“Mohamed A. Marahiel”的意思、由来-中文百科全书

德国马尔堡大学教授，德国科学院院士，英国皇家化学会院士。非核糖体多肽（NRPS）和核糖体多肽（RPS）抗生素领域的大牛。主要研究NRPS的晶体结构，合成机理，组合生物合成和chemoenzymatic synthesis，和酶催化反应机理。代表分子太多，surfactin等等主要来之bacillus。

M. A. Marahiel 教授在开罗大学及哥根廷大学化学专业学习.1977年，他获得了哥根廷大学的微生物与生化专业的博士学位。随后他在柏林工业大学获得助理教授的职位，1987年获得教授资格。三年后他来到马尔堡大学化学系担任教授。1978及1986年他以德国科学基金会研究员的身份前往John Innes Institute in Norwich (UK)和哈佛大学biolabs从事研究。2004年他成为德国科学院院士及英国皇家化学会院士。

目前他的主要研究方向为NRPS的晶体结构，合成机理，组合生物合成和chemoenzymatic synthesis 多肽类抗生素，铁运载体，压力调控蛋白。目前已在nature，science，Angew.Chem, JACS等世界顶级杂志发表论文200多篇，总H-index 59，是微生物天然产物生物合成领域的顶级科学家。

近五年主要发表文章：

　2011
Miethke, M., Hou, J. and Marahiel, M.A. (2011) The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Biochemistry 50, 10951-10964.
Albrecht, A.G., Landmann, H., Nette, D., Burghaus, O., Peuckert, F., Seubert, A., Miethke, M. and Marahiel, M.A. (2011) The frataxin homologue fra plays a key role in intracellular iron channeling in Bacilus subtilis. ChemBioChem 12, 2052-2061.
Knappe, T.A., Manzenrieder, F., Mas-Moruno, C., Linne, U., Sasse, F., Kessler, H., Xie, X. and Marahiel, M.A. (2011) Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew. Chem. Int. Ed. Engl. 50, 8714-8717.
Peuckert, F., Ramos-Vega, A.L. Miethke, M., Schwörer, C.J., Albrecht, A.G., Oberthür, M. and Marahiel, M.A. (2011) The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates. Chem. & Biol. 18, 907-919.
Robbel, L., Helmetag, V., Knappe, T.A. and Marahiel, M.A. (2011) Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin. Biochemistry 50, 6073-6080.
Giessen, T.W., Kraas, F.I. and Marahiel, M.A. (2011) A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry 50, 5680-5692.
Hou, J., Robbel, L. and Marahiel, M.A. (2011) Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem. Biol. 18, 655-664.
Bosello, M., Robbel, L., Linne, U., Xie, X. and Marahiel, M.A. (2011) Biosynthesis of the siderophore Rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococus jostiiRHA1. J. Am. Chem.Soc. 133, 4587-4595.
Miethke, M., Pierik, A.J., Peuckert, F., Seubert, A. and Marahiel, M.A. (2011) Identification and characterization of a novel-type ferric siderophore reductase from a Gram-positive extremophile. J. Biol. Chem. 286, 2245-2260.
Albrecht, A.G., Peuckert, F., Landmann, H., Miethke, M., Seubert, A. and Marahiel, M. A. (2011) Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis. FEBS Lett. 585, 465-470.
Zirah, S., Afonso, C., Linne, U., Knappe, T., Marahiel, M. Rebuffat, S. and Tabet, J.-C. (2011) Topoisomer differentiation of molecular knots by FTICR MS: Lessons from class II Lasso peptides. J. Am. Soc. Mass. Spectrom. 22, 467-479.
Kuznedelov, K., Semenova, E., Knappe, T.A., Mukhamedyarov, D., Srivstava, A., Chatterjee, S., Ebright, R.H., Marahiel, M.A. and Severinov, K. (2011) The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. J. Mol. Biol. 412, 842-848.
van der Ploeg, R., Mäder, U., Homuth, G., Schaffer, M., Denham, E.L., Monteferrate, C.G., Miethke, M., Marahiel, M.A., Harwood, C.R., Winter, T., Hecker, M., Antelmann, H. and van Dijl, J.M. (2011) Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. PLoS one, in press.　

　2010　

　Bugdahn, N., Peuckert, F., Albrecht, A.G., Miethke, M., Marahiel, M.A. and Oberthür, M. (2010) Direct identification of a siderophore import protein using synthetic petrobactin ligands. Angew. Chem. Int. Ed. Engl. 49, 10210-10213.
Robbel, L. and Marahiel, M.A. (2010) Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery.
J. Biol. Chem. 285: 27501-27508.
Kraas, F.I., Helmetag, V., Wittmann, M., Strieker, M. and Marahiel, M.A. (2010) Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem. Biol. 17: 872-880.
see also: Chooi, Y.-H. and Tang, Y. (2010) Adding the lipo to lipopeptides: Do more with less. Chem. Biol. 17, 791-793.
Chillappagari, S., Seubert, A., Trip, H., Kuipers, O.P., Marahiel, M.A. and Miethke, M. (2010) Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J. Bacteriol. 192: 2512-2524.
Strieker, M., Tanovic, A. and Marahiel, M. (2010) Nonribosomal peptide synthetases: structures and dynamics. Curr Opin. Struct. Biol. 20: 234-240.
Robbel, L., Knappe, T., Linne, U., Xie, X. and Marahiel, M. (2010) Erythrochelin - a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea. FEBS J. 277: 663-676.
Albrecht, A.G., Netz, D.J., Miethke, M., Pierik, A.J., Burghaus, O., Peuckert, F., Lill, R. and Marahiel, M. (2010) SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis.
J. Bacteriol. 192: 1643-1651.
Knappe, T.A., Linne, U., Xie, X. and Marahiel, M. (2010) The glucagon receptor antagonist I-32169 constitutes a new class of lasso peptides. FEBS Lett. 584: 785-789.
Enck, S., Kopp, F., Marahiel, M.A. and Geyer, A. (2010) The reversible macrocyclization of Tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization. Org. Biomol. Chem. 8: 559-563.
Winterberg, B., Uhlmann, S., Linne, U., Lessing, F., Marahiel, M.A., Eichhorn, H., Kahmann, R. and Schirawski (2010) Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis. Mol. Microbiol. 75: 1260-1271.

　2009　

　Knappe, T.A., Linne, U., Robbel, L. and Marahiel, M.A. (2009) Insights into the biosynthesis and stability of the lasso peptide capistruin.
Chem. Biol. 16: 1290-1298.
see also: Rosengren, K.J. and Craik, D.J. (2009) How bugs make lassos. Chem. Biol. 16: 1211-1212.
Marahiel, M.A. (2009) Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis.
J. Pept. Sci. 15: 799-807.
Strieker, M., Nolan, E.M., Walsh, C.T. and Marahiel, M.A. (2009) Stereospecific synthesis of threo- and erythro-ß-hydroxyglutamic acid during kutzneride biosynthesis. J. Am. Chem. Soc. 131: 13523-13530.
Peuckert, F., Miethke, M., Albrecht, A.G., Essen, L.-O. and Marahiel, M.A. (2009) Structural basis and stereochemistry of triscatecholate siderophore binding by FeuA. Angew. Chem. Int. Ed. Engl. 48: 7924-7927.
Marahiel, M. A. and Essen, L.-O. (2009) Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains. Methods Enzymol. 458: 337-351.
Strieker, M. and Marahiel, M.A. (2009) The structural diversity of acidic lipopeptide antibiotics. ChemBioChem 10: 607-616.
Robbel, L., Hoyer, M. and Marahiel, M.A. (2009) TioS T-TE - prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides. FEBS J. 276: 1641-1653.
Chillappagari, S., Miethke, M., Trip, H., Kuipers, O.P. and Marahiel, M. (2009) Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis. J. Bacteriol. 191: 2362-2370.
Mendoza-Mendoza, A., Berndt, P., Djamei, A., Weise, C., Linne, U., Marahiel, M., Vranes, M., Kämper, J. and Kahmann, R. (2009) Physical-chemical plant-derived signals induce differentiation in Ustilago maydis. Mol. Microbiol. 71: 895-911.
Duquesne, S., Destoumieux-Garzon, D., Zirah, S., Knappe, T.A., Goulard, C., Peduzzi, J., Marahiel, M.A. and Rebuffat, S. (2009) Post-translational modification and folding of a lasso-type gene-encoded antimicrobial peptide require two enzymes only in Escherichia coli. Adv. Exp. Med. Biol. 611: 35-36.
Hur, G.H., Meier, J.L., Baskin, J., Codelli, J.A., Bertozzi, C.R., Marahiel, M.A., Burkart, M.D. (2009) Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem. Biol. 16: 372-381.
Helmetag, V., Samel, S.A., Thomas, M.G., Marahiel, M.A. and Essen, L.-O. (2009) Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J. 276: 3669-3682.
Roberts, A.A., Copp, J.N., Marahiel, M.A. and Neilan, B.A. (2009) The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity. ChemBioChem 10: 1869-1877.
Moldt, J., Pokorny, R., Orth, C., Linne U., Geisselbrecht, Y., Marahiel, M.A., Essen, L.O. and Batschauer, A. (2009) Photoreduction of the folate cofactor in members of the photolyase family. J. Biol. Chem. 284: 21670-21783.

　2008　

　Tanovic, A., Samel, S.A., Essen, L.-O. and Marahiel, M.A. (2008) Crystal structure of the termination module of a nonribosomal peptide synthetase. Science 321: 659-663.
see also: Everts, S. (2008) Peptide-producing powerhouses. C & EN 6: 48-51.
Koglin, A., Löhr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Güntert, P., Wagner, G., Walsh, C.T., Marahiel, M.A. and Dötsch, V. (2008) Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature 454: 907-911.
Knappe, T.A., Linne, U., Zirah, S., Rebuffat, S., Xie, X. and Marahiel, M.A. (2008) Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensisE264. J. Am. Chem. Soc. 130: 11446-11454.
Kopp, F., Linne, U., Oberthür, M. and Marahiel, M.A. (2008) Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes. J. Am. Chem. Soc. 130: 2656-2666.
Miethke, M., Schmidt, S. and Marahiel, M. A. (2008) The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibaction secretion in Bacillus subtilis. J. Bacteriol. 190: 5143-5152.
Strieker, M., Essen, L.-O., Walsh, C.T. and Marahiel, M.A. (2008) Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. ChemBioChem 9: 374-376.
Wittmann, M., Linne, U., Pohlmann, V. and Marahiel, M.A. (2008) Role of DptE and DptF in the lipidation reaction of daptomycin. FEBS Journal 275: 5343-5354.
Pohlmann, V. and Marahiel, M.A. (2008) delta-Amino group hydroxylation of l-ornithine during coelichelin biosynthesis. Org. Biomol. Chem. 6: 1843-1848.
Samel, S.A., Marahiel, M.A. and Essen, L.O. (2008) How to tailor non-ribosomal peptide products - new clues about the structures and mechaisms of modifying enzymes. Mol. Biosyst. 4: 387-393.
Yonus, H., Neumann, P, Zimmermann, S., May, J.J., Marahiel, M.A. and Stubbs, M.T. (2008) Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J. Biol. Chem. 283: 32484-32491.
Enck, S., Kopp, F., Marahiel, M.A. and Geyer, A. (2008) The entropy balance of nostocyclopeptide macrocyclization analysed by NMR spectroscopy. ChemBioChem 9: 2597-2601.

　2007　

　Kopp, D. and Marahiel, M.A. (2007) Where chemistry meets biology: the chemoenzymatiac synthesis of nonribosomal peptides and polyketides. Curr. Op. Biotechnol. 18: 513-520.
Fujimori, D., Hrvatin, S., Neumann, C., Strieker, M., Marahiel, M.A. and Walsh, C.T. (2007) Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc. Natl. Acad. Sci. USA 104: 16498-16503.
Teichmann, B., Linne, U., Hewald, S., Marahiel, M.A. and Bölker, M. (2007) A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis.Mol. Microbiol. 66: 525-533.
Mahlert, C., Kopp, F., Thirlway, J., Micklefield, J. and Marahiel, M.A. (2007) Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. J. Am. Chem. Soc. 129: 12011-12018.
Miethke, M., and Marahiel, M.A. (2007) Siderophore-based iron acquisition and pathogen control.
Microbiol. Mol. Biol. Rev. 71: 413-451.
Kopp, F. and Marahiel, M.A. (2007) Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat. Prod. Rep. 24: 735-749.
Samel, S.A., Schönafinger, G., Knappe, T.A., Marahiel, M.A. and Essen L.-O. (2007) Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure 15: 781-792.
Wiegeshoff, F., Marahiel, M.A. (2007) Characterization of a mutation in the acetolactate synthase of Bacillus subtilisthat causes a cold-sensitive phenotype. FEMS Microbiol. Lett. 272: 30-34.
Azim-Zadeh, O., Hillebrecht, A., Linne, U., Marahiel, M.A., Klebe, G., Lingelbach, K. and Nyalwidhe, J. (2007) Use of biotin derivatives to probe conformational changes in proteins. J. Biol. Chem. 282: 21609-21617.
Copp, J.N., Roberts, A.A., Marahiel, M.A., Neilan, B.A. (2007) Characterization of PPTNs, a cyanobacterial phosphopantetheinyl transferase from Nodularia spumigena NSOR10. J. Bacteriol. 189: 3133-3139
Strieker, M., Kopp, F., Mahlert, C., Essen, L.-O., Marahiel, M.A. (2007) Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol. 2: 187-196.
Linne, U., Schäfer, A., Stubbs, M.T., Marahiel, M.A. (2007). Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains. FEBS Lett. 581: 905-910.
Hoyer, K.M., Mahlert, C., Marahiel, M.A. (2007). The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem. Biol. 14: 13-22.
Bisseret, P., Thielges, S., Bourg, S., Miethke, M., Marahiel, M. and Eustache, J. (2007) Synthesis of a 2-indolylphosphonamide derivative with inhibitory activity against yersiniabactin biosynthesis. Tetrahedron Letters 48: 6080-6083.
Paungmoung, P., Punya, J., Pongpattanakitshote, S., Jeamton, W., Vichisoonthonkul, T., Bhumiratana, S., Tanticharoen, M., Linne U., Marahiel, M.A. and Cheevadhararak, S. (2007) Detection of nonribosomal peptide synthetase genes in Xylaria sp. BCC1067 and cloning of XyNRPSA. FEMS Microbiol. Lett. 274: 260-268.　

　2006　

　Kopp, F., Mahlert, C., Grünewald, J., Marahiel, M.A. (2006) Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J. Am. Chem. Soc. 128: 16478-16479.

　Miethke, M., Westers, H., Blom, E.J., Kuipers, O.P. and Marahiel, M.A. (2006) Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis. J. Bacteriol. 188: 8655-8657.

　Stein, D. B., Linne, U., Hahn, M. and Marahiel, M. A. (2006) Impact of epimerization domains on the intermodular transfer of enzyme-bound intermediates in nonribosomal peptide synthesis. ChemBioChem 7: 1807-1814.

　Kopp, F., Grünewald, J., Mahlert, C. and Marahiel, M. A. (2006) Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry 45: 10474-10481.

　Wagner, B., Schumann, D., Linne, U., Koert, U. and Marahiel, M. A. (2006) Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. J. Am. Chem. Soc. 128: 10513-10520.

　Miethke, M., Klotz, O., Linne, U., May, J. J., Beckering, C. L. and Marahiel, M. A. (2006) Ferri-bacillibactin uptake and hydrolysis in Bacillus subtilis. Mol. Microbiol. 61: 1413-1427.

　Hewald, S., Linne, U. Scherer, M. Marahiel, M. A., Kamper, J. and Bolker, M. (2006) Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis. Appl. Environ. Microbiol. 72: 5469-5477.

　Samel, S.A., Wagner, B., Marahiel, M. A. and Essen, L. O. (2006) The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide.
J. Mol. Biol. 359: 876-889.

　Koglin, A., Mofid, M. R., Lohr, F., Schafer, B., Robov, V. V., Blum, M. M., Mittag, T., Marahiel, M. A., Bernhard, F. and Dotsch, V. (2006) Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science 312: 273-276.

　Grünewald, J., Mahlert, C., Kopp, F. and Marahiel, M. A. (2006) Chemoenzymatic pathways towards novel peptide antibiotics. Anti-Infective Agents in Medicinal Chemistry 5: 227-243.

　Schoenafinger, G., Schracke, N., Linne, U. and Marahiel, M. A. (2006) Formylation domain: An essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. J. Am. Chem. Soc. 128: 7406-7407.

　Wiegeshoff, F., Beckering, C. L., Debarbouille, M. and Marahiel, M. A. (2006) Sigma L is important for cold shock adaptation of Bacillus subtilis. J. Bacteriol. 188: 3130-3133.

　Wagner, B., Sieber, S. A., Baumann, M. and Marahiel, M. A. (2006) Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem 7: 595-597.

　Grünewald, J. and Marahiel, M. A. (2006). Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol. Mol. Biol. Rev. 70: 121-146.

　Miehtke, M., Bisseret, P., Beckering, C. L., Vignard, D., Eustache, J. and Marahiel, M. A. (2006) Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. FEBS J. 273: 409-419.

　Hunger, K., Beckering, C. L., Wiegeshoff, F., Graumann, P. L. and Marahiel, M. A. (2006) Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with cold shock protein B in Bacillus subtilis. J. Bacteriol. 188: 240-248.

词条	Mohamed A. Marahiel
释义	德国马尔堡大学教授，德国科学院院士，英国皇家化学会院士。非核糖体多肽（NRPS）和核糖体多肽（RPS）抗生素领域的大牛。主要研究NRPS的晶体结构，合成机理，组合生物合成和chemoenzymatic synthesis，和酶催化反应机理。代表分子太多，surfactin等等主要来之bacillus。 M. A. Marahiel 教授在开罗大学及哥根廷大学化学专业学习.1977年，他获得了哥根廷大学的微生物与生化专业的博士学位。随后他在柏林工业大学获得助理教授的职位，1987年获得教授资格。三年后他来到马尔堡大学化学系担任教授。1978及1986年他以德国科学基金会研究员的身份前往John Innes Institute in Norwich (UK)和哈佛大学biolabs从事研究。2004年他成为德国科学院院士及英国皇家化学会院士。目前他的主要研究方向为NRPS的晶体结构，合成机理，组合生物合成和chemoenzymatic synthesis 多肽类抗生素，铁运载体，压力调控蛋白。目前已在nature，science，Angew.Chem, JACS等世界顶级杂志发表论文200多篇，总H-index 59，是微生物天然产物生物合成领域的顶级科学家。近五年主要发表文章：　2011 Miethke, M., Hou, J. and Marahiel, M.A. (2011) The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Biochemistry 50, 10951-10964. Albrecht, A.G., Landmann, H., Nette, D., Burghaus, O., Peuckert, F., Seubert, A., Miethke, M. and Marahiel, M.A. (2011) The frataxin homologue fra plays a key role in intracellular iron channeling in Bacilus subtilis. ChemBioChem 12, 2052-2061. Knappe, T.A., Manzenrieder, F., Mas-Moruno, C., Linne, U., Sasse, F., Kessler, H., Xie, X. and Marahiel, M.A. (2011) Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew. Chem. Int. Ed. Engl. 50, 8714-8717. Peuckert, F., Ramos-Vega, A.L. Miethke, M., Schwörer, C.J., Albrecht, A.G., Oberthür, M. and Marahiel, M.A. (2011) The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates. Chem. & Biol. 18, 907-919. Robbel, L., Helmetag, V., Knappe, T.A. and Marahiel, M.A. (2011) Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin. Biochemistry 50, 6073-6080. Giessen, T.W., Kraas, F.I. and Marahiel, M.A. (2011) A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry 50, 5680-5692. Hou, J., Robbel, L. and Marahiel, M.A. (2011) Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem. Biol. 18, 655-664. Bosello, M., Robbel, L., Linne, U., Xie, X. and Marahiel, M.A. (2011) Biosynthesis of the siderophore Rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococus jostiiRHA1. J. Am. Chem.Soc. 133, 4587-4595. Miethke, M., Pierik, A.J., Peuckert, F., Seubert, A. and Marahiel, M.A. (2011) Identification and characterization of a novel-type ferric siderophore reductase from a Gram-positive extremophile. J. Biol. Chem. 286, 2245-2260. Albrecht, A.G., Peuckert, F., Landmann, H., Miethke, M., Seubert, A. and Marahiel, M. A. (2011) Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis. FEBS Lett. 585, 465-470. Zirah, S., Afonso, C., Linne, U., Knappe, T., Marahiel, M. Rebuffat, S. and Tabet, J.-C. (2011) Topoisomer differentiation of molecular knots by FTICR MS: Lessons from class II Lasso peptides. J. Am. Soc. Mass. Spectrom. 22, 467-479. Kuznedelov, K., Semenova, E., Knappe, T.A., Mukhamedyarov, D., Srivstava, A., Chatterjee, S., Ebright, R.H., Marahiel, M.A. and Severinov, K. (2011) The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. J. Mol. Biol. 412, 842-848. van der Ploeg, R., Mäder, U., Homuth, G., Schaffer, M., Denham, E.L., Monteferrate, C.G., Miethke, M., Marahiel, M.A., Harwood, C.R., Winter, T., Hecker, M., Antelmann, H. and van Dijl, J.M. (2011) Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. PLoS one, in press.　　2010　　Bugdahn, N., Peuckert, F., Albrecht, A.G., Miethke, M., Marahiel, M.A. and Oberthür, M. (2010) Direct identification of a siderophore import protein using synthetic petrobactin ligands. Angew. Chem. Int. Ed. Engl. 49, 10210-10213. Robbel, L. and Marahiel, M.A. (2010) Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J. Biol. Chem. 285: 27501-27508. Kraas, F.I., Helmetag, V., Wittmann, M., Strieker, M. and Marahiel, M.A. (2010) Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem. Biol. 17: 872-880. see also: Chooi, Y.-H. and Tang, Y. (2010) Adding the lipo to lipopeptides: Do more with less. Chem. Biol. 17, 791-793. Chillappagari, S., Seubert, A., Trip, H., Kuipers, O.P., Marahiel, M.A. and Miethke, M. (2010) Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J. Bacteriol. 192: 2512-2524. Strieker, M., Tanovic, A. and Marahiel, M. (2010) Nonribosomal peptide synthetases: structures and dynamics. Curr Opin. Struct. Biol. 20: 234-240. Robbel, L., Knappe, T., Linne, U., Xie, X. and Marahiel, M. (2010) Erythrochelin - a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea. FEBS J. 277: 663-676. Albrecht, A.G., Netz, D.J., Miethke, M., Pierik, A.J., Burghaus, O., Peuckert, F., Lill, R. and Marahiel, M. (2010) SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis. J. Bacteriol. 192: 1643-1651. Knappe, T.A., Linne, U., Xie, X. and Marahiel, M. (2010) The glucagon receptor antagonist I-32169 constitutes a new class of lasso peptides. FEBS Lett. 584: 785-789. Enck, S., Kopp, F., Marahiel, M.A. and Geyer, A. (2010) The reversible macrocyclization of Tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization. Org. Biomol. Chem. 8: 559-563. Winterberg, B., Uhlmann, S., Linne, U., Lessing, F., Marahiel, M.A., Eichhorn, H., Kahmann, R. and Schirawski (2010) Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis. Mol. Microbiol. 75: 1260-1271. 　2009　　Knappe, T.A., Linne, U., Robbel, L. and Marahiel, M.A. (2009) Insights into the biosynthesis and stability of the lasso peptide capistruin. Chem. Biol. 16: 1290-1298. see also: Rosengren, K.J. and Craik, D.J. (2009) How bugs make lassos. Chem. Biol. 16: 1211-1212. Marahiel, M.A. (2009) Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis. J. Pept. Sci. 15: 799-807. Strieker, M., Nolan, E.M., Walsh, C.T. and Marahiel, M.A. (2009) Stereospecific synthesis of threo- and erythro-ß-hydroxyglutamic acid during kutzneride biosynthesis. J. Am. Chem. Soc. 131: 13523-13530. Peuckert, F., Miethke, M., Albrecht, A.G., Essen, L.-O. and Marahiel, M.A. (2009) Structural basis and stereochemistry of triscatecholate siderophore binding by FeuA. Angew. Chem. Int. Ed. Engl. 48: 7924-7927. Marahiel, M. A. and Essen, L.-O. (2009) Chapter 13. Nonribosomal peptide synthetases mechanistic and structural aspects of essential domains. Methods Enzymol. 458: 337-351. Strieker, M. and Marahiel, M.A. (2009) The structural diversity of acidic lipopeptide antibiotics. ChemBioChem 10: 607-616. Robbel, L., Hoyer, M. and Marahiel, M.A. (2009) TioS T-TE - prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides. FEBS J. 276: 1641-1653. Chillappagari, S., Miethke, M., Trip, H., Kuipers, O.P. and Marahiel, M. (2009) Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis. J. Bacteriol. 191: 2362-2370. Mendoza-Mendoza, A., Berndt, P., Djamei, A., Weise, C., Linne, U., Marahiel, M., Vranes, M., Kämper, J. and Kahmann, R. (2009) Physical-chemical plant-derived signals induce differentiation in Ustilago maydis. Mol. Microbiol. 71: 895-911. Duquesne, S., Destoumieux-Garzon, D., Zirah, S., Knappe, T.A., Goulard, C., Peduzzi, J., Marahiel, M.A. and Rebuffat, S. (2009) Post-translational modification and folding of a lasso-type gene-encoded antimicrobial peptide require two enzymes only in Escherichia coli. Adv. Exp. Med. Biol. 611: 35-36. Hur, G.H., Meier, J.L., Baskin, J., Codelli, J.A., Bertozzi, C.R., Marahiel, M.A., Burkart, M.D. (2009) Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem. Biol. 16: 372-381. Helmetag, V., Samel, S.A., Thomas, M.G., Marahiel, M.A. and Essen, L.-O. (2009) Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J. 276: 3669-3682. Roberts, A.A., Copp, J.N., Marahiel, M.A. and Neilan, B.A. (2009) The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity. ChemBioChem 10: 1869-1877. Moldt, J., Pokorny, R., Orth, C., Linne U., Geisselbrecht, Y., Marahiel, M.A., Essen, L.O. and Batschauer, A. (2009) Photoreduction of the folate cofactor in members of the photolyase family. J. Biol. Chem. 284: 21670-21783. 　2008　　Tanovic, A., Samel, S.A., Essen, L.-O. and Marahiel, M.A. (2008) Crystal structure of the termination module of a nonribosomal peptide synthetase. Science 321: 659-663. see also: Everts, S. (2008) Peptide-producing powerhouses. C & EN 6: 48-51. Koglin, A., Löhr, F., Bernhard, F., Rogov, V.V., Frueh, D.P., Strieter, E.R., Mofid, M.R., Güntert, P., Wagner, G., Walsh, C.T., Marahiel, M.A. and Dötsch, V. (2008) Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature 454: 907-911. Knappe, T.A., Linne, U., Zirah, S., Rebuffat, S., Xie, X. and Marahiel, M.A. (2008) Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensisE264. J. Am. Chem. Soc. 130: 11446-11454. Kopp, F., Linne, U., Oberthür, M. and Marahiel, M.A. (2008) Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes. J. Am. Chem. Soc. 130: 2656-2666. Miethke, M., Schmidt, S. and Marahiel, M. A. (2008) The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibaction secretion in Bacillus subtilis. J. Bacteriol. 190: 5143-5152. Strieker, M., Essen, L.-O., Walsh, C.T. and Marahiel, M.A. (2008) Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. ChemBioChem 9: 374-376. Wittmann, M., Linne, U., Pohlmann, V. and Marahiel, M.A. (2008) Role of DptE and DptF in the lipidation reaction of daptomycin. FEBS Journal 275: 5343-5354. Pohlmann, V. and Marahiel, M.A. (2008) delta-Amino group hydroxylation of l-ornithine during coelichelin biosynthesis. Org. Biomol. Chem. 6: 1843-1848. Samel, S.A., Marahiel, M.A. and Essen, L.O. (2008) How to tailor non-ribosomal peptide products - new clues about the structures and mechaisms of modifying enzymes. Mol. Biosyst. 4: 387-393. Yonus, H., Neumann, P, Zimmermann, S., May, J.J., Marahiel, M.A. and Stubbs, M.T. (2008) Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J. Biol. Chem. 283: 32484-32491. Enck, S., Kopp, F., Marahiel, M.A. and Geyer, A. (2008) The entropy balance of nostocyclopeptide macrocyclization analysed by NMR spectroscopy. ChemBioChem 9: 2597-2601. 　　　2007　　Kopp, D. and Marahiel, M.A. (2007) Where chemistry meets biology: the chemoenzymatiac synthesis of nonribosomal peptides and polyketides. Curr. Op. Biotechnol. 18: 513-520. Fujimori, D., Hrvatin, S., Neumann, C., Strieker, M., Marahiel, M.A. and Walsh, C.T. (2007) Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc. Natl. Acad. Sci. USA 104: 16498-16503. Teichmann, B., Linne, U., Hewald, S., Marahiel, M.A. and Bölker, M. (2007) A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis.Mol. Microbiol. 66: 525-533. Mahlert, C., Kopp, F., Thirlway, J., Micklefield, J. and Marahiel, M.A. (2007) Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. J. Am. Chem. Soc. 129: 12011-12018. Miethke, M., and Marahiel, M.A. (2007) Siderophore-based iron acquisition and pathogen control. Microbiol. Mol. Biol. Rev. 71: 413-451. Kopp, F. and Marahiel, M.A. (2007) Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat. Prod. Rep. 24: 735-749. Samel, S.A., Schönafinger, G., Knappe, T.A., Marahiel, M.A. and Essen L.-O. (2007) Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure 15: 781-792. Wiegeshoff, F., Marahiel, M.A. (2007) Characterization of a mutation in the acetolactate synthase of Bacillus subtilisthat causes a cold-sensitive phenotype. FEMS Microbiol. Lett. 272: 30-34. Azim-Zadeh, O., Hillebrecht, A., Linne, U., Marahiel, M.A., Klebe, G., Lingelbach, K. and Nyalwidhe, J. (2007) Use of biotin derivatives to probe conformational changes in proteins. J. Biol. Chem. 282: 21609-21617. Copp, J.N., Roberts, A.A., Marahiel, M.A., Neilan, B.A. (2007) Characterization of PPTNs, a cyanobacterial phosphopantetheinyl transferase from Nodularia spumigena NSOR10. J. Bacteriol. 189: 3133-3139 Strieker, M., Kopp, F., Mahlert, C., Essen, L.-O., Marahiel, M.A. (2007) Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol. 2: 187-196. Linne, U., Schäfer, A., Stubbs, M.T., Marahiel, M.A. (2007). Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains. FEBS Lett. 581: 905-910. Hoyer, K.M., Mahlert, C., Marahiel, M.A. (2007). The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem. Biol. 14: 13-22. Bisseret, P., Thielges, S., Bourg, S., Miethke, M., Marahiel, M. and Eustache, J. (2007) Synthesis of a 2-indolylphosphonamide derivative with inhibitory activity against yersiniabactin biosynthesis. Tetrahedron Letters 48: 6080-6083. Paungmoung, P., Punya, J., Pongpattanakitshote, S., Jeamton, W., Vichisoonthonkul, T., Bhumiratana, S., Tanticharoen, M., Linne U., Marahiel, M.A. and Cheevadhararak, S. (2007) Detection of nonribosomal peptide synthetase genes in Xylaria sp. BCC1067 and cloning of XyNRPSA. FEMS Microbiol. Lett. 274: 260-268.　　　　2006　　Kopp, F., Mahlert, C., Grünewald, J., Marahiel, M.A. (2006) Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J. Am. Chem. Soc. 128: 16478-16479. 　Miethke, M., Westers, H., Blom, E.J., Kuipers, O.P. and Marahiel, M.A. (2006) Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis. J. Bacteriol. 188: 8655-8657. 　Stein, D. B., Linne, U., Hahn, M. and Marahiel, M. A. (2006) Impact of epimerization domains on the intermodular transfer of enzyme-bound intermediates in nonribosomal peptide synthesis. ChemBioChem 7: 1807-1814. 　Kopp, F., Grünewald, J., Mahlert, C. and Marahiel, M. A. (2006) Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry 45: 10474-10481. 　Wagner, B., Schumann, D., Linne, U., Koert, U. and Marahiel, M. A. (2006) Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. J. Am. Chem. Soc. 128: 10513-10520. 　Miethke, M., Klotz, O., Linne, U., May, J. J., Beckering, C. L. and Marahiel, M. A. (2006) Ferri-bacillibactin uptake and hydrolysis in Bacillus subtilis. Mol. Microbiol. 61: 1413-1427. 　Hewald, S., Linne, U. Scherer, M. Marahiel, M. A., Kamper, J. and Bolker, M. (2006) Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis. Appl. Environ. Microbiol. 72: 5469-5477. 　Samel, S.A., Wagner, B., Marahiel, M. A. and Essen, L. O. (2006) The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide. J. Mol. Biol. 359: 876-889. 　Koglin, A., Mofid, M. R., Lohr, F., Schafer, B., Robov, V. V., Blum, M. M., Mittag, T., Marahiel, M. A., Bernhard, F. and Dotsch, V. (2006) Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science 312: 273-276. 　Grünewald, J., Mahlert, C., Kopp, F. and Marahiel, M. A. (2006) Chemoenzymatic pathways towards novel peptide antibiotics. Anti-Infective Agents in Medicinal Chemistry 5: 227-243. 　Schoenafinger, G., Schracke, N., Linne, U. and Marahiel, M. A. (2006) Formylation domain: An essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. J. Am. Chem. Soc. 128: 7406-7407. 　Wiegeshoff, F., Beckering, C. L., Debarbouille, M. and Marahiel, M. A. (2006) Sigma L is important for cold shock adaptation of Bacillus subtilis. J. Bacteriol. 188: 3130-3133. 　Wagner, B., Sieber, S. A., Baumann, M. and Marahiel, M. A. (2006) Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem 7: 595-597. 　Grünewald, J. and Marahiel, M. A. (2006). Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol. Mol. Biol. Rev. 70: 121-146. 　Miehtke, M., Bisseret, P., Beckering, C. L., Vignard, D., Eustache, J. and Marahiel, M. A. (2006) Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. FEBS J. 273: 409-419. 　Hunger, K., Beckering, C. L., Wiegeshoff, F., Graumann, P. L. and Marahiel, M. A. (2006) Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with cold shock protein B in Bacillus subtilis. J. Bacteriol. 188: 240-248.
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