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词条 万一千
释义

人名,为中山大学化学院,副教授、博士生导师。对肿瘤药物肝素酶抑制剂、抗肿瘤、抗艾滋病药物及老年病和代谢病治疗药物、FXR特异性拮抗剂、新型AT2受体选择性激动剂、微波辅助快速化学反应等项研究,成果显著分别在国际国内获奖,论文在多个报刊发表,出版杂志等影响巨大。

个人简介

性别:男

最高学位:博士

现任职称:副教授,博士生导师

个人履历

1980年9月~1984年7月, 湖南师范大学,学士学位。

1984年7月~1989年9月,湖南省常德卫生学校, 教师。

1989年9月~1992年7月, 南开大学, 硕士学位,导师:周秀中教授。

1992年9月~1995年7月, 中山大学, 博士学位,导师:曾陇梅教授。

1995年7月~1998年8月,中山大学化学系,任讲师和副教授,从事天然产物化学的研究,参加过国家自然科学基金和广东省基金的课题的研究。

1998年9月~1999年2月在香港浸会大学化学系作访问研究,从事有机传感器的研究。

1999年3月~2000年2月在LUND大学有机化学和生物有机化学系访问研究,从事手性催化剂配体和活性天然产物全合成的研究。

2000年3月~2000年9月在中山大学化学院工作。

2000年9月~2003年1月在瑞典UPPSALA大学生物医药中心有机药物化学系作博士后研究。研究的方向是药物设计与合成;微波辅助快速反应方法学研究。

成就及荣誉

1. Wan,Yiqian; Wallinder, Charlotta; Plouffe, Bianca; Beaudry, Helene; Mahalingam, A. K.; Wu, Xiongyu; Johansson, Berndt;Holm, Mathias; Botoros, Milad; Karlen, Anders; Pettersson, Anders; Nyberg, Fred; Faendriks, Lars; Gallo-Payet, Nicole;Hallberg, Anders; Alterman, Mathias. Design, Synthesis, and Biological Evaluation of the First Selective Nonpeptide AT2 Receptor Agonist. Journal of Medicinal Chemistry (2004), 47(24), 5995-6008.

2. Alterman,Mathias; Mahalingam, Kannan; Hallberg, Anders; Wan, Yiqian; Mcneeney, Stephen Philip. (Vicore Pharma AB, Swed.). Preparation of azolylcarbonylphenylthiophenes and related compounds as angiotensin II agonists. PCT Int. Appl. (2004), 85 pp. CODEN: PIXXD2 WO 2004046141 A1 20040603 Designated States W: AE, AG, AL,AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI,GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK,MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ,UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW. Designated States RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR,IE, IT, LU, MC, NL, PT, SE, TR, BF, BJ, CF, CG, CI, CM, GA, ML, MR, NE, SN, TD, TG. Patent written in English.Application: WO 2003-GB5037 20031119. Priority: US 2002-427936 20021121. CAN 141:23524 AN 2004:453212

贡献

3. Alterman, Mathias; Hallberg, Anders; Wan, Yiqian; Mahalingam, Kannan; Mcneeney, Stephen Phillip. (Vicore Pharma AB, Swed.). A preparation of novel thiophene derivatives, useful as angiotensin II receptor agonists. PCT Int.Appl. (2004), 64 pp. CODEN: PIXXD2 WO 2004046137 A1 20040603 Designated States W: AE, AG, AL, AM, AT,AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW,MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG,US, UZ, VC, VN, YU, ZA, ZM, ZW. Designated States RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU,MC, NL, PT, SE, TR, BF, BJ, CF, CG, CI, CM, GA, ML, MR, NE, SN, TD, TG. Patent written in English. Application:WO 2003-GB5013 20031119. Priority: US 2002-427942 20021121. CAN 141:7115 AN 2004:453209

4. Wu, Xiongyu; Mahalingam, A. K.; Wan, Yiqian; Alterman, Mathias. Fast microwave-promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO)6 as carbon monoxide sources. Tetrahedron Letters(2004), 45(24), 4635-4638.

5. Wan,Yiqian; Wallinder, Charlotta; Johansson, Berndt; Holm, Mathias; Mahalingam, A. K.; Wu, Xiongyu; Botros, Milad; Karlen,Anders; Pettersson, Anders; Nyberg, Fred; Faendriks, Lars; Hallberg, Anders; Alterman, Mathias. First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo. Journal of Medicinal Chemistry (2004), 47(6), 1536-1546.

6. Wan, Yiqian; Wu, Xiongyu; Kannan, Mahalingam A.; Alterman, Mathias. Boron trichloride as an efficient and selective agent for deprotection of tert-butyl aryl sulfonamides. Tetrahedron Letters (2003), 44(24), 4523-4525.

论文

7. Wan, Yiqian; Alterman, Mathias; Larhed, Mats; Hallberg, Anders. Formamide as a Combined Ammonia Synthon and Carbon Monoxide Source in Fast Palladium-Catalyzed Aminocarbonylations of Aryl Halides. Journal of Combinatorial Chemistry (2003), 5(2), 82-84.

8. Larhed, Mats; Alterman,Mathias; Wan, Yiqian; Hallberg, Anders; Kaiser, Nils-Fredrik. (Swed.). One-pot carbonylation reaction with metal carbonyl as carbon monoxide source. U.S. Pat. Appl. Publ. (2002), 23 pp. US 2002161266 A1 20021031 Patent written in English. Application: US 2001-14562 20011214.Priority: US 2000-255143 20001214. CAN 137:337460 AN 2002:833570

9. Wan, Yiqian; Alterman, Mathias; Hallberg, Anders. Palladium-catalyzed amination of aryl bromides using temperature-controlled microwave heating. Synthesis (2002), (11), 1597-1600.

10. Wan, Yiqian; Alterman, Mathias; Larhed, Mats; Hallberg, Anders. Dimethylformamide as a Carbon Monoxide Source in Fast Palladium-Catalyzed Aminocarbonylations of ArylBromides. Journal of Organic Chemistry (2002), 67(17), 6232-6235.

报刊

11. Kaiser, Nils-Fredrik; Larhed, Mats; Hallberg, Anders; Alterman, Mathias; Wan, Yiqian. (Personal Chemistry I Uppsala AB, Swed.). One-pot carbonylation reaction with metal carbonyl as carbon monoxide source. PCT Int. Appl.(2002), 48 pp. CODEN: PIXXD2 WO 2002048072 A2 20020620 Designated States W: AE, AG, AL, AM, AT, AU,AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM,HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO,NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM,ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM. Designated States RW: AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR, BF, BJ, CF, CG, CI, CM, GA, ML, MR, NE, SN, TD, TG. Patent written in English. Application: WO 2001-EP14596 20011212. Priority: DK 2000-1879 20001214. CAN 137:32955 AN 2002:465945

12. Sarvary, Ian; Wan, Yiqian; Frejd, Torbjorn. Novel cyclic and bicyclic 1,3-diols as catalysts for diethylzinc addition to aldehydes. Journal of the Chemical Society, Perkin Transactions 1 (2002), (5), 645-651

13. 万一千, 苏镜娱 ,曾陇梅等, A Convergent Synthesis of (E,E,E)-3,7,13-trimethl-6-(I-propenyl)-7,14-Dihydroxy-2,8,12-tetradecatrien-1- Methylal, Chinese Chemical Letters(Eng), 1996, 7(2), 109

14. 万一千, 苏镜娱,曾陇梅, 海绵Phyllospongia sp.中的两种新的 Scalarane-型二倍半萜, 高等学校化学学报, 1996, 17(11), 1747

15. 万一千, 曾志, 曾陇梅, 软珊瑚Labophytum catelai的甾类化合物研究, 中山大学学报, 1996, vol.35(增), 171-172.

16. 万一千, 苏镜娱, 曾陇梅, 海绵Spongia officinalis的化学成分研究, 中国海洋药物, 1997, 16(1), 1-3.

17. 万一千, 苏镜娱,曾陇梅. Chemical Study on the Marine Sponge Phyllospongia sp., Book of Abstracts for Fifth Eurasia Conference on Chemical Sciences, pp316, Zhongshan university press, 1996, Guangzhou.

18. 万一千, 苏镜娱,曾陇梅, 海绵Phyllospongia sp.的代谢物研究 (2), 中山大学学报, 1997, 36(1), 116-118.

19.万一千,刘青,软珊瑚Labophytum catelai的化学成分研究(Ⅱ),热带海洋,1997,16(3), 78-82.

20. 万一千, 苏镜娱,曾陇梅, Ceramide from the Marine Sponge Phyllospongia sp., Acta Scientiarum Naturalium Universitatis zhongshan (Sun-Yatsenz), 1997, 36(5), 113-115.

21. 万一千, 刘青, 曾陇梅,苏镜娱, The Secondary Metabolites of Marine Sponge Phyllospongia foliascens, 中山大学学报, 1998, 37(3), 81~84

杂志

22. 曾陇梅,杨善淼, 苏镜娱,吴建青,万一千, 包工藤甲素全合成的研究(II), 高等学校化学学报, 1998, 19(5), 737-740

23. 晏日安,万一千,环柠檬醛合成方法改进,化学世界,1998, 4, 173-174.

24.曾志,曾陇梅,万一千,甾醇的质谱学裂解规律(3),质谱学报,1996, 17(4), 13

25. 官智,何延红,万一千,反相硅胶的简便制备方法,化学通报 1998, (12), 57.

26.万一千,苏镜娱,曾陇梅,刘青,符雄,海绵Phyllospongia foliascens中的两个新的二倍半萜,海洋可持续发展论文集,161, 海洋出版社,1998, 北京

27.万一千,苏镜娱,曾陇梅,海绵Phyllospongia sp.的化学成分研究,97海岸海洋资源与环境学术研讨会论文集,258,香港科技大学出版

28. 万一千, 周秀中,刘伟文; 1,1'-(四甲二硅基) 双[环戊二烯基钨的合成], 南开大学学报(自然科学版), 1994, 4, 94

29.Yiqian Wan, The First Selective Non-Peptide AT2 Agonist Might Provide a New Therapy for Disease Such as Duodenal Mucosal Alkaline Secretion Disorder: Its Reasonable Design and Chemistry. (lecture presentation). WHTS' 2nd Annual Congress of International Drug Discovery Science and Technology (IDDST), Beijing, Nov. 1-4, 2004.

30. Charlotta Wallinder, Yiqian Wan, Bianca Plouffe, Hélène Beaudry, MahalingamAK, Xiongyu Wu, Berndt Johansson, Mathias Holm, Milad Botros, Anders Karlén, Anders Pettersson, Fred Nyberg, Lars F?ndriks, Nicole Gallo-Payet, Anders Hallberga and Mathias Altermana. First Selective Nonpeptide AT2 Receptor Agonist. Design, Synthesis and Biological Evaluation (poster presentation). XVIII International Symposium on Medicinal Chemistry, Copenhagen & Malmo, August15-19, 2004.

31. Xinhai Zhu, Yan Ma, Huacan Song, Zunle Xu, Yiqian Wan*. A General and Highly Efficient Microwave-assisted Ullmann Coupling Reaction of Phenols and Aryl Bromide (poster presentation), International Symposium on Chemicals and Pharmaceuticals, Guangzhou, Dec. 16-8, 2004.

32. 万一千,朱新海,王金龙,陈功,马彦,宋化灿,许遵乐,二芳基醚的水热合成法,中国发明专利,申请号:200510033059.1.

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