中国科学院上海生命科学研究院营养科学研究所 博士 研究员

结构生物学与营养科学研究组组长

个人简介：

1997年于复旦大学物理学系获学士学位；1999年于美国纽约城市大学物理学系获硕士学位；2004年于纽约州立大学石溪分校生物物理及生理学系获博士学位；2004年至2009年在哥伦比亚大学生物学系从事博士后研究；2009年加入中国科学院上海生命科学研究院营养科学研究所。

研究领域：

利用结构生物学、生物化学等手段来研究蛋白质等生物大分子的结构与功能的联系，理解它们功能的分子机理。目前的研究方向包括：1)对核受体等重要的转录因子的结构与功能的研究；2)对在DNA的损伤反应过程中起重要作用的蛋白的结构与功能的研究。

近期论文：

1. Xiang S, Callaghan MM, Watson KG, Tong L. A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proc Natl Acad Sci U S A. 2009 Dec; 106 (49): 20723-27.

2. Sinturel F, Pellegrini O, Xiang S, Tong L, Condon C, Bénard L, Real-time fluorescence detection of exoribonucleases. RNA. 2009 Nov; 15(11): 2057-62.

3. Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L, A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure. 2009 Jun 10; 17(6): 823-32.

4. Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L, Structure and function of the 5’®3’ exoribonuclease Rat1 and its activating partner Rai1. Nature. 2009 Apr 9; 458(7239): 784-8.

5. Xiang S, Usunow G, Lange G, Busch M, Tong L. 1-deoxy-D-xylulose 5-phosphate synthase (DXS), a crucial enzyme for isoprenoids biosynthesis. Book chapter, T.J. Bach Ed. (in press)

6. Xiang S, Tong L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat Struct Mol Biol. 2008 Mar; 15(3): 295-302.

7. Khan JA*, Xiang S*, Tong L. Crystal structure of human nicotinamide riboside kinase. Structure. 2007 Aug; 15(8): 1005-13. (*-equal contribution authors)

8.Xiang S, Usunow G, Lange G, Busch M, Tong L. Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis. J Biol Chem. 2007 Jan 26; 282(4): 2676-82.

9. Nichols JD, Xiang S, Schindelin H, Rajagopalan KV. Mutational analysis of Escherichia coli MoeA: two functional activities map to the active site cleft. Biochemistry. 2007 Jan 9; 46(1): 78-86.

10. Xiang S, Kim EY, Connelly JJ, Nassar N, Kirsch J, Winking J, Schwarz G, Schindelin H. The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor. J Mol Biol. 2006 May 26; 359(1): 35-46.

11. Tian G, Xiang S, Noiva R, Lennarz WJ, Schindelin H. The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites. Cell. 2006 Jan; 124(1): 61-73.

12. Karakas E, Wilson HL, Graf TN, Xiang S, Jaramillo-Busquets S, Rajagopalan KV, Kisker C. Structural insights into sulfite oxidase deficiency. J Biol Chem. 2005 Sep 30; 280(39): 33506-15.

13. Xiang S, Nicolas J, Rajagopalan KV, Schindelin H. The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. Structure. 2001 Apr 4; 9(4): 299-310.

14. Sato S, Xiang S, Raleigh D. On the relationship between protein stability and folding kinetics: a comparative study of the N-terminal domains of RNase HI, E. coli and Bacillus stearothermophilus L9. J Mol Biol. 2001 Sep 21; 312(3): 569-77.