个人简介

研究方向

代表性论著

个人简介

曾步兵，男，现任华东理工大学药学院教授。

1987年9月至1990年7月 江苏省高邮第一中学读高中。

1990年9月至1994年7月 青岛化工学院（现青岛科技大学）应用化学系工业分析专业, 获学士学位。

1994年9月至1997年7月 中国药科大学药学院药物化学专业, 获硕士学位。

导师: 廖清江教授

1997年9月至2000年7月 中国科学院上海有机化学研究所生命有机国家重点实验室有机化学专业,获博士学位。

导师: 吴毓林教授和吴厚铭教授

研究方向

1. 开展具有抗肿瘤生理活性的天然产物全合成;

2. 活性天然产物类似物的合成和构效关系研究;

代表性论著

1. Bu-Bing Zeng, Yikang Wu, Qian Yu, Yu-Lin Wu,etc. Enantiopure Simple Analogues of Annonaceous Acetogenins with Remarkable Selective Cytotoxicity towards Tumors Cell Lines, Angew. Chem. Int. Ed. 2001,1934-1937.

2. Sheng Jiang, Zhong-Hai Liu, Gang Shen, Bu-Bing Zeng, Xiao-guang Chen, Yu-Lin Wu, and Zhu-Jun Yao, Mimicry of Annonaceous Acetogenins: Enantioselective Synthesis of a (4R)-Hydroxy Analogue Having Potent Antitumor Activity. J. Org. Chem., 2002,3404-3408.

3. Bu-Bing Zeng, Bruce S. King Palladium-Catalyzed Synthesis of Water-Soluble Symmetric 9,10-Distituted Anthracenes, Synthesis, 2002, 2335-2337.

4. Bu-Bing Zeng, Yikang Wu, and Yu-Lin Wu, etc. Studies on Mimicry of Naturally Occurring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity against Human Tumor Cells. Chem. Eur. J., 2003,282-290.

5. Andrew D. Cohen, Bu-Bing Zeng, S. Bruce King, and John P. Toscano. Direct Observation of an Acyl Nitroso Species in Solution by Time-Resolved IR Spectrocopy. J. Am. Chem. Soc., 2003,1444-1445.

6. Bu-Bing Zeng, Jinming Huang, Marcus Wright and S. Bruce King, Synthesis and Evaluation of Water Soluble N-Hydrooxyurea derived Acyl Nitroso-9, 10-Dimethylanthracene Cycloadducts as Nitroxyl (HNO) Donors, Bioorg. & Med. Chem. Lett. 2004, 5565-5568.

7. Lee, A. M.; Ross, C. T.; Zeng, B.-B.; Singleton, S. F. A Molecular Target for Suppression of the Evolution of Antibiotic Resistance: Inhibition of the Escherichia coli RecA Protein by N6-(1-Naphthyl)-ADP. J. Med. Chem.; 2005; 5408-5411.

8. Leslie B. Poole, Bu-Bing Zeng, Sarah A. Knaggs, Mamudu Yakubu, and S. Bruce King, Synthesis of Chemical Probes to Map Sulfenic Acid Modifications on Proteins.Bioconjugate Chem., ASAP.