词条 | 邵宁生 |
释义 | 人物简介邵宁生,男,1965年2月14日出生,军事医学科学院基础医学研究所研究员,博士研究生导师,生物化学研究室主任。 兼任北京市生物化学与分子生物学学会副理事长,中国生物化学与分子生物学学会RNA专业委员会委员;中国生物医药产业协会委员;《生物化学与生物物理进展》杂志、《中国实验血液学》杂志、《生理科学进展》、《医学分子生物学杂志》编委。 简历1992年军事医学科学院基础医学研究所获博士学位; 1995年7月-1998年4月美国Thomas Jefferson大学和Allegheny大学博士后; 2003以后任职军事医学科学院。 主要研究方向1. 非编码RNA结构与功能研究,主要是miRNA在生命过程及重大疾病发生发展过程中的功能研究。 2. 随机生物文库技术包括随机肽库技术及SELEX技术在重大疾病及传染性病原微生物诊断和治疗方面的应用基础研究。 3. 革兰氏阳性菌毒素产生及其调控机制的研究,这方面的研究对认识革兰氏阳性菌感染的防治具有重要意义。 科研著述与获奖情况先后承担和参加国家“973”课题、国家“863” 课题、国家自然科学基金两地模式项目、国家自然科学基金面上项目、北京市自然科学基金面上项目共计20余项。申请国家发明专利10余项,已经获得授权5项,申请国际PCT专利4项。在国内外专业杂志发表研究论文及综述90余篇,其中国外SCI杂志发表研究论文30余篇。参编学术专著和译著7部。获北京科技进步二等奖2项(2003,2008)。 承担主要科研项目: 1. 国家“973”课题子课题(学术骨干):非编码RNA及其调控网络研究,2005-2010; 2. 北京市科技攻关项目:组织切片SELEX技术用于卵巢癌特异标记物研究,2009-2011; 3. 国家“863”基金课题:耐药金葡菌毒力刺激因子抑制肽的研究,2001-2005; 4. 国家“863”基金课题:致病微生物aptamer特征谱技术的建立及其应用,2006-2008; 5. 国家基金面上课题:体外micoRNA 模型的建立及microRNA对靶mRNA翻译阻抑机制的研究,2005-2007。 发表的主要研究论文1. Li S, Xu H, Ding H, Huang Y, Cao X, Yang G, Li J, Xie Z, Meng Y, Li X, Zhao Q, Shen B, Shao N(corresponding author). Identification of an aptamer targeting hnRNPA1 by tissue slide-based SELEX. J Pathology 2009 Feb (Epub ahead of print) 2. Sun Qiang , Zhang Yan , Yang Guang , Chen Xiaoping , Zhang Yingai, Cao Guojun,Wang Jian, Sun Yanxun, Zhang Peng, Fan Ming, Shao Ningsheng and Yang Xiao(co-corresponding author).Transforming growth factor-b-regulated miR-24 promotes skeletal muscle differentiation. Nucl Acid Res 2008;38:2690-9 3. Cai Y, Shao N, Rao R, Aysola P, Reddy V, Oprea-llies G, Lee L, Okoli J, Partridge E, Reddy ESP, Rao VN. BRCA1 has antitumor activity in TN breast, ovarian and prostate cancers. Oncogene 2007 ;261-7 4. Liu H, Guo S, Roll R, Li J, Diao Z, Shao N, Riley MR, Cole AM, Robinson JP, Snead N, Shen G, Guo P. Phi29 pRNA vector for efficient escort of hammerhead ribozyme targeting surviving in multiple cancer cells. Cancer Biology & Therapy 2007,6: 697-704 5. Tang J, Yu T, Guo L, Xie J, Shao N, He Z. In vitro selection of DNA aptamer against abrin toxin and aptamer-based abrin direct detection. Biosens Bioelectron 2006, 10:1016 6. Li J, Yang G, Li S, Cao G, Zhao Q, Liu X, Fan M, Shen B, Shao N (corresponding author). 3’-Poly(A) tail enhances siRNA activity against exogenous reporter genes in MCF-7 cells. J RNAi and Gene Silencing 2006, 2:195-204 7. Dong J, Liu C, Zhang J, Xin ZT, Yang G, Gao B, Mao CQ, Liu NL, Wang F, Shao NS, Fan M, Xue YN. Selection of Novel Nickel-binding Peptides from Flagella Displayed Secondary Peptide Library. Chem Bio Drug Des. 2006 Aug;68(2):107-12 8. Xie W, Shao N (co-corresponding author), Ma X, Ling B, Wei Y, Ding Q, Yang G, Liu N, Wang H, Chen K.Bacteria endotoxin Lipopolysaccharide induces upregulation of glyceraldehyde- 3- phosphate dehydrogenase in rat liver and lungs. Life Sciences.2006 Oct 4;79(19):1820-7 9. Tang J, Xie J, Shao N, Yan Y. DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods. Electrophoresis. 2006, 29(7):1303-11. 10. Yang G, Gao Y, Dong J, Xue Y, Fan M, Shen B, Liu C, Shao N(corresponding author). A novel peptide isolated from phage library to substitute a complex system for a vaccine against staphylococci infection. Vaccine. 2006, 24(8):1117-23. 11. Yang G, Gao Y, Dong J, Liu C, Xue Y, Fan M, Shen B, Shao N (corresponding author).A novel peptide screened by phage display can mimic TRAP antigen epitope against Staphylococcus aureus infections. J Biol. Chem. 2005, 280: 27431-27435 12. Cao G, Liu Z, Liu X, Zhang J, Zhang D, Liu N, Ding H, Fan M, Shen B, Shao N (corresponding author). Identification of the RNA chaperone activity of recombinant human tumor necrosis factor alpha in vitro. Biochem Biophys Res Commun. 2005, 11;328:573-9. 13. Liu X,Cao G, Ding H, Zhang D, Yang G, Liu N, Fan M, Shen B, Shao N (corresponding author). Screening of functional antidotes of RNA aptamers against bovine thrombin, FEBS Letters. 2004, 562:125-128 14. Yang G, Cheng H, Liu C, Xue Y, Gao Y, Liu N, Gao B, Wang D, Li S, Shen B, Shao N (corresponding author). Inhibition of staphylococcus aureus pathogenesis in vitro and in vivo by RAP-binding peptides, Peptides. 2003, 24:1823-1828 15. Liu X, Zhang D, Cao G, Yang G, Ding H, Liu G, Fan M, Shen B, Shao N (corresponding author). RNA apatamers specific for bovine thrombin. J Mol Recognition. 2003, 16:23-27 16. Wang C, Zhaning M, Yang G, Zhang D, Ding H, Wang H, Fan M, Shen B, Shao N(corresponding author). Single stranded DNA aptmers that bind differentiated but not parental cells: subtractive systematic evolution of ligands by exponential enrichment. J Biotechnol. 2003, 102:15-22 17. Xin Z, Liu C, Dong B, Gao Y, Shao N, Liu W, Zhang J, Dong J, Ling S, Xue Y.A subtractive fluorescence-activated cell-sorting strategy to identify mimotopes of HBV- preS protein from bacterially displayed peptide library. J Immunol Methods. 2004, 293(1-2):13-21. 18. Xin ZT, Liu C, Gao YP, Mao CQ, Zhao A, Zhang J, Shao NS, Ling SG, Yang NX . Identification of mimotopes by screening of a bacterially displayed random peptide library and its use in eliciting an immune response to native HBV-preS Vaccine 2003, 21(27-30):4373-9 19. Zhang J, Zheng L, Zhao A, Gao B, Liu NL, Wang F, Dong J, Xin ZT, Shao NS, Wang HX, Xue YN. Identification of anti-TNFalpha peptides with consensus sequence. BBRC 2003, 31;310(4):1181-7 20. Zhang X, Li Q, Shi Y, Wu J, Shao N, Liu G, Sun M. Specific oligobodies against human brain acetylcholinesterase Brain Res 2003, 989(2):147-51 |
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