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词条 郝爱友
释义

姓 名 郝爱友

性 别 男

出生日期 1966.05.27

职 称 教授(博导)

工作单位 山东大学有机化学研究所

电 话

传 真

参见 http://202.194.4.238/chemnew/teachers/showdetail.aspx?tea_id=215

学术简介 ◇

1985.09-1989.07 山东师范大学化学系,学习(本科生)

1989.09-1992.07 山东大学化学院,学习(硕士研究生)

1992.09-1995.08 中科院兰州化学物理研究所,学习(博士研究生)

1995.08-1997.09 山东大学化学与环境学院,讲师

1997.09-2001.09 山东大学化学与环境院,副教授

2001.09起 山东大学化学与化工学院,教授

2003年 有机化学博士生导师

【主讲课程】

有机化学

【研究领域和兴趣】

研究领域和兴趣】主要研究领域和兴趣包括:有机合成; 药物合成; 有机超分子化学; 功能分子的设计与合成; 功能新材料的设计与合成等。

【功能分子的设计与合成】主要研究、设计、合成具有应用背景的功能分子,如药物、香料、甜味分子、染料等等。 【有机超分子化学】

重点研究功能化有机超分子聚集体、超微环境的设计合成与性能;

非常重视功能性超微环境中的“酶”模拟反应,智能材料的设计合成等。

相对于以共价键为基础,以分子为研究对象的传统分子化学(molecular chemistry)而言,以多种弱相互作用力(或称次级键)为基础,以2个以上分子通过这种弱相互作用高层次组装为研究对象的化学,可定义为“超越分子概念的化学”,也称为超分子化学(supermolecular chemistry)。

与原子间由化学键作用而形成分子的分子化学不同,超分子化学是研究分子间相互作用缔结而形成复杂有序且具有特定功能的分子聚集体的科学,这种分子聚集体简称超分子。换言之,超分子化学是研究通过非共价键作用形成功能体系的科学。

超分子作用是一种具有分子识别能力的分子间相互作用,通过对分子间相互作用的精确调控,超分子化学逐渐发展成为一门新兴的分子信息化学,它包括在分子水平和结构特征上的信息存储,以及通过特异性相互作用的分子识别过程,实现在超分子尺寸上的修正、传输和处理。它是化学和多门学科的交叉领域,它不仅与物理学、材料科学、信息科学、环境科学等相互渗透形成了超分子科学,而更具有重要理论意义和潜在前景的是在生命科学中的研究和应用。例如生物体内小分子和大分子之间高度特异的识别在生命过程中的调控,生物体内的信息输送( 电子转移、能量传递、物质传输和化学转换)和生物体中受体-底物相互作用等,其基本现象都离不开超分子化学范畴。

未来超分子体系的特征应为“自适应化学,将在有机合成的“酶”模拟化、智能材料的构筑等领域发挥关键作用。

【功能新材料的设计与合成】

主要研究、设计、合成具有应用背景的功能材料、复合制剂等,如有机光电材料、储能材料、合成燃料、食品医药化妆品辅助材料,以及乳化剂、粘合剂、精细化工等。

主要论著】【教材】

1.《精编有机化学教程》(第二版),国家“十一五”规划教材

山东大学出版社,2009,08

2. 《精编有机化学教程》(第一版)

山东大学出版社,2003,07

科研项目】【科研项目】 作为主持人已完成或正在承担的课题有20余项,其中国家自然科学基金1项,国家及省部级课题7项。 近几年的科研项目主要有: 1.乳酸环糊精衍生物医用材料,2008-2011; 2.新型防堵塞涂层的开发,2009; 3.提取1-硝基蒽醌,2007-2009; 4.新型控环释材料羟丁基环糊精衍生物,2006-2008; 5.葡萄糖基环糊精衍生物,2006-2007; 6.润滑油添加剂结构分析;2006; 7.省科技厅:合成功能性大环分构筑高性能药用模型,1999-2003; 8.国家自然科学基金:构筑楔筒状空腔的主体分子新模型,2000-2002; 9.省科技厅:新型聚酸酐、聚酸酐微粒及纳米微粒,2002-2003; 10.教育厅:智能提取剂:硅胶载改性环糊精衍生物省,2002-2003; 11.省科技厅:2,3,5-三甲氧基苯甲醛的合成,2003-2004; 12.省科技厅:强力医药控缓释新材料:含低聚乳酸基团的环糊精衍生物的制备,2003-2004【科研成果】 近几年在国内外杂志发表科研论文100多篇(参见附件)。

【2008年以来文章目录】

1. Reversible Vesicles Based on One and Two Head Supramolecular Cyclodextrin Amphiphile Induced by Methanol;

Carbohydrate Research, Available online 6 February 2010;

Wei An, Huacheng Zhang, Lizhen Sun, Aiyou Hao*, Jingcheng Hao, Feifei Xin

2. Synthesis and Application of Doubly Bridged Cyclodextrins Dimer;

Chin.J.Org.Chem., 2010, available online on Feb 23, 2010;

Huacheng Zhang, Zhaona Liu, Wei An, Aiyou Hao*, Lizhen Sun

3. Progress in Molecular Imprinting Technology Based on Cyclodextrins;

Prog.Chem.(in Chinese), 2010,22(5),888-897;

Tao Sun, Yuanyuan Li, Huacheng Zhang, Aiyou Hao*

4. Multi-responsive Cyclodextrin Vesicles Assembled by “Supramolecular Bola-amphiphiles”;

Supramolecular Chemistry, 2010, Vol. 22, No. 5, 297–310;

Huacheng Zhang, Jian Shen, Zhaona Liu, Aiyou Hao*, Yan Bai, Wei An

5. pH-responsive vesicle-like particles based on inclusion complexes between cyclodextrins and methyl orange;

Colloids and Surfaces A: Physicochem. Eng. Aspects,358 (2010) 115–121;

Huacheng Zhang1, Lizhen Sun1, Zhaona Liu,Wei An, Aiyou Hao*, Feifei Xin, Jian Shen

6. N-ferrocenylmethyldodecan-1-amine;

Acta Crystallographica Section E: Structure Reports Online, Volume 66, Part 3, pages m301;

Lizhen Sun, Wei An, Huacheng Zhang, Feifei Xin, A.-Y. Hao*

7. Crystal structure of a new cyclomaltoheptaose hydrate form: β-cyclodextrin·7.5 H2O;

Carbohydrate Research,2010,345 , 685–688;

Jian-Ye Li, Dao-Feng Sun, Ai-You Hao*, Hong-Yuan Sun, Jian Shen

8. Redox-responsive vesicles prepared from supramolecular cyclodextrin amphiphiles;

Carbohydrate Research,2010,345,87–96;

Zhang H, An W, Liu Z, Hao A Y*, Hao J, Shen J, Zhao X, Sun H, Sun L

9. Synthesis and thermotropic properties of novel double-chained quaternary ammonium chlorides with symmetric and asymmetric hydrocarbon chain length;

Journal of Molecular Structure 923 (2009) 127–131;

Zhaoyun Ding, Aiyou Hao

10. Simple and Practical Procedure for the Preparation of Benzofurazan-N-oxides in the Presence of Cyclodextrin in Neutral Condition;

Synthetic Communications, 2009, 39(23), 4309-4314;

Tao Sun; Aiyou Hao*; Jian Shen; Liqiang Song

11. Controllable Vesicles Based on Unconventional Cyclodextrin Inclusion Complexes;

Carbohydrate Research, 2009, 344, 15, 2028-2035;

Huacheng Zhang, Jian Shen, Zhaona Liu, Yan Bai, Wei An and Aiyou Hao*

12. New cyclodextrin derivative 6-O-(2-hydroxybutyl)-β-cyclodextrin: preparation and its application in molecular binding and recognition;

Carbohydrate Research, 2009,344, 1999–2004;

Hong Yuan Sun , Yan Bai , Ming Gang Zhao, Ai You Hao*, Gui Ying Xu, Jian Shen, Jian Ye Li, Tao Sun,Hua Cheng Zhang

13. A Convenient One-step Synthesis of Methyl 2-Benzamidomethyl -3-Oxobutanoate;

Organic Process Research & Development, 2009, 13, 645–646;

Mingyong Chao, Aiyou Hao*, and Hui Wang

14. An Improved and Scaleable Preparation of 7-Amino-3-vinylcephem-4-carboxylic acid;

Organic Process Research & Development, 2009, 13, 924–927;

Mingyong Chao and Aiyou Hao*

15. A convenient preparation of ethoxymethoxymethane and its effect on the solubility of methanol-gasoline blends;

Chinese Chemical Letters, 2009, 20(8), 973-976

Shanjian Cao, Aiyou Hao*, Hongyuan Sun, Tao Sun

16. New cyclodextrin derivative 6-O-(2-hydroxyl-3-betainylpropyl)-β-cyclodextrin: preparation and its application for enantiomer separation of drugs by capillary electrophoresis;

J Incl Phenom Macrocycl Chem, 2009, 65(3), 427-430;

Hongyuan Sun,Aiyou Hao*, Yanli Yang,Chenfu Zhu,Jianye Li,Jian Shen,Mingjing Yin

17. The surface property and aggregation behavior of a hydrophobically modified cyclodextrin;

Colloid Polym. Sci., 2009, 10, 1-17;

Yan Bai,Gui-Ying Xu,Hong-Yuan Sun,Xiao-Deng Yang,Ai-You Hao,Jin-Yu Pang,Hou-Jian Gong,Ming-Qi Ao

18. Enantioseparation in capillary electrophoresis using 6-oligo-(lactic acid)cyclomaltoheptaose as a chiral selector;

Anal. Sci., 2009, 25(11), 1315-1318;

Yang Y, Zhu C, Shen J, Hao A Y

19. Organic Reactions Catalyzed by Cyclodextrins as Nanoreactors;

Chinese Journal of Organic Chemistry (in Chinese), 2009, 29(5), 681-688;

Sun Tao; Hao Aiyou*; Shen Jian

20. Synthesis and Application of Cyclodextrin Vesicles;

Chinese Journal of Organic Chemistry (in Chinese), 2009, 29(2), 166-173;

Zhang Huacheng; Hao Aiyou*; Li Ganzuo; Sun Hongyuan

21. Molecular Printboard;

Chemistry (in Chinese), 2009, (2), 105-111;

Zhang Huacheng; Hao Aiyou*; Shen Jian; An Wei

22. Method for synthesis of ethylene glycol methyl ether acrylate;

Chemical Reagents (in Chinese), 2008, 30(12), 947;

ZHANG Hua-cheng; HAO Ai-you*; CAO Shan-jian

23. Application of Cyclodextrins in Green Organic Synthesis;

Progress in Chemistry (in Chinese), 2008, 20(11), 1694-1698;

Sun Hongyuan; Hao Aiyou*; Yin Mingjing; Zhang Huacheng; Shen Jian

24. Synthesis and Application of Glycocluster and Glycodendrimer with Pentaerythritol Derivatives as Scaffolds;

Chinese Journal of Organic Chemistry (in Chinese), 2008, 28(9), 1515-1522;

ZHANG Hua-Cheng; HAO Ai-You*; DU Guang-Yan; SHEN Jian

25. A convenient preparation of 6-oligo(lactic acid)cyclomaltoheptaose as kinetically degradable derivative for controlled release of amoxicillin;

Carbohydrate Research, 2008, 343, 15, 2517-2522;

Jian Shen, Aiyou Hao*, Guangyan Du, Huacheng Zhang, Hongyuan Sun

26. Interaction between cetyltrimethylammonium bromideand β-cyclodextrin: surface tension and interfacialdilational viscoelasticity studies;

Colloid. Polym. Sci., 2008, 286, 1475–1484;

Yan Bai,Gui-Ying Xu,Xia Xin,Hong-Yuan Sun,Hong-Xing Zhang,Ai-You Hao,Xiao-Deng Yang,Lin Yao

27. Progress in Cyclodextrin-Calix[n]arene and Prospect of Its Future Development;

Chinese Journal of Organic Chemistry (in Chinese), 2008, 28(6), 954-963;

ZHANGHua-Cheng; HAO Ai-You*; SHEN Jian

28. Supramolecular Interaction between the Calix [n] arene Derivatives and the Cavity of Cyclodextrin;

Chemistry (in Chinese), 2008, (4), 256-264;

Zhang Huacheng; Hao Aiyou*; Shen Jian

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