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词条 郑成超
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郑成超 男,1962年1月生,山东临朐人。博士,教授,博士生导师,长江学者创新团队负责人。现任山东农业大学生命科学学院院长。主讲本科生《Gene cloning and DNA analysis》和《基因工程实验》课程;硕士生《生物化学与分子生物学专业英语》;博士生《生物化学与分子生物学专题讨论》。主要研究方向:植物重要功能基因的克隆、鉴定与利用和基因表达调控元件的鉴定与应用。

简介

2004年入选国家“新世纪百千万人才工程”国家级人才,兼任山东生物化学与分子生物学学会副理事长。1982年毕业于山东农业大学留校任教至今,先后获山东农业大学农学硕士和中国农业大学理学博士学位。1992年1月至1996年1月赴美国加利福尼亚大学戴维斯分校植物生物学系留学,主要从事植物分子生物学方面的研究。2001年作为教育部选派的高级访问学者赴美国北卡罗莱纳大学合作研究,主要进行了转基因表达调控的研究。近五年来主持承担了国家“863”、 国家“973”、国家转基因植物研究专项和国家自然科学基金等多项课题,在重要功能基因、特异启动子克隆与功能鉴定等方面均获得了许多拥有我国自主知识产权的研究成果,克隆并在GenBank注册基因26个,申请专利3项。

主持的科研项目

国家转基因植物研究专项《植物叶片高效特异表达启动子及表达载体的研制》;国家“863”计划项目《棉花耐盐基因的分离、功能鉴定与应用》;国家“973”计划项目《作物应答高盐、低温胁迫的分子调控机理》;国家自然科学基金《PNZIP基因的生物学功能鉴定与分析》;国家自然科学基金《拟南芥转录因子AT103突变体分离及其功能研究》;

国家自然科学基金《一个新型棉花CCCH锌指转录因子的功能鉴定与分析》。

科研成果与获奖

2004年入选国家“新世纪百千万人才工程”国家级人才。

1996年,获山东省“青春立功”一等功和山东省新长征突击手称号。

在重要功能基因、特异启动子克隆与功能鉴定等方面均获得了许多拥有我国自主知识产权的研究成果,克隆并在GenBank注册基因26个,申请专利3项。

在《Plant Physiology》、《Plant Molecular Biology》、《中国科学》和《科学通报》等国内外著名学术刊物上发表论文40多篇。

主要研究论文

1、Zheng CC, Porat R, Lu P, O’Neill SD. PNZIP is a novel mesophyll-specific cDNA that is regulated by phytochrome and a circadian rhythm and encodes a protein with a leucine zipper motif. Plant Physiology, 1998, 116:27~35

2、Zheng CC, Bui AQ, O’Neill SD. Abundance of an mRNA encoding a HMG DNA-binding protein is regulated by light and an endogenous rhythm. Plant Molecular Biology. 1993, 23:813~823

3、 张可伟,郑成超(通讯作者)。强MAR的分离及体外功能鉴定。科学通报,2002,47(20):1572- 1577

4、杨宇涛,郑成超(通讯作者)。一个光合组织特异表达强启动子的分离及功能分析。中国科学,2003,33(4):298-306.

5、李宏,郑成超(通讯作者)。6个植物MARs序列的ARS功能鉴定与分析。科学通报,2003,48(24):2544- 2548

6、Ning Liu, Cheng-Chao Zheng(通讯作者), NTZIP antisense plants show reduced chlorophyll levels, Plant Physiology and Biochemistry. 2004,42(4):321-327

7、Changai Wu, Zheng Chengchao(通讯作者). The cotton GhNHX1 gene encoding a novel putative tonoplast Na+/H+ antiporter plays an important role in salt stress. Plant and Cell Physiology, 2004,45(5): 489-496

8、Hai-Yan Li, Cheng-Chao Zheng(通讯作者). Colonization by the Arbuscular Mycorrhizal Fungus Glomus versiforme Induces a Defense Response Against the Root-knot Nematode Meloidogyne incognita in the Grapevine (Vitis amurensis Rupr.), Which Includes Transcriptional Activation of the Class III Chitinase Gene VCH3. Plant and Cell Physiology, 2006, 47(1): 154–163

9、Xiao Wang, Chengchao Zheng(通讯作者). Isolation and purification of honokiol and magnolol from cortex magnoliae officinalis by high-speed counter-current chromatography. Journal of chromatography A. 2004, 1036(2):171-175.

10、Xiao Wang, Chengchao Zheng(通讯作者) An efficient new method for extraction, separation and purification of psoralen and isopsoralen from Fructus Psoraleae by supercritical fluid extraction and high-speed counter-current chromatography。Journal of chromatography A. 2004,.1055:135-140

11、Xiao Wang, Chengchao Zheng(通讯作者). Application of preparative high-speed counter-current chromatography for separation and purification of arctiin from Fructus Arctii, Journal of chromatography A. 2004, 1063: 247-251

12、Hua Xue, Cheng-Chao Zheng(通讯作者), TM2, a novel strong matrix attachment region isolated from tobacco, increases transgene expression in transgenic rice calli and plants. Theoretical and Applied Genetics. 2005, 110:620-627

13、Hongxin Zhang and Cheng-Chao Zheng(通讯作者).Expression and characterization of Helicobacter pylori heat-shock protein A (HspA) protein in transgenic tobacco (Nicotiana tabacum) plants. Biotechnology and Appllied Biochemistry. 2006,43, 33–38

14、 Da-Peng Shan, Jin-Guang Huang, Yu-Tao Yang, Ying-Hui Guo and Cheng-Chao Zheng*. Cotton GhDREB1 increases plant tolerance to low temperature and is negatively regulated by gibberellic acid. New Phytologist 2007. 176: 70–81

15、 Meng-Meng Zhanga, Lu-Sha Ji, Hua Xue, Yu-Tao Yang, Chang-Ai Wu and Cheng-Chao Zheng*. High transformation frequency of tobacco and rice via Agrobacterium-mediated gene transfer by flanking a tobacco matrix attachment region Physiologia Plantarum 2007.129: 644–651.

16、 Dong Wang, Yinghui Guo, Changai Wu, Guodong Yang, Yingying Li and Chengchao Zheng*. Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice. BMC Genomics 2008, 9:44

17、 Hanhua Liu, Xin Tian, Yanjie Li, Changai Wu and Chengchao Zheng*.Microarray-based analysis of stress-regulated microRNAs in Arabidopsis thaliana. RNA 2008, 14: 836-843

18、 Xin Huang · Wei Zhu · Silan Dai · Shupeng Gai ·Guosheng Zheng ·Chengchao Zheng*. The involvement of mitochondrial phosphate transporter in accelerating bud dormancy release during chilling treatment of tree peony (Paeonia suVruticosa). Planta 2008, 228(4):545-52

19、 Xiyan Yu, Xiufeng Wang, Wenqian Zhang, Tingting Qian, Guimin Tang, Yankui Guo, Chengchao Zheng*. Antisense Suppression of an Acid Invertase Gene (MAI1) in Muskmelon Alters Plant Growth and Fruit Development.Journal of Experimental Botany. 2008, 59(11):2969-77.

20、 Jiedao Zhang, Longtao Lu, Lusha Ji, Guodong Yang, Chengchao Zheng*. Functional characterization of a tobacco matrix attachment region-mediated enhancement of transgene expression. Transgenic Research. 2009, 18:377-385

21、 Hongxin Zhang and Cheng-Chao Zheng* Oral immunogenicity and protective efficacy in mice of a carrot-derived vaccine candidate expressing UreB subunit against Helicobacter pylori. Protein Expression and Purification. 2009, 69:127-131

22、 Tongtong Xue, Xinzheng Li, Wei Zhu, Changai Wu, Guodong Yang, and Chengchao Zheng*. Cotton metallothionein GhMT3a, a reactive oxygen species scavenger, increased tolerance against abiotic stress in transgenic tobacco and yeast. Journal of Experimental Botany.2009, 60: 339-349

23、 Ying-Hui Guo, Yue-Ping Yu, Dong Wang, Chang-Ai Wu, Guo-Dong Yang, Jin-Guang Huang and Cheng-Chao Zheng*. GhZFP1, a novel CCCH-type zinc finger protein from cotton, enhances salt stress tolerance and fungal disease resistance in transgenic tobacco by interacting with GZIRD21A and GZIPR5. New Phytologist 2009, 183: 62–75

24、 Yu-Tao Yang, Yan-Li Yu, Guo-Dong Yang, Jie-Dao Zhang and Cheng-Chao Zheng*, Tissue-specific expression of the PNZIP promoter is mediated by combinatorial interaction of different cis-elements and a novel ranscriptional factor. Nucleic Acids Research 2009, 37(8):2630–2644

25、 Jin-Guang Huang, Mei Yang, Pei Liu, Guo-Dong Yang, Chang-Ai Wu and Cheng-Chao Zheng*. GhDREB1 enhances abiotic stress tolerance, delays GA-mediated development and represses cytokinin signaling in transgenic Arabidopsis. Plant, Cell & Environment, 2009, 32, 1132–1145

26、 YanLi Yu, YanZe Li, LingLi Li, JinXing Lin, ChengChao Zheng* Overexpression of PwTUA1, a pollen-specific tubulin gene, increases pollen tube elongation by altering the distribution of α-tubulin and promoting vesicle transport. Journal of Experimental Botany, 2009, 60(9):2737-49

27、 Yanjie Li, Yaru Fu, Lusha Ji, Changai Wu,Chengchao Zheng*. Characterization and expression analysis of the Arabidopsis mir169 family. Plant Science 2010,178: 271-280

28、 Jin-Guang Huang, Mei Yang, Pei Liu, Guo-Dong Yang, Chang-Ai Wu,Cheng-Chao Zheng*. Genome-wide profiling of developmental, hormonal or environmental responsiveness of the nucleocytoplasmic transport receptors in Arabidopsis. Gene. 2010, 451:38-44

29、 Dongmei Xi, Wushuang Liu, Guodong Yang, Changai Wu, Cheng-chao Zheng*. Seed-specific overexpression of antioxidant genes in Arabidopsis enhances oxidative stress tolerance during germination and early seedling growth. Plant Biotechnology Journal, 2010, 8:796-806.

30、 Hao Huan, Sheng-Dong Qi, Fang Qi, Chang-Ai Wu, Guo-Dong Yang and Cheng-Chao Zheng*. NtKTI1, a Kunitz trypsin inhibitor with antifungal activity from Nicotiana tabacum, plays an important role in tobacco’s defense response. FEBS Journal 2010, 277:4076-4088.

31、 Yanjie Li, Yaru Fu, Jinguang Huang, Changai Wu and Chengchao Zheng*Insight into the transcriptional regulation during the early development of the maize brace root.FEBS Journal 2010

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