苏自奋 研究员，男 1958 年 12 月生

研究方向： 同位素及辐射生物医学技术研究

工作单位： 四川大学原子核科学与技术研究所

研究员。 1988 年 3 月年从中科院化学所分析化学专业研究生毕业并获得博士学位。 1989 年德国洪堡学者。从 1989 年起从事放射药物开发及研究，先后在德国、加拿大、美国的国际知名科研单位与众多的化学家、药物学家、药剂师、肿瘤科专家、以及核医学科专家共同工作过。

研究领域：

肿瘤特异性藕联药物的开发研究 ；

特异性多肽抗癌药物的开发研究 ；

疾病的分子显像研究；

新型高性能乏氧肿瘤细胞显像剂及放射药物的研究开发

新型高灵敏高特异性肿瘤新生血管显像剂及放射药物的研究开发；

结合中药研究提高抗癌药物效果的基础及应用问题；

结合分子显像技术研究具有优越抗癌效果的中草药、合成药、生化药以及相关基础问题的研究；

脑瘤放射药物的研究开发。

发表文章选录

1. Zi-Fen Su, Jiang He, Mary Rusckowski, and Donald J. Hnatowich. (2003) In Vitro Cell Studies of Technetium -99m labelled RGD-HYNIC Peptide, a comparison of Tricine and EDDA as Co-ligands. Nucl. Med. Biol. 30, 141-9.

2. Zi-Fen Su, Guozheng Liu, Suresh Gupta, Zhihong Zhu, Mary Rusckowski and Donald J. Hnatowich (2002) In Vitro and In Vivo Evaluations of a Technetium -99m Labeled Cyclic RGD Peptide as a Specific Marker of a V b 3 Integrin for Tumor Imaging. Bioconjug. Chem ., 13 , 561-70.

3. Zi-Fen Su, James R. Ballinger, A. M. Rauth, Douglas N. Abrams, and Mervyn W. Billinghurst. (2000) A Novel Amine-dioxime Chelator for Technetium -99m : Synthesis and Evaluation of 2-Nitroimidazole-containing Analogs as Markers for Hypoxic Cells. Bioconjugate Chemistry, 11 , 652-63.

4. Zi-Fen Su, Xiuguo Zhang, James R. Ballinger, A. M. Rauth, Alfred Pollak, and John R. Thornback. (1999) Synthesis and Evaluation of Two Technetium-99mTc-Labeled Peptidic 2-Nitroimidazoles for Imaging Hypoxia. Bioconjugate Chemistry , 10 , 897-904.

5. Wang J, Chen P, Su ZF, Vallis K, Sandhu J, Cameron R, Hendler A, Reilly RM.(2001) Amplified delivery of indium-111 to EGFR-positive human breast cancer cells. Nucl Med Biol . 28 (8):895-902.

6. Li YQ, Ballinger JR, Nordal RA, Su ZF, Wong CS. (2001) Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res. 61 , 3348-54.

7. Xiuguo Zhang, Zi-Fen Su, James R. Ballinger, A. M. Rauth, Alfred Pollak, and John R. Thornback, Targeting Hypoxia in Tumors Using 2-Nitroimidazole with Peptidic Chelator for Technetium -99m : Effect of Lipophilicity. Bioconjugate Chemistry , 11 , 401-7.

8. K Utsunomiya , J R Ballinger, X. Zhang, Z-F Su, T Tsuchida, and M Ichise. (1999) Comparison Of The Kinetics Of 99m Tc-Sestamibi and 99m Tc-Tetrofosmin In A Multidrug-Resistant Tumour Cell Line. Eur. J. Nucl. Med . 26 (9), 1047

9. K. Schwochau, K.H. Linse and Z.F. Su. (1992) Synthesis, Characterization and Biodistribution of the Cationic Technetium(I)-1,10-Phenanthroline Chelate., Appl. Radiat. Isotope , 43(9), 1079-82.

10. Z.F. Su, K.H. Linse, H.J. Steinmetz and K. Schwochau. (1992) Preparation and Evaluation of Cationic 99 Tc/ 99m Tc Dimethoxy- and Diethoxyl-Hexanedione Dioxime Complexes. J. Labelled Comp. Radiopharm. , XXXI(1), 61-70.