周海梦 博士

教授，博导

1970年，清华大学工程化学系 本科

1981年，清华大学应用化学 硕士

1986年，中国科学院生物物理所 博士

现任清华大学教授，分子酶学实验室主任

主要科研领域与方向：主要研究方向为酶的结构与功能研究。包括酶的化学修饰、酶的催化动力学、酶结构改变对生物活性的影响等。目前集中于蛋白质折叠的研究，包括蛋白质折叠中间体、折叠途径等研究。

Selected Publications:

Zhao TJ, Ou WB, Xie Q, Liu Y, Yan YB* & Zhou HM*. 2005. Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch. J Biol Chem. 280(14):13470-13476.

Meng FG, Hong YK, He HW, Lyubarev AE, Kurganov BI, Yan YB* & Zhou HM*. 2004. Osmophobic effect of glycerol on irreversible thermal denaturation of rabbit creatine kinase. Biophys J. 87:2247-2254.

Pan JC, Yu Z, Su XY, Sun YQ, Rao XM & Zhou HM*.2004. Unassisted refolding of urea-denatured arginine kinase from shrimp Feneropenaeus chinensis: evidence for two equilibrium intermediates in the refolding pathway. Protein Sci. 13:1892-1901.

Meng FG, Park YD& Zhou HM*. Role of proline, glycine, and heparin sodium as protein folding aids during refolding of rabbit muscle creatine kinase. Int. J. Biochem. Cell Biol. 33:701-709.

Ou WB, Luo W, Park YD & Zhou HM*. 2001. Chaperone-like activity of peptidyl-prolyl cis-trans isomerase during creatine kinase refolding. Protein Sci. 10:2346-2353.

Ou WB, Park YD & Zhou HM*. 2001. Molecular mechanism for osmolytes protection of creatine kinase against guanidine denaturation. Eur. J. Biochem. 268:5901-5911.