俞飚，男，1967年11月生于浙江省湖州市。 本科毕业于北京大学技术物理系(1989.7)，于中科院上海有机化学研究所获硕士(1992.7) 和博士学位(1995.7)，纽约大学博士后(1995.8)。历任中科院上海有机化学研究所助理研究员(1996.9)， 副研究员(1997.9)，研究员(1999.12)。现任生命有机化学国家重点实验室副主任，所长助理，中国科学技术大学兼职博导，中国海洋大学兼职教授，国际碳水化合物组织中国代表，国际专业期刊Carbohydrate Research 编委等。已发表论文150余篇， 申请专利14项，在国际和国内学术会议上作邀请报告40余次。

主要研究方向

2001年以后论文目录

获得荣誉

曾获中国化学会青年化学奖(1998年); 中科院杰出青年(2000年); 国家杰出青年基金(1999年); 上海市科技启明星和学科带头人基金(1999,2002,2006年); 首批新世纪百千万人才工程国家级人选(2004年); 上海市自然科学二等奖(2006年)等: 国家自然科学二等奖（2010）。

主要研究方向

具有重要生理活性的复杂寡糖、糖缀合物及其它天然产物，如：动物糖胺聚糖(如肝素)和特征肿瘤抗原、微生物抗生素、植物和海洋糖苷(如皂甙和黄酮甙)等的全合成、合成方法学和化学生物学.

其它研究内容还涉及：中药；天然产物的分离鉴定；糖基转移酶和糖苷水解酶抑制剂；兼亲分子的超分子化学等.

2001年以后论文目录

（部分）

1. Total synthesis of Lobatoside E, a potent antitumor cyclic triterpene saponin. C. Zhu, P. Tang, B. Yu, J. Am. Chem. Soc. 2008, 130, 5872-5873.

2. Gold(I) catalyzed glycosidation of 1,2-anhydrosugars. Y. Li, P. Tang, Y. Chen, B. Yu, J. Org. Chem. 2008, 73, 4323-4325.

3. Synthesis of Betavulgaroside III, a representative triterpene seco-glycoside. S. Zhu, Y. Li, B. Yu, J. Org. Chem. 2008, 73, 4978-4985.

4. Isoflavone glycosides: synthesis and evaluation as α-glucosidase inhibitor. G. Wei, B. Yu, Eur. J. Org. Chem. 2008, 3156-3163.

5. Effective synthesis of nucleosides with glycosyl trifluoroacetimidates as donors. J. Liao, J. Sun, B. Yu, Tetrahedron Lett. 2008, 49, in press.

6. An efficient glycosylation protocol with glycosyl ortho-alkynylbenzoates as donors under the catalysis of Ph3PAuOTf. Y. Li, Y. Yang, B. Yu, Tetrahedron Lett. 2008, 49, 3604-3608.

7. Effective protection of the N-sulfate of glucosamine derivatives with the 2,2,2-trichloroethyl group. J. Chen, B. Yu, Tetrahedron Lett. 2008, 49, 1682-1685.

8. A proline-catalyzed aldol approach to the synthesis of 1-N-iminosugars of the D-glucuronic acid type. C. Chen, B. Yu, Tetrahedron Lett. 2008, 49, 672-674.

9. Dioseptemlosides A-H: cholestane and spirostane glycosides from the rhizomes of Dioscorea septemloba. X.-T. Liu, Z.-Z. Wang, W. Xiao, H.-W. Zhao, J. Hu, B. Yu, Phytochemistry 2008, 69, 1411-1418.

10. Synthesis of a tetrasaccharide substrate of heparanase. J. Chen, Y. Zhou, C. Chen, W. Xu, B. Yu, Carbohydr. Res. 2008, in press.

11. Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. M. Zha, Q. Guo, Y. Zhang, B. Yu, Y. Ou, C. Zhong, J. Ding, J. Mol. Biol. 2008, 379, 568-578.

12. Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells. R. C. Y. Ong, J. Lei, R. K. Y. Lee, J. Y. N. Cheung, K. P. Fung, C. Lin, H. P. Ho, B. Yu, M. Li, S. K. Kong, Cancer Lett. 2008, 261, 158-164.

13. Total synthesis of Candicanoside A, a potent antitumor saponin bearing a rearranged steroid side chain. P. Tang, B. Yu, Angew. Chem. Int. Ed. 2007, 46, 2527-2530.

14. Carbohydrate chemistry in the total synthesis of saponins. B. Yu, Y. Zhang, P. Tang, Eur. J. Org. Chem. 2007, 5145-5161. (Review)

15. Synthesis of steroidal saponins bearing an aromatic E ring. Z. Wang, M. Li, X. Liu, B. Yu, Tetrahedron Lett. 2007, 48, 7323-7326.

16. N-Dimethylphosphoryl-protection in the efficient synthesis of glucosamine-containing oligosaccharides with alternate N-acyl substitutions. Y. Yang, B. Yu, Tetrahedron Lett. 2007, 48, 7049-7052.

17. The N-dimethylphosphoryl-protected glucosamine trichloroacetimidate as an effective glycosylation donor. Y. Yang, B. Yu, Tetrahedron Lett. 2007, 48, 4557-4560.

18. The cytotoxicity of saponins correlates with their cellular internalization. Y. Wang, Y. Zhang, B. Yu, ChemMedChem 2007, 2(3), 888-291. (Cover Picture)

19. Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins. Y. Wang, Y. Zhang, Z. Zhu, S. Zhu, Y. Li, M. Li, B. Yu, Bioorg. Med. Chem. 2007, 15, 2528-2532.

20. Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities. P. Tang, F. Mamdani, X. Hu, J. O. Liu, B. Yu, Bioorg. Med. Chem. Lett. 2007, 17, 1003-7.

21. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. W. Peng, P. Tang, X. Hu, J. O. Liu, B. Yu, Bioorg. Med. Chem. Lett. 2007, 17, 5506-5509.

22. Antibacterial diterpenoids from Sagittaria pygmaea. X. -T. Liu, Y. Shi, B. Yu, I. D. Williams, H. H. -Y. Sung, Q. Zhang, J. -Y. Liang, N. Y. Ip, Z. -D. Min, Planta Med. 2007, 73, 86-90.

23. Synthesis, cytotoxicity, and hemolytic activity of 6’-O-substituted dioscin derivatives. W. Li, Z. Qiu, Y. Wang, Y. Zhang, M. Li, J. Yu, L. Zhang, Z. Zhu, B. Yu, Carbohydr. Res. 2007, 342, 2705-2715.

24. Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues. S. Zhu, Y. Zhang, M. Li, J. Yu, L. Zhang, Y. Li, B. Yu, Bioorg. Med. Chem. Lett. 2006, 16, 5629-5632.

25. Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue. M. Li, B. Yu, Org. Lett. 2006, 8(13), 2679-2682.

Chem. 2005, 70, 10354-10367.