专家信息(教育经历 工作经历)

科学研究：(研究方向 承担课题情况：)

教学情况：(讲授课程： 人才培养情况： 招生情况： PROFESSIONAL EXPERIENCE EDUCATION INTERESTS)

专家信息

谷立川（1974.2-）男，河北省赞皇县人。汉族，山东大学微生物技术国家重点实验室教授，博士生导师。

教育经历

1998 年 9 月 -2002 年 1 月 博士研究生，中科院生物物理研究所。

1995 年 9 月 -1998 年 7 月 硕士研究生，山东大学化学与化工学院。

1991 年 9 月 -1995 年 7 月 本科生，山东大学物理系。

工作经历

2006 年 6 月 - 至今 教授，山东大学微生物技术国家重点实验室。

2002 年 8 月 -2006 年 6 月 博士后研究人员，普林斯顿大学分子生物学系。

2002 年 1 月 -2002 年 8 月 研究人员，中科院生物物理研究所。

科学研究：

研究方向

1. 致病微生物蛋白质的结构与功能。

2. 重要微生物代谢途径相关酶的结构与功能研究；

3. 基于蛋白质结构的药物设计。

承担课题情况：

863重大项目,2006AA02A324，重要致病微生物蛋白质的结构研究，490万元。

教学情况：

讲授课程：

结构生物学

人才培养情况：

目前在读博士生2人，硕士生4人。

招生情况：

2009年博士招生计划：博士生2人。毕业后适合于从事生物学的基础研究，或者国际著名制药公司从事药物开发工作。

PROFESSIONAL EXPERIENCE

Jun 2006 - present Professor in State Key Laboratory of Microbial Technology, Shandong University. Jinan 250100, P. R. China. Aug 2002 - Jun 2006 Postdoctoral fellow in Department of Molecular Biology at Princeton University, Princeton, NJ08544, USA Jan 2002 – Aug 2002 Research associate in Institute of Biophysics, Chinese Academy of Science, Beijing 100101, P. R. China.

EDUCATION

Sep 1998 - Jan 2002 PhD. Biochemistry and Molecular Biology, Chinese Academy of Science, Beijing 100101, P. R. China. Sep 1995 - Jul 1998 M.S. Physical Chemistry, School of Chemisty and Chemichal Engineering, Shandong University, Jinan 250100, P. R. China. Sep 1991 – Jul 1995 B.S. Physics, Department of Physiscs Shandong University, Jinan 250100, P. R. China. RESEARCH

INTERESTS

The research in my laboratory is aimed at understanding the structural and molecular mechanisms involved in important cellular process, with focus on

· Key enzymes in the pollutants microbial degradation pathways;

· Key components in DNA repair system;

· Virulence factors of important pathogens. Our approaches encompass a variety of biochemical and biophysical methods, in which X-ray crystallography is the most important technique. PUBLICATIONS：

1. Min Hu, Lichuan Gu , Philip D. Jeffrey, and Yigong Shi. (2006). Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53/MDM2 Pathway. PloS Biology 4, e27

2. Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu , Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue, and Yigong Shi (2005). Structure of the CED-4/CED-9 complex reveals insights into programmed cell death in Caenorhabditis elegans . Nature 437, 831–837 .

· Liang Feng*, Suiping Zhou*, Lichuan Gu* , David A. Gell, Joel P. Mackay, Mitchell J. Weiss, Andrew J. Gow and Yigong Shi. Structure of oxidized -haemoglobin bound to AHSP reveals a protective mechanism for haem. Nature. 2005 Jun 2;435(7042):697-701. ( *These authors contributed equally ).

· Liang Feng*, David A*. Gell, Suiping Zhou*, Lichuan Gu , Yi Kong, Jianqing Li, Min Hu, Nieng Yan, Christopher Lee, Anne M. Rich, Robert S. Armstrong, Peter A. Lay, Andrew J. Gow, Mitchell J. Weiss, Joel P. Mackay, and Yigong Shi. Molecular Mechanism of AHSP-mediated Stabilization of alpha-hemoglobin. Cell. 2004 Nov 24;119(5):629-40. ( *These authors contributed equally ).

· Nieng Yan*, Lichuan Gu *, David Kokel*, Jijie Chai, Wenyu Li, Aidong Han, Lin Chen, Ding Xue, and Yigong Shi. Structural, Biochemical, and Functional Analyses of CED-9 Recognition by the Proapoptotic Proteins EGL-1 and CED-4. Mol Cell. 2004 Sep 24;15(6):999-1006. ( *These authors contributed equally ).

· Eric N. Shiozaki, Lichuan Gu , Nieng Yan, and Yigong Shi. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell. 2004 May 7;14(3):405-12.

· Sujuan Xu, Lichuan Gu , Qingyan Wang, Yuyan Shu, Shiying Song, Zhengjiong Lin. Structure of a king cobra phospholipase A2 determined from a hemihedrally twinned crystal.Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1574-81.

· Sujuan Xu, Lichuan Gu , Tao Jiang, Yuangcong Zhou, Zhengjiong Lin. Structures of cadmium-binding acidic phospholipase A(2) from the venom of Agkistrodon halys Pallas at 1.9A resolution. Biochem Biophys Res Commun. (2003) 300(2):271-7.

· Lichuan Gu , Zhiqing Wang, Shiying Song, Yuyan Shu, Zhengjiong Lin. Crystal structures of an acidic phospholipase A(2) from the venom of Naja Kaouthia. Toxicon. (2002) 40(7):917-22.

· Lichuan Gu , Hailong Zhang, Shiying Song, Yuancong Zhou, Zhengjiong Lin. Structure of an acidic phospholipase A2 from the venom of Deinagkistrodon acutus. Acta Crystallogr D Biol Crystallography. (2002) 58(Pt 1):104-10.