简介

研究方向

职称

主要研究成果

承担研究项目

所获荣誉

代表学术论文

简介

1980-1985 清华大学核子物理工程专业，学士学位

1985-1988 清华大学生物物理专业，硕士学位

1989-1990 美国杜克大学植物遗传系

1991-1994 美国德州大学西南医学中心，生物化学与分子生物学专业，博士学位

1994-1996 美国麻省理工学院(MIT)生物系, 哈佛休斯医学研究所，研究助理

1996-1999 美国格兰素威康研究所结构化学系，一级研究院

1999-2001 美国格兰素威康研究所结构化学系，二级研究员

2001-2002 美国GSK研究所结构科学部，高级研究人员

2002-2007.3 美国Van Andel研究所结构科学部实验室负责人，资深PI/教授

2007.3-2009.12 美国Van Andel研究所结构科学部实验室负责人，杰出PI/教授

2010.1-至今 美国Van Andel研究所结构科学与药物发现中心主任，实验室负责人，杰出PI/教授

2010.7-至今 2009年入选国家千人计划,现担任中国科学院上海药物研究所研究员

研究方向

蛋白质结构与药物开发

职称

千人计划，研究员

主要研究成果

专利:1. Activators of PPAR delta. US Patent Number 6,710,063. Issued 03/23/2004.

2. Activator of PPAR delta. US Patent Number 6,723,740. Issued 04/20/2004.

3. Activator of PPAR delta. US Patent Application Serial Number 10/383,011. Filed 03/06/2003.

4. Crystallized PPARα Ligand Binding Domain Polypeptide and Screening Methods Employing Same. US Patent Application Serial Number 10/467,048. Filed 08/01/2003.

5. Crystallized Glucocorticoid Receptor Ligand Binding Domain Polypeptide and Screening Methods Employing Same. US Patent Application Serial Number 10/484,061. Filed 01/16/2004.

6. Ligands for Orphan Nuclear Hormone Receptor Steroidogenic Factor-1 (SF-1). US Patent Application Serial Number 11/348,207. Filed 02/06/2006.

7. Ligands for Mineralocorticoid Receptor (MR) and Methods for Screening for or Designing MR Ligands. PCT Patent Application Serial Number PCT/US2006/044620. Filed 11/15/2006.

文章:2009年发表ABA受体研究新成果文章“脱落酸受体晶体结构与分子机制” 发表在《自然》封面文章，被《科学》杂志评为2009年十大突破之一。

承担研究项目

1.12/01/07-11/30/12，Van Andel研究所研究项目，项目负责人

2.08/01/09-06/30/13，美国NIH RO1，项目负责人

3.08/01/07-06/30/11，美国NIH RO1，项目负责人

4.07/01/06-07/31/11，美国NIH RO1，项目负责人

5.08/01/05-07/31/10，美国NIH RO1，项目负责人

6.01/01/08 -12/31/09，Schering-Plough Corporation，项目负责人

7.“千人计划” 启动资金, 国家多个重大专项或基金项目

所获荣誉

1993年获美国德州大学西南医学中心the Twenty-Fifth Sigma Xi研究生研究奖1999年获格兰素威康杰出研究奖2001年9月获GSK杰出研究奖

代表学术论文

2009-2011年发表论文

2009-2011年发表论文

1.He Y, Xu Y, Zhang C, Gao X, Dykema, KJ, Martin KR, Ke J, Hudson EA, Khoo SK, Resau JH, Alberts AS, MacKeigan JP, Furge KA, and Xu HE (2011). Identification of a lysosomal pathway that potently modulates glucocorticoid signaling and inflammation response. Science Signaling (2011) (in press).

2.Serkan K, Beddow SA, Samuel VT, Miller P, Previs, SF, Suino-Powell K, Schulman G, Xu HE, Kliewer SA, and Mangelsdorf D (2011) FGF19 is a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (in press)

3.Huh JR, Leung MWL, Huang P, Ryan DA, Krout MR, Malapaka R, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, and Littman DR. (2011). Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity.Nature (in press).

4.Zhou XE, Suino-Powell KM, Xu Y, Chan CW, Kruse SW, Reynolds R, Engel JD, Xu HE. (2010) The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. J Biol Chem. 2010 Nov 9. [Epub ahead of print] (featured as Paper of the week)

5.Pal K, Swaminathan K, Xu HE, Pioszak AA.(2010). 2.Structural basis for hormone recognition by the human CRFR2alpha G protein-coupled receptor. J Biol Chem. 2010 Oct 21. [Epub ahead of print]

6.Melcher K, Zhou XE, and Xu HE (2010) Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling. Current Opinion in Structural Biology (In press).

7.Tolbert WD, Daugherty-Holtrop J, Gherardi E, Vande Woude G, and Xu HE (2010) Structural basis for agonism and antagonism of hepatocyte growth factor. PNAS, 107:13264-9.

8.Melcher K, Xu Y, Ng LM, Zhou XE, Soon FF, Suino-Powell KM, Chinnusamy V, Kovach A, , Cutler SR, Li J, , Yong ELZhu JK, Xu HE (2010) Identification and Mechanism of ABA Receptor Antagonism. Nature Structural& Molecular Biology 17(9):1102-8.

9.Powell E, Huang SX, Xu Y, Rajski SR, Wang Y, Peters N, Guo S, Xu HE, Hoffmann FM, Shen B, Xu W. (2010) Identification and characterization of a novel estrogenic ligand actinopolymorphol A. Biochem Pharmacol. 80(8):1221-9. PMID: 20599778

10.Pal K, Kumar S, Sharma S, Garg SK, Alam MS, Xu HE, Agrawal P, Swaminathan K. (2010). Crystal Structure of Full-length Mycobacterium tuberculosis H37Rv Glycogen Branching Enzyme: INSIGHTS OF N-TERMINAL {BETA}-SANDWICH IN SUBSTRATE SPECIFICITY AND ENZYMATIC ACTIVITY. JBC 285(27):20897-903. EPUB 2010 MAY 5.

11.Pioszak AA, Harikumar KG, Parker NR, Miller LJ, Xu HE. (2010) Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. JBC 285(16):12435-44. Epub 2010 Feb 19. PMID: 20172855

12.Zhou XE, Suino-Powell KM, Li J, He Y, Mackeigan JP, Melcher K, Yong EL, and Xu HE (2010) Identification of SRC3/AIB1 as A Preferred Coactivator for Hormone-Activated Androgen Receptor. JBC, January 19 Epub. (Featured as the cover article and the paper of the week by JBC). Mar 19;285(12):9161-71. PMID: 20086010

13.Schopfer FJ, Cole MP, Groeger A, Chen CS, Woodcock SR, Khoo N, Golin-Bisello F, Motanya UN, Rudolph TK, Rudolph V, Bonacci G, Baker PRS, Batthyany CI, Xu HE, Y. Chen YE, Hallis TM, and Freeman BA (2010) Covalent Peroxisome Proliferator-Activated Receptor γ Binding by Nitro-Fatty Acids: Endogenous Ligands Act as Selective Modulators. JBC, 2010 Apr 16;285(16):12321-33.

14.Epub 2010 Jan 22.Zhou XE, Suino-Powell K, Ludidi PL, McDonnell DP, Xu HE (2010) Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. Protein Expr Purif. 71(1):21-7.

15.Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE (2009) A gate-latch-lock mechanism for hormone signaling by abscisic acid receptors. Nature 2009 Dec 3;462(7273):602-8 (Cover Article, featured as one of top 10 breakthroughs of 2009 by Science). PMID: 19898420

16.Pioszak AA, and Xu HE. (2009) Molecular recognition of parathyroid hormone-related peptide (PTHrP) by the extracellular domain of its G protein-coupled receptor PTH1R. JBC, 2009 Aug 12. [Epub ahead of print] PMID: 19674967

17.Knudsen, BS., Zhao P, Resau J, Cottingham S, Gherardi E, Xu HE, Berghuis B, Daugherty J, Grabinski T, Toro J, Giambernardi T, Skinner RS, Gross M, Hudson E, Kort E, Lengyel E, Ventura A, West RA, Xie Q, Hay R, Vande Woude G, and Cao B. 2009. A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings. Applied Immunohistochemistry and Molecular Morphology 17(1): 56–67.

18.Wang Z, Zhou XE, et al, Xu HE, Mangelsdorf DJ. (2009) Control of Nematode Parasitism by Conserved Nuclear Receptor Signaling. PNAS 106, 9138-43.

19.Miao J, Kanamaluru D, Min G, Yau PM, Ellis E, Storm S, Suino-Powell K, Xu HE, Kemper JK (2009). Stability of Small Heterodimer Partner (SHP) is increased by bile acids and fibroblast growth factor 19. Genes and Development, 23:986-96.

20.Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RV, Xu HE, Turk J, and Semenkovich CF (2009) Identification of the Physiologically Relevant Endogenous Ligand for PPARα in Liver. Cell, 138(3):476-88. PMID: 19646743