecular mechanisms involved. Biochem. Pharmacol.,70: 417 - 425(2005).

40. Hou DX*, Tong X, Terahara N, Luo D, Fujii M: Delphinidin 3 - sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species - mediated mitochondrial pathway. Arch. Biochem. Biophys., 440: 101 - 109 (2005).

39. Uto T, Fujii M, Hou DX*: Inhibition of lipopolysaccharide - induced cyclooxygenase - 2 transcription by 6 - (methylsulfinyl)hexyl isothiocyanate, a chemopreventive compound from Wasabia japonica (Miq.) Matsumura, in mouse macrophages. Biochem. Pharmacol., 70:1772 - 1784(2005).

38. Uto T, Fujii M, Hou DX*: 6 - (methylsufinyl)hexyl isothiocyanate suppresses inducible nitric oxide expression through the inhibition of Janus kinase 2 - mediated JNK pathway in lipopolysaccharide - activated murine macrophages. Biochem. Pharmacol., 70:1211 - 1221(2005).

37. Yoshimoto M, Kurata - Azuma R, Fujii M, Hou DX, Ikeda K, Yoshidome T, Osako M: Enzymatic production of caffeic acid by koji from plant resources containing caffeoylquinic acid derivatives. Biosci. Biotech. Biochem., 69:1777 - 1781 (2005).

36. Hou DX*, Uto T, Tong X, Takeshita T, Tanikawa S, Imamura I, Ose T, Fujii M: Involvement of reactive oxygen species - independent mitochondrial pathway in gossypol - induced apoptosis. Arch. Biochem. Biophys., 428:179 - 187(2004).

35. Hou DX*, Kai K, Li J - J, Lin S, Terahara N, Wakamatsu M, Fujii M, Young MR, Colburn N: Anthocyanidins inhibit activator protein - 1 activity and cell transformation: structure - activity relationship and molecular mechanisms. Carcinogenesis, 25:29 - 36(2004).

34. Hou DX*, Fujii M, Terahara N, Yoshimoto N: Molecular mechanisms behind the chemopreventive effects of anthocyanidins (Review). J. Biomed.Biotech., 5: 321 - 325(2004).

33. Tong X, Lin S, Fujii M, Hou DX*: Molecular mechanisms of echinocystic acid - induced apoptosis in HepG2 cells, Biochem. Biophys. Res. Commu., 321: 539 - 546(2004).

32. Tong X, Lin S, Fujii M, Hou DX*: Echinocystic acid induces apoptosis in HL - 60 cells through mitochondria - mediated death pathway. Cancer Letters, 212:21 - 32(2004).

31. Wang J, Yu Y, Hashimoto F, Sakata Y, Fujii M and Hou DX*: Baicalein induces apoptosis through ROS - mediated mitochondrial dysfunction pathway in HL - 60 cells. Int. J. Molec. Med., 14:627 - 632 (2004).

30. Yoshimoto M, Kurata - Azuma R, Fujii M, Hou DX, Ikeda K, Yoshidome T, Osako M: Phenolic composition and radical scavenging activity of sweetpotato - derived shochu distillery by - products treated with koji. Biosci. Biotech. Biochem., 68:2477 - 2483 (2004).

29. Ozeki M, Tamae D, Hou DX, Wang T, Lebon T, Spitz DR, Li JJ: Response of cyclin B1 to ionizing radiation: regulation by NF - kB and mitochondrial antioxidant enzyme MnSOD. Anticancer Res., 24: (2004)

28. Rabah IO, Hou DX, Komine S - I and Fujii M: Potential chemopreventive properties of extract from baked sweet potato (Ipomoea batatas. Lam. cv. Koganesengan). J. Agri. Food Chem., 52: 7152 - 7157(2004).

27. Hou DX*: Potential mechanisms of cancer chemoprevention by anthocyanins (Review). Current Mol. Med., 3:149 - 159(2003).

26. Hou DX*, Ose T, Lin S, Harazono K, Imamura I, Kubo M, Uto T, Terahara N, Yoshimoto M, Fujii M: Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: Structure - activity relationship and mechanisms involved. Int. J. Oncology, 23: 705 - 712(2003).

25. Lin S, Fujii M, Hou DX*: Rhein induces apoptosis in HL - 60 cells via reactive oxygen species - independent mitochondrial death pathway. Arch. Biochem. Biophys., 418: 99 - 107(2003).

24. Lin S, Li J - J, Fujii M, Hou DX*: Rhein inhibits TPA - induced activator protein - 1 activation and cell transformation by blocking JNK - dependent pathway. Int. J. Oncology, 22:829 - 833(2003).

23. Konczak - Islam I, Yoshimoto M, Hou DX, Terahara N, Yamakawa O: Potential chemopreventive properties of anthocyanin - rich aqueous extracts from in vitro produced tissue of sweetpotato (Ipomoea batatas L.). J.Agric.Food.Chem., 51: 5916 - 5922(2003).

22. Okamoto S, Inafuku K, Ting Z, Maeda Y, Hou DX, Tang YF, Yun ZH, Xu W, Shi L, Hashiguchi T: Blood protein polymorphisms in native chicken breeds in Yunnan province of China. Anim. Sci. J., 74: 471 - 476(2003).

21. Okada M, Akimaru H, Hou DX, Takahashi T, Ishii S: Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc. The EMBO J., 21:675(2002).

20. Hou DX*, Arimura M, Fukuda M, Oka T, Fujii M: Expression of cell adhesion molecules and albumin genes in primary culture of rat hepatocytes. Cell Biol. Int., 25: 239 - 244 (2001).

19. Hou DX*, Kunitake T, Kusuda J, Fujii M: Primary culture of chicken hepatocytes as an in vitro model for determining the influence of dioxin. Biosci. Biotechnol. Biochem., 65: 218 - 221 (2001).

18. Ushikai M, Miyaji Y, Kawabe K, Hou DX, Okamoto S, Maeda Y: Sequence of a quail calpain cDNA. J. Anim. Sci., 79: 775 - 776(2001).

17. Hou DX*, Fukuda M, Johnson JA, Miyamori K, Ushikai M, Fujii M: Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element - involved activation. Int. J. Oncol. 18:1175 - 1179 (2001).

16. Hou DX*, Fukuda M, Fujii M, Fuke Y: Transcriptional regulation of nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase in murine hepatoma cells by 6 - (methylsufinyl) hexyl isothiocyanate, an active principle of wasabi (Eutrema Wasabi Maxim.). Cancer Letters, 161:195 - 200 (2000).

15. Hou DX*, Fukuda M, Fujii M, Fuke Y: Induction of NADPH: quinone oxidoreductase in murine hepatoma cells by methylsufinyl isothiocyanates: Methyl chain length - activity study. Int. J. Mol. Med., 6:441 - 444 (2000).

14. Inoue Y, Ose T, Mukai S, Ehira S, Yonekura M, Hou DX, Fujii M: Inhibition of the acid lipase activity by apolipoprotein A - I in the presence oflysosomal proteases. Biosci. Biotechnol. Biochem., 63: 937 - 939(1999).

13. Akimaru H, Chen Y, Dai P, Hou DX, Nonaka M,Smolik SM, Armstrong S, Goodman RH, Ishii S: Drosophila CBP is a co - activator of cubitus interruptus in hedgehog signalling. Nature, 386:735 - 738(1997).

12. Akimaru H, Hou DX, Ishii S: Drosophila CBP is required for dorsal - dependent twist gene expression. Nature Genet., 17: 211 - 214 (1997).

11. Hou DX, Akimaru H, Ishii S: Trans - activation by the Drosophila myb gene product requires a Drosophila homologue of CBP. FEBS Letters, 413:60 - 64 (1997).

10. Dai P, Akimaru H, Tanaka Y, Hou DX, Yasukawa T, Kanei - Ishii C,Takahashi T, Ishii S: CBP as a transcriptional coactivator of c - Myb. Genes & Develop., 10:528 - 540(1996).

9. Soeda E, Hou DX, Osoegawa K, Atsuchi Y, Yamagata T, Shimokawa T, Kishida H, Soeda E, Okano S, Chumakov I, Cohen D, Raff M, Gardiner K, Graw SL, Patterson D, DeJong P, Ashworth LK, Slezak T, Carrano AV: Cosmid assembly and anchoring to human chromosome 21. Genomics, 25, 73 - 84(1995).

8. Hou DX*, Kishida H, Shimokawa T, Soeda E: Isolation of human chromosome 21 - specific cosmids and their uses in mapping of cosmid contigs on chromosomal subregions. Jpn. J. Human Genet., 39:411 - 420 (1994).

7. Hou DX* Wang Y, Yamashita H, Okamoto S, Yokoyama K, Soeda E, Sarai A: Evolutionary conservation of chymotrypsinogen gene: Genomic analysis and protein modeling. Jpn. J. Human Genet., 39:235 - 242(1994).

6. Hou DX*, Ozawa K, Tomita N, Maeda Y, Hashiguchi T, Yokoyama K, Soeda E: Genomic cloning and partial characterization of human chymotrypsinogen gene. Jpn. J. Human Genet., 38:371 - 380(1993).

5. Yokoyama K, Hou DX, Gao H, Tang X, Kitabayashi I, Nishikura K: Inhibition of expression of a mouse a - globin gene by plasmids that include antisense　oligonucleotides. Cell Struct. Funct., 17:433 - 442(1992).

4. Tanaka Y, Tang X, Hou DX Gao H, Kitabayashi I, Gachelin G, Yokoyama K: Phenotypic conversion of SV40 - immortalized human diploid fibroblasts to senescing cells by introduction of an antisense gene for SV40 - T antigen. Cell Struct. Funct., 17:351 - 362 (1992).

3. Hou DX, Maeda Y, Okamoto S, Hashiguchi T: Structural difference of chymotrypsinogens forming chymotrypsin variants in Japanese quail. Biochem. Genet., 28:571 - 576(1990).

2. Hou DX, Maeda Y, Okamoto S, Hashiguchi T: Purification and characterization of chymotrypsinogen from pancreas of Japanese quail (Coturnix coturnix japonica). Comp. Biochem. Physiol., 97B:761 - 766(1990).

1. Hou DX Maeda Y, Okamoto S, Hashiguchi T: Genetic studies on pancreatic proteinase in Japanese quail. Biochem. Genet., 27:469 - 479(1989).

13. RECENT INVITED SPEAKER:

- “Anthocyans and human health: evidence from cellular investigations”. 232nd National Meeting of American Chemistry Society. San Francisco, USA. Sept, 2006.

- “Nutrigenomics of bioactive compounds” in the International Symposium: Paradigm Shift - Foodomics/Nutrigenomic 2006, Korean, Feb. 2006

- “Nutrigenomics, a powerful approach for developing functional foods” in the Forum for Food and Human Health, Kagoshima, Japan, Jan, 2005.

- “A novel approach to prevent inflammation by targeting cyclooxygenase - 2 gene with food factors "in 59th Congress of The Japanese Society for Nutrition and Food Science”. Tokyo, Japan, May, 2005.

- “Molecular mechanism of apoptosis induction by polyphenolic compounds: Targeting reactive oxygen species (ROS) and mitochondria“ World Conference on Magic Bullets Celebrating Paul Ehrlich’s 150th Birthday Nürnberg, Germany, Sept., 2004

- “Do anthocyanins contribute to cancer prevention? - Introduction to molecular evidence (Plenary lecture)” In 3rd International Workshop on Anthocyanins”. Sydney, Australia, Jan. 2004.

- “Molecular views of anthocyanins contributing cancer chemoprevention” in 8th World Congress on Advances in Oncology and 6th International Symposium on Molecular Medicine”, Greece, Crete, Oct. 2003.

- “Signal transduction and gene regulation by active natural compounds” in the Joined Congress of Japanese three - Societies in Biochemistry, Nutrition and Food. Kagoshima, Japan, 2003. Kagoshima, Sept. 2003.

- “The antitumor functions of anthocyanins: molecular evidences” in the International Symposium of Blueberry”. Tokyo, May, 2003.

- “Development on screening cancer chemopreventive foods” in the Seminar for Biotechnology and Food Science, organized by Economic Ministry of Japan. Kagoshima, Sept. 2002.

- “Anthocyanins for human health benefits” in the International Symposium of Blueberry. Tokyo, May, 2002.

- “Molecular mechanisms of cancer chemoprevention by Wasabi, Japanese radish” in “6th World Congress on Advances in Oncology and 4th International Symposium on Molecular Medicine”, Greece, Crete, Oct. 2001.