个人资料

姓名：洪学传

性别：男

职称或职务: 博士、楚天学者特聘教授、博士生导师

学习简历

1993.9 - 1997.7 天津大学攻读应用化学系精细化工专业学士学位

1993.9 - 1997.7 天津大学攻读管理学院技术经济学士双学位

1997.9 - 1999.11 天津大学免试攻读化工学院应用化学专业硕士学位

1999.12 -2000.7 日本北海道大学药学院和触媒化学研究中心研修生

2001.1 - 2005.7 美国密苏里大学哥伦比亚分校攻读有机化学博士学位

工作简历

1997.9 - 1999.11 天津大学化工学院97级本科生辅导员

2005.9 - 2007.9美国爱默里大学博士后研究员

2007.10- 2010. 10AMRI, Albany, NY, USA 资深科学家

2010.10- 2011.4武汉大学药学院, 教授

2011.5-至今武汉大学药学院, 楚天学者特聘教授，武汉大学药学院邓子新院士创新团队成员。

业绩概要

1)国内国际核心化学期刊上发表论文37篇及英文专著一章。

2)率先发现了以手性亚砜亚胺(sulfoximine)为手性助剂的不对称的1,4-加成反应, 使在芳香基团, 杂环共扼环的α位引入手性烷基手性中心更加容易。反应具有广泛 的普遍性和绝对的立体选择性。

3)在美国国立卫生研究院(NIH), Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) 和 CV Therapeutics 的支持下, 利用这特定的化学设计, 合成了一系列具有绝对构像的抗结核病的天然或非天然化合物例如(+)-curcumeme, (+)-curcuphenol, pesudoteroxazole, erogorgiaene, colombiasin A 和 elisapterosin B及分子改造, 开发出了一些选择性地高, 毒性小的抗结核剂。

4)发现用改进的aza-Achmatowicz 方法合成多取代吡咯。确定铑(II)催化吲哚环加成串联反应的相对立体构像。设计, 合成了一系列具有高生物活性的天然化合物例如kopsifoline的核 心结构。

5)曾从事各类癌症药物和肥胖症的小分子药物等发现，合成, 研制及工业开发。其中一个临床III药在2009年9月得到美国FDA批准。

获奖情况

2004Breckenridge Lyons Award for Outstanding Graduate Research, University of Missouri-Columbia.

2004Gordon Research Conference on Organic Reactions and Process Chair Award.

研究领域

药物化学，有机化学，分子影像(Molecular Imaging)

研究兴趣与方向

1.活性天然产物的全合成

2.化学合成药物的开发与研究

3.运用现代生物学技术进行药物开发

4.用于肿瘤光声成像的分子探针的研制和开发

已发表的学术论文

著作：

1.“Recent Progress in the Chemistry of 2,1-Benzothiazines”

Xuechuan Hong; Michael Harmata. Progress in Hetereocyclic Chemistry, Chapter 1, G. W. Gribble and J. A. Joule, eds, Pergamon Press, Vol 20, pp 1–43 (2008)

发表论文：

1．“Metal-free direct amidation of peptidyl thiol esters with -amino acid esters.” Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong* and Zixin Deng, Green Chem., 2011, 13“The Intramolecular, Stereoselective Addition of Sulfoximine Carbanions to α,β-Unsaturated Esters.”Michael Harmata; Xuechuan Hong. J. Am. Chem.l Soc.2003, 125(19), 5754–5756. , 2723

2.

3. “Asymmetric Organocatalysis of [4+3] Cycloaddition Reactions.” Michael Harmata; Sunil K. Ghosh; Xuechuan Hong; Sumrit Wacharasindhu; Patrick Kirchhoefer. J. Am. Chem.l Soc. 2003, 125(8), 2058–2059.

4. “A Cycloaddition Protocol for the Assembly of the Heterocyclic Framework Associated with the Kopsifoline Alkaloids.”Xuechuan Hong; Stefan France; José M. Mejía-Oneto; Albert Padwa. Org. Lett. 2006, 8, 5141–5144.

5. “Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong. Org. Lett. 2005, 7(16), 3581–3583.

6.“Benzothiazines in Synthesis. Toward the Synthesis of Pseudopteroxazole.”Michael Harmata; Xuechuan Hong; Charles L. Barnes. Org. Lett.2004, 6(13), 2201–2203.

7."Benzothiazines in Organic Synthesis.The Preparation of Enantiomerically Pure 4-Substituted Quinolones” Michael Harmata; Xuechuan Hong. Org. Lett. 2007, 9, 2901–2904.

8.“Benzothiazines in Synthesis. Stereoselective Synthesis of Erogorgiaene.”Michael Harmata; Xuechuan Hong;Peter R. Schreiner. J. Org. Chem.2008, 73, 1290–1296.

9. “Synthesis of 2,4-Disubstituted Pyrroles by Rearrangements of 2-Furanyl Carbamates.”Sezgin Kiren; Xuechuan Hong; Carolyn A. Leverett; Albert Padwa.Org. Lett. 2009, 11(6), 1233–1235.

10. “A dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.” Xuechuan Hong; Stefan France; Albert Padwa. Tetrahedron, 2007, 63, 5962–5976.

11. “Rhodium Carbenoid Induced Cycloadditions of Diazo Ketoamides Across Indolyl π-Bonds.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Synlett, 2007, 775–779.

12. “Lewis Acid Promoted a-Hydroxy b-Dicarbonyl to a-Ketol Ester Rearrangement.” Xuechuan Hongıa-Oneto; Albert Padwa. Tetrahedron Lett. 2006, 47, 8387–8390.;Jose M. Mej

13. “Photodesulfonylation of Indoles Initiated by Electron Transfer from Triethylamine.”Xuechuan Hong; José M. Mejía-Oneto; Stefan France; Albert Padwa. Tetrahedron Lett.2006, 47, 2409–2412.

14. “Palladium-catalyzed Cross-coupling Reactions of a Sulfoximine with Aryl Dichlorides under Microwave Irradiation.”Michael Harmata; Xuechuan Hong. Synlett, 2007, 969–973.

国际学术会议报告

1. “Studies of the Chemistry of 2,1-Benzothiazines and an Approach to the Synthesis of Antitubercular Natural Products.” Xuechuan Hong*nd International Symposium on Organic Synthesis and Drug Development,Nanjing, China, October 14-16, 2010.. Presented at 2

2. “Benzothiazines in Synthesis. Synthesis of Enantiomerically Pure 3,4-Dihydroquinolin-2(1H)-ones.” Michael Harmata; Xuechuan Hong*. ORGN-029l presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.

3. "Benzothiazines in Synthesis. A Route to Chiral Cyclobutanes” Michael Harmata; Weijiang Ying and Xuechuan Hong. ORGN-515 presented at the 231 National Meeting of the American Chemical Society, Atlanta, GA, March 26-30, 2006.

4.“Benzothiazines in Synthesis. Stereoselective Synthesis of Diastereomers of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. ORGN-060 presented present at the 228 National Meeting of the American Chemical Society, Philadelphia, August 22-26, 2004.

5. “Microwave-assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. ORGN-165 presented at the 228 National Meeting of the American Chemical Society, Philadelphia, August 22-26, 2004.

6. “Towards a Synthesis of Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.

7. “Microwave-assisted N-arylation of a Sulfoximine with Aryl Chlorides.” Michael Harmata; Xuechuan Hong*. Presented at the Gordon Research Conference on Organic Reactions and Processes, July 18-23, 2004.

8.“Benzothiazines in Synthesis. Towards Pseudopteroxazole.” Michael Harmata; Xuechuan Hong*. ORGN-061 presented at the 228National Meeting of the American Chemical Society, Philadelphia, August 22-26, 2004.

9. “Towards a Synthesis of Erogorgiaene.” Michael Harmata; Xuechuan Hong*. Paper #48 presented at the 38 Annual Midwest Regional Meeting of the American Chemical Society, Columbia, November 5-7, 2003.

博士后招聘

本研究组拟招收具有以下专业研究背景博士后1-2名：

1.活性天然化合物的全合成

2.肿瘤光声成像的分子探针的研制和开发