基本介绍

研究内容

发表文章(期刊文章 会议全文)

基本介绍

臧玉峰　医学博士

杭州师范大学认知与脑疾病研究中心（Center for Cognition and Brain Disorders, CCBD）副主任

北京师范大学认知神经科学与学习国家重点实验室（研究员，博士生导师）

浙江大学理学院（兼职教授，2006-)

首都医科大学精神病学系（系务委员，2007-)

地址：北京新街口外大街19号

研究兴趣：静息状态功能磁共振的计算方法学及其在神经精神疾病的应用研究

研究内容

目前主要研究兴趣为静息状态功能磁共振计算方法及其在精神疾病中的应用研究。针对静息态脑功能磁共振信号特点，与同事提出“局部一致性”（regional homogeneity, ReHo）计算方法（Zang et al., 2004），该方法主要适用于静息状态功能磁共振，但也可用于任务状态。另外，还提出了“低频振幅”的计算方法（amplitude of low frequency fluctuation, ALFF），这两种方法均已经被用于神经精神障碍的研究。臧玉峰课题组宋晓伟、严超赣等人将ReHo和ALFF方法，以及功能连接等方法集成为一个针对静息态脑功能磁共振数据处理的免费软件（Resting-State fMRI Data Analysis Toolkit (REST), 在应用研究方面，臧玉峰博士与国内多家医疗单位的专家展开了合作，内容涉及注意缺陷多动障碍、抑郁症、精神分裂症、Alzheimer氏病、癫痫、帕金森氏病等。

发表文章

期刊文章

Wang J, Wang L, Zang Y, Yang H, Tang H, Gong Q, Chen Z, Zhu C, He Y. Parcellation-dependent small-world brain functional networks: A resting-state fMRI study. Hum Brain Mapp. 2008 Jul 22. [Epub ahead of print]

Wu T, Long X, Zang Y, Wang L, Hallett M, Li K, Chan P. Regional homogeneity changes in patients with Parkinson's disease. Hum Brain Mapp. 2008 Jul 22. [Epub ahead of print]

Han Y, Yang Y, Lv YT, Zhu CZ, He Y, Tang HH, Gong QY, Luo YJ, ZANG YF, Dong Q. Gray matter density and white matter integrity in pianist’s brain: a combined structural and diffusion tensor MRI study. Neurosci Lett. 2008 (In press)

Cao Q, Zang Y, Zhu C, Cao X, Sun L, Zhou X, Wang Y. Alerting deficits in children with attention deficit/hyperactivity disorder: Event-related fMRI evidence. Brain Res. 2008 Jul 11;1219:159-68.

Zou QH, Zhu CZ, Yang Y, Zuo XN, Long XY, Cao QJ, Wang YF, Zang YF. An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: Fractional ALFF. J Neurosci Methods. 2008 Jul 15;172(1):137-41.

Long XY, Zuo XN, Kiviniemi V, Yang Y, Zou QH, Zhu CZ, Jiang TZ, Yang H, Gong QY, Wang L, Li KC, Xie S, Zang YF. Default mode network as revealed with multiple methods for resting-state functional MRI analysis. J Neurosci Methods. 2008 Jun 30;171(2):349-55.

Lv YT, Yang H, Wang DY, Li SY, Han Y, Zhu CZ, He Y, Tang HH, Gong QY, Zang YF. Correlations in spontaneous activity and gray matter density between left and right sensoritmotor areas of pianists. Neuroreport. 2008 Apr 16;19(6):631-4..

Wang L, Zhu C, He Y, Zang Y, Cao Q, Zhang H, Zhong Q, Wang Y. Altered small-world brain functional networks in children with attention-deficit/hyperactivity disorder. Hum Brain Mapp. 2008 Jan 24; [Epub ahead of print]

Zhu CZ, Zang YF, Cao QJ, Yan CG, He Y, Jiang TZ, Sui MQ, Wang YF. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder. Neuroimage. 2008 Mar 1;40(1):110-20.

Yuan Y, Zhang Z, Bai F, Yu H, Shi Y, Qian Y, Zang Y, Zhu C, Liu W, You J. White matter integrity of the whole brain is disrupted in first-episode remitted geriatric depression. Neuroreport. 2007 Nov 19;18(17):1845-9.

Tian L, Jiang T, Liang M, Zang Y, He Y, Sui M, Wang Y. Enhanced resting-state brain activities in ADHD patients: A fMRI study. Brain Dev. 2007 Nov 28; [Epub ahead of print]

Zuo XN, Zhu CZ, Zang YF. Mean mutual information ratio: a new method for ranking components of ICA. Progress in Natural Science 2007 17:154-160.

Wu T, Zang Y, Wang L, Long X, Li K, Chan P. Normal aging decreases regional homogeneity of the motor areas in the resting state. Neurosci Lett. 2007 Aug 23;423(3):189-193.

Wu T, Zang Y, Wang L, Long X, Hallett M, Chen Y, Li K, Chan P. Aging influence on functional connectivity of the motor network in the resting state. Neurosci Lett. 2007 Jul 18;422(3):164-8.

Chen C, Zhou X, Chen C, Dong Q, Zang Y, Qiao S, Yang T, Dong Q. The neural basis of processing anomalous information. NeuroReport. 2007 May 28;18(8):747-51.

Yang H, Long XY, Yang YH, Yan H, Zhu CZ, Zhou XP, Zang YF, Gong QY. Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI. Neuroimage. 2007 May 15;36(1):144-52.

Zhou X, Chen C, Zang Y, Dong Q, Chen C, Qiao S, Gong Q. Dissociated brain organization for single-digit addition and multiplication. Neuroimage. 2007 Apr 1;35(2):871-80.

He Y, Wang L, Zang Y, Tian L, Zhang X, Li K, Jiang T. Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study. Neuroimage. 2007 Apr 1;35(2):488-500.

Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, Tian LX, Jiang TZ, Wang YF. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev. 2007 Mar;29(2):83-91.

Xie S, Xiao JX, Gong GL, Zang YF, Wang YH, Wu HK, Jiang XX. Voxel-based detection of white matter abnormalities in mild Alzheimer disease. Neurology. 2006 Jun 27;66(12):1845-9.

Cao Q,Zang Y, Sun L, Sui M, Long X, Zou Q, Wang Y. Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport. 2006 Jul 17;17(10):1033-6.

Tian L, Jiang T, Wang Y, Zang Y, He Y, Liang M, Sui M, Cao Q, Hu S, Peng M, Zhuo Y. Altered resting-state functional connectivity patterns of anterior cingulate cortex in adolescents with attention deficit hyperactivity disorder. Neurosci Lett. 2006 May 29;400(1-2):39-43.

Wang L, Zang Y, He Y, Liang M, Zhang X, Tian L, Wu T, Jiang T, Li K. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI. Neuroimage. 2006 Jun;31(2):496-504.

He Y, Zang Y, Jiang T, Gong G, Xie S, Xiao J. Handedness-related functional connectivity using low-frequency blood oxygenation level-dependent fluctuations. Neuroreport. 2006 Jan 23;17(1):5-8.

Gong G, Jiang T, Zhu C, Zang Y, He Y, Xie S, Xiao J. Side and handedness effects on the cingulum from diffusion tensor imaging. Neuroreport. 2005 16:1701-5.

Zang YF, Jin Z, Weng XC, Zhang L, Zeng YW, Yang L, Wang YF, Seidman LJ, Faraone SV. Functional MRI in Attention Deficit Hyperactivity Disorder: Evidence for Hypofrontality. Brain Dev. 2005 27:544-50.

Sun L, Jin Z, Zang YF, Zeng YW, Liu G, Yang L, Seidman LJ, Faraone SV, Wang YF. Differences between Attention-deficit Disorder with and without hyperactivity: A 1H-magnetic resonance spectroscopy study. Brain Dev. 2005, 27:340-4.

Lu YL, Jiang TZ, and Zang YF, Single-Trial Variable Model for Event-Related fMRI Data Analysis, IEEE Transactions on Medical Imaging. 2005, 24:236-245

Gong GL, Jiang TZ, Zhu CZ, Zang YF, Wang F, Xie S, Xiao JX and Guo XM. Asymmetry Analysis of Cingulum Based on Scale-Invariant Parameterization by Diffusion Tensor Imaging. Human Brain Mapping. 2004 28;24(2):92-98

王培织, 臧玉峰, 蒋田仔，朱朝喆，王建哲，田丽霞，梁猛，贺永. AFNI 和 SPM 脑图像空间标准化的效果比较. 中国医学影像技术. 2004, 20:1650-1653

Zang YF, Jiang TZ, Lu YL, He Y, Tian LX, Regional Homogeneity Approach to fMRI Data Analysis. NeuroImage, 2004, 22:394-400.

Jiang TZ*, Yong He Y*, Zang YF* and Weng XC. Modulation of functional connectivity during the resting state and the motor task. Human Brain Mapping, 2004, 22:63–71.(*: Equal contribution)

Lu YL, Jiang TZ and Zang YF, Split-merge based region growing method for fMRI activation detection, Human Brain Mapping, 2004, 22(4):271-9.

Lu YL, Jiang TZ, Zang YF, Region Growing Method for the Analysis of fMRI Data. NeuroImage. 2003, 20: 455-465.

Zang YF, Jia FC, Weng XC, Li EZ, Wang YF, Hazeltine E, Ivry R. Functional organization of the primary motor cortex characterized by event-related fMRI during movement preparation and execution. Neurosci Lett 2003, 337:69–72.

Gu Y, Zang YF, Weng XC, Jia FC, Li EZ, Wang JJ. Involvement of secondary motor areas in externally-triggered single-finger movements of dominant and non-dominant hands. Chinese Science Bulletin 2003, 48:1569-1575

Lu YL, Zang YF, Jiang TZ, A Modified Temporal Self-Correlation Method for Analysis of fMRI Time Series, NeuroInformatics. 2003, 1, 259-270.

Zang YF, Gu BM, Qian QJ, Wang YF. Objective Measurement of the Balance Dysfunction in Attention Deficit Hyperactivity Disorder Children. Chinese Journal of Clinical Rehabilitation. 2002; 6(9):1372-3.

Jin Z, Zang YF, Zeng YW, Zhang L, Wang YF. Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a (1)H-magnetic resonance spectroscopy study. Neurosci Lett 2001 Nov 23; 315:45-8.

Cui SZ, Li EZ, Zang YF, Weng XC, Ivry R, Wang JJ. - Both sides of human cerebellum involved in preparation and execution of sequential movements.NeuroReport 2000; 11:3849-3853.

会议全文

Zhu CZ, Zang YF, Liang M, Tian LX, He Y, Sui MQ, et al. Discriminative Analysis of Brain Function at Resting-state for Attention Deficit/Hyperactivity Disorder. In: Duncan J, Gerig G, editors. MICCAI 2005, LNCS 3750. Berlin: Springer-Verlag; 2005. p. 468-75.

He Y, Zang YF, Jiang TZ, Liang M, Gong GL. Detecting Functional Connectivity of the Cerebellum Using Low Frequency Fluctuations (LFFs). In: Barillot C, Haynor DR and Hellier P editors. MICCAI 2004, LNCS 3217. Berlin: Springer-Verlag; 2004. p. 907-15.

He Y, Zang YF, Jiang TZ, Lu YL, Weng XC, Detection of Functional Networks in the Resting Brain. 2nd IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'04), April 15-18, 2004, Arlington, USA.