个人简介

教育经历

研究领域：

代表论著：

个人简介

董四君，男，博士，研究员，博士生导师。从事环境荷尔蒙的分子作用机理研究，主要研究领域为传统医学的临床应用及环境内分泌干扰物的分子机制的研究。承担日本新能源和产业技术综合开发机构(NEDO)研究项目及日本文部省科学技术振兴会研究项目。发表论文10篇，其中SCI论文8篇，获授权日本专利2项。

教育经历

1990年获得中国农业大学动物遗传育种专业学士学位

2001年获日本筑波大学生物系统学专业硕士学位

2004年获东京农工大学生物工学专业博士学位

2004-2007年在日本产业技术综合研究所从事博士后研究

2007-2008年任日本国际统合医科学研究所研究员，从事环境荷尔蒙的分子作用机理研究。

研究领域：

环境分子毒理、复合污染的健康风险评价和致病机理，中医药在环境健康领域的应用研究

代表论著：

1. Dong S, Kiyama R. 2009. Characterization of Estrogenic Activity of Ginsenosides in MCF-7 Cells using a Customized DNA Microarray. Food Chem. 113: 672-678. .

2. Dong S, Ying S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Takahara H. 2008. Crucial Role of MZF1 and Sp1 for the transcriptional regulation of the Peptidylarginine Deiminase Type I Gene (PADI1) in Human Keratinocytes. Journal of Investigative Dermatology 128(3):549-557.

3. Dong S, Inoue A, Zhu Y, Tanji M, Kiyama R.2007. Activation of rapid signaling pathways and the subsequent transcriptional regulation for the proliferation of breast cancer MCF-7 cells by the treatment with an extract of glycyrrhiza glabra root. Food and Chemical Toxicology 45: 2470–2478.

4. Dong S, Zhang Z, Takahara H. 2007. Estrogen-enhanced PADI4 expression in MCF-7 cells mediated by ER-promoted transfactors AP-1, NF-Y and SP1. Molecular Endocrinology 21: 1617-1629

5. Dong S, Kanno T, Yamaki A, Kojima T, Shirawa M, Kawada A, Mechin MC, Chavanas S, Serre G, Simon M, Takahara H. 2006. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Biochemical Journal 397(3):449-459

6. Dong S, Kojima T, Shiraiwa M, Mechin MC, Chavanas S, Serre G, Simon M, Kawada A, Kawada A, and Takahara H. 2005. Regulation of the expression of peptidylarginine deiminase type II gene (PADI2) in human keratinocytes involves Sp1 and Sp3 transcription factors. Journal of Investigative Dermatology 124(5):1026-1033.

7. Ying S, Dong S, Kawada A, Kojima T, Chavanas S, Mechin MC, Adoue V, Serre G, Simon M, Takahara H. 2009. Transcriptional Regulation of Peptidylargine Deiminase Expression in Human Keratinocytes. J Dermatol Sci. 53(1):2-9.

8. Chavanas S, Adoue V, Méchin MC, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. 2008. Long-range enhancer associated with chromatin looping allows AP-1 regulation of the peptidylarginine deiminase 3 gene in differentiated keratinocyte. PLoS ONE. 3(10):e3408.

9. Adoue V, Chavanas S, Coudane F, Méchin MC, Caubet C, Ying S, Dong S, Duplan H, Charveron M, Takahara H, Serre G, Simon M. 2008. Long-Range Enhancer Differentially Regulated by c-Jun and JunD Controls Peptidylarginine Deiminase-3 Gene in Keratinocytes. J Mol Biol. 384(5):1048-1057.

10. Zhou Y, Kogiso M, Asakawa M, Dong S, Kiyama R, Shimizu T. 2009. Antimicrobial Nanotubes as Delivery Vehicles Consisting of Ag-Embedded Peptidic Lipid-Bilayer Membranes. Adv. Mater. 21, 1-4.