肖智雄(人物简介 研究方向 研究内容)

工作经历(简历 荣誉)

代表性论文

肖智雄

人物简介

美国波士顿大学医学院教授、四川大学生命科学学院院长

研究方向

肿瘤分子生物学，信号传递，细胞生长代谢与衰老，转化医学。

研究内容

抗肿瘤基因p53 和Rb 及家族成员的功能和调控

DNA 损伤和细胞胁迫对细胞生长，调控，代谢和衰老的调控及信号传导通路

蛋白质磷酸化，乙酰化，泛素化及甲基化对肿瘤发生重要蛋白的调控

基因表达调控，计算机生物模型及其运用

抗癌药物筛选和鉴定以及转化医学应用研究

工作经历

简历

四川大学生物系生物化学专业获理学学士学位(1982年)和理学硕士学位（1985年）。四川大学生物系助教(1985)教育部中美生化和分子生物学留美项目（CUSBMBEA）选拔获选，留学美国（1986）获美国麻省大学（University of Massachusetts at Amherst）分子生物学博士学位（1990）哈佛大学博士后（1991-1995）美国波士顿大学医学院生化系和医学系助理教授（1996），副教授（2001），正教授（2007）。第四军医大学客座教授（1998-2002）中国协和医科大学客座教授(1999-2004)四川大学客座教授（1998-2004）。国家千人计划第一批人选者(2009)四川大学千人计划特聘教授（2010-）中央党校培训班（2010，4）

荣誉

中组部首批千人计划入选者

代表性论文

1、Hiroyuki Inuzuka,Alan Tseng,Daming Gao,Bo Zhai,Qing Zhang,Shavali Shaik,Lixin Wan,Xiaolu L. Ang,Caroline Mock,Haoqiang Yin,Jayne M. Stommel,Steven Gygi,Galit Lahav,John Asara,Zhi-Xiong Jim Xiao,William G. Kaelin, Jr.,J. Wade Harper and Wenyi Wei. Phosphorylation by Casein Kinase I Promotesthe Turnover of the Mdm2 Oncoprotein via the SCFb-TRCP Ubiquitin Ligase. Cancer Cell,in press.

2、Du, W., Wu, J., Walsh, EM., Zhang, Y., Chen, CY., and Xiao ZX, Nutlin-3aaffects expression and function of retinoblastoma protein: a role of retinoblastoma protein in cellular response to nutlin-3a. J. Biol. Chem. 284: 26315-26321, 2009.

3、Qiu, W., Wu, J., Walsh, W. M., Zhang, Y., Chang, C-Y., Fujita, J., and Xiao ZX.Retinoblastoma protein modulates gankyri-MDM2 inregulation of p53 stability and chemosensitivity in cancer cells. Oncogene27:4034-4043, 2008.

4、Jin Y, Zeng SX, Sun XX, Lee H, Blattner C, Xiao Z,Lu H.MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with MDM2. Mol. Cell. Biol. 28:1218-1229, 2008.

5、Chang, DLF., Qiu, W.. Ying, H., Zhang, Y., Chen, CY., and Xiao ZX.ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2.Oncogene26: 4627-4634, 2007.

6、Ying, H. and Xiao, ZX.Targeting retinoblastoma protein for degradation by proteasomes. Cell Cycle5:506-508, 2006.Ying,H., Chang,DL., Zheng, H.,McKeon, F., and Xiao, Z.X.The DNA-binding and transactivation activities are essential for TAp63 protein degradation. Mol. Cell. Biol.25:6154-6164, 2005.

7、Sdek, P., Ying, H., Chang,DL., Qiu, W.,Zheng, H.,Allday, MJ and Xiao, Z.X.MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. Mol. Cell20:699-708, 2005.

8、Sdek, P., Ying, H., Zheng, H., Margulis, A., Tang, X., Tian, K. and Xiao. Z.X.The central acidic domain of MDM2 is critical in inhibition of retinoblastoma -mediated suppression of E2Fand cell growth. J. Biol. Chem. 279: 53317-22. 2004

9、Murray, S.A., Zheng, H., Gu, L. and Xiao, Z.X. IGF-1 activates p21 to inhibit UV-induced cell death. Oncogene22: 1703-1711, 2003.

10、Zheng, H., You, H., Zhou, X. Z., Murray, S.A., Uchida, T., Wulf, G., Gu, L., Tang, X., Lu, K.P. and Xiao, Z.X.The Prolyl isomerase Pin1 is a novel regulator of p53 ingenotoxic response. Nature419: 849-853 (with News and Views 419:795-797), 2002.

11、Xiao, Z.X.,Chen, J., Levine, A. J., Modjtahedi, N., Xing, J., Sellers, W. R. and Livingston, D. M.Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature, 375, 694-698, 1995.

12、Xiao, Z.X.Ginsberg, D., Ewen, M. and Livingston, D. M.Regulation of the Grossman, S.R., Perez, M., Joseph, M., Mansur, C.,Xiao, Z.X., Kumar, S., Howley, P.M. and Livingston, D.M.p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell2: 405-415, 1998.

13、Xiao, Z.X.Ginsberg, D., Ewen, M. and Livingston, D. M.Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. USA. 93, 4633-4637, 1996.