孙宇辉：理学博士、楚天学者特聘教授、武汉大学药学院教授、博士生导师。从事天然产物生物合成的分子遗传学、生物化学及组合生物合成研究。曾获得国家自然科学二等奖等奖项

学习简历：

1988.9―1992.7 江西农业大学 攻读植物遗传育种专业学士学位

1997.9―2001.3 华中农业大学 攻读生物化学与分子生物学专业硕士学位

2001.3―2004.3 上海交通大学 攻读生物化学与分子生物学专业博士学位

工作简历：

1992.7―1998.9 江西农业大学 生物技术研究开发中心 研究实习员（初级）

1998.9―2002.10 江西农业大学 生物技术研究开发中心 助理研究员（中级）

2002.10―2006.11 江西农业大学 生物工程系 副教授

2006.11―2009.11 江西农业大学 生物工程与技术学院 教授

2005.1―2010.5 剑桥大学 生物化学系 Royal Society China Fellow，Senior Research Associate

2010.5― 武汉大学药学院 楚天学者特聘教授

业绩概要:

对具有重要基础和应用价值的活性天然产物的生物合成机制及其分子改造进行了多年广泛而深入的探索和积累，在国外权威学术期刊，如“Nature﹒Chemical Biology”、“Chemistry & Biology”、“ChemBioChem”、“Journal of Bacteriology”、“Microbiology”、“Applied Microbiology and Biotechnology”、“Archives of Microbiology”、“FEMS Microbiology Letters”共发表研究论文13篇，分别在第13届（2005）和第15届（2009）International Symposium on the Biology of Actinomycetes，第4届Chemistry and Biology of Natural Products（2008），第2届Natural Products Conference（2009）国际专业会议上受邀进行大会报告。此外，合作编译国外专业教材一本，获国家发明专利2项并荣获多项国家和省（部）级奖励。

获奖情况：

国家自然科学二等奖（2008）

江西省自然科学二等奖（2007）

全国优秀博士论文提名（2007）

江西省高校科技成果奖（2006）

上海市研究生优秀成果(学位论文)奖（2006）

上海市科技进步一等奖（2004）

研究领域：

天然产物生物合成的分子遗传学、生物化学及组合生物合成

研究兴趣与方向:

基于微生物的活性天然产物生物合成途径的发现与开发。针对性地从微生物中寻找具有重要基础和应用价值的活性天然产物，一方面，以参与天然产物生物合成途径相关基因与蛋白的结构与功能为主要内容，探索其生物合成的酶促催化机制，从分子遗传学和生物化学的角度阐明结构新颖、活性特异的天然产物的生物合成机理，在分子水平上回答其生物合成的一些重要问题，并进而为蛋白分子和酶促产物的改造提供结构基础和理论依据，为新药物的组合生物合成提供精确的“分子装配线路图”。另一方面通过对新的酶促反应和代谢途径的发现和功能分析，对这些酶促代谢途径进行改进和优化，在此基础上创造出“非天然”的天然产物分子。同时，采用分子定向进化等技术，获得更高效率、更好稳定性和使用性的新型酶分子，解析酶分子的催化动力学及酶蛋白的晶体结构和催化的分子机制，使之能更为有的放矢地利用天然产物生物合成途径来主动性地高产或创新微生物药物。

国际学术期刊论文:

1. Yuhui Sun*, Frank Hahn, Yuliya Demydchuk, James Chettle, Manuela Tosin, Hiroyuki Osada, and Peter F. Leadlay* (2010) In vitro reconstruction of tetronate RK-682 biosynthesis. Nature Chemical Biology 6:99-101. (*, co-corresponding author)

2. Yuhui Sun, Xinyi He, Jingdan Liang, Xiufen Zhou and Zixin Deng (2009) Analysis of functions in plasmid pHZ1358 influencing its genetic and structural stability in Streptomyces lividans 1326. Applied Microbiology and Biotechnology 82:303-310.

3. David H. Kwan*, Yuhui Sun*, Frank Schulz, Hui Hong, Bojana Popovic, Joalice C.C. Sim-Stark, Stephen F. Haydock and Peter F. Leadlay (2008) Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases. Chemistry & Biology 15: 1231-1240. (*, co-first author)

4. Yuliya Demydchuk*, Yuhui Sun*, Hui Hong, James Staunton, Jonathan B. Spencer and Peter F. Leadlay (2008) Analysis of the tetronomycin gene cluster: insights into the biosynthesis of a polyether tetronate antibiotic. ChemBioChem 9: 1136-1145. (*, co-first author)

5. Yuhui Sun, Hui Hong, Fraser Gillies, Jonathan B. Spencer and Peter F. Leadlay (2008) Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics. ChemBioChem 9:150-156.

6. Barbara M. Harvey, Tatiana Mironenko, Yuhui Sun, Hui Hong, Zixin Deng, Peter F. Leadlay, Kira J. Weissman and Stephen F. Haydock (2007) Insights into polyether biosynthesis from analysis of the nigericin biosynthetic gene cluster in Streptomyces sp. DSM4137. Chemistry & Biology 14: 703-714.

7. Yuhui Sun, Hui Hong, Markiyan Samborskyy, Tatiana Mironenko, Peter F. Leadlay and Stephen F. Haydock (2006) Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin. Microbiology 152: 3507-3515.

8. Tiangang Liu, Delin You, Chiara Valenzano, Yuhui Sun, Jialiang Li, Qing Yu, Xiufen Zhou, David E. Cane and Zixin Deng (2006) Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis. Chemistry & Biology 13: 945-955.

9. Yuhui Sun, Xiufen Zhou, Hui Dong, Guoquan Tu, Min Wang, Bofei Wang and Zixin Deng (2003) A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin. Chemistry & Biology 10: 431-441.

10. Yuhui Sun, Xiufen Zhou, Guoquan Tu and Zixin Deng (2003) Identification of a gene cluster encoding meilingmycin biosynthesis among multiple polyketide synthase contigs isolated from Streptomyces nanchangensis NS3226. Archives of Microbiology 180: 101-107.

11. Yuhui Sun, Xiufen Zhou, Jun Liu, Kai Bao, Guiming Zhang, Guoquan Tu, Tobias Kieser and Zixin Deng (2002) ‘Streptomyces nanchangensis’, a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters. Microbiology 148: 361-371.

12. Xiuhua Pang, Yuhui Sun, Liu Jun, Xiufen Zhou and Zixin Deng (2002) A linear plasmid temperature-sensitive for replication in Streptomyces hygroscopicus 10-22. FEMS Microbiology Letters 208: 25-28.

13. Xiuhua Pang, Xiufen Zhou, Yuhui Sun and Zixin Deng (2002) Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions. Journal of Bacteriology 184: 1958-1965.

14.Yuhui Sun, Xiufen Zhou, Jun Liu, Kai Bao, Guiming Zhang, Guoquan Tu, Tobias Kieser and Zixin Deng (2002) ‘Streptomyces nanchangensis’, a producer of the insecticidal polyether antibiotic nanchangmycin and the antiparasitic macrolide meilingmycin, contains multiple polyketide gene clusters. Microbiology 148:361-371.

15. Xiuhua Pang, Yuhui Sun, Liu Jun, Xiufen Zhou and Zixin Deng (2002) A linear plasmid temperature-sensitive for replication in Streptomyces hygroscopicus 10-22. FEMS Microbiology Letters208:25-28.

16.Xiuhua Pang, Xiufen Zhou, Yuhui Sun and Zixin Deng (2002) Physical map of the linear chromosome of Streptomyces hygroscopicus 10-22 deduced by analysis of overlapping large chromosomal deletions. Journal of Bacteriology 184:1958-1965.

国际学术会议邀请报告:

1. One-pot biosynthesis of the call cycle protein phosphatase inhibitor RK-682: mechanism insight into tetronate ring formation. The 15th International Symposium on the Biology of Actinomycetes, August 2009, China.

2. Insight into tetronate ring formation in tetronate antibiotics. The 2nd Natural Products Conference, March 2009, Antigua.

3. Divergent origins of tetronate rings in non-identical twin tetronate polyether antibiotics. The 4th Chemistry and Biology of Natural Products, June 2008, UK.

4. Identification of a gene cluster encoding meilingmycin biosynthesis among multiple PKS contigs isolated from Streptomyces nanchangensis NS3226. The 13rd International Symposium on the Biology of Actinomycetes. December 2003, Australia.

国际学术会议论文摘要:

1. Yuhui Sun, Yuliya Demydchuk, James Chettle, Hiroyuki Osada and Peter F. Leadlay. One-pot biosynthesis of the call cycle protein phosphatase inhibitor RK-682: mechanism insight into tetronate ring formation. The 15th International Symposium on the Biology of Actinomycetes, August 2009, China.

2. Yuhui Sun, Yuliya Demydchuk, Manuela Tosin, Hui Hong, James Chettle and Peter Leadlay. Insight into tetronate ring formation in tetronate antibiotics. The 2nd Natural Products Conference, March 2009, Antigua.

3.YuhuiSun, Yuliya Demydchuk, Hui Hong, Jonathan B. Spencer and Peter F. Leadlay. Divergent origins of tetronate rings in non-identical twin tetronate polyether antibiotics. The 4th Chemistry and Biology of Natural Products, June 2008, UK.

4. Yuhui Sun, Tatiana Mironenko, Hui Hong and Stephen Haydock. Cloning and sequence analysis of an antifungal macrocyclic polyhydroxylactone related to azalomycin F4 from a strain of Streptomyces violaceoniger. The 14th International Symposium on the Biology of Actinomycetes. August 2007, UK.

5. Yuhui Sun, Xiufen Zhou,Hui Dong, Guoquan Tu,Min Wang, Bofei Wang and Zixin Deng. A Complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin. The 13rd International Symposium on the Biology of Actinomycetes. December 2003, Australia.

6. Yuhui Sun, Jialiang Li,Xiufen Zhou,Hui Dong, Guoquan Tu,Min Wang, Bofei Wang, and Zixin Deng. Targeted mining of structural diversities by the comparative analysis of unknown PKS gene cluster in Streptomyces nanchangensis NS3226. The 13rd International Symposium on the Biology of Actinomycetes. December 2003, Australia.

7. Yuhui Sun, Xiufen Zhou,Guoquan Tu and Zixin Deng. Identification of a gene cluster encoding meilingmycin biosynthesis among multiple PKS contigs isolated from Streptomyces nanchangensis NS3226. The 13rd International Symposium on the Biology of Actinomycetes. December 2003, Australia.

8. Yuhui Sun, Xiufen Zhou, Juan Liu, Kai Bao, Guiming Zhang, Guoquan Tu, Tobias Kieser and Zixin Deng. Two polyketide gene clusters for insecticidal polyether nanchangmycin and the anthelmintic macrolide meilingmycin isolated from Streptomyces nanchangensis NS3226. The 12th International Symposium on the Biology of Actinomycetes. August 2001, Canada.

9. Yuhui Sun, Jun Liu, Guiming Zhang, Xiufen Zhou, Guoquan Tu and Zixin Deng. Five repetitive polyketide synthase (PKS) gene clusters isolated from Streptomyces nanchangensis NS3226. The 11th International Symposium on the Biology of Actinomycetes. October 1999, Greece.

10. Yuhui Sun, Guiming Zhang, Jun Liu, Xiufen Zhou, Gguoquan Tu and Zixin Deng. Three repetitive polyketide synthase (PKS) gene clusters isolated from Streptomyces nanchangensis NS3226. General Meeting of the International Program on Rice Biotechnology. September 1999, Thailand.

国际合作：

剑桥大学生物化学系Herchel Smith讲席教授、英国皇家学会院士（FRS）、英国皇家化学会院士(FRSC) Peter Leadlay (http://www.bio.cam./~pflgroup/)

博士后招聘：

本研究组拟招收具有以下专业研究背景博士后2名：

1. 天然产物的分离提取与结构鉴定

2. 放线菌的生物化学与分子遗传学