简历：

研究领域：

代表论著：(近四年代表论文： 国际会议论文：)

承担科研项目情况：

简历：

唐亚雄，男，汉族，中共党员，硕士生导师。1993年毕业于四川大学生物工程系，1993-1997年在江苏省镇江制药有限责任公司工作，1997-2002年在四川大学生命科学学院攻读硕士、博士学位，期间在中国科学院微生物研究所植物基因组学国家重点实验室完成博士论文，遗传学理学博士。2003-2005年先后在美国Memorial Sloan-Kettering Cancer Center、University of Miami从事博士后研究工作，2005-2008年在美国University of California Irvine从事Junior Specialist工作。2009年作为人才引进加盟中国科学院成都生物研究所，现任中国科学院成都生物研究所天然产物研究中心一级副研究员，主要从事针对Wnt信号通路的新型分子靶向抗癌药物以及活性抗癌化合物的筛选与分子药理学研究，已在Cancer Research、Cancer Prevention Research、Neoplasia、Molecular Cancer Therapeutics、International Journal of Cancer、Molecular Cancer等肿瘤研究领域国际主流期刊上发表数篇研究论文，相关论文已被SCI他引近50余次。

研究领域：

1. 基于Wnt信号通路的分子靶向特异性干扰蛋白质与多肽抗肿瘤药物研究

2. 活性抗癌小分子化合物的筛选、构效关系及分子药理学研究

代表论著：

近四年代表论文：

1. Guo Y, Xie J, Rubin E, Tang YX, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Research 2008, 68(9):3350-60. (2009 IF: 7.543)

2. Tang Y, Simoneau AR, Xie J, Shahandeh B, Zi X. Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53. Cancer Prevention Research 2008, 1(6):439-51. (2009 IF: 6.000)

(Perspectives: Rajesh Agarwal and Gagan Deep. Kava, a Tonic for Relieving the Irrational Development of Natural Preventive Agents. Cancer Prevention Research 2008, 1(6):409-412.)

3. Tang Y, Simoneau AR, Liao W, Guo Y, Hoang BH, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Molecular Cancer Therapeutics 2009, 8(2): 458-68. (2008 IF: 5.003)

4. Tang Y, Li X, Liu Z, Simoneau AR, Xie J, Zi X. Flavokawain B, a kava chalcone, exhibits robust apoptotic mechanisms on androgen receptor-negative, hormone-refractory prostate cancer cell lines and reduces tumor growth in a preclinical model. International Journal of Cancer 2010, 127(8):1758-68. (2008 IF: 4.734)

5. Yee DS, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, Hoang BH, Zi X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Molecular Cancer 2010, 9(1):162. (2008 IF: 5.362)

6. Gao Y, An J, Zhu Q, Li F, Ma C, Wang M, Tang Y*. Inhibitory effect of Raddeanin A in human non-small cell lung cancer H460 cells. Chinese Journal of Applied and Environmental Biology 2010, 16 (5): 637-641.

7. Tang Y, Parmakhtiar B, Simoneau AR, Xie J, Fruehauf J, Lilly M, Zi X. Lycopene enhances docetaxel’s effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia 2011, 13(2):108-119. (2009 IF: 5.025)

国际会议论文：

1. Tang Y, Simoneau AR, Zi X. Induction of Bim expression by Flavokawain A, a novel chalcone from the kava plant, is necessary for its apoptotic effect in androgen-independent prostate cancer cell lines. Proc Am Assoc Cancer Res 49:1258, 2008.

2. Tang Y, Simoneau AR, Yi G, Xie J, Hoang BH, Zi X. Ectopic expression of Wnt inhibitory factor-1(WIF1) in prostate cancer PC-3 cell line decreases cellular invasiveness and tumor growth associated with both in vitro and in vivo increased expression of E-cadherin and decreased expression of Vimentin. Am Urol Assoc The Journal of Urology 181(4):511-512, 2009.

3. Peng Su, Yarong Gao, Wei Liang*, Yaxiong Tang*, Anti-cancer potential of Frzb, a secreted Wnt antagonist on human hepatocellular carcinoma, The 6th Sino-US Chemistry Professors Conference, June 14-17, 2010. (Oral Presentation)

承担科研项目情况：

分别主持国家自然科学基金面上项目、中国科学院“西部之光”人才培养计划重点项目、中国科学院生物物理研究所生物大分子国家重点实验室开放课题、教育部留学回国人员启动基金、四川省杰出青年学术技术带头人培育计划各一项，作为项目副组长联合主持国家自然科学基金重大研究计划“基于化学小分子探针的信号转导过程研究”项目。