词条 | 胡黔楠 |
释义 | 姓名:胡黔楠 性别:男 职务/职称: 副教授 通讯地址(含邮编):430071 武汉市武汉大学药学院 学习简历: 1997年6月,中南工业大学(现中南大学)化学系,学士,导师:严规有教授 2001年6月,中南大学化学化工学院,硕士,导师:任凤莲教授 2004年6月,中南大学,博士,导师:梁逸曾教授 工作简历: 2004年10月至2007年2月,德国,爱尔兰根-纽伦堡大学,计算机化学中心,Johann Gasteiger教授小组,博士后。 2007年2月至2008年7月,美国,加州大学欧文分校,信息和计算机科学学院,Pierre Baldi教授实验室,博士后。 2008年8月至2010年2月,日本,京都大学,生物信息学中心,Minoru Kanehisa教授,产官学提携研究员。 2010年3月起,武汉大学,药学院,副教授。 业绩概要: 一直从事生物信息学和系统生物学在药物开发中的应用研究,参与了中国、德国、美国以及日本等国多个横向和纵向的交叉学科科研项目的科学研究和商业软件开发。在国内外知名刊物上发表科学论文20多篇,其中10多篇在国际性刊物上发表,被科学引文索引(SCI)收录10多篇。多次受邀作为国际刊物《Journal of Chemical Information and Modeling》和《Chemometrics and Intelligent Laboratory Systems》的审稿人。 : 中国化学会优秀青年论文奖 (2004) 陈新民奖(2003) 研究领域: 化学信息学,系统生物学,药物分子设计,化学计量学,生物信息学 研究兴趣与方向: (1) Systems drug design (2) Network-based drug metabolism prediction (3) Computer-aided drug screening and synthsis (4) Molecular basis of Traditional Chinese Medicines (5) Genome-wide association study 科研成果(至少应有近五年的代表性成果): 1. Qian-Nan Hu, Zhe Deng, Huanan Hu, Dong-Sheng Cao, Yi-Zeng Liang (2011)RxnFinder: Biochemical Reaction Search Engines Using Molecular Structures, Molecular Fragments, and Reaction Similarity. Bioinformatics 27(17): 2465-2467. 2. Dong-Sheng Cao, Qian-Nan Hu, Qing-Song Xu, Yan-Ning Yang, Jian-Chao Zhao, Hong-Mei Lu, Liang-Xiao Zhang, Yi-Zeng Liang(2011)In silico classification of human maximum recommended daily dose based on modified random forest and substructure fingerprint. Analytica Chimica Acta 692, 50-56. 3. Dong-Sheng Cao, Bing Wang, Mao-Mao Zeng, Yi-Zeng Liang, Qing-Song Xu, Liang-Xiao Zhang, Hong-Dong Li, Qian-Nan Hu (2011) A new strategy of exploring metabolomics data using Monte Carlo tree. Analyst 136(5):947-54. 4. Dong-Sheng Cao, Yi-Zeng Liang, Qing-Song Xu, Qian-Nan Hu, Liang-Xiao Zhang, Guang-Hui Fu (2011)Exploring nonlinear relationships in chemical data using kernel-based methods. Chemometrics and Intelligent Laboratory Systems 107(1), 106-115. 5. Dong-Sheng Cao, Yi-Zeng Liang, Qing-Song Xu, Liang-Xiao Zhang, Qian-Nan Hu and Hong-Dong Li (2011) Feature importance sampling-based adaptive random forest as a useful tool to screen underlying lead compounds. Journal of Chemometrics 25(4), 201–207. 6. Emrin Zitha-Bovens, Peter Maas, Dick Wife, Johan Tijhuis, Qian-Nan Hu, Thomas Kleinöder, Johann Gasteiger(2009) COMDECOM: Predicting the Lifetime of Screening Compounds in DMSO Solution. Journal of Biomolecular Screening 14, 557-565. 7. Qian-Nan Hu, Yi-Zeng Liang., Xu, Q. S., Fang, K. T., Peng, X. L. and Yin, H (2005) Structural Features within Degree Distributions of Topological Graphs. J. Math. Chem. 37 (1), 37-56. 8. Xiao-Ling Peng, Qian-Nan Hu, Yi-Zeng Liang (2005) Variable Selection via Nonconcave Penalty Function in Structure-Boiling Points Correlations. J. Mol. Str.: THEOCHEM 714 (2-3), 235-242. 9. Shansheng Yang, Wencong Lu, Nianyi Chen, Qian-Nan Hu(2005) Support vector regression based QSPR for the prediction of some physicochemical properties of alkyl benzenes. Journal of Molecular Structure: THEOCHEM 719(1-3), 119-127. 10. Ya-Li Wang, Yi-Zeng Liang, Ben-Mei Chen, Bo-Yan Li, Qian-Nan Hu(2005)LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. Analytical and Bioanalytical Chemistry 383 (2), 247-254. 11. Qian-Nan Hu, Yi-Zeng Liang, Hong Yin, Xiao-Ling Peng, Kai-Tai Fang (2004) Structure Interpretation of Topological Index (2) Molecular Connectivity Index, Kappa Index and E-State Index. J. Chem. Inf. Comput. Sci. 44, 1193-1201. 12. Xiao-Ling Peng, , Kai-Tai Fang, Qian-Nan Hu, Yi-Zeng Liang (2004) Impersonality of the Connectivity Index and Recomposition of Topological Indices According to Different Properties.Molecule, 9, 1089-1099. 13. Qian-Nan Hu, Yi-Zeng Liang, Xiao-Ling Peng, Hong Yin, Kai-Tai Fang (2004) Structure Interpretation of Topological Index (1) External Factor Variable Connectivity Index. J. Chem. Inf. Comput. Sci. 44, 437-446. 14. Qian-Nan Hu, Yi-Zeng Liang, Feng-Liang Ren (2003) Molecular Graph Center, A Novel Approach to Locate the Center of a Molecule and a New Centric Index. J. Mol. Str.: THEOCHEM 635/1-3, 105-113. 15. Huang, L. F., Liang, Y. Z., Guo, F. Q., Qian-Nan Hu, Chen, B. M(2003) Rapid simultaneous determination of arginine and methylated arginines in human urine by high-performance liquid chromatographymass spectrometry. Anal. Chem. Acta 487, 145-153. 16. Qian-Nan Hu, Yi-Zeng Liang, Ya-Li Wang, Cheng-Jian Xu, Zhong-Da Zeng, Kai-Tai Fang, Xiao-Ling Peng, Yin Hong (2003) External Factor Variable Connectivity Index. J. Chem. Inf. Comput. Sci. 43, 773-778. |
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