1.重庆市国土资源和房屋管理局副局长

2.高级工程师（湖南长沙）

3.高级讲师（湖北崇阳）

4.电子科技大学经济管理学院副教授 陈光宇(简介 教学 科研)

5.江西省农业科学院副院长 陈光宇(职务 学会职务 主要业绩)

6.美国新泽西州州立罗格斯大学高级教授

中国医学科学院整形外科副主任医师(业务专长 工作成就)

1.重庆市国土资源和房屋管理局副局长

陈光宇，男，汉族，籍贯四川，1965年11月生于贵州，中共党员。重庆交通学院工学学士。工程师职称。

1983年09月——1987年07月，重庆交通学院本科学习；

1987年07月——1989年03月，重庆市规划局建管处工作；

1989年03月——1993年03月，重庆市规划院工作；

1993年03月——1995年06月，重庆市规划局南岸区办科长；

1995年06月——1998年05月，重庆市规划局北碚区办副主任，主持全面工作，党支部书记、北碚区政协委员；

1998年06月——2001年10月，重庆市规划局南岸区办主任，党支部书记、南岸区政协委员（2000年9月—2003年3月重庆交通学院研究生班学习）；

2001年10月——2003年02月，重庆市规划局南岸区分局局长、党支部书记、南岸区政协委员）2002年9月至今重庆市委党校行政管理研究生班学习）；

2003年02月——2004年04月，重庆市规划局市政规划管理处处长；

2004年04月——，中共重庆市委党校副校长、重庆行政学院副院长。

经2012年2月20日市人民政府第120次常务会议决定：任命陈光宇为重庆市国土资源和房屋管理局副局长。

2.高级工程师（湖南长沙）

陈光宇，高级工程师。湖南长沙人。1944年毕业于重庆兵工大学兵器制造系。建国后，历任中国白城兵器试验中心弹道研究试验所主任工程师试验技术研究所总工程师、高级工程师，中国兵工学会弹道学会第一届副主任。1979年加入中国共产党。对常规兵器弹道学的研究较深。1986年被国防科工委追授为“献身国防科技事业的模范”。

3.高级讲师（湖北崇阳）

陈光宇 男，1928年11月出生，湖北崇阳人。高级讲师。1965年毕业于武汉师范学院中文系。现任湖北省崇阳县中等师范学校中文函授辅导教师。兼咸宁教育学院高师函授《古汉语》课讲师及湖北大学成人教育学院高师函授中文专业辅导教师。主要贡献：一生主要从事语文教学和研究工作。1980年被评为崇阳县先进工作者，1983年被评为咸宁地区优秀函授教师，1985年获县委和县人民政府颁发的光荣从事教育工作32年的荣誉证书，1987年被湖北大学评为优秀函授辅导教师，1989年获湖北大学从事高师函授教育十年的荣誉证书。编著有《诗经概述》、《中国古代神话概述》、《先秦诸子散文概述》、《先秦历史散文概述》、《古汉语讲义》等；论文有《论蒲松龄和聊斋志异》、《论文章憎命达》等。

4.电子科技大学经济管理学院副教授 陈光宇

教授、博士（后）

简介

1991年7月 四川大学计算机科学系 工学学士学位

2002年1月 西南交大经济管理学院 工商管理硕士学位

2005年12月 电子科技大学管理学院 管理科学与工程博士学位

中国工程物理研究院激光聚变研究中心博士后

教学

本科课程 质量管理（Qualilty Management)

本科课程 电子商务 （E-Commerce）

本科课程 管理信息系统 (Management Information Systems)

MBA课程 供应链管理 (Supply Chain Management)

项目管理课程 项目管理信息系统 (Project Management Information Systems)

科研

发表论文：

[1] 陈光宇，黄锡滋，张小民，等. 不完全覆盖的多阶段任务系统可靠性综合分析[J]. 系统工程学报，2007,22（5）: 539-545

[2] 陈光宇，杨 东，张小民，等. 激光装置片放组件的氙灯可靠性分析[J]. 强激光与粒子束，2007，19（7）：1125-1128

[3] 陈光宇，黄锡滋，唐小我. 不完全覆盖的多阶段任务系统可靠性集成分析[J]. 系统工程理论与实践，2006,26（4）: 1-8 (EI 06229913404）

[4] Guangyu Chen,Xizi Huang,Xiaowo Tang. A BDD&SEA Based Analysis of Phased-Mission System Reliability[C]. Proceedings Annual Reliability and Maintainability,2006: 456-463. EI

[5] 陈光宇，黄锡滋，唐小我. 不完全覆盖的多层次系统可靠性分析[J]. 系统工程学报，2005,20（5）: 504-510

[6] 陈光宇，黄锡滋，唐小我. 多阶段系统可靠性的混合式分析[J]. 系统工程理论与实践，2005,25（2）: 86-93 (EI 05149026345）

[7] Guangyu Chen,Xizi Huang,Xiaowo Tang. Reliability Analysis of Hierarchical Systems[C]. Proceedings Annual Reliability and Maintainability,2005: 146-151 (SCI BCA63 ),(EI 05479494754,06219892323）

[8] Guangyu Chen,Xizi Huang,Xiaowo Tang. Analysis of PMS Reliability,and Importance with imperfect coverage[J]. Journal of Electronic Science & Technology of China 2005,3（2）:182-186

[9] 陈光宇，黄锡滋，唐小我. 故障树模块化分析系统可靠性[J].电子科技大学学报. 2006,35（6）: 989-992. (EI 070510401070）

[10] 陈光宇，但莹荧，张小民. FRACAS信息系统的流程与功能分析[J]. 科学学与科学技术管理（ 增刊），2007,28（1）: 72-75

[11] 陈光宇，黄锡滋. 软件可靠性学科发展现状及展望[J]. 电子科技大学学报（社科版），2002,4（3）: 99-102

主持和参与中国工程物理研究院博士后流动站、总装和国家自然科学基金资助的多项研究课题。在研究项目两项。

5.江西省农业科学院副院长 陈光宇

职务

江西省农业科学院 副院长

江西省归国华侨联合会 副主席

农业部肉及肉制品质量监督检验测试中心 主任

绿色食品产品质量定点检测中心（南昌） 主任

中国南方航天育种技术研究中心主任

学会职务

中国园艺学会芦笋分会理事长

中国仪器仪表学会农业仪器运用技术学会副理事长

中国遗传学会理事

江西省遗传学会副理事长

江西省生物工程学会副理事长

主要业绩

国家公益性行业（农业）科研项目首席专家，为国内芦笋产业化和研究方面的领头人，从国外引进了第一批芦笋种质资源，培育了中国第一个具有自主知识产权的芦笋品种“井冈701”和第一个四倍体紫色芦笋新品种“井冈红”，主持制定了中国三个芦笋行业标准；进行了芦笋抗癌物质提取和降血压降血脂物质的研究，主持实施“风沙化土地的治理和芦笋产业化”五年，将生态和经济效益紧密结合，培育了非常耐盐碱的芦笋品种，可以在盐碱地种植。2013年世界芦笋大会（第十三届）首次在中国召开，任大会主席。

1997年建立了全国第一个部级肉类质检中心，获得国家授权成立“绿色食品产品质量定点监测中心”，担任主任；发明并建立了“基因转移的能量理论”，已被国际同行认可并于1999年被美国Biored生物工程技术公司开发成为产品推向国际市场，2002年作为基本原理被编入美国生物技术专业教科书；发明了电脑速记及软件，已获得国家发明专利，现被上海大学等院校列入课程；主持完成了上海市高新技术重大项目“上海农业生物基因中心”筹建；主持完成了国家级“井冈山国家农业科技园”的总体规划，2004年通过国家科技部专家评审，被评价为建立了一种新的现代农业模式；获得国家科技进步一等奖1项、三等奖1项；省科技进步二等奖1项；省科技发明三等奖1项。1992年获得国务院特殊津贴专家称号，2001年被评为省学科带头人。

6.美国新泽西州州立罗格斯大学高级教授

简历

姓名： 陈光宇 （Kuang Yu Chen）

生日：1946 年4 月4 日

国籍：美国（2003 年入籍）

学习简历：耶鲁大学化学博士

学士 台湾大学化学系National Taiwan University,Chemistry,1967

硕士 耶鲁大学化学系Yale University,Chemistry,1971

博士 耶鲁大学化学系Yale University,Chemistry,1973

博士後Postdoc，耶鲁医学院 药理学系Yale Medical School,Pharmacology 1973-75

专业职务： 美国新泽西州州立罗格斯大学高级教授

从事专业： 本科生老师，博士导师

任职单位： 罗格斯大学，化学及化学生物学系。

学术兼职：罗格斯大学，东亚学系兼任教授。

工作简历：

1975-77 研究员，耶鲁医学院 药理学系

1977-82 助教授，新泽西州立罗格斯大学 化学及化学生物系

1982-87 副教授，新泽西州立罗格斯大学 化学及化学生物系

1984-85 访问学者，哈佛医学院 生物物理系

1987-1995 正教授，新泽西州立罗格斯大学 化学及化学生物系

1995- 高级教授，新泽西州立罗格斯大学 化学及化学生物系

科研项目

我们实验室长期以来从事分子生物学、化学生物学的研究工作。近年来的研究工作主要集中在

（1）多胺（Polyamines）以及eIF5A 蛋白因子的生物功能。（2）筛选具抗癌，消炎，抗肥肿或抗

衰老活性之天然物及小分子化合物。（3）白藜芦醇衍生物合成及生理活性。

主要科研项目如下：

1．多胺及eIF5A 计划：多胺的新陈代谢控制在生物体极为重要，多胺功能复杂，其调控失误是

许多病理主因。多胺在生物体中最重要功能之一是修饰eIF5A。eIF5A 为生物界唯一含有非常氨

基酸 hypusine 之蛋白质。它存在于所有真核细胞及古老细菌之中。eIF5A 上之hypusine 是经由

DS (deoxyhypusine synthase) 蛋白酶以多胺中的精胺（spermidine）加以修饰。移除eIF5A 或抑制

其修饰会导至细胞生长停止及凋亡。本小组是最早发现eIF5A 之实验室之一，也是首先完成纯

化及克隆DS 蛋白酶工作的实验室。目前我们以不同生物模型来研究eIF5A 功能及其作用机理。

2．筛选计划：我们利用各种细胞测定方法（cell-based assays），基因表达测定方法（gene

expression profiling）及生物信息库资料（bioinformatics）来发展高通量筛选流程，进行天然物及

合成化合物库的筛选以便迅速辨识具有生物活性（包括抗癌，消炎，抗肥肿，或抗衰老）的小

分子化合物。

3．白藜芦醇计划：以白藜芦醇为先导化合物，我们得到高活性的抗肿瘤化合物，目前研究其

与线粒体的可能关系及其在细胞凋亡及肿瘤细胞的诱导分化之作用机理。

4。细胞老化机理研究计划：我们利用人体细胞研究NF-Y 转录因子及多胺同eIF5A 对控制细胞

老化的影响。

5。肿瘤细胞分化机理研究：特别着重研究多胺在神经节肿瘤细胞分化过程的作用，并研究多

胺衍生化合物对肿瘤细胞分化的影响。

主要学术成就

1. 我们实验室是最早发现eIF5A 的两个实验室之一，是第一个发现NAD+ 在eIF5A 修饰的关键

功能。此发现促成我们成为最先纯化并且克隆DS 蛋白酶的实验室。我们也是第一个发现

eIF5A 可以与RNA 结合的实验室。我们最近成功的证明eIF5A 在细胞体内与活化的核糖体

结合，是探讨eIF5A 功能的一大突破。我们的eIF5A 研究连续为NIH 及美国癌症学会（ACS）

支持达20 多年。

2. 发现NF-Y 转录因子与细胞老化有密切关系。我们实验室在eIF5A 及细胞老化的工作促成本

人被选为AAAS Fellow。

3. 首先发现红茶素多酚抑制COX2 酶，具有抗癌及消炎作用。并且开发了数项高通量筛选技

术可以寻找具抗肿瘤，抗炎活性的小分子化合物。拥有三项美国国家专利局的专利。由罗

格斯大学衍生的生技公司WellGen 取得使用权。

4. 我们实验室迄今毕业有17 位博士，20 位硕士，并训练了15 位後博士。实验室历年的成员

来自世界各地，包括中国（含台湾、香港）、美国、日本、韩国、印度、德国、俄罗斯、

巴基斯坦、哥斯达黎加等国家。

重要学术活动

1997,2007 Gordon Conference on Polyamines,Section Chair and invited speaker

1994-1998 Member,Biological and Clinical Aging Review Committee A,NIH

1996-2000 学术期刊Biological Signal 编委

1998-2002 学术期刊Biogerontology编委

2000 Member,University Promotion Review Committee

2004-2008 Member,University Promotion Review Committee

2004 Keynote Speaker,8th National Symposium on Applied Chemistry,China

2004 Keynote Speaker,The Chinese American Chemical Society,Philadelphia

2004 陕西师范大学化学与材料学院兼任教授

2007 吉林大学生命科学院兼任教授

2008 罗格斯大学孔子学院董事

欧美香港台湾各大学论文或基金会评审，及教授升等之校外评审。

两次任罗格斯大学全校区教授升等评审会委员

特殊奖励：

1995 Johnson and Johnson Discovery Award

1998 当选美国科学协进会 (American Association for the Advancement of Science (AAAS)) Elected

Fellow，当选证书： “For fundamental contributions to the biochemistry of cellular aging and the

enzymatic process of hypusine formation,a reaction essential for cell survival.”

* AAAS Fellow 是美国学术界的殊荣之一。

学术论文 （peer reviewed Journals）：

Chemical Biology and Life Science

1. Wang,K.T.,Chen,K.Y. and Weinstein,B. Amino acids and peptides XV. Separation of Nbenzyloxycarbonyl

amino acids and esters. J. Chromatog.,32,591-592,1968.

2. Chen,K.Y. and Wang,J.H. Effects of manganese extraction on oxygen generation and EPR

signal II in spinach chloroplasts. Bioinorganic Chemistry,3,339-352,1974.

3. Tsai,C.M.,Chen,K.Y. and Canellakis,E.S. Isolation and characterization of the plasma

membrane of L-1210 cells: Iodination as a marker of the plasma membrane. Biochim. Biophys.

Acta,401,196-221,1975.

4. Chen,K.Y.,Tsai,C.M. and Canellakis,E.S. Comparison of physical and immunological properties

of plasma membranes of two mouse leukemia cell lines,P-388 and L-1210. Cancer Res.,35,

2403-2412,1975.

5. Chen,K.Y.,Heller,J.S. and Canellakis,E.S. Studies on the regulation of ornithine decarboxylase

activity by the microtubules: The effect of colchicine and vinblastine. Biochem. Biophys. Res.

Commun.,68,401-408,1976.

6. Chen,K.Y.,Heller,J.S. and Canellakis,E.S. The inhibition of the induction of ornithine

decarboxylase by cations. Biochem.,Biophys. Res. Commun.,70,212-219,1976.

7. Chen,K.Y. and Canellakis,E.S. Enzyme regulation in neuroblastoma cells in a salts-glucose

medium: The induction of ornithine decarboxylase by asparagine and glutamine. Proc. Natl. Acad.

Sci.,USA 74,3791-3795,1977.

9. Canellakis,E.S.,Heller,J.S.,Kyriakidis,D. and Chen,K.Y. The intracellular levels of ornithine

decarboxylase,its half-life and a hypothesis relating polyamine sensitive membrane receptors to

growth. Adv. Polyamine Res.,1,17-30,1978.

10. Chen,K.Y.,Kramer,R.H. and Canellakis,E.S. Isolation and characterization of surface

glycoproteins from L-1210,P-388 and HeLa cells. Biochim. Biophys. Acta,507,107-118,1978.

11. Heller,J.S.,Chen,K.Y.,Wong,W.F. and Canellakis,E.S. The modulation of the induction of

ornithine decarboxylase by spermine,spermidine and diamines. J. Cell. Physiol.,96,225-234,

1978.

12. Liu,A.Y.-C.,Fiske,W.W. and Chen,K.Y. Regulation of cyclic AMP-binding protein in N-18 mouse

neuroblastoma cells. Cancer Res.,40,4100-4108,1980.

13. Chen,K.Y. Differences in the mode of regulation of ornithine decarboxylase activity in

undifferentiated versus differentiated mouse N18 neuroblastoma cells. FEBS Letters,119,307-

311,1980.

14. Chen,K.Y. and Rinehart,C.A.,Jr. Difference in putrescine transport in undifferentiated versus

differentiated mouse NB-15 neuroblastoma cells. Biochem. Biophys. Res. Commun.,101,243-

249,1981.

15. Liu,A.Y.-C.,Chan,T. and Chen,K.Y. Induction of regulatory subunit of type cAMP-dependent

protein kinase in differentiated N-18 mouse neuroblastoma cells. Cancer Res.,41,4579-4587,

1981.

16. Chen,K.Y. and Liu,A.Y.-C. Differences in polyaminemetabolism of the undifferentiated and

differentiated neuroblastoma cells. Metabolic labeling of an 18,000-Mr protein by [14C]-

putrescine and the conversion of putrescine to GABA. FEBS Letters,134,71-74,1981.

17. Chen,K.Y.,Prespe,V.,Parken,N. and Liu,A.Y.-C. Change of ornithine decarboxylase activity

and polyamine contents upon differentiation of mouse NB-15 neuroblastoma cells. J. Cell.

Physiol.,110,258-290,1982.

18. Chen,K.Y. and Rinehart,C.A.,Jr. Identification of exposed surface glycoproteins in

undifferentiated and differentiated mouse N-18 neuroblastoma cells. Biochim. Biophys. Acta,685,

61-70,1982.

19. Chen,K.Y.,Kyriakidis,D.A. and Canellakis,E.S. The inhibition of the serum-stimulated increase

of ornithine decarboxylase by ionophores and local anesthetics. Biochim. Biophys. Acta,716,72-

78,1982.

20. Viceps-Madore,D.,Chen,K.Y.,Tsou,H. and Canellakis,E.S. Ornithine decarboxylase activity in

cells maintained in salts-glucose solution. I. Requirements for Na+,amino acids and protein

synthesis. Biochim. Biophys. Acta,717,305-315,1982.

21. Chen,K.Y. and Liu,A.Y.-C. Differences in the mode of regulation of ornithine decarboxylase and

tyrosine aminotransferase of H-35 rat hepatoma cells: Effects of medium composition. Biochim.

Biophys. Acta,755,244-252,1983.

22. Chen,K.Y. and Liu,A.Y.-C. The role of polyamines in the differentiation of mouse neuroblastoma

cells. Adv. Polyamine Res.,4,743-755,1983.

23. Chen,K.Y. An 18,000-dalton protein metabolically labeled by polyamine in various mammalian

cell lines. Biochim. Biophys. Acta,756,395-402,1983.

24. Chen,K.Y.,Nau,D. and Liu,A.Y.-C. Effect of inhibitors of ornithine decarboxylase on the

differentiation of mouse neuroblastoma cells. Cancer Res.,43,2812-2818,1983.

25. Chen,K.Y. Transglutaminase catalyzed incorporation of putrescine into surface proteins of

mouse neuroblastoma cells. Molecular and Cellular Biochemistry,58,91-98,1984.

26. Chen,K.Y. and Verma,R. Spermine specifically inhibits the phosphorylation of an 11,000-dalton

nuclear protein in various cultured mammalian cell lines. Biochem. Biophys. Res. Commun.,118,

710-716,1984.

27. Rinehart,C.A.,Jr. and Chen,K.Y. Characterization of the polyamine transport system in mouse

neuroblastoma cells: Effects of sodium and system A amino acids. J. Biol. Chem.,259,4750-4756,

1984.

28. Rinehart,C.A.,Jr. and Chen,K.Y. Identification of the insulin receptor in undifferentiated and

differentiated NB-15 mouse neuroblastoma cells by affinity labeling. Biochim. Biophys. Acta,802,

515-521,1984.

29. Chen,K.Y. and Martynowicz,H. Lack of detectable polyamines in an extremely halophilic

bacterium. Biochem. Biophys. Res. Commun. 124,423-429,1984.

30. Chen,K.Y. and McLaughlin,M.G. Differences in the decay kinetics of EPR signals of

incorporated stearic acid spin labels in undifferentiated versus differentiated mouse

neuroblastoma cells. Biochim. Biophys. Acta,845,189-195,1985.

31. Liu,A.Y.-C. and Chen,K.Y. Differential effects of the tumor promoter phorbol-12-myristate-13-

acetate on the morphological and biochemical differentiation of N-18 mouse neuroblastoma cells.

J. Cell. Physiol. 125,387-392,1985.

32. Verma,R. and Chen,K.Y. Spermine inhibits the phosphorylation of the11,000- and 10,000-

dalton nuclear proteins catalyzed by nuclear kinase NI in NB-15 mouse neuroblastoma cells. J.

Biol. Chem. 261,2890-2896,1986.

33. Chen,K.Y. and Chang,Z.F. Age dependency of the metabolic conversion of polyamines into

amino acids in IMR-90 human embryonic lung diploid fibroblasts. J. Cell. Physiol. 128,27-32,

1986.

34. Liu,A.Y.-C.,Chang,Z.F. and Chen,K.Y. Increased cAMP-dependent protein kinase activity in

aging human diploid fibroblasts. J. Cell. Physiol. 128,149-154,1986.

35. Chen,K.Y.,Chang,Z.F. and Liu,A.Y.-C. Changes of serum-induced ornithine decarboxylase

activity and putrescine content during aging of IMR-90 human diploid fibroblasts. J. Cell. Physiol.

129,142-146,1986.

36. Chen,K.Y. and Chang,Z.F. A marked increase of fucosylation of glycoproteins in human diploid

fibroblasts (IMR-90） during senescence in vitro Biochem. Biophys. Res. Commun.,142,767-774,

1987.

37. Liu,A.Y.-C.,Kamalakannan,V. and Chen,K.Y. Identification of functional cAMP-dependent

protein kinase in a'neurite-minus'mouse neuroblastoma cell line. Biochim. Biophys. Acta,928,

235-239,1987.

38. Chen,K.Y. and Cheng,S. Polyamine Metabolism in an obligately alkalophilic Bacillus

alcalophilus that grows at pH 11.0. Biochem. Biophys. Res. Commun.,150,185-191,1988.

39. Liu,A.Y.-C.,Lin,Z.,Kamalakannan,V. and Chen,K.Y. Induction and quantitation of the RI

cAMP-binding protein in clonal mouse neuroblastoma cell lines: Evidence that the increase in RI is

not related to neurite outgrowth. J. Neurosci. Res. 19,303-311,1988.

40. Chen,K.Y. and Dou,Q.P. NAD+ stimulated the spermidine-dependent hypusine formation on

the 18,000-dalton protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.

FEBS Letters,229,325-328,1988.

41. Chen,K.Y. and Dou,Q.P. Isolation and characterization of an 18,000-dalton hypusine-containing

protein from NB-15 mouse neuroblastoma cells. Biochim. Biophys. Acta,971,21-28,1988.

42. Chang,Z.F. and Chen,K.Y. Regulation of ornithine decarboxylase and other cell-cycle

dependent genes during senescence of IMR-90 and human fibroblasts. J. Biol. Chem.,263,

11431-11435,1988.

43. Hsu,L.,Jeng,A. and Chen,K.Y. Induction of neurite outgrowth from chick embryonic ganglia

explants by activators of protein kinase C. Neuroscience Letter 99,257-262,1989.

44. Chen,K.Y.,Chang,Z.F.,Pang,J.H,He,G.S.,Liu,A.Y.-C. Polyamine metabolism and cell cycledependent

gene expression in IMR-90 human diploid fibroblasts during senescence in culture.

Exp. Gerontol.,24,523-537,1989.

45. Dou,Q.P. and Chen,K.Y. Two hypusine-containing proteins identified by metabolic labeling in

chick embryo fibroblasts. J. Chinese Chem. Soc.,36,443-450,1989.

46. Yang,Y.C.,Chen,K.Y.,Seyfzadeh,M. and Davis,R.H. Deoxyhypusine/hypusine formation on a

21,000-dalton cellular protein in a Neurospora crassa mutant in vitro and in vivo. Biochim.

Biophys. Acta,1033,133-138,1990.

47. Dou,Q.P. and Chen,K.Y. Characterization and reconstitution of a cell free system for NAD+-

dependent deoxyhypusine formation on the 18,000-dalton eIF-4D precursor. Biochim. Biophys.

Acta,1036,128-137,1990.

48. Chen,Z.P. and Chen,K.Y. Differentiation of a mouse neuroblastoma variant cell line whose

ornithine decarboxylase gene has been amplified. Biochim. Biophys. Acta,1133,1-8,1991.

49. Liu,A.Y.-C.,Choi,H.,Lee,Y. and Chen,K.Y. Molecular events involved in transcriptional

activation of heat shock genes become progressively refractory to heat stimulation during aging of

human diploid fibroblasts. J. Cellular Physiol. 149,560-566,1991.

50. Chen,Z.P. and Chen,K.Y. Mechanism of regulation of ornithine decarboxylase gene expression

in a variant mouse neuroblastoma cell line. J. Biol. Chem. 267,6946-6951,1992.

51. Knapp,S.,Hale,J.J.,Bastos,M.,Molina,A. and Chen,K.Y. Synthesis of hypusine and other

polyamines using dibenzyltriazones for amino protection. J. Org. Chem.,57,6239-6256,1992.

52. Mehta,S.,Hsu,L.,Jeng,A. and Chen,K.Y. Neurite outgrowth and protein phosphorylation in

chick embryonic sensory ganglia induced by a brief exposure to 12-O-tetradecanoylphorbol-13-

acetate. J. Neurochem.,60,972-981,1993.

53. Pang,J.H and Chen,K.Y. A "CCAAT" binding protein,CBP/tk,may be involved in the regulation

of thymidine kinase gene expression in human IMR-90 diploid fibroblasts during senescence. J.

Biol. Chem.,268,2909-2916,1993.

54. Yang,Y.C.,Bastos,M. and Chen,K.Y. Effects of osmotic stress and growth stage on cellular pH

and polyphosphate metabolism in Neurospora crassa as studied by 31P nuclear magnetic

resonance spectroscopy. Biochim. Biophys. Acta. 1179,141-147,1993.

55. Pang,J.H. and Chen,K.Y. A global change of expression of G1/S phase genes in IMR-90

human diploid fibroblasts during senescence. J. Cell. Physiol. 160,531-538,1994.

56. Tao,Y. and Chen,K.Y. PCR based cloning of full length Neurospora eIF-5A cDNA:

Polyhistidine-tagging and overexpression for protein affinity binding. Biochemical Journal,

302,517-525,1994.

57. Tao,Y.,Skrenta,H.M. and Chen,K.Y. Deoxyhypusine synthase assay based on the use of

polyhistidine-tagged substrate and metal chelate affinity chromatography. Anal. Biochem.,

221,103-108,1994.

58. Chen,Z.P. and Chen,K.Y. A marked difference in the effect of asparagine on the regulation of

ornithine decarboxylase gene expression in NIH 3T3 and ras-transformed NIH 3T3 cells. Cancer

Letters,86,97-103,1994.

59. Tao,Y. and Chen,K.Y. Purification of deoxyhypusine synthase from Neurospora crassa to

homogeneity by substrate elution affinity chromatography. J. Biol. Chem.,270,383-386,1995.

60. Good,L.,Chen,J. and Chen,K.Y. Analysis of sequence specific binding of cis-elements in the

human thymidine kinase gene promoter during G1/S phase transition. J. Cell. Physiol.,163,636-

644,1995.

61. Huang,E.,Carrucio,L.,Liu,A.Y. and Chen,K.Y. Rapid activation of the heat shock transcription

factor by hypoosmotic stress in mammalian cells. Biochemical J.,307,347-352,1995.

62. Tao,Y. and Chen,K.Y. Molecular cloning and functional expression of Neurospora

deoxyhypusine synthase cDNA and identification of yeast,deoxyhypusine synthase cDNA. J. Biol.

Chem.,270,23984-23987,1995

63. Pang,J.H. and Chen,K.Y. The age-dependent binding of CBP/tk,a CCAAT binding protein,is

deregulated in transformed and immortalized mammalian cells but absent in premature aging cells.

Experimental Gerontology,31,97-109,1996.

64. Yan,Y.P.,Tao,Y. and Chen,K.Y. Molecular cloning and functional expression of human

deoxyhypusine synthase cDNAs based on expressed sequence tag information. Biochem. J.,315,

429-434,1996.

65. Good,L.F. and Chen,K.Y. Cell cycle- and age-dependent transcriptional regulation of human

thymidine kinase gene: The role of NF-Y in the CBP/tk binding complex. Biol. Signals,5,163-169,

1996.

66. Good,L.F.,Dimri,G.P.,Campisi,J. and Chen,K.Y. Regulation of dihydrofolate reductase gene

expression and E2F components in IMR-90 human diploid fibroblasts during growth and

senescence. J. Cell. Physiol.,168,580-588,1996.

67. Chen,Z.P.,Yan,Y.P.,Ding,Q.,Potenza,J.A.,Knapp,S.,Schugar,H.J. Chen,K.Y. Effects of

inhibitors of deoxyhypusine synthase on the differentiation of mouse neuroblastoma and

ertthroleukemia cells. Cancer Letters,105,233-239,1996

68. Liu,A.Y.-C.,Chen,K.Y. and Denhardt,D.T. Transcription Factors and Cell Aging. Biol. Signals,5,

127-129,1996.

69. Chen,Z.P and Chen K.Y. Dramatic attenuation of hypusine formation on eukaryotic initiation

factor 5A during senescence of IMR-90 human diploid fibroblasts. J. Cell. Physiol.,170,541-548,

1997.

70. Chen,Z.P. and Chen,K.Y. Marked elevation of hypusine formation on eukaryotic initiation factor

5A in v-Ha-ras transformed mouse NIH3T3 cells. Cancer Letters,115,235-241,1997.

71. Liu,Y.P.,Nemeroff,M.,Yan,Y.P. and Chen,K.Y. Interaction of eukaryotic initiation factor 5A with

human immunodeficiency type I virus Rev response element and U6 snRNA requires

deoxyhypusine or hypusine modification. Biol. Signals,6,166-174,1997.

72. Chen,K.Y. and Liu,A.Y.-C. Hypusine formation on eukaryotic initiation factor 5A,biochemistry

and function. Biol. Signals,6,105-109,1997.

73. Caruccio,L.,Bae,S.,Liu,A.Y-C. And Chen,K.Y. Rapid activation of the heat shock factor,HSF1,

by hyper- and hypo-osmotic stress in mammalian cells. Biochemical J.,327,341-347,1997.

74. Chen,K.Y. Transcription factors and the down-regulation of G1/S boundary genes in human

diploid fibroblasts during senescence. Frontiers in Bioscience,2,d417-426,1997.

75. Verma,R. and Chen,K.Y. Spermine stimulates the phosphorylation of the nuclear matrix

proteins catalyzed by nuclear kinase II. Frontiers in Bioscience,2,a26-30,1997.

76. Tiku,M.,Yan,Y.P.and Chen,K.Y. Electron Spin resonance/spin trapping evidence for hydroxyl

radical formation by chondrocytes and cartilage. Free Radical Research,29,177-187,1998.

77. Chen,Z.P. and Chen,K.Y. Green tea epigallocatechin gallate shows pronounced growth

inhibitory effect on cancerous cells but not on their normal counterparts. Cancer Letters,129,

173-179,1998.

78. Chen,K.Y. Study of polyphosphate metabolism by 31P nuclear magnetic resonance

spectroscopy. in “Progesss in Molecular and Subcellular Biology” (ed. Schroder,H.C.),Springer

Verlag,Germany,pp. 253-273,1999

79. Jao,D. and Chen,K.Y. Chemistry and biological function of hypusine-containing eIF-5A. J.

Chinese Chemical Society,46,727-734,1999.

80. Matuoka,K. and Chen,K.Y. Nuclear factor Y (NF-Y) and cellular senescence. Exp. Cell Res.,

253,365-371,1999.

81. Chen,K.Y.,Lu,Jiebo and Liu,A.Y.-C. The activation of trans-acting factors in response to hypoand

hyper-osmotic stress in mammalian cells. in “Environmental Stressors and Gene Responses”

（eds. Storey,K. and Storey,J),Elsevier Press,Amsterdam,pp. 141-155,2000.

82. Lu,J.B.,Park,J.,Liu,A.Y-C. and Chen,K.Y. Osmotic stress-induced activation of HSF1 DNA

binding activity is dramatically attenuated in senescent human cells. J. Cell. Physiol.,184,183-

190,2000.

83. Matuoka,K. and Chen,K.Y. Possible role of subunit A of nuclear factor Y (NF-Y) in normal

human diploid fibroblasts during senescence. Biogerontology,1,261-271,2000.

84. Lu,J.B.,Ho,C.-T.,Ghai,G. and Chen,K.Y. Differential effects of theaflavin monogallates on cell

growth,apoptosis and Cox-2 gene expression in cancerous versus normal cells. Cancer

Research,60,6465-6471,2000.

85. Lu,J.,Chen,Z.P.,Yan,Y.P.,Knapp,S.,Schugar,H. and Chen,K.Y. 6-Aminohexanoic

hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells. Cancer Lett.,

160,59-66,2000.

86. Xu,A. and Chen,K.Y. Hypusine is required for a sequence-specific interaction of eukaryotic

initiation factor 5A with post-SELEX RNA. J. Biol Chem.,276,2555-2561,2001.

87. Lu,J.B.,Ho,C.-T.,Ghai,G. and Chen,K.Y. Resveratrol analog,3,4,4',5-tetrahydroxystilbene,

differentially induces pro-apoptotic p53/Bax gene expression and inhibits the growth of

transformed cells but not their normal counterparts. Carcinogenesis,22,321-328,2001.

88. Matuoka,K.,Chen,K.Y. and Tenegawa,K. Rapid reveresion of aging phenotypes by

nicotinamide through possible modulation of histone acetylation. Cellular Molecular Life Sciences,

58,2108-2116,2001.

89. Jao,D.L. and Chen,K.Y. Subcellular localization of the hypusine-containing eukaryotic initiation

factor 5A by immunofluorescent staining and Green Fluorescent protein tagging. J. Cell. Biochem.,

86,590-600,2002.

90. Matuoka,K. and Chen,K.Y. Transcriptional regulation of cellular senescence by the CCAAT boxbinding

proteins CBF/NF-Y. Aging Research Reviews,1,639-651,2002.

91. Matuoka,K. and Chen,K.Y. Telomerase positive human diploid fibroblasts are resistant to

replicative senescence but not premature senescence induced by chemical reagents.

Biogerontology,3,365-372,2002.

92. Matuoka,K.,Chen,K.Y. and Takenawa,T. A positive role of phosphatidylinositol 3-kinase in

aging phenotype expression in cultured human diploid fibroblasts. Archives Gerontology and

Geriatrics,36,203-219,2003.

93. Gosslau,A. and Chen,K.Y. Nutraceuticals,apoptosis,and disease prevention. Nutrition,20,95

102,2004,

94. Xu,A.Jao,D.L. and Chen,K.Y. Identification of mRNA that binds to eukaryotic initiation factor 5A

by affinity co-purification and differential display. Biochemical Journal,384,585-590,2004

95. Gosslau,A.,Chen,M.,Ho,C.-T. and Chen,K.Y. A methoxy derivative of resveratrol analog

exhibits potent and striking differential growth inhibitory effect against human cancer cells. British

J. Cancer,92,513-521,2005.

96. Fang,F.,Sang,S.,Chen,K.Y.,Gosslau,A.,Ho,C.-T.,and Rosen,R.T. Isolation and identification

of cytotoxic compounds from bay leaf (Laurus nobilis). Food Chem.,93,497-501,2005

97. Jao,D.L. and Chen,K.Y. Tandem affinity purification revealed the hypusine-dependent binding of

eukaryotic initiation factor 5A to the translating 80S ribosomal complex. J. Cell. Biochem. 97,583-

598,2006.

98. Chatterjee,I.,Gross,S.R. Kinzy,T.G. and Chen,K.Y. Rapid depletion of mutant eukaryotic

initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell

cycle progression. Mol. Genet. Genomics,275,264-276,2006.

99. Yang,J.,Oza,J.,Bridges,K,Chen,K.Y. and Liu,A. Y.-C. Neural differentiation and the

attenuated heat shock response. Brain Res. 1203,39-50,2008.

100. Gosslau,A.,Pabbaraja,S.,Knapp and Chen,K.Y. Trans- and cis-stilbene polyphenols

induced rapid perinuclear mitochondrial clustering and p53-independent apoptosis in cancer

cells but not normal cells. European J. Pharmacology,587,25-34,2008.

101. Oza J.,Yang J.,Chen K.Y.,Liu A.Y. Changes in the regulation of heat shock gene expression in

neuronal cell differentiation. Cell Stress Chaperones. 13,73-84,2008.

102. Yang J.,Bridges K.,Chen K.Y.,Liu A.Y. Riluzole increases the amount of latent HSF1 for an

amplified heat shock response and cytoprotection. PLoS ONE. 3（8）:e2864,2008.

103. Lu,J.,Gosslau,A.,Liu,A.Y.-C. and Chen,K.Y. PCR differential display-based identification of

regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by

black tea polyphenol theaflavin monogallate. European J Pharmacology,601,66-72,2008.

104. Gosslau,A.,Jao,D.,Liu,A.Y-C. and Chen,K.Y. Thermal killing of human colon cancer cells Is

associated with the loss of eukaryotic initiation factor 5A. J Cell Physiol,219,485-493,2009.

105. Lee,Y.K.,Liu,D.,Lu,J,Chen,K.Y. and Liu,A Y.-C. Aberrant regulation and modification of

heat shock factor 1 in senescent human diploid Fibroblasts. J Cellular Biochemistry 106,267-278,

2009.

106. Gosslau,A.,Jao,D.,Huang,M-T.,Evans,D.,Rawson,N.E. and Chen,K.Y. Effects of the black

tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo. Mol.

Nutrition and Food Res.,in press,2010.

Paleography and Ancient Chinese

1. Chen,K.Y. 从玄鸟生商的传说看甲骨文中隹王一词 Zhui Wang in Oracle Bone Language: Possible

relationship to the bird totem of Shang Dynasty （1700-1100 BC). Journal of Chinese Linguistics,

22,101-113,1994

2. Chen,K.Y. New interpretation of the temple name of Shang King Pan Geng. Journal of Chinese

Linguistics,29,340-350,2001

3. Chen,K.Y. The Book of Odes: A Case Study of the Chinese Hermeneutic Tradition. in

<Interpretation and Intellectual Change>,p.47 - 62,Transaction Publishers,2005

4. Chen,K.Y. 商代多伯多臣与肉食者 Shang Dai Duobo Duochen yu Ruoshizhe. 《花园庄东地甲骨论

丛》Huayuan Zhuang Dongdi Jiagu Lun Cong,pp 209-222,2006

5. Chen,K.Y. 试论汉字起源定点与世界古文字溯源比较 On the dating of the origin of Chinese writing

and a comparison with other original writings. 文博Wenbo Journal,145,26-34,2008

6. Chen,K.Y. 世界四种古文字的起源时空与文字构造 Time,space,and the structure of the four

original written languages. Gu Wenzi Yanjiu Journal of Chinese Paleographic Study 古文字研究，

27,1-16,2008

7. Chen,K.Y. 儿氏家谱刻辞之“子”与花东卜辞之“子”，《纪念王懿荣发现甲骨文110 周年国际学

术研讨会论文集》 164-173， 2009

专利

（1） patent no: US 6,790,869 B2 (Sep,14,2004） Resveratrol analogs for prevention of disease,

（2） patent no: US 7,201,928 B1 (Apr,10,2007） Extracts of orange peel for prevention and treatment

of cancer

（3） patent no: US 7,238,376 B2 (Jul,3,2007） Black tea extract for prevention of disease

中国医学科学院整形外科副主任医师

陈光宇，男，1985年毕业于中国医科大学医疗系。大学本科、医学学士。

从1985年就职于中国医学科学院整形外科医院，历任住院医师、主治医师、副主任医师。从事整形美容医疗、教学、科研工作24年余。自1985年以来，多次参加整形美容外科国内（北京、上海、）及国际（中日、中日韩、）研讨会及修复重建外科（上海、济南、哈尔滨）的学术会议。2004年8月起任中国医学科学院整形外科医院瘢痕综合治疗中心副主任。

中华医学会医疗事故技术鉴定专家库成员；

中华医学会整形美容分会会员。

北京医疗整形美容质量控制和改进中心医疗组专家；

北京市医疗整形美容协会第二届专家委员会委员；

北京医学会医疗事故技术鉴定专家库成员；

业务专长

1.面颈部综合整形美容：

微创重睑术、切开法、埋线法重睑（双眼皮）成型术、各种失败双眼皮修复术。

鼻部综合美容（各种假体隆鼻术、鼻尖整形、鼻翼缩小）， 歪鼻及驼峰鼻的治疗，鼻部失败手术的修复。

眼袋整形术（去皮 去肌肉 去脂）、内路无痕眼袋整形术。

各种假体隆颏术。

经典面部年轻化（全颜面除皱术）、小切口面部年轻化美容术。

颊脂垫切除、口唇整形。

乳房整形美容：假体隆乳术、自体脂肪移植丰胸术、乳房乳头缩小术、乳头内陷整形、乳房上提术，巨乳修复术。

微创手术治疗腋臭。

先天畸形（上睑下垂、斜颈、唇腭裂及继发畸形、副耳及招风耳）。

无反弹吸脂法形体雕塑美容术。

妇科整形（处女膜修复术、阴道紧缩术、阴唇缩小术）。

2.整形专业：

面颈部瘢痕（凹陷 增生）的综合治疗。

具有18年应用皮肤扩张器治疗人体组织缺损的临床经验。

各种烧伤、外伤所致手畸形整形修复治疗。

可熟练应用显微外科技术行皮瓣游离移植手术。

痣及各种体表肿瘤的治疗。

熟练掌握各类先天畸形的整形外科治疗。

工作成就

主要从事美容外科手术，以及先天性畸形的矫治，烧伤、创伤后畸形的修复重建。作为术者每年完成了千余例各种整形、美容外科手术。曾获院校医疗成就三等奖及第三人身份北京市石景山区科技进步三等奖。在教学方面，作为导师组主要成员，已协助培养毕业了数名硕士生和博士生。同时担任进修生及国家继续教育课程的教学工作。在核心期刊参与发表论文20余篇。

参与编译书籍

《临床技术操作规范－整形外科分册》

《整形外科特色治疗技术》