魏成喜，男, 1982年12月生, 2005年毕业于延边大学获学士学位，2010年获得医学博士学位。2009年9月，就职于内蒙古民族大学附属医院神经外科研究所。2010年3月，师从延边大学生理学教研室邱德来教授和金清华教授学习神经科学研究。

[主要研究方向与兴趣]

一直从事药物化学科研工作，研究方向为：

1、先导化合物的寻找与结构优化。

2、临床药物新的活性筛选。

3、老年痴呆治疗机制研究。

4、心脑血管机制研究。

[主要参与的科研项目]

1. 吡唑烷酮类化合物的合成及抗癫痫作用研究，国家自然科学基金课题，2005-2007。

2．喹喔啉酮衍生物的合成及抗癫痫作用研究．国家自然科学基金课题，2008-2010。

3. 二苯甲基哌嗪类衍生物的合成和抗癫痫作用及作用机制研究。国家自然科学基金课题，2009-2011。

4. 抗癫痫新药三唑喹酮的研制，教育部重点项目，2007-2009。

5. 三唑酮并喹啉类化合物的合成及抗癫痫作用研究，教育部留学回国启动项目，2008-2010。

[获奖]

1. 延边大学医学部第七届研究生学术月论文二等奖。

2. 延边大学“第七届研究生学术活动月”优秀论文。

3. 2008届研究生科研奖。

4. 2008届研究生优秀硕士学位论文。

[近年主要发表论文]

近几年发表论文：

1. Wei CX, Guan LP, Jia JH, Chai KY, Quan ZS. Synthesis of 2-substituted-6-

(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as potential anticonvulsant agents. Arch Pharm Res.

2009; 32(1):23-31.

2. Wei CX, Li FN, Zhao LX, Zhao LM, Quan ZS. Synthesis of 2-substituted-7-

heptyloxy-4,5-dihydro[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with

anticonvulsant activity. Arch Pharm (Weinheim). 2007;340(9):491-5.

3. Wei CX, Zhang W, Quan ZS, Han RB, Jiang RS, Piao FY. Synthesis,

Anticonvulsant Evaluation of 2,3,4,5-Tetrahydro-7-alkoxy-1H-2-benzazepin- 1-ones.

Letters in Drug Design & Discovery, 2009,6, 548-553

4. Wei CX, Wu D, Sun ZG, Chai KY, Quan ZS. Synthesis of 6-(3-substituted-4H-

1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazoles as potential anticonvulsant agents.

Med Chem Res. 2009. Published online.

5. Wei CX, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun, and Zhe-Shan Quan.Synthesis and

Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res. 2010; 33

(5): 655-62.

6. Wei CX, Guo Z, Li FN and Quan ZS. Synthesis and Anticonvulsant Activity Alkoxy-[1,2,4]triazolo[3,4-a]

phthalazin-3(2H)-ones. Asian Journal of Chemistry. Vol. 23, No. 1 (2011), inpress.

7. Sun XY, Wei CX, Deng XQ, Sun ZG, Quan ZS. Evaluation of the anticonvulsant

activity of 6-(4-chlorophenyoxyl)-tetrazolo[5,1-a]phthalazine in various experimental

seizure models in mice. Pharmacol Rep. 2010, 62, 273-277.

8. Sun XY, Wei CX, Deng XQ, Sun ZG, Quan ZS. Synthesis and primary

anticonvulsant activity evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine

derivatives. Arzneimittel Forschung / Drug Research. 2010; 60(6): 289-92.

9. Deng XQ, Wei CX, Li FN, Sun ZG, Quan ZS. Design and synthesis of 10-alkoxy-5,

6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant

activity. Eur J Med Chem. 2010 (45), 3080-3086.

10. Hu C, Sun ZG, Wei CX, Quan ZS, Synthesis and Anticonvulsant Activity of Some

Cinnamylpiperazine Derivatives. Letters in Drug Design & Discovery, 2010; 7(9):

661-4.

11. Deng XQ, Wei CX, Song MX, Chai KY, Sun ZG, and Quan ZS.Synthesis and

Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy- tetrazolo[1,5-

a] quinolines. Bull. Korean Chem. Soc. 2010, 31(2): 447-452

12. Deng XQ, Wei CX, Song MX, Quan ZS. Synthesis and antidepressant-like action

of 9-alkoxy-7H-furo[3,2-g]chromen-7-ones in mice. Arzneimittelforschung. [In press]

13. Wang HJ, Wei CX, Deng XQ, Li FL, Quan ZS. Synthesis and evaluation on

anticonvulsant and antidepressant activities of 5-Alkoxy-tetrazolo[1,5-a]

quinazolines. Arch Pharm (Weinheim).2009; 342(11): 671-5.

14. Guo LJ, Wei CX, Jia JH, Zhao LM, Quan ZS. Design and synthesis of

5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur

J Med Chem. 2009; 44(3):954-8.

15. Guan LP, Wei CX, Deng XQ, Sui X, Piao HR, Quan ZS. Synthesis and

anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med

Chem. 2009; 44(9): 3654-7.

16. Sun XY, Wei CX, Chai KY, Piao HR, Quan ZS. Synthesis and anti-inflammatory

activity evaluation of novel 7-alkoxy-1-amino-4,5-dihydro[1,2,4]triazole[4,3-a]

quinolines. Arch Pharm (Weinheim). 2008; 341(5):288-93.

17. Zhang LQ, Guan LP, Wei CX, Deng XQ, Quan ZS. Synthesis and anticonvulsant

activity of some 7-alkoxy-2H-1,4-benzothiazin-3(4H)-ones and 7-alkoxy-4H- [1,2,4]

triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull (Tokyo). 2010; 58(3): 326-

31.

18. Sun XY, Hu C, Deng XQ, Wei CX, Sun ZG, Quan ZS.Synthesis and anti-

inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4] triazolo

[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem. 2010; 45(11): 4807-12.

19. Sun XY, Zhang L, Wei CX, Piao HR, Quan ZS. Characterization of the

anticonvulsant activity of doxepin in various experimental seizure models in mice.

Pharmacol Rep. 2009; 61(2): 245-51.

20. Zhang L, Guan LP, Sun XY, Wei CX, Chai KY, Quan ZS. Synthesis and

anticonvulsant activity of 6-alkoxy-[1,2,4]triazolo[3,4-a]phthalazines. Chem Biol

Drug Des. 2009; 73(3): 313-9.

21. Sun XY, Zhang L, Wei CX, Piao HR, Quan ZS. Design, synthesis of 8-alkoxy- 5,6-

dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity. Eur J Med

Chem. 2009; 44(3):1265-70.

22. Sun XY, Guan LP, Zhang L, Wei CX, Piao HR, Quan ZS. Design, Synthesis and

Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]

phthalazin-4-one Derivatives. J. Braz. Chem. Soc. 2009, 20(5), 826-831.