邱荣国

著名科学家

主要学历及工作经历:

1983 武汉大学病毒学学士

1986 武汉大学病毒生化硕士

1986-1989 中山医科大学助教、讲师

1990-1992　University of California-San Francisco 研究学者

1992-1997 美国恩尼克斯生物制药有限公司助理科学家

1997 Utrecht University 细胞与分子生物学博士

1998-2000　University of California-Berkeley 博士后

2000-2002 美国寇山生命科学有限公司科学家

2003-2006 美国北进缘有限公司总裁

2006-今 大连理工大学教授、博士生导师

研究领域（研究课题）:

分子靶向抗肿瘤新药的研制；药物作用机制和信号传导研究；细胞的生长和极性调控及癌变机理研究；药物基因组学及药物新靶点的发现；多药耐药性的分子机理研究

主要在研课题：

1．国家863计划目标导向专题：组合生物合成技术开发新型埃博霉素抗肿瘤新药。2007.1-2010.12

2．北京市海淀区科技项目：蛋白磷酸酶I特异性抑制剂TMC作为抗癌药的研制2006.1-2007.12；

3．中美合资企业合作资金：国家一类抗癌新药UTD1的开发及临床研究。2003-；

指导硕、博士生研究方向:

分子靶向抗肿瘤新药的研制；

药物作用机制及信号传导；

药物基因组学；

小GTPases与细胞生长和细胞极性的调控

出版著作和论文:

在国内外权威学术期刊上发表论文30余篇，影响因子总和超过200，被他人引用3000多次。论文所发期刊包括Nature, Cell, Curr. Biol.，Genes & Dev., PNAS, Mol. Cell. Biol., JBC等。

主要论文：

1. P. Li, Z. Deng, Z. Hu and　R.-G. Qiu: In Vivo and In Vitro Studies for Evaluating Metabolic Interaction of a Anticancer Drug Candidate UTD1 on Dog and Human Cytochrome P450 Isoforms, Accepted，Academic J. Shanghai Jiaotong University, 2007

2. L. Tang, R.-G. Qiu, Y. Li, and L. Katz: Generation of Novel Epothilone Analogs with Cytotoxic Activity by Biotransformation, J. Antibiotics 56:16-23, 2003

3. R. Arslanian, L. Tang, S. Blough, R.-G. Qiu, L. Katz and J. R. Carney: A New Cytotoxic Epothilone From Modified Polyketide Synthases Heterologously Expressed in Myxococcusxanthus, J. Nat. Prod. 65:1061-1064, 2002.

4. N. Malecz, P. McCabe, C. Spaargaren, R.-G. Qiu and M. Symons: Synaptojanin 2, a Novel Effector that Regulates Clathrin-mediated Endocytosis, Curr. Biol. 10: 1383-1386, 2000

5. M. Ahram, M. Sameni, R.-G. Qiu, D. Kirn and B. Sloane: Rac1-induced Invasion: Intracellular Proteolysis of Extracellular Matrix, Exp. Cell Res. 260: 292-303, 2000

6. R.-G. Qiu, A. Abo and G. S. Martin: A Human Homologue of the C. elegans Polarity Determinant Par-6 Links Rac and Cdc42 to PKCz Signaling and Cell Transformation, Curr. Biol. 10: 697-707, 2000

7. B. Anand-Apte, B. Zetter, A. Viswanathan, R.-G. Qiu, R. Ruggieri, J. Chen and M. Symons: PDGF and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and ERK Pathways, J. Biol. Chem. 272: 30688-30692, 1997

8. R.-G. Qiu, A. Abo, F. McCormick and M. Symons: Cdc42 Regulates Anchorage-independent Growth and Is Necessary for Ras Transformation, Mol. Cell. Biol. 17: 3449-3458, 1997

9. R.-G. Qiu: All the Roads Leading to Rho: Rho-like GTPases and Cell Signaling (a review), in The Role of Rho-like GTPases in Cell Proliferation and Ras Transformation, p13-73, Published by FEBO-druk, Enschede, the Netherlands, 1997

10. M. Falasca, A. Carvelli, C. Iurisci, R.-G. Qiu, M. Symons and D. Corda: Fast Receptor-induced Formation of Glycerophosphoinositol-4-phosphate, a Putative Novel Intracellular Messenger in the Ras Pathway, Mol. Biol. Cell. 8: 443-453, 1997

11. J. A. Hess, A H. Ross, R.-G. Qiu, M. Symons and J. Exton: Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors, J. Biol. Chem. 272: 1615-1620, 1997

12. M. Hart, S. Sharma, N. elMastry, R.-G. Qiu, P. McCabe, P. Polakis and G. Bollag: Cloning of a Novel GDP/GTP Exchange Factor for Rho GTPase, J. Biol. Chem. 271: 25452-25458, 1996

13. M. Peppelenbosch, L. Tertoolen, A. Vries-Smits, R.-G. Qiu, M. Symons, S. de Laat, and J. Bos: Rac-dependent and -independent Pathways Mediate Growth Factor Induced Ca2+ Influx,　J. Biol. Chem. 271: 7883-7886, 1996

14. R.-G. Qiu, J. Chen, F. McCormick, and M. Symons: A Role for Rho in Ras Transformation, Proc. Natl. Acad. Sci. USA 92: 11781-11785, 1995

15. M. Peppelenbosch, R.-G. Qiu, A. de Vries-Smits, L. Tertoolen, S. de Laat, F. McCormick, A. Hall, M. Symons, and J. Bos: Rac Mediates Growth Factor-Induced Arachidonic Acid Release, Cell 81: 849-856, 1995

16. P. Hawkins, A. Eguinoa, R.-G. Qiu, D. Stokoe, F. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens: PDGF Stimulates an Increase in GTP-Rac via Activation of Phosphoinositide 3-Kinase, Curr. Biol. 5: 393-403, 1995

17. A. Siddiqi, J. Smith, A. Ross, R.-G. Qiu, M. Symons, and J. Exton: Regulation of Phospholipase D in HL60 Cells: Evidence for a Cytosolic Phospholipase D, J. Biol. Chem. 270: 8466-8473, 1995

18. R.-G. Qiu, J. Chen, D. Kirn, F. McCormick, and M. Symons: An Essential Role for Rac in Ras Transformation, Nature 374: 457-459, 1995

19. K. Malcom, A. Ross, R.-G. Qiu, M. Symons, and J. Exton: Activation of Rat Liver Phospholipase D by the Small GTP-binding Protein RhoA, J. Biol. Chem. 269: 25951-25954, 1994

20. C. van Genderen, R. Okamura, I. Farinas, R.-G. Qiu, T. Parslow, L. Bruhn, and R. Grosschedl: Development of Several Organs That Require Inductive Epithelial-mesenchymal Interactions Is Impaired in LEF-1 Deficient Mice, Genes & Dev. 8: 2691-2703, 1994

21.A. Milatovich, R.-G. Qiu, R. Grosschedl, and U. Francke: Gene for a Tissue-specific Transcriptional Activator (EBF or Olf-1), Expressed in early B Lymphocytes, Adipocytes, and Olfactory Neurons, Is Located on Human Chromosome 5, Band q34, and Proximal Mouse Chromosome 11, Mamm. Genome 5: 211-215, 1994

22. T. Jenuwein, W. Forrester, R.-G. Qiu, and R. Grosschedl: The Immunoglobulin m Enhancer Core Establishes Local Factor Access in Nuclear Chromatin Independent of Transcriptional Stimulation, Genes & Dev. 7: 2016-2032, 1993

科研成果及所受奖励:

作为主要负责人成功开发了中国国家一类抗癌新药UTD1。已获得中国食品和药品监督管理局颁发的临床批件并已进入临床试验。

是多项发明专利的发明人。

其它奖励：

2000-2002 美国癌症学会Diane Beardsley 研究奖

1998-1999 美国卫生研究院（NIH）博士后研究奖（NRSA）

在读硕士、博士人数:n