个人简介

主要研究领域

主持的重点科研项目

所获重要学术成果、奖励

发表的重要论文

个人简介

蔡真，女，医学博士、博士生导师。浙江大学医学院附属第一医院内科血液学教授、主任医师。浙江大学医学院附属第一医院血液科、骨髓移植中心副主任，城站院区血液科主任。毕业于原浙江医科大学医学系、1990年获内科学血液学硕士学位、2001年获内科学血液学博士学位。中华医学会血液学分会青年委员，中国抗癌协会血液学分会秘书；浙江省医学会血液学分会常委、浙江省抗癌协会血液分会副主任委员兼秘书、浙江省免疫学会血液分会副理事、浙江省医药卫生高层次创新人才和151培养人才。

分别于1991-1992年、2000-2001年、2004年、2008年以访问学者身份在德国吕贝克大学，洪堡大学、图宾根大学和美国MD Anderson癌症中心进行基础和临床研究。从事肿瘤细胞癌基因表达，化疗药物的机理以及有关细胞趋化因子和造血干细胞等血液学相关的基础和临床研究。

近年来已在《Leukemia》、《Blood》、《Ann N Y Acad Sci.》、《Leukemia & Lymphoma》、《J Chin Med》和《中华血液学杂志》等国外和国内一级刊物发表论文60余篇。承担国家自然科学基金、省自然科学基金、卫生部专项基金和教育部博士点专项基金、省科技厅重点和卫生厅等10余项课题。从事肿瘤细胞癌基因表达，化疗药物的机理以及有关细胞趋化因子和造血干细胞等血液学相关的基础和临床研究。近年来已在国外和国内一级刊物发表论文60余篇。承担国家自然科学基金、教育部、卫生部、省自然科学基金、省科技厅重点和卫生厅等10余项课题。先后以课题负责人或主要参与者获国家科学技术进步二等奖 1项、浙江省科学技术进步一等奖 2项、浙江省科学技术进步二等奖3项和浙江省医药卫生科技创新一等奖2项。

主要研究领域

研究恶性血液病的基础和临床。擅长治疗急、慢白血病、多发性骨髓瘤、骨髓增生异常综合征、恶性淋巴瘤及再生障碍性贫血。研究白血病细胞信号传导及发生、发病机理；研究多发性骨髓瘤生物学行为及其与细胞遗传学和免疫逃逸的关系；研究造血干细胞移植GVHD的发生和防治。

主持的重点科研项目

1.项目名称: 溶酶体凋亡途径在白血病细胞分化过程中的作用及机理研究

项目来源：教育部高等学校博士学科点专项基金

起止时间: 2006.1-2008.12

2.项目名称:一种新型Rab蛋白（Rab7b）在白血病细胞分化及凋亡途径中

的作用及机理研究

项目来源：国家自然基金面上项目

起止时间: 2006.1-2008.12

3.项目名称: 天然免疫分子TLR4在造血干细胞移植后GVHD中的作用及其机

制研究

项目来源：国家自然基金面上项目

起止时间: 2007.1-2009.12

4.项目名称: 荧光原位杂交技术检测多发性骨髓瘤和慢性淋巴细胞白血病

染色体

项目来源：卫生部

起止时间: 2007.1-2010.12

5.项目名称: 浙江省卫生高层次创新人才培养工程

项目来源：浙江省卫生厅

起止时间: 2007.7-2012.6

6.项目名称: 内毒素诱导信号传导通路在TLR4基因缺失对急性移植物抗

宿主病发病机制的影响研究

项目来源：卫生部科学研究基金

起止时间: 2009.7-2011.12

7.项目名称: 多发性骨髓瘤临床及基础研究

项目来源：浙江省科技厅重大科技专项和优先主题先

起止时间: 2009.7-2011.12

8.项目名称: TLRs参与多发性骨髓瘤免疫逃逸机制研究

项目来源：国家自然基金面上项目

起止时间: 2010.1-2012.12

所获重要学术成果、奖励

国家科学技术进步二等奖 1项

浙江省科学技术进步一等奖 2项

浙江省科学技术进步二等奖3项

浙江省医药卫生科技创新一等奖 2项

发表的重要论文

1. He DH, Chen TY, Yang MJ, Zhu XH, Wang C, Cao X, Cai Z. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. J Mol Med. 2011; 89 (2):137-150.

2. Bao HY, Lu PL, Li Y, Wang LJ, Li HY, He DH, Yang Y, Zhao Y, Yang L, Wang M, Yi Q, Cai Z. Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy drug attack. Cancer Biol Ther. 2011; 11(1):58-67.

3. Luo Y, Zhao Y, Tan Y, Shi J, Han X, Zheng Y, Li L, He J, Xie W, Ye X, Cai Z, Lin M, Huang H. Imatinib combined with myeloablative allogeneic hematopoietic stem cell transplantation for advanced phases of chronic myeloid leukemia. Leuk Res. 2011 Feb 25. [Epub ahead of print]

4.Qian Z, Zhang L, Cai Z, Sun L, Wang H, Yi Q, Wang M. Lenalidomide synergizes with dexamethasone to induce growth arrest and apoptosis of mantle cell lymphoma cells in vitro and in vivo. Leuk Res. 2010 Nov 1. [Epub ahead of print]

5. Zheng W, Guan M, Zhu L, Cai Z, Chung V, Huang H, Yen Y. Bortezomib therapeutic effect is associated with expression and mutation of FGFR3 in human lymphoma cells. Anticancer Res. 2010 Jun;30(6):1921-30.

6. Xiao H, Cao W, Lai X, Luo Y, Shi J, Tan Y, He J, Xie W, Meng X, Zheng W, Zheng G, Han X, Jin L, Zhang L, Wang Y, Yu X, Cai Z, Lin M, Ye X, Huang H. Immunosuppressive cytokine gene polymorphisms and outcome after related and unrelated hematopoietic cell transplantation in Chinese population. Biol Blood Marrow Transplant. 2010 May 7. [Epub ahead of print]

7. Zheng Y, Cai Z, Wang S, Zhang X, Qian J, Hong S, Li H, Wang M, Yang J, Yi Q. Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis. Blood. 2009,114(17): 3625-3628.

8. Zheng W, Wei G, Ye X, He J, Li L, Wu W, Shi J, Zhang J, Huang W, Xie W, Luo Y, Xue X, Lin M, Huang H, Cai Z. Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: a Chinese Experience. Leuk Rec. 2009; 33(12) :1615-1618.

9. Shi JM, Cai Z, Huang H, Ye XJ, He JS, Xie WZ, Zhang J, Zhou XY, Luo Y, Lin Y, Li L, Zheng WY, Wei GQ, Lin MF. Role of CT-guided percutaneous lung biopsy in diagnosis of pulmonary fungal infection in patients with hematologic diseases. Int J Hematol. 2009; 89(5):624-627.

10.Wang M, Sun L, Qian J, Han X, Zhang L, Lin P, Cai Z, Yi Q. Cyclin D1 as a universally

expressed mantle cell lymphoma-associated tumor antigen for immunotherapy. Leukemia. 2009; 23:1320-1328.

11. Yao M, Liu X, Li D, Chen T, Cai Z, Cao X. Late endosome/lysosome-localized Rab7b

suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol. 2009; 183(3):1751-1758.

12. Zhang L, Qian Z, Cai Z, Sun L, Wang H, Bartlett JB, Yi Q, Wang M. Synergistic antitumor

effects of lenalidomide and rituximab on mantle cell lymphoma in vitro and in vivo. Am J Hematol. 2009; 84(9):553-559.

13. Qiu L, He J, Ye X, Xie W, Shi J, Zheng W, Sun J, Zhu X, Cai Z, Huang H, Lin M. Invasive

pulmonary fungal infection accompanied by severe hemoptysis in patients with hematologic diseases: a report of nine cases. Int J Hematol. 2009 ,90(1):108-112.

14. Zhao Y, Liu L, Wang Y, Wu G, Lai X, Cao W, Luo Y, Tan Y, Shi J, Xie W, Ye X, Cai Z, Lin

M, Huang H. Efficacy and prognosis of chronic myeloid leukemia treated with imatinib mesylate in a Chinese population. Int J Hematol. 2009 ,89(4): 445 -451.

15. Bao HY, Wang LJ, Yang Y, Cai Z. TLR4 signals are involved in multiple myeloma cell proliferation and apoptosis. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Sep;38(5):465-9. Chinese.

16. Hu J, He DH, XUE XK, Gao L, Wu WJ, Han XY, Cai Z. Homoharringtonine-induced apoptosis

of MDS cell line MUTZ-1 cells is mediated by the endoplastic reticulum stress pathway. Leukemia &Lymphoma. 2007; 48(5):964-977.

17. Wang Y Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X. Lysosome-associated small Rab

GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood. 2007; 110(3): 962-971.

18. Xue X, Cai Z, Seitz G, Kanz L, Moehle R, Weisel K. Differential effects of G protein-coupled

receptors on hematopoietic progenitor cell growth depends on their signaling capacities. Ann N Y Acad Sci. 2007; 1106:180-181.

19. Xue XK, Sun WJ, Hu J, Yao HP, Cai Z. Influence on the immune function of the human

peripheral blood mononuclear cells transfected by retrovirus-mediated HSV-tk gene. Chin Med J. 2006 ;119(12):1038-1041.

20. Meng XJ, Lin MF, Cai Z. Relationship between the IFN-gamma producing cells specific for recipient and acute graft versus host disease. Zhonghua Xue Ye Xue Za Zhi. 2006 Feb;27(2):95-8. Chinese.

21. Bao HY, Cai Z. Expression of survivin mRNA in HHT-induced cell apoptosis of hematological malignancy cell lines. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Mar;35(2):204-8. Chinese.

22. Wu WJ, Cai Z. Inhibition effect of fludarabine on the growth of myelodysplastic syndrome cell line MUTZ-1 and its mechanism. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Mar;35(2):

136-42. Chinese.

23. Shi JM, Huang H, Cai Z, Luo Y, Ye XJ, Zhang J, Li L, He JS, Xie WZ, Zheng WY, Meng XJ,

Lin MF. Study on unrelated donor allogeneic bone marrow transplantation with Bu-CY2 conditioning regimen for myelodysplastic syndrome. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Mar;35(2):122-6. Chinese.

24. Xie WZ, Lin MF, Huang H, Cai Z. Homoharringtonine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of telomerase. Am J Chin Med. 2006;34(2): 233-44.

25. Meng XJ, Lin MF, Cai Z. Detection, enrichment and expansion of T lymphocytes mediating alloresponse based on cytokine. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006 Jan;35(1):39-44. Chinese.

26. Cai Z, Bao HY, Lin MF. Correlation between suvivin mRNA expression and homoharringtonine induced apoptosis of malignant hematopoietic cells. Chin Med J. 2005; 118(7):548-554.

27. Wei GQ, Lin MF, Huang H, Cai Z. Cytomegalovirus infection of myeloma cell line KM3 and its effect on IL-6 mRNA expression in the cells. Zhonghua Xue Ye Xue Za Zhi. 2004 Oct;25(10):596-9. Chinese.

28. Huang H, Cai Z, Lin MF, Xie WZ, Liang B, Li L, He JS, Luo Y, Zheng WY, Zhang J, Ye XJ, Hu XR, Chen SY, Jin AY. Treatment of childhood leukemia with unrelated donor allogeneic bone marrow transplantation. Zhonghua Er Ke Za Zhi. 2004 Nov;42(11):835-9. Chinese.

29. Lin MF, Xiong H, Cai Z, Wang YG. Study on the relationship between the inhibitors of apoptosis proteins and the apoptosis of myelodysplastic syndrome cell line cells induced by aclacinomycin in vitro. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):606-9. Chinese.

30. Cen H, Lin MF, Huang H, Cai Z. Monocytic differentiation of bone marrow-derived hematopoietic precursors controlled by mesenchymal stem cell in absence of exogenous hematopoitic growth factors. Shi Yan Sheng Wu Xue Bao. 2004 Apr;37(2):139-44. Chinese.

31. Wei GQ, Lin MF, Huang H, Cai Z. Human cytomegalovirus protects multiple myeloma cell line KM3 cells from apoptosis induced by growth factor withdrawal. Chin Med J (Engl). 2004 Jun;117(6):903-7.

32. Huang WY, Cai Z, Sun WJ, Lu GH. The effects of mycophenolic acid on the maturation and immunologic function of murine bone marrow-derived dendritic cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Apr;12(2):207-12. Chinese.

33. Lin MF, Wei GQ, Huang H, Cai Z. Human cytomegalovirus induces alteration of beta-actin mRNA and microfilaments in human embryo fibroblast cells. J Zhejiang Univ Sci. 2004 Jun;5(6):733-7.

34. Cai Z, Bao HY, Ludwig WD, Wuchter C. Expression and significance of apoptosis protein inhibitor survivin and XIAP, in patients with myelodysplastic syndromes and in the cell line MUTZ-1. Zhonghua Xue Ye Xue Za Zhi. 2004 Jan;25(1):26-30. Chinese.

35. Liang B, Huang H, Cai Z, Xie WZ, Li L, He JS, Luo Y, Meng XJ, Zheng WY, Zhang J, Ye XJ, Hu XR, Chen SY, Jin AY, Lin MF. A comparison of clinical outcomes between HLA allele matched and 1 - 2 alleles mismatched unrelated allogeneic bone marrow transplantations. Zhonghua Xue Ye Xue Za Zhi. 2004 Feb;25(2):74-7. Chinese.

36. Tong HY, Lin MF, Xiong H, Cai Z. Inhibition effect of arsenic trioxide on the growth of human MDS cell line MUTZ-1 cells. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Jan;33(1):68-72, 79. Chinese.

37. He JS, Huang H, Cai Z, Li L, Ye XJ, Zhang J, Hu XR, Jin AY, Lin MF. Treatment of one case of adult chronic myelogenous leukemia by two units of unrelated umbilical cord blood transplantation. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2003 Oct;11(5):508-11. Chinese.

38. Sun WJ, Lin MF, Cai Z, Kellner U, Parwaresch R. Detection and analysis of bcl-1/IgH rearrangement in mantle cell lymphoma. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2002 Aug;31(4):239-244. Chinese.

39. Lin M, Meng X, Cai Z, Ye X. Expression and clinical significance of anti-apoptosis gene, survivin, in acute leukemia. Zhonghua Xue Ye Xue Za Zhi. 2002 May;23(5):251-3. Chinese.

40. Cai Z, Lin M, Wuchter C, Ruppert V, Dörken B, Ludwig WD, Karawajew L. Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation. Leukemia. 2001, 15:567-574.

41. Wuchter C, Krappmann D, Cai Z, Ruppert V, Scheidereit C, Dörken B, Ludwig WD, Karawajew L. In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kB activity. Leukemia. 2001; 15: 921-918.