简介

主要研究经历

目前研究方向

近年来发表的论文

简介

博士，女，中国药科大学教授，中国药科大学生命科学与技术学院教授，博士生导师。国际光学工程协会（SPIE）会员、美国光学学会（OSA）会员，中国光学学会高级会员，江苏省计量测试学会理事，江苏省生物医学工程生物光子学会理事。2005年江苏省“青蓝工程”中青年学术带头人。多种国际杂志的特约审稿人，现任中国药科大学国际交流与合作处处长。

主要研究经历

顾月清教授1997年于南京航空航天大学测试计量技术及仪器专业获工学博士学位，主要研究光纤传感器实现体内药物的微创实时监测。1999底赴美国宾夕法尼亚大学（University of Pennsylvania）医学院从事博士后研究，主要从事近红外分子探针在活体动物内的分布研究。2002年转至美国德州大学（University of Texas）进行近红外光谱及成像以监测各种临床治疗的研究。期间作为课题负责人分别获得美国国防部博士后基金及新研究者基金的资助，于2003年被聘为该校生物医学工程系的研究助理教授。2004年底于中国药科大学建立生物医学工程学研究室，主要是将各种光谱及成像技术应用于药物研发的各环节中，已获得多项国家自然科学基金的资助。

目前研究方向

1） 设计荧光探针及光学检测系统，实现大分子药物体内动力学过程的无损在位实时监测；

2） 设计并合成各种肿瘤特异性标志物的靶向分子探针，以实现肿瘤的早期分子诊断；

3） 设计并合成各种高分子纳米药物载体，以实现肿瘤的主动/被动靶向治疗；

4） 从基因水平设计特异性DNA序列探针，以研究肿瘤的生长、转移机制；

5） 利用病毒载体实现疾病的早期诊断及治疗。

近年来发表的论文

Submitted manuscript:

Fei Liu, Xinyang Chen, Dawei Deng, Yueqing Gu*, “Folate conjugated near infrared fluorescence probe for in vivo optical molecular imaging of cancer”, submitted to International Journal of Cancer.

Xinyang Chen, Fei Liu, Yueqing Gu*, “In vivo tumor imaging in mice with near-infrared - low density lipoprotein conjugates” submitted to Investigative Radiology

Hanyan Chen，Yueqing Gu*. “Characterization of CdHgTe/CdS quantum dots for noninvasive imaging of spinal cord in mouse model” submitted to Nanotechnology.

Jian zhang, Yueqing Gu*, “In vivo anti-tumor efficacy of docetaxel-loaded thermally responsive nanohydrogel”, submitted to Nanotechnology

Publications:

Da-Wei Deng, Peng Li, Yueqing Gu. “The simple synthesis and structural analysis of angled nanocrystals”, Crystal Research and Technology, 2009, in press.

Yueqing Gu, Jian Zhang, Haiyan Chen, “Dynamic properties of different kind of nanoparticles in mouse model after intravenous administration”, Proc. SPIE, 2009, 71900F1-F9

Da-Wei Deng, Yueqing Gu. “Spontaneous transition and concomitant self-assembly of CdTe nanoparticles into CdS nanosheets induced by L-cysteine”, Proc. SPIE, 2009, 719017-1–12.

Jian Zhang, Haiyan Chen, Lin Xu, Yueqing Gu*. The targeted behavior of thermally responsive nanohydrogel evaluated by NIR system in mouse model. Journal of Controlled Release, 2008, 131, 34-40.

Haiyan Chen, Yueqing Gu*, Yuzhu Hu, Real time in vivo non-invasive optical imaging of temperature sensitive co-polymeric nanohydrogel, Nanotechnology, 2008, 19, 185707

Huimin Qian Yueqing Gu*, Minwang, Samuel Achilefu, “Optimization of the near-infrared fluorescence labeling for in vivo monitoring of a protein drug distribution in animal model” J Fluorescence, 2008

Yueqing Gu, Zhiyu Qian, Yunli Song, In Vivo Near Infrared Techniques for Protein Drug Development, Encyclopaedia of Heathcare Information System, IGI Global , 2008

Haiyan Chen, Yuanqing Wang, Jing Xu, Jian Zhang, Yuzhu Hu, Yueqing Gu*, Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model. J Fluoresc. 2008, 18, 801-811.

Haiyan Chen, Yueqing Gu*, Yuzhu Hu, “Comparison of two polymeric carrier formulations for controlled release of hydrophilic and hydrophobic drugs”, Journal of Materials Science: Materials in Medicine, 2008 Feb;19(2):651-8.

Haiyan Chen, Yueqing Gu*, Yuzhu Hu, Zhiyu Qian, “Characterization of pH and temperature sensitive hydrogen nanoparticle for controlled drug release, PDA Journal of Pharmaceutical Science and Technology, 2007, Jul-Aug;61(4):303-13

Hao Gao, Yueqing Gu*, Qingneng Ping, “The implantable 5-fluororacil-loaded poly (L-lactic acid) fibers prepared by wet-spinning from suspension”, Journal of Controlled Release, 2007 Apr ;118(3):325-32.

Haiyan Chen, Jian zhang, Yueqing Gu*, “Characterization of Target effect of Nano- hydrogel by Real Time Optical Imaging using Near-infrared Fluorescent Quantum Dots”, Proceeding of International Symposium on Biophotonics, Nanophotonics and Metamaterials. IEEE Xplore,2006 (EI index)

Huimin Qian, Yueqing Gu, “Near-infrared fluorescent labeling of L-asparaginase”, Proceeding of International Symposium on Biophotonics, Nanophotonics and Metamaterials. IEEE Xplore, 2006 (EI index)

Qiong Wu, Zhiyu Qian, Yueqing Gu, “An Optimization Algorithm to Inverse Problem in 2-D Optical Computed Tomography by BP Neural Network，” International Symposium on Biophotonics, Nanophotonics and Metamaterials. IEEE Xplore,2006 (EI index)

Yueqing Gu, Yunlin, Song, Anca Constantinescu “tumor vascular contents assessed non-invasively by near infrared spectroscopy and 19F NMR spectroscopy of perfulubron” Chinese Optics Letters, Vol.3 (suppl),2005

Zhiyu Qian Yueqing Gu, “In vivo measurement of absorption coefficient in rat brain and statistic analysis”, Chinese Optics Letters. Vol.3(suppl),2005

Yueqing Gu, R. P. Mason, Hanli Liu, “Estimated fraction of tumor vascular blood contents sampled by near infrared spectroscopy and 19F magnetic resonance spectroscopy” Optics Express, vol.13, No.5, 1724-1733(2005)

Yueqing Gu, Wei Chen, Mengna Xia, Hanli Liu, “Effect of photothermal therapy on breast tumor vascular contents: noninvasive monitoring by NIR Spectroscopy”, Photochemistry and Photobiology, Vol 81(3) (2005)

Yueqing Gu, Vikram Kodibagkar, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu, “Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance”, Optics in Health Care and Biomedical Optics, Proceedings of SPIE, vol 5630, Beijing, 2005