丁忠仁(1968～)， 河南淮滨人。复旦大学上海医学院研究员，博士生导师。美国血液学会(ASH)、国际血栓与止血学会(ISTH)会员。国家自然科学基金心血管药理专业同行评议专家。于1990年、1993年和1998年分别从河南医科大学、中山医科大学分别获得医学学士、硕士和博士学位。

1993年7月－ 1995年8月在广州白云山制药总厂药物研究所从事抗生素的新药研发。1998年9月起在北京协和医院从事”纤溶酶原激活物抑制剂1 （PAI-1）多态性的研究”，2000年8月被评为“副研究员”。2000年8月起在在美国天普大学医学院Sol Sherry血栓研究中心从事血小板ADP受体的激活机制和以P2Y12受体为靶点的抗血小板药研究。2007年9月起在复旦大学上海医学院从事科研、教学工作。主要研究血小板激活的机制、抗血小板药作用机理和以P2Y12受体为靶点的抗血小板药的研发。与北京化工大学合作，首次报道了一种同时作用于血小板P2Y12受体和磷酸二酯酶、具有抗血小板活性的全新化合物BF0801。通过对BF0801进行结构改造，得到一种作用机制类似、活性更强的新化合物BF061，其抗血栓活性和氯吡格雷相似（小鼠FeCl3血栓模型），但出血副作用更小。承担国家自然科学基金（面上项目）两项、上海市科委“浦江计划”人才项目一项、科技部新药创制子课题一项， 2008年首批首轮入选“上海高校特聘教授”(东方学者)。

近年来发表的文章:

1. Liang Hu, Zhichao Fan, Hongguang Du, Ran Ni, Si Zhang, Kanhua Yin, Jianqin Ye, Yan Zhang, Xunbin Wei, Xiaohui Zhang, Peter L. Gross, Satya P. Kunapuli, Zhongren Ding*. BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thromb Haemost2011; 106(6): 1203-14(*corresponding author)

2. Guocheng Liu, Jiaxi Xu, Ki Chul Park, Ning Chen, Si Zhang, Zhongren Ding, Feng Wang，Hongguang Du. Novel synthesis approach and antiplatelet-activity evaluation of 6-alkylamino-2,4-dialkyl(aryl)thiopyrimidines. Tetrahedron, 2011;67: 5156-5161

3. Zhang S, Hu L, Du H, Guo Y, Zhang Y, Niu H, Jin J, Zhang J, Liu J, Zhang X, Kunapuli SP, Ding Z*. BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism. Thromb Haemost2010; 104(4): 845 – 57 (*corresponding author)

4.Zhongren Ding, Yamini S. Bynagari, Sripal R. Mada, Joseph A Jakubowski, Satya P. Kunapuli. Involvement of extracellular cysteines and oligomeric structures in P2Y12 receptor antagonizing effects of clopidogrel and prasugrel. J Thromb Haemost2009; 7(1): 232 – 4

5. Zhongren Ding, Soochong Kim, Satya P. Kunapuli. Identification of a potent P2Y12 receptor inverse agonist at constitutively active mutant of human P2Y12 receptor. Mol Pharmacol2006; 69(1): 338 - 345.

6. Zhongren Ding, Florin Tuluc, Kavita R. Bandivadekan, Lili Zhang, Jianguo Jin, Satya P. Kunapuli. Arg333 and Arg334 in the C-terminus of the human P2Y1 receptor are crucial for Gq coupling. Am J Physiol - Cell Physiol. 2005; 288(3): C559-67.

7. Zhongren Ding*, Jia-Qi Pan. Distribution of PAI-1 promoter 4G/5G polymorphism in Chinese and functional characterization using a luciferase reporter vector. Ann Hematol: 2005; 84(3): 183-187 (*corresponding author).

8. Haripriya Shankar, Swaminathan Murugappan, Jianguo Jin, Soochong Kim Zhongren Ding, Kevin Wickman, Satya P. Kunapuli. Role of G-protein gated inwardly- rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses.Blood2004: 104(5):1335-43.

9. John Meshki, Florin Tuluc, Ovidiu Bredetean, Zhongren Ding, Satya P. Kunapuli. Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y(2) receptor. Am J Physio l - Cell Physiol2004; 286(2): C264-271.

10. Robert T. Dorsam, Swaminathan Murugappan, Zhongren Ding, Satya P. Kunapuli. Clopidogrel: interactions with the P2Y12 receptor and clinical relevance. Hematology2003; 8(6): 359 - 365.

11. Satya P. Kunapuli, Zhongren Ding, Robert T. Dorsam, Soochong Kim, Swaminathan Murugappan, Todd M. Quiton. ADP receptors-Targets for developing antithrombotic agents. Curr Pharm Design2003; 9 (28): 2303 - 16.

12. Zhongren Ding, Soochong Kim, Robert T. Dorsam, Jianguo Jin, and Satya P. Kunapuli. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, C17 and C270. Blood 2003; 101 (10): 3908-3914.