| 词条 | 周俭民 |
| 释义 | 周俭民周俭民，博士，中国科学院遗传与发育生物学研究所研究员。他的实验室致力于植物与微生物间相互作用机理的研究。当前的研究主要集中于拟南芥和假单孢杆菌/黄单胞菌间互作的模式体系。主要研究兴趣为植物与病原物的相互作用的分子机理。研究方向为植物识别不同病原微生物并激发免疫反应的分子机制，并且将从分子生化功能上阐明病原菌效应因子是如何抑制植物宿主细胞免疫反应的。 教育经历1994年 普度大学园艺系，博士学位 1987年 中国科学院遗传所， 硕士学位 1984年 四川大学生物系，学士学位 工作经历2012年-现在 中国科学院遗传与发育生物学研究所, 研究员 2010年-2012 北京生命研究所资深研究员 2004年-2010年 北京生命研究所高级研究员 2002年-2005年 堪萨斯州立大学植物病理系副教授 1997年-2002年 堪萨斯州立大学植物病理系助教授 1994年-1997年 普度大学农学系，博士后研究员(指导教授Gregory Martin) 学术兼职/服务2011-现在 Associate Editor, PLoS Pathogen 2009年-现在 MPMI，编委 2007年-现在 Molecular Plant,编委 2007年 植物基因组学重点实验室学术委员会委员 2005年 NIH HIBP study section 成员 2003年 美国农业部NRI基金植物遗传机理专家组成员 1996年-现在 Cell Host & Microbe, Science，Plant Cell, Plant Journal, Plant Physiology, MPMI, Mol Plant Pathology, Trends in Genetics, Plant Mol Biol, Physiol., Mol. Plant Pathology, Molecular Plant审稿人 1997年-2003年 美国NSF, USDA NRI, USDA BARD基金项目评审员 研究概述我们的主要研究兴趣是植物与病原微生物间相互作用的机理。植物可以感受病原菌的入侵，并且启动防卫反应成功地抵御病原菌的感染。而病原菌通过对寄主的适应，能够克服寄主的免疫反应，引发病害。 我们的工作主要以拟南芥和假单孢杆菌间互作为模式回答如下问题：植物是怎样感受病原菌并激活先天免疫反应的？其信号传导的分子机理是什么？病原菌的致病蛋白是如何克服植物免疫系统的？对这些问题的回答，有利于农业生产中对病害的控制。另外，因为动植物先天免疫机理的相似性和植物遗传易操作性，我们的工作还有助对动物先天免疫的认识。 The long term-interest of our laboratory concerns interactions betweenplants and pathogenic microbes. The research uses the Arabidopsis-Pseudomonassyringae model system to address the following fundamental questions. How doplants sense pathogens and activate innate immune responses? What are themolecular mechanisms underlying these processes? How do pathogen virulenceproteins overcome host immunity? 部分发表文章Feng Feng and Jian-Min Zhou* (2012). Plant-bacterial pathogen interactions mediated by type IIIeffectors. Curr. Opin. Plant Biol. (invited review), doi: 10.1016/j.pbi.2012.03.004. Feng Feng, Fan Yang, Wei Rong, Xiaogang Wu, Jie Zhang, She Chen, ChaozuHe, and Jian-Min Zhou (2012). A Xanthomonas uridine 5’-monophosphatetransferase inhibits plant immune kinases. Nature, doi:10.1038/nature10962. Tingting Xiang, Na Zong, Jie Zhang, Jinfeng Chen, Mingsheng Chen, andJian-MinZhou (2011). BAK1 is nota target of the Pseudomonas syringae effector AvrPto. MPMI, 24, 100-107. Jie Zhang and Jian-Min Zhou (2010). Plant innate immunity triggered by microbial molecular signatures. MolecularPlant (invited review), 5,783-793. Yujing Wang, Jifeng Li, Shuguo Hou, Xingwei Wang, Yuan Li, Dongtao Ren,She Chen, Xiaoyan Tang, and Jian-Min Zhou (2010). A Pseudomonas syringae ADP-Ribosyltransferase inhibits ArabidopsisMitogen-Activated Protein Kinase Kinases. PlantCell, 22, 2033-2044. Jie Zhang, Wei Li, Tingting Xiang, Zixu Liu, Kristin Laluk, Xiaojun Ding,Yan Zou, Minghui Gao, Xiaojuan Zhang, She Chen, Tesfaye Mengiste, Yuelin Zhang,and Jian-Min Zhou. (2010). Receptor-likecytoplasmic kinases integrate signaling from multiple plant immune receptorsand are targeted by a Pseudomonas syringae effector. Cell Host & Microbe, 7, 290-301. Yan Li, QingQing Zhang, Jiangguang Zhang, Liang Wu, Yijun Qi, and Jian-MinZhou. (2010). Identification of miRNAsinvolved in Pathogen-Associated Molecular Pattern-triggered plant innateimmunity. Plant Physiol., 152, 2222-231. Cui, H., Wang, Y., Xue, L., Chu, J., Yan,C., Fu, J., Chen, M., Innes, R.W., and Zhou, J.-M. (2010). Pseudomonassyringae effector protein AvrBperturbs Arabidopsis hormone signaling by activating MAP KINASE 4. CellHost & Microbe, 7, 164-175. Huamin Chen, Li Xue, Satya Chintamanani, Hugo Germain, Huiqiong Lin,Haitao Cui, Run Cai, Jianru Zuo, Xiaoyan Tang, Xin Li, Hongwei Guo, and Jian-MinZhou (2009). ETHYLENEINSENSITIVE3 and ETHYLENE INSENSITIVE 3-LIKE1 repress SALICYLICACID INDUCTION DEFICIENT2 expression tonegatively regulate plant innate immunity.Plant Cell, 25, 2527-2540. Haitao Cui, Tingting Xiang, and Jian-Min Zhou (2009). Plant immunity: A lesson frompathogenic bacterial effector proteins. CellularMicrobiology (invited review), 11, 1453-1461. Huamin Chen, Yan Zou, Yulei Shang, Huiqiong Lin, Yujing Wang, Run Cai,Xiaoyan Tang, and Jian-Min Zhou (2008). Firefly luciferase complementation imaging assay forprotein-protein interactions in plants. PlantPhysiol. 146: 368-376. Jian-Min Zhou and Jijie Chai (2008). Plant pathogenic bacterial type III effectorssubdue host responses.Curr Opin Microbiol(invited review), 11, 179-185. Linjie Chen, Huayi Wang, Jie Zhang, Lichuan Gu, Niu Huang, Jian-MinZhou, and Jijie Chai (2008). Structuralbasis for the catalytic mechanism of phosphothreonine lyase. NatStruct Mol Biol, 15, 101-102. Tingting Xiang, Na Zong, Yan Zou, Yong Wu, Jie Zhang, Weiman Xing, Yan Li,Xiaoyan Tang, Lihuang Zhu, Jijie Chai, and Jian-MinZhou (2008). Pseudomonassyringae effector AvrPto blocksinnate immunity by targeting receptor kinases. CurrBiol, 18, 74-80. Weiman Xing, Yan Zou, Qun Liu,Jianing Liu, Xi Luo, Qingqiu Huang, She Chen, Lihuang Zhu, Ruchang Bi, QuanHao, Jia-Wei Wu, Jian-Min Zhou, and Jijie Chai (2007). Structural basis for activation of plant immunityby bacterial effector protein AvrPto. Nature, 449, 243-247. Jie Zhang, Feng Shao, Yan Li, Haitao Cui, Linjie Chen, Hongtao Li, YanZou, Chengzu Long, Lefu Lan, Jijie Chai, She Chen, Xiaoyan Tang, and Jian-MinZhou (2007). A Pseudomonassyringae Effector Inactivates MAPKsto Suppress PAMP-Induced Immunity. Cell Host & Microbe, 1,175-185. Hongtao Li, Hao Xu, Yan Zhou, Jie Zhang, Chengzu Long, Shuqin Li, SheChen, Jian-Min Zhou, Feng Shao (2007).The phosphothreonine lyase activity of a bacterial type III effector family. Science 315, 1000-1003. Yulei Shang, Xinyan Li, Haitao Cui, Ping He, Roger Thilmony, SatyaChintamanani, Julie Zwiesler-Vollick, Suresh Gopalan, Xiaoyan Tang, and Jian-MinZhou (2006). RAR1, a centralplayer in plant immunity, is targeted byPseudomonas syringae effector AvrB. PNAS, 103, 19200-19205. Xiaoyan Tang and Jian-Min Zhou (2006). Regulation of the type III secretion system inphytopathogenic bacteria. MPMI (review), 19, 1159-1166. Xinyan Li, Huiqiong Lin, Weiguo Zhang, Yan Zou, Jie Zhang, Xiaoyan Tang,and Jian-Min Zhou (2005). Flagellininduces innate immunity in nonhost interactions that is suppressed by Pseudomonassyringae effectors.PNAS, 102, 12990-12995. Fangming Xiao, S. Mark Goodwin, Yanmei Xiao, Zhaoyu Sun, Douglas Baker,Xiaoyan Tang, Matthew A. Jenks, and Jian-Min Zhou (2004) Arabidopsis CYP86A2 represses Pseudomonas syringae type III genes and is required for cuticle development. EMBOJ., 23, 2903-2913. Ping He, Satya Chintamanani, Zhongying Chen, Lihuang Zhu, Barbara N.Kunkel, James R. Alfano, Xiaoyan Tang, and Jian-MinZhou (2004). Activation of aCOI1-dependent pathway in Arabidopsis by Pseudomonassyringae type III effectors andcoronatine. The Plant Journal, 37, 589-602. Li Kang, Jianxiong Li, Tiehan Zhao, Fangming Xiao, Xiaoyan Tang, RogerThilmony, ShengYang He, and Jian-Min Zhou (2003). Interplay of the Arabidopsis nonhost resistance gene NHO1 with bacterial virulence. PNAS,100, 3519-3524. Ping He, Bernd Friebe, Bikram Gill, and Jian-MinZhou (2003). Allopolyploidyalters gene expression in the highly stable hexaploid wheat.PlantMolecular Biology, 52, 401-414. Thara Venkatappa, John Fellers, and Jian-MinZhou (2003). Inplanta induced genes of Pucciniatriticina.Molecular Plant Pathology, 4, 51-56. Fangming Xiao, Ming Lu, Tiehan Zhao, Xiaoyan Tang, and Jian-MinZhou (2003). Pto mutants differentially activate Prf-dependent, AvrPto-independent resistance andgene-for-gene resistance. Plant Physiology, 131, 1239-1249. Fang-Ming Xiao, Xiaoyan Tang, and Jian-Min Zhou (2001). Expression of 35S::Pto globally activates defense gene expression in tomatoplants. Plant Physiology, 126, 1637-1645. Ming Lu, Xiaoyan Tang, and Jian-Min Zhou. (2001) Arabidopsis NHO1 is required for general resistance against Pseudomonas bacteria. Plant Cell, 13, 437-447. Libo Shan, Venkatappa Thara, Gregory Martin, Jian-Min Zhou, and XiaoyanTang (2000). The Pseudomonas AvrPto protein is differentially recognized bytomato and tobacco and is localized to the plant plasma membrane. Plant Cell, 12, 2323-2338. |
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