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词条 薛挺
释义

博士,特任副教授。2004至2009年就读于中国科学技术大学生命学院分子微生物实验室,获博士学位;随后留校从事博士后研究,博士后工作期间获中国博士后科学基金46批面上资助及第三批特别资助;2011年6月任生命科学学院特任副教授。主要从事金黄色葡萄球菌致病性调控的相关研究,研究成果发表于 Infection and Immunity, Medical Microbiology and Immunology, Cell Research等国际学术期刊。

主要研究兴趣

1.金黄色葡萄球菌的群体感应、二元信号系统及转录因子网络对致病性调控的分子机制;

2. 金黄色葡萄球菌中新型small RNA的探寻及其与致病性相关的上下游调控通路;

3. 金黄色葡萄球菌与宿主相互作用的分子机制。

代表性论文

1.T. Xue*, Y. You, D. Hong, H. Sun, and B. Sun*. Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming.Infection and Immunity. (2011) 79:2154-2167.

2.T. Xue*φ, Y. Youφ, F. Shang and B. Sun*. Rot and Agr system modulate fibrinogen- binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325. Medical Microbiology and Immunology. (2011) In press. (φco-1st author)

3.T. Xue*φ, X. Zhangφ, and B. Sun*. QrrB, the novel staphylococal small RNA, couples Agr quorum sensing to virulence regulation. (2011). In preparation. (φco-1st author)

4.T. Xue, L. Zhao, H. Sun, X. Zhou, and B. Sun*. LsrR binding-site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Cell Research. (2009) 19:1258-1268.

5.F. Shangφ, T. Xueφ, H. Sun, L. Xing, S. Zhang, Z. Yang, L. Zhang and B. Sun*. The Staphylococcus aureus GGDEF protein (GdpS) influences protein A gene expression in a c-di-GMP independent manner.Infection and Immunity. (2009) 77:2849-2856.(φco-1st author)

6.L. Zhao, T. Xue, F. Shang, H. Sun, and B. Sun*. Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence.Infection and Immunity. (2010) 78:3506-3515.

7.E. Fei, X. Ma, C. Zhu, T. Xue, J. Yan, Y. Xu, J. Zhou, and G. Wang*. Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression. The Journal of biological chemistry. (2010) 285: 38630-38640.

8. Ma, J., Z. Ren, Y. Ma, L. Xu, Y. Zhao, C. Zheng, Y. Fang, T. Xue, B. Sun, and W. Xiao*. Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. The Journal of biological chemistry. (2009) 284:34600-34606.

9.X. Wang, S. Foday, T. Xue, and B. Sun*. Methylobacterium salsuginis sp. nov., isolated from seawater.International Journal of Systematic Environmental Microbioly (2007) 57:1699-1703.

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