个人简介：

研究领域：

近期论文：

个人简介：

1996年于中山大学医学院解剖学与神经生物学专业获博士。先后在中国科学院上海脑研究所，美国伊利偌斯大学医学院解剖学与细胞生物学系和美国康奈尔大学医学院神经科学系从事博士后研究。1998-1999年任郧阳医学院副教授，解剖学教研室主任。2003年底加入中国科学院上海生科院营养科学研究所，2004年入选中国科学院“百人计划”。2006年入选上海市“浦江人才计划”。现任中国科学院上海生命科学研究院营养科学研究所研究员，博士研究生导师，神经营养科学研究组组长。

研究领域：

· 阐明代谢性氧化损伤引起神经元死亡的可能细胞、分子生物学机制，寻找能客观反映老龄健康的生物学标记，和防治延缓老年性神经元死亡的分子靶点。

· 探讨酒精滥用等环境因素对神经系统发育和衰老影响的细胞、分子生物学机制。

· 神经退行性疾病的营养干预。寻找可以延缓老年性神经退行性疾病的生物活性小分子。为神经退行性疾病的预防性营养干预和膳食指导提供生物学理论基础。

近期论文：

Yang G, Meng Y, Li W, Yong Y, Fan Z, Ding HQ, Wei YZ, Luo J, Ke ZJ*. Neuronal MCP-1 Mediates Microglia Recruitment and Neurodegeneration Induced by the Mild Impairment of Oxidative Metabolism. Brain Pathol. 2011;21(3):279-297.

Yong Y, Ding H, Fan Z, Luo J, Ke ZJ*. Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson's disease. Neurochem Res. 2011, 36(3):367-74.

Lee SC, Yang G, Liu Y, Zhao L, Xu J, Zhang X, Wan Y, Feng C, Fan ZQ, Liu Y, Luo J, Ke ZJ*. ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol Neurodeger. 2010, 5:54. (27 November 2010)

Xu M, Bower KA, Wang S, Frank JA, Chen G, Ding M, Wang S, Shi X, Ke ZJ, Luo J. Cyanidin-3-Glucoside Inhibits Ethanol-induced Invasion of Breast Cancer Cells Overexpressing ErbB2. Mol. Cancer2010 Oct 29;9:285.

Zhang QP, Yang G, Li WX, Fan Z, Sun AY, Luo J, Ke ZJ*. Thiamine deficiency increases b-secretase activity and accumulation of β-amyloid peptides. Neurobiol. Aging. 2011;32(1):42-53.

Wang X, Meng D, Chang Q, Pan J, Zhang Z, Chen G, Ke ZJ, Luo J, Shi X. Arsenic Inhibits Neurite Outgrowth by Inhibiting LKB1-AMPK Signaling Pathway. Environ Health Perspect. 2010;118(5):627-34.

Xu M, Bower KA, Chen G, Shi X, Dong Z, Ke ZJ, Luo J. Ethanol Enhances the Interaction of Breast Cancer Cells Over-Expressing ErbB2 with Fibronectin. Alcohol Clin Exp Res. 2010;34(5):751-60.

Xu G, Xiong Z, Yong Y, Wang Z, Ke ZJ, Xia Z, Hu Y. Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum. Neuroscience. 2010;167(1):174-84.

You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke ZJ, Li W, Li C, Liu Y. Signaling through Tyr985 of Leptin Receptor as an Age/diet-dependent Switch in the Regulation of Energy Balance. Mol Cell Biol. 2010;30(7):1650-9.

Ke ZJ, Wang X, Fan Z, Luo J. Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. Alcohol Clin Exp Res. 2009;3 3(6):1097-103.

Chen, G., Bower, KA., Xu, M., Ding, M., Wang SY., Shi, X., Ke, ZJ., Luo, J. Cyaniding-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase 3 beta. Neurotox. Res. 2009, 15:321-331.

Liu Y., Chen, G., Ma, C., Bower, KA., Xu, M., Fan, Z., Shi, X., Ke, ZJand Luo, J. Over-expression of GSK3beta sensitizes neuronal cells to ethanol toxicity. J. Neurosci Res. 2009; 87: 2793-2802.

Zhang, Q., Ding, H., Li, W., Fan, Z., Sun, A., Luo, J., Ke, ZJ*. Senscence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism. Brain Res. 2009; 1264: 111-118.

Chen YY, Chen G, Fan Z, Luo J, Ke ZJ. GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochem Pharmacol. 2008; 76(1):128-138.

Ma C, Bower KA, Chen G, Shi X, Ke ZJ, Luo J. Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells. J Biol Chem. 2008; 283(14):9248-56.

Chen G, Ma C, Bower KA, Shi X, Ke ZJ, Luo J. Ethanol promotes endoplasmic reticulum stress-induced neuronal death: Involvement of oxidative stress. J Neurosci Res. 2008; 86(4):937-46.

Wang X, Fan ZQ, Wang B, Luo J, Ke ZJ. Activation of PKR by mild impairment of oxidative metabolism in neurons. J Neurochem. 2007, 103(6):2380-2390.

Ma C, Wang J, Gao Y, Gao TW, Chen G, Bower KA, Odetallah M, Ding M, Ke ZJ, Luo J. The Role of Glycogen Synthase Kinase 3 beta in the Transformation of Epidermal Cells. Cancer Res. 2007, 67(16):7756-64.

Cai G, Wang J, Xin X, Ke ZJ, Luo J. Phosphorylation of Glycogen Synthase Kinase-3 beta at Serine 9 Confers Cisplatin Resistance in Ovarian Cancer Cells. Int J Oncol. 2007, 31(3):657-62.

Chen G, Fan ZQ, Wang X, Ma C, Bower KA, Shi X, Ke ZJ, Luo J. Brain-derived Neurotrophic Factor Suppresses Tunicamycin-induced Upregulation of CHOP in Neurons. J Neurosci Res. 2007, 85(8):1674-1684.

Wang X, Wang BW, Fan ZQ, Shi XL, Ke ZJ, and Luo J. Thiamine Deficiency Induces Endoplasmic Reticulum Stress in Neurons. Neurosciences. 2007, 144(3):1045-56.