牛 雪 梅 (Xuemei NIU)

1972年6月出生于广西桂林，研究员，云南大学学术学科带头人。

Laboratory for Conservation and Utilization of Bio-resources

Yunnan University

Kunming 650091

Yunnan, China

教育和工作经历

1989年9月-1993年7月, 广西师范大学化学系, 获理学学士

1993年9月-1996年7月, 广西师范大学化学系, 获理学硕士, 有机化学(药物合成)

1996年8月-1999年2月, 广西师范大学化学化工系, 讲师, 有机化学

1999年3月-2001年12月, 中国科学院昆明植物研究所, 获理学博士, 植物化学

2002年1月-2003年6月, 中国科学院昆明植物研究所, 助理研究员, 植物化学, 天然产物化学

2003年7月-2004年2月, 中国科学院昆明植物研究所, 副研究员, 植物化学, 天然产物化学

2004年3月- 2004年9月, 香港中文大学中医学院, 博士后, 高等真菌的次生代谢产物

2004年10月-2006年3月, 德国莱布尼兹天然产物及感染生物学研究所生物有机化学系, DAAD-Leibniz博士后, 微生物次生代谢产物

2006年4月-2007年7月, 德国马普化学生态研究所生物化学系, 博士后, 化学生态学

2007年11月--, 云南大学生物资源保护与利用重点实验室, 研究员, 次生代谢产物及功能

EDUCATION AND EXPERIENCE:

09/1989-07/1996, Studies of Chemistry at Department of Chemistry, Guangxi Normal University, China:

Master’s thesis on 'synthesis of allantoin’

07/1996-03/1999, Lecturer at Department of Chemistry, Guangxi Normal University, Guilin, China

03/1999-12/2001, PhD thesis at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences

01/2002-06/2003, Assistant Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences

07/2003-12/2007, Associate Professor at State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences

03/2004-09/2004, Postdoctoral Fellow at School of Chinese Medicine, The Chinese University of Hongkong,

10/2004-03/2006, Postdoctoral Fellow at Leibniz Institute for Natural Product Research and Infection Biology Hans-Kn?ll-Institute (HKI),Jena, Germany

04/2006-07/2007, Postdoctoral Fellow at Department of Biochemistry, & Research Group Biosynthesis/NMR, Max Planck for Chemical Ecology, Jena, Germany

11/2007-present, Professor at Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, China

AWARD：

2004.10-2006.3, Postdocoral fellowship by German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD)-Leibniz

主要研究方向：

微生物和植物中的天然产物的分离和结构鉴定

捕食线虫真菌的化学防御机制

应用酶和微生物的生物转化

植物与相关微生物之间的化学相互作用

RESEARCH INTERESTS：

Isolation and structure elucidation of natural products from microorganisms and plants in Yunnan

Use of enzymes and microorganisms for biotransformations

Chemical defense mechanism of nematode-trapping fungi

Chemical interaction between plants and the associated microorganisms

承担的主要科研项目：

目前承担或参与国家自然科学基金委、云南省科技厅等在研项目。

PUBLICATIONS (2002-):

1. Xuemei Niu, Hans-Martin Dahse, Klaus-Dieter Menzel, Olivier Lozach, Grit Walther, Laurent Meijer, Susanne Grabley, and Isabel Sattler. “Butyrolactone I Derivatives from Aspergillus terreus Carrying an Unusual Sulfate Moiety”, Journal of Natural Products, 2008,71, 689-692.

2. Xueshi Huang, Jian He, Xuemei Niu, Klaus-Dieter Menzel, Hans-Martin Dahse, Susanne Grabley, Hans-Peter Fiedler, Isabel Sattler, and Christian Hertweck. “Benzopyrenomycin, a Cytotoxic Bacterial Polyketide Metabolite with a Benzo[a]pyrene-Type Carbocyclic Ring System”. Angewandte Chemie Internationaol Edition, 2008, 47, 1-5.

3. Sheng-Hong Li, Xuemei Niu, Stefan Zahn, Jonathan Gershenzon, Jennie Weston, Bernd Schneider. “Diastereomeric stilbene glucoside dimers from the bark of Norway spruce (Picea abies)”. Phytochemistry, 2008, 69, 772-782.

4. Xuemei Niu, Shenghong Li, Helmar G?rls, Dieter Schollmeyer, Matthias Hilliger, Susanne Grabley, Isabel Sattler. “Abyssomicin E, a highly functionalized polycyclic metabolite from Streptomyces species“. Organic Letters, 2007, 9(13), 2437-2440.

5. Xuemei Niu, Shenghong Li, Handong Sun, Chuntao Che. “Two new lanostanoids from Ganodermaresinaceum”.Journal of Asian Natural Products Research, 2007, 9(7), 659-664.

6. Yu Zhao, Xuemei Niu, Liping Qian, Zeyuan Liu, Qinshi Zhao and Handong Sun. “Synthesis and cytotoxicity of some new eriocalyxin B derivatives”. European Journal of Medicinal Chemistry, 2007, 42(4), 494-502.

7. Xuemei Niu, Shenghong Li, Handong Sun, Chuntao Che. “Prenylated phenolics from Ganoderma fornicatum”. Journal of Natural Products, 2006, 69(9), 1364-1365.

8. Jieming Zou, Lisheng Wang, Xuemei Niu, Handong Sun, Yajian Guo. “Phenylethanoid glycosides from Picria felterrae Lour”. Journal of Integrative Plant Biology, 2005, 47(5), 632-636.

9. Jianchao Chen, Xuemei Niu, Zhongrong Li, Minghua Qiu. “Four new cucurbitane glycosides from Hemsleya jinfushanensis”. Planta Medica, 2005, 71(10), 983-986.

10. Weilie Xiao, Shenghong Li, Xuemei Niu, Yu Zhao, Handong Sun. ”Rapulasides A and B, two novel intermolecular rearranged biiridoid glucosides from the roots of Heracleum rapula”. Tetrahedron Letters, 2005, 46, 5743-5746.

11. Shenghong Li, Jia Wang, Xuemei Niu, Yunheng Shen, Hongjie Zhang, Handong Sun, Malin Li, Qine Tian, Yang Lu, Peng Cao, and Qitai Zheng. Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) Hara. Organic Letters, 2004, 6, 4327-4330.

12. Xuemei Niu, Minghua Qiu, Zhongrong Li,Yang Lu, Peng Cao, Qitai Zheng. ”Two novel 3,4-seco-trinorlanostane triterpenoids isolated from Ganoderma fornicatum”. Tetrahedron Letters, 2004, 45(14), 2989-2993.

13. Xuemei Niu, Shenghong Li, Lixin Wu, Ling Li, Lihui Gao, Handong Sun. ”Two new coumarin derivatives from the roots of Heracleum rapula”. Planta Medica, 2004, 70(6), 578-581.

14. Xuemei Niu, Shenghong Li, Zhi Na, Zhongwen Lin, Handong Sun. “Two novel ent-abietane diterpenoids from Isodon xerophilus”.Helvetica Chimica Acta, 2004, 87(8), 1951-1957.

15. Gang Xu, Liyan Peng, Xuemei Niu, Qinshi Zhao, Rongtao Li, Handong Sun. ”Novel diterpenoids from Salvia dugesii”. Helvetica Chimica Acta, 2004, 87(4), 949-955.

16. Xuemei Niu, Shenghong Li, Qinshi Zhao, Shuangxi Mei, Zhongwen Lin, Handong Sun, Yang Lu, Cheng Wang, Qitai Zheng, ”Novel ent-Abietane Diterpenoids from Isodon eriocalyx var. laxiflora”. Helvetica Chimica Acta, 2003, 86(2), 299-306.

17. Xuemei Niu, Shenghong Li, Zhi Na, Shuangxi Mei, Qinshi Zhao, Handong Sun, ”Chemical Constituents from Isodon eriocalyx var. laxiflora”. Chinese Traditional and Herbal Drugs, 2003, 34(4),12-15.

18. Shenghong Li, Hongjie Zhang, Xuemei Niu, Ping Yao, Handong Sun, and Harry H. S. Fong, “Chemical Constituents of Two Taxaceae Plants: Amentotaxus yunnanensis and Torreya yunnanensis”. Journal of Natural Products, 2003, 66(7), 1002-1005.

19. Shenghong Li, Hongjie Zhang, Ping Yao, Xuemei Niu, Wei Xiang, and Handong Sun, “Two New Lignans from Taxus yunnanensis”. Chinese Journal of Chemistry, 2003, 21(7), 926-930.

20. Shenghong Li, Hongjie Zhang, Xuemei Niu, Ping Yao, Handong Sun, and Harry H. S. Fong, “Novel Taxanes from the Chinese Yew Taxus yunnanensis”. Tetrahedron, 2003, 59(1), 37-45.

21. Quanbin Han, Bei Jiang, Jixia Zhang, Xuemei Niu, and Handong Sun, “Two Novel ent-kaurene Diterpenoids from Isodon rubescens”. Helvetica Chimica Acta, 2003, 86(5), 773-777.

22. Xuemei Niu, Shenghong Li, Qinshi Zhao, Zhongwen Lin, Handong Sun, Yang Lu, Cheng Wang, and Qitai Zheng, ”Two Novel ent-Kaurane Diterpenoids Isolated from Isodon eriocalyx var. laxiflora”. Tetrahedron Letters, 2002, 43(4), 661-664.

23. Xuemei Niu, Shenghong Li, Qinshi Zhao, Zhongwen Lin, Handong Sun, Yang Lu, Lili Zhang, Qitai Zheng, ”A Novel Diterpene Hydroperoxide, Glutinosin C, from Isodon glutinosa”. Tetrahedron Letters, 2002, 43(30), 5277-5280.

24. Xuemei Niu, Shenghong Li, Malin Li, Qinshi Zhao, Shuangxi Mei, Zhi Na, Sujun Wang, Zhongwen Lin, and Handong Sun, ”Cytotoxicent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora”. Planta Medica, 2002, 68(6), 528-533.

25. Xuemei Niu, Shenghong Li, Shuangxi Mei, Zhi Na, Qinshi Zhao, Zhongwen Lin, Handong Sun, ”Cytotoxic 3,20-Epoxy-ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflora”. Journal of Natural Products, 2002, 65(12), 1892-1896.

26. xuemei niu, shenghong li, bei jiang, qinshi zhao, handong sun, ”constituents from the Roots of Heracleum rapula Franch”. Journal of Asian Natural Products Research, 2002, 4(1), 33-41.

27. Shenghong Li, Hongjie Zhang,Shengxiang Qiu, Xuemei Niu, Bernard D. Santarsiero, Andrew D Mesecar, Harry H. S. Fong, Norman R. Farnsworth, Handong Sun, ”Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus”. Tetrahedron Letters, 2002,43(29), 5131-5134.

28. Shenghong Li, Xuemei Niu, Liyan Peng, Hongjie Zhang, Pin Yao, and Handong Sun, ”Ent-kaurane Diterpenoids from the Leaves of Isodon xerophilus”.Planta Medica, 2002, 68(10), 946-948.

29. Shenghong Li, Hongjie Zhang, Xuemei Niu, Ping Yao, Handong Sun, and Harry H. S. Fong, ”Taxuyunnanines S-V, New Taxoids from Taxus yunnanensis”. Planta Medica, 2002, 68(3), 253-257.

30. Shuangxi Mei, Bei Jiang, Xuemei Niu, Malin Li, Zhi Na, Zhongwen Lin, Chaoming Li, Handong Sun, ”Abietane Diterpenoids from Coleus xanthanthus”. Journal of Natural Products, 2002, 65(5), 633-637.

31. Zhi Na, Wei Xiang, Xuemei Niu, Shuangxi Mei, Zhongwen Lin, Chaoming Li, Handong Sun. ”Diterpenoids from Isodon enanderianus”. Phytochemistry, 2002, 60(1), 55-60.

32. Zhi Na, Bei Jiang, Xuemei Niu, Zhongwen Lin, Chaoming Li, Handong Sun. ”Two New ent-Kauranoids from Isodon tenuifolia”. Acta Botanica Sinica, 2002, 44(4), 477-480.

33. Shenghong Li, Hongjie Zhang, Ping Yao, Xuemei Niu, Handong Sun, and Harry H. S. Fong, ”Non-taxane Compounds from Taxus yunnanensis”. Journal of Asian Natural Products Research, 2002, 4(2), 147-154.