基本信息

主要研究领域

近期代表性论文

基本信息

职称职务： 武汉大学基础医学院院长

出　生： 1965年4月于河南省夏邑县

学　位： 博士

毕业学校： 联邦德国布伦瑞克理工大学

学科专业： 微生物学、病毒学、分子生物学

实验室位置： 生科院大楼4013, 4125

主要研究领域

RNA病毒（冠状病毒和丙肝病毒）的基因组复制和与宿主细胞相互作用的分子机理；病毒免疫逃逸的分子机制；基于RNA干扰（RNAi）的艾滋病毒基因治疗。

近期代表性论文

1. Peng X, Pan J, Gong R, Liu Y, Kang S, Feng H, Qiu G, Guo D, Tien P, Xiao G.. (2006). Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein: implication for its fusion mechanism. J Biol Chem. 2006 Nov 14; [Epub ahead of print].

2.Hussain Snawar, Ji’an Pan, Yu Chen, Yalin Yang, Jing Xu, Yu Peng, Ying Wu, Chaoyang Li, Ying Zhu, Po Tien, Deyin Guo*. (2005). Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. Journal of Virology 79:5288-95.

3. Zhaoyang Li, Yong Xiong, Yu Peng, Ji’an Pan, Yu Chen, Xiaoyun Wu, Snawar Hussain, Po Tien, Deyin Guo*. (2005). Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Lett. 579, 3100-6.

4. Zhu, Y., M. Liu, W. Zhao, J. Zhang, X. Zhang, K. Wang, C. Gu, K. Wu, Y. Li, C. Zheng, G. Xiao, H. Yan, J. Zhang, D. Guo, P. Tien, and J. Wu. (2005). Isolation of virus from a SARS patient and genome-wide analysis of genetic mutations related to pathogenesis and epidemiology from 47 SARS-CoV isolates. Virus Genes 30: 93-102.

5. Deyin Guo*, Carl Spetz, Mart Saarma & Jari Valkonen. (2003) Two plant proteins, including a novel RING-finger protein, interact with the potyviral multifunctional protein HC-Pro. Molecular Plant-Microbe Interactions 16, 405-410.

6. Deyin Guo*, Minna-Liisa Rajam?ki, Mart Saarma & Jari PT Valkonen. (2001). Towards a protein interaction map of potyviruses: protein interaction matrixes of two potyviruses based on the yeast two-hybrid system. Journal of General Virology 82, 935-939.