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词条 黄晓华
释义

黄晓华,从事化学与生物学交叉研究领域,主要研究方向为生物无机化学,即将生物物理化学研究手段、细胞化学方法与细胞生物学技术优化组合,研究稀土元素、重金属离子、医用纳米材料对细胞及其生物酶分子的结构、功能及其微观化学过程的影响。

南京师范大学化学院教授

在研项目

(1)稀土对辣根的剂量效益评价及其研究(GFZ20612108,2007-2009)

(2)重金属Tb作用于植物细胞膜的微观化学行为研究(2009-2012)

(3)聚氨酯无机仿生表面构建的关键技术及生物医用研究(2009-2012)

(4)稀土作用于辣根细胞膜的若干生物无机化学行为研究(2010-2012)

成果介绍

作为项目主持人近三年来, 完成中美合作项目、国家自然科学基金、国家发改委、江苏省高技术及教育部重点项目等8项、在研项目3项。在J.Biol.Inorg.Chem., J.Phys.Chem., Dalton Transactions, Ecotoxicology and Environmental Safety, Annals of Botany,Electrochimica Acta., J. Electro. Chem.,J. Mater. Chem.等学术期刊上合作发表SCI论文60余篇(其中第一及通信作者42篇)。被国外SCI期刊如Journal of Physical Chemistry(B、C), Dalton Transactions, International Journal of Biological Sciences, Biological Trace Element Research, Langmuir, Ecotoxicology and Environmental Safety, Annals of Botany, Environmental Chemistry Letters等他引223次,单篇最高引用17次。2007年应邀在 “13th International Conference on Biological Inorganic Chemistry(ICBIC13,维也纳)”会上报告;2009年又收到“ICBIC14,日本”会议报告的邀请。获得1项美国专利及6项中国(授权)发明专利。其中,一项特色研究成果用于出口经济作物,05-07连续三年该产品获得欧盟生态证书及出口美国、加拿大、丹麦、德国等国家和地区,净增经济效益96万美元。

近三年主持的国家及江苏省主要项目

(1)稀土生态转光膜分子设计及研制(BG2005040. 2005-2007);

(2)稀土离子对辣根植物过氧化酶的结构和生物活性影(20471030, 2005-2007);

(3)稀土离子对辣根植物过氧化酶的毒害机理(IFZ2051210,2006-2008);

近三年完成的主要研究成果代表

(1) Huang, X.H., Zhou, Q., Lu,T.H., Guo, S.F (2009). Design and preparation of plant growth regulator of rare earth element-amino acid-vitamine, United States Patent(EFSID;4978659;PCT/CN07/01912).

(2) Guo , X.Y., Yin,W.Q., Sun, X.H., Huang, X.H.*,. Lu, T.H.(2009). Study on intreaction between Eu(III) and thermosensitive microsphere. Polym.Bull. 62:337-344.

(3) Guo, S.F., Cao, R., Lu, A.H., Zhou, Q., Lu, T.H., Ding, X.L., Li, C.J., Huang, X.H.* (2008) One of the Possible Mechanisms for the Inhibition Effect of Tb (III) on Peroxidase Activity in Horseradish (Armoracia Rusticana) Treated with Tb (III). Journal of Biological Inorganic Chemistry. 13(4): 587-597.

(4) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Inhibition Mechanism of Tb-III on Horseradish Peroxidase Activity. Chemistry & Biodiversity. 5(10): 2050-2059.

(5) Ye, Y.X., Wang, L.H., Huang, X.H.*, Lu, T.H., Ding, X.L., Zhou, Q.*, Guo, S.F. (2008) Subcellular Location of Horseradish Peroxidase in Horseradish Leaves Treated with La(III), Ce(III) and Tb(III). Ecotoxicology and Environmental Safety. 71(3): 677-684.

(6) Wang, L.H., Huang, X.H.*, Zhou, Q.* (2008) Effects of Rare Earth Elements on the Distribution of Mineral Elements and Heavy Metals in Horseradish. Chemosphere. 73(3): 314-319.

(7) Liu, H.K. *, Huang, X.H.*, Lu, T.H., Wang, X.J., Sun, W.Y., Kang, B.S. (2008) Discrete and Infinite 1d, 2d/3d Cage Frameworks with Inclusion of Anionic Species and Anion-Exchange Reactions of Ag3l2 Type Receptor with Tetrahedral and Octahedral Anions. Dalton Transactions. (24): 3178-3188.

(8) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2008) Spectroscopic Studies of Interactions Involving Horseradish Peroxidase and Tb3+. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. 70(4): 818-823.

(9) Zhou, H., Lu, T.H., Shi, H.X., Dai, Z.H., Huang, X.H.* (2008) Direct Electrochemistry and Electrocatalysis of Catalase Immobilized on Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode and Its Application. Journal of Electroanalytical Chemistry. 612(2): 173-178.

(10) Guo, X.Y., Lu, T.H., Huang, X.H.* (2008) Eu(III)-Modified Properties of Thermosensitive Core-Shell Microspheres. Colloid and Polymer Science. 286(4): 469-473.

(11) Guo, X.Y., Chen, M.Q., Lu, T.H., Huang, X.H.* (2008) Effect of Tb(III) on the Properties of P(Nipam-Co-St) Copolymer Microspheres. Journal of Polymer Research. 15(2): 141-145.

(12) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007)Inhibition Effect of Tb(III) on Horseradish Peroxidase Activity. Journal of Biological Inorganic Chemistry. 12, (S1): S203.

(13) Guo, X.S., Zhou, Q., Zhu, X.D., Lu, T.H., Huang, X.H.* (2007) Migration of a Rare Earth Element Cerium(III) in Horseradish. Acta Chimica Sinica. 65(17): 1922-1924.

(14) Guo, X.S., Zhou, Q., Lu, T.H., Fang, M., Huang, X.H.* (2007) Distribution and Translocation of Ce-141 (III) in Horseradish. Annals of Botany. 100(7): 1459-1465.

(15) Guo, S.F., Zhou, Q., Lu, T.H., Ding, X.L., Huang, X.H.* (2007) Interaction between La3+ and Mp-11 in the Physiological Solution. Electrochimica Acta. 52(5): 2032-2038.

(16) Zhao, B.*, Rong, Y.Z., Huang, X.H., Shen, J.S. (2007) Experimental and Theoretical Study on the Structure and Electronic Spectra of Imiquimod and its Synthetic Intermediates. Bioorganic & Medicinal Chemistry Letters. 17(17): 4942-4946.

(17) Huang, X.H.*, Guo, S.F., Zhou, Q., Lu, T.H.*, Ding, X.L. (2007) Effect of La3+ on Structure and Electrochemical Reaction of Microperoxidase-11 in Imitated Physiological Solution. Journal of Electroanalytical Chemistry. 600(2): 227-235.

(18) Yin, W.Q., Chen, M.Q., Lu, T.H., Akashi, M., Huang, X.H.* (2007) Properties of Complex of Tb(III) and Poly(N-Isopropylacrylamide)-G-Poly(N-Isopropylacrylamide-Co-Styrene) Core-Shell Nanoparticles. Journal of Alloys and Compounds. 432(1-2): L18-L21.

东风总医院副主任医师

黄晓华男,副主任医师,硕士研究生。

1995年毕业于华西医科大学,从事骨科临床研究与教学工作十余年。曾参与完成多项骨科科研研究,并取得湖北省重大科研成果奖.曾到北京大学附属人民医院骨关节科进修学习。熟练掌握了关节镜技术,对骨与关节疾病的诊断治疗积累了丰富的临床经验,对四肢骨折及关节损伤的治疗有独到见解。

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