词条 | 滕脉坤 |
释义 | 滕脉坤, 男,1956年1月生,教授、博士生导师。 现任中国科技大学生命科学学院院长助理,分子生物学与细胞生物学系常务副主任。中国毒理学会理事,生物毒素毒理专业委员会主任,中国生物物理学会、中国晶体学会会员。 作为访问学者,曾分别在美国麻省理工学院生物系(1986-1988)、美国依里洛依大学厄本-香槟分校生理与生物物理系(1988-1989)、美国普度大学生命科学系(1992)、美国哈佛大学医学院Dana-Farber肿瘤研究所(1996-1997)等进修和交流。多年从事生物大分子晶体学和结构与功能关系研究,主要从事DNA寡聚核苷酸及其DNA-药物复合物的晶体学;病毒晶体学;T-细胞受体及其复合物的晶体学等;葡萄糖异构酶蛋白质工程中的结构测定和蛋白质分子设计等研究;中国尖吻蝮蛇蛇毒蛋白的结构测定和结构与功能关系研究工作。 多年来主持和参与了多项国家和中国科学院的重点和重大课题的研究工作。获教育部高等教育科学技术二等奖(排名第三,2000年);安徽省教育厅科技进步一等奖(排名第三,2000年)。在Immunity, The EMBO Journal, PNAS, Current Biology,Biochemistry, Nucleic Acids Res., Acta Cryst. D, 中国科学,科学通报等国际、国内著名学术刊物共发表论文近五十篇。 研究方向:生化与分子生物学,结构生物学。 发表的代表性文章: 1. Z. L. Zhu, P. Gong, M. K. Teng and L. W. Niu, Purification, crystallization and preliminary crystallographic analysis of AHP IX-bp, a zinc ion and pH-dependent coagulation factor IX binding protein from Agkistrodon halys Pallas venom, Acta Cryst. D59, 547-550, (2003). 2. J. Y. Zang, M. K. Teng and L. W. Niu, Purification, characterization, crystallization and preliminary X-ray diffraction of AHP IX-bp, a novel zinc dependent coagulation factor IX binding protein from the venom of Agkistrodon halys Pallas, Acta Cryst. D59, 730-733, (2003). 3. X. Y. Tu, Q. Q. Huang, X. H. Lou, M. K. Teng and L. W. Niu, (2002), Purification, N-terminal sequencing, crystallization and preliminary X-ray diffraction analysis of atratoxin, a new short-chain α-neurotoxin from the venom of Naja naja atra. Acta Cryst. D58, 839-842. 4. S. J. Liu, Z. L. Zhu, J. P. Sun, Z. Q. Zhu, Q. Q. Huang, M. K. Teng and L. W. Niu, (2002), Purification, crystallization and preliminary X-ray crystallographic analysis of agkaggregin, a C-type lectin-like protein from Agkistrodon acutus venom. Acta Cryst. D58, 675-678. 5. Q. Q. Huang, X. Y. Zhu, N. Li, W. H. Deng, T. B. Chen, P. F. Rao, M. K. Teng and L. W. Niu, (2000), Characterization, crystallization and preliminary X-ray diffraction analysis of Acutohaemolysin, haemolytic toxin from Agkistrodon acutus venom, Acta Cryst. D, 2000, D56: 907-911. 6. X. Y. Zhu, M. K. Teng, L. W. Niu, C. Xu, Y. Z. Wang, (2000), Structure of xylose isomerase from Streptomyces Diastaticus No. 7 strain M1033 at 1.85Å resolution, Acta Cryst. D56, 129-136. 7. 5. G. P. Zhu, C. Xu, M. K. Teng, L. M. Tao, X. Y. Zhu, C. J. Wu, J. Hang, L. W. Niu and Y. Z. Wang, (1999), Increasing the thermostability of D-xylose isomerase by introduction of a proline into the turn of a random coil, Protein Engineering, 2 (8), 635-638.. 8. 6. Q. Q. Huang, M. K. Teng and L. W. Niu, , (1999), Protein crystallization with a combination of hard and soft precipitants, Acta Cryst. D55, 1444-1448. 9. 7. Y. Ghendler, M. K. Teng, J. H. Liu, T. Witte, J. Liu, K. S. Kim, P. S. Kern, H. C. Chang, J. H. Wang and E. L. Reinherz, (1998), Differential thymic selection outcomes stimulated by focal structural alteration in peptide/MHC ligands, Proc. Natl. Acad. Sci. U.S.A., 95, 10061-10066 . 10. 8. M. K. Teng, A. Smolyar, A. G. D. Tse, J. Liu, R. E. Hussey, J. H. Liu, H. C. Cheng, S. G. Nathenson, E. L. Reiherz and J. H. Wang, (1998), Crystal Structure of N15 TCR in Complex with its Peptide/MHC(pMHC) Ligand: Identification of a common docking topology with substantial variation among different TCR-pMHC complexes, Current Biology, 8, 409-412. 11. 9. P. S. Kern, M. K. Teng, A. Smolyar, J. H. Liu, J. Liu, R. E. Hussey, R. Spoerl, H. C. Chang, E. L. Reinherz and J. H. Wang, (1998), Structural basis of CD8 co-receptor function revealed by crystallographic analysis of a murine CD8aa ectodomain fragment in complex with H-2Kb, Immunity, 9, 519-530. 12. 10. W. M. Gong, X. Y. Zhu, S. J. Liu, M. K. Teng and L. W. Niu, (1998), Crystallographic sequence and crystal structure of acutolysin A, a three-disulfide hemorrhagic zinc-metalloproteinase from the snake venom of Agkistrodon acutus, J. Mol. Biol., 283(3), 657-668. 13. 11. W. M. Gong, M. K. Teng and L. W. Niu, , (1997), 0.27nm resolution crystal structure of Haemorrhagin Ⅰ from snake venom of Agkistrodon acutus, 科学通报, 42(4), 333-336. 14. 12. M. K. Teng, Y. C. Liaw, G. A. van der Marel, J. H. van Boom and A. H.-J. Wang, (1989), Effects of the O2' hydroxyl group on Z-DNA conformation: structure of Z-RNA and (araC)-[Z-DNA]. Biochemistry, 28(2), 4923-4928. 15. 13. M. K. Teng, N. Usman, C. A. Frederick and A. H.-J. Wang, (1988), The molecular structure of the complexes of hoechst 33258 and DNA dodecamer d(CGCGAATTCGCG). Nucleic Acids Res. 16(6), 2671-2690. |
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