ProSci 公司简介

1. ProSci Incorporated

ProSci Incorporated 於1998年成立于世界生物城之一的美国加州圣地亚哥市，从事抗体等科研试剂的研发、生产和销售。 ProSci是世界最早和最大的细胞凋亡抗体生产厂家和供应商，公司现拥有17000多种单、多克隆抗体，产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。公司的抗体大都经免疫亲和层析纯化，具有高纯度、高亲和力、特异性强等特点，所有的ProSci抗体都经过了严格的验证测试和质量控制，已保证高质量的产品。ProSci的抗体广销於世界30多个国家和地区，得到欧美日等生物医学界科研人员和生物制药公司的研发人员的广泛接受。ProSci的产品已应用在1281篇SCI论文中，其中2011年的有228篇，ProSci的经销商和客户都对ProSci的产品质量和服务十分满意。我们的抗体可用于免疫印迹（Western blot），免疫组织化学（IHC），免疫细胞化学（ICC），酶联免疫吸附实验（ELISA）和细胞流式分析（FACS）等方面。此外，ProSci还提供标记二抗，重组蛋白，细胞和组织裂解液，细胞涂片，组织切片，多肽等产品与抗体配套使用。ProSci在美国拥有完整的免疫学试剂开发、生产、检测的生产线，包括自己的厂房和实验动物基地，可为您的研究提供信得过的抗体等科研试剂。

2. 普赛生物（苏州）有限公司

普赛生物（苏州）有限公司是美国ProSci在国内的全资子公司，位于苏州工业园区东南大学苏州研究院。自2010年9月成立后短短的几个月内，产品销售已遍及全国。普赛生物拥有高品质和高覆盖率的抗体库，将为国内的科研单位提供所有美国公司原装进口的优质抗体产品。

3. 我们的优势

ProSci致力于给全世界生物医药领域的科学家们提供最好的抗体等科研试剂产品，并努力成为他们研究的首选和最好的伙伴。

这是我们一直为之努力的优质服务

·可靠的产品质量和全面的说明书

·详细准确且不断更新的数据资料

·丰富的在线资源和全面的技术支持

·快捷可靠的物流运输

·专业的技术人员提供的优质售后服务

4. 质量保证和产品应用文献

ProSci的客户包括美国国立卫生研究院（NIH），美国国家疾控中心（CDC），麻省理工学院（MIT），耶鲁大学以及诺华制药等许多知名大学研究机构和制药公司，国内的客户有：中科院上海生科院，中国国家疾控中心，中国医学科学院北京协和医院，香港大学巴斯德研究所等等。ProSci的产品已应用在1281篇SCI论文中，其中2011年的有228篇，ProSci的经销商和客户都对ProSci的产品质量和服务十分满意，ProSci公司在2003、2007、2010年度，都被《Nature》评为最佳抗体研发、生产和服务供应商。

发表杂志名称　应用文献数　影响因子

Nature　4　35.74

Cell　7　32.4

Nature Immunology　7　25.66

Journal of Experimental medicine　8　14.77

Molecular Cell　7　14.19

Journal of Molecular Cell Biology　15　13.4

Genes & Development　4　12.88

Gut　8　10.61

Blood　24　10.56

The EMBO Journal 　7　10.12

Journal of Cell Biology　11　9.92

PNAS　28　9.77

Circulation research　6　9.5

Cell Death and Differentiation 　30　9.05

Cancer research　63　8.23

Oncogene 　18　7.41

Journal of Neuroscience　17　7.27

Faseb Journal　6　6.5

Journal of Cell science　8　6.29

Journal of Immunology 　34　5.75

The Journal of Biological chemistry　93　5.33

Molecular cancer therapeutics　11　5.22

The American Journal of Pathology　10　5.22

Journal of Virology　31　5.19

ProSci 2011年部分最新产品应用文献

1. Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways. Liyun Sang et al. Cell,13 May 2011 145(4) pp. 513 - 528. TCTN2 antibody (ProSci, San Diego, California, USA)

2. Functional complementation between FADD and RIP1 in embryos and lymphocytes.Haibing Zhang et al. Nature, 2 March 2011 471, 373-376. RIP3 antibody (ProSci, San Diego, California, USA)

3. Mechanisms of necroptosis in T cells. Irene L. Ch’en et al.J. Exp. Med., Apr 2011; 208: 633 - 641.Ripk3 antibody (ProSci Inc.).

4. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. Xianpei Jia et al.J Mol Cell Biol, Aug 2011; 3: 230 - 238. Antibodies used included polyclonal anti-SOX2, STIM1 (ProSci Inc.), Orai1 (ProSci Inc.).

5. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria.Lisa S. Shock et al.PNAS, Mar 2011; 108: 3630 - 3635. Cells were transfected using Polyjet liposomes (ProSci) (HCT116).

6. Disruption of Src function potentiates Chk1-inhibitor–induced apoptosis in human multiple myeloma cells in vitro and in vivo. Yun Dai et al.Blood, Feb 2011; 117: 1947 - 1957. expression of Bim using an antibody (ProSci).

7. Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma. Peter Kamper et al.Blood, Jun 2011; 117: 6638 - 6649. anti-GNAI3 (XW-7212; WB dilution 1:200 ProSci Incorporated).

8. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Adeeb H. Rahman et al.Blood, Mar 2011; 117: 3123 - 3130.probed with rabbit anti-mouse MyD88 antibody (2127; ProSci).

9. Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-B–inducing kinase while activating both canonical and alternative nuclear factor-B pathways.Lan V. Pham et al.Blood, Jan 2011; 117: 200 - 210. polyclonal BR3 (ProSci).

10. Store-Operated Ca2+ Entry in Sensory Neurons: Functional Role and the Effect of Painful Nerve Injury. Geza Gemes et al.J. Neurosci., Mar 2011; 31: 3536 - 3549. anti-STIM1 rabbit polyclonal antibody (1:500; ProSci; catalog #4119), and anti-Orai1 rabbit polyclonal antibody (1:1000; ProSci, catalog #4281).

11. β-Agonist-associated Reduction in RGS5 Expression Promotes Airway Smooth Muscle Hyper-responsiveness.Zhao Yang et al.J. Biol. Chem., Apr 2011; 286: 11444 - 11455. anti-RGS5 primary antibody (Prosci, 1:250).

12. Bit-1 Mediates Integrin-dependent Cell Survival through Activation of the NFB Pathway. Genevieve S. Griffiths et al.J. Biol. Chem., Apr 2011; 286: 14713 - 14723. rabbit anti-Bit-1 polyclonal antibody (1:100; ProSci) or anti-FAK antibody (1:100; ProSci).

13. Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons.Jia Qi et al.J. Immunol., Jun 2011; 186: 6417 - 6426. rabbit polyclonal Ab against TLR3, TLR7, and TLR9 (1:1000; Prosci, Poway, CA).

14. The C Proteins of Human Parainfluenza Virus Type 1 Limit Double-Stranded RNA Accumulation That Would Otherwise Trigger Activation of MDA5 and Protein Kinase R. Jim Boonyaratanakornkit et al.J. Virol., Feb 2011; 85: 1495 - 1506. HPIV1 C proteins shared by C, C Y1, and Y2 by ProSci (Poway, CA), against a synthetic peptide.

15. Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.Angela E. Zolner et al.Nucleic Acids Res., Aug 2011; 10.1093. phospho-specific antibodies to serine 114, (ProSci Inc).

16. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability.Ariane Scoumanne et al.Nucleic Acids Res., Jan 2011; 39: 213 - 224. Anti-PCBP4 was from ProSci Incorporated (Poway, CA, USA).

17. Cancer-Associated Loss-of-Function Mutations Implicate DAPK3 as a Tumor-Suppressing Kinase. John Brognard et al.Cancer Res., Apr 2011; 71: 3152 - 3161. DAPK3 (ZIPK) antibody was purchased from ProSci Incorporated.

18. MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer.Wei Shi et al.Cancer Res., Apr 2011; 71: 2926 - 2937. SKA2 protein was detected using a rabbit anti-SKA2 antibody (ProSci Inc.).